Potent mammalian cerebroprotection and neuronal cell death inhibition are afforded by a synthetic antioxidant analogue of marine invertebrate cell protectant ovothiols

European Journal of Neuroscience

Volumn 18, Issue 5, 2003, Pages 1110-1120

  Vamecq, Joseph ^a,b   Maurois, Pierre ^c   Bac, Pierre ^c   Bailly, Fabrice ^d   Bernier, Jean Luc ^d   Stables, James P ^e   Husson, Isabelle ^f   Gressens, Pierre ^f  

^a INSERM   (France)

^b UNIV LILLE   (France)

^c UNIVERSITÉ PARIS SACLAY   (France)

^d UNITÉ DE CATALYSE ET DE CHIMIE DU SOLIDE   (France)

^e Preclinical Pharmacological Section   (United States)

^f HÔPITAL ROBERT DEBRÉ   (France)

Author keywords

Developing brain; Ovothiol; Oxidative stress; Recycling mechanisms; Thioredoxin

Indexed keywords

1 METHYL 2 (3 TRIFLUOROMETHYLPHENYL) 4 MERCAPTOIMIDAZOLE; 4 AMINOBUTYRIC ACID; CALCIUM CHANNEL BLOCKING AGENT; ETHOSUXIMIDE; GLUTATHIONE; IBOTENIC ACID; MFP 4MI; NEUROPROTECTIVE AGENT; OVOTHIOL A; PHENOBARBITAL; PHENYTOIN; SODIUM CHANNEL; SODIUM CHANNEL BLOCKING AGENT; THIOL DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; AUDIOGENIC SEIZURE; BRAIN INJURY; BRAIN MATURATION; DRUG POTENCY; FEMALE; GRAY MATTER; INVERTEBRATE; MALE; MOUSE; NERVE CELL NECROSIS; NEUROPROTECTION; NEUROTOXICITY; NEWBORN; NONHUMAN; PRIORITY JOURNAL; WHITE MATTER;

ANIMALS; ANIMALS, NEWBORN; BEHAVIOR, ANIMAL; BENZIMIDAZOLES; BRAIN; BRAIN INJURIES; CELL DEATH; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EPILEPSY, REFLEX; EXCITATORY AMINO ACID AGONISTS; FOOD, FORMULATED; HYDROGEN PEROXIDE; IBOTENIC ACID; IN SITU NICK-END LABELING; MAGNESIUM DEFICIENCY; METHYLHISTIDINES; MICE; MICE, INBRED STRAINS; NEUROPROTECTIVE AGENTS; OXIDATION-REDUCTION; PYROGALLOL; PYRUVATE DECARBOXYLASE; RANDOM ALLOCATION; ROTATION; THIOREDOXIN; TIME FACTORS;

EID: 0141502213     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.2003.02846.x     Document Type: Article

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