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Volumn 35, Issue 1, 2009, Pages 41-47

γH2AX and cleaved PARP-1 as apoptotic markers in irradiated breast cancer BT474 cellular spheroids

Author keywords

H2AX; Apoptosis; Breast cancer cells; BT474; Cell spheroids; PARP; Radiation effects

Indexed keywords

GAMMA HISTONE H2AX; HISTONE H2AX; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; UNCLASSIFIED DRUG; H2AFX PROTEIN, HUMAN; HISTONE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PARAFFIN; PARP1 PROTEIN, HUMAN; TUMOR MARKER;

EID: 67649435451     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo_00000311     Document Type: Article
Times cited : (25)

References (38)
  • 1
    • 0030871780 scopus 로고    scopus 로고
    • Apoptosis: An indicator of radiosensitivity in vitro?
    • Olive PL and Durand RE: Apoptosis: an indicator of radiosensitivity in vitro? Int J Radiat Biol 71: 695-707, 1997.
    • (1997) Int J Radiat Biol , vol.71 , pp. 695-707
    • Olive, P.L.1    Durand, R.E.2
  • 2
    • 0033929767 scopus 로고    scopus 로고
    • Radiation-induced apoptosis
    • Verheij M and Bartelink H: Radiation-induced apoptosis. Cell Tissue Res 301: 133-142, 2000.
    • (2000) Cell Tissue Res , vol.301 , pp. 133-142
    • Verheij, M.1    Bartelink, H.2
  • 3
    • 0035527317 scopus 로고    scopus 로고
    • New concepts in radiation-induced apoptosis: 'premitotic apoptosis' and 'postmitotic apoptosis'
    • Shinomiya N: New concepts in radiation-induced apoptosis: 'premitotic apoptosis' and 'postmitotic apoptosis'. J Cell Mol Med 5: 240-253, 2001.
    • (2001) J Cell Mol Med , vol.5 , pp. 240-253
    • Shinomiya, N.1
  • 6
    • 2342459790 scopus 로고    scopus 로고
    • DNA damage-induced apoptosis
    • Norbury CJ and Zhivotovsky B: DNA damage-induced apoptosis. Oncogene 23: 2797-2808, 2004.
    • (2004) Oncogene , vol.23 , pp. 2797-2808
    • Norbury, C.J.1    Zhivotovsky, B.2
  • 7
    • 14644407525 scopus 로고    scopus 로고
    • The role of apoptosis in cancer development and treatment response
    • Brown JM and Attardi LD: The role of apoptosis in cancer development and treatment response. Nat Rev 5: 231-237, 2005.
    • (2005) Nat Rev , vol.5 , pp. 231-237
    • Brown, J.M.1    Attardi, L.D.2
  • 8
    • 24044438464 scopus 로고    scopus 로고
    • Apoptotic pathways and therapy resistance in human malignancies
    • Viktorsson K, Lewensohn R and Zhivotovsky B: Apoptotic pathways and therapy resistance in human malignancies. Adv Cancer Res 94: 143-196, 2005.
    • (2005) Adv Cancer Res , vol.94 , pp. 143-196
    • Viktorsson, K.1    Lewensohn, R.2    Zhivotovsky, B.3
  • 11
    • 0003685223 scopus 로고    scopus 로고
    • Arnold Publisher and Hodder Headline Group, London
    • Steel GG: Basic Clinical Radiobiology. Arnold Publisher and Hodder Headline Group, London, 2002.
    • (2002) Basic Clinical Radiobiology
    • Steel, G.G.1
  • 14
    • 33749266047 scopus 로고    scopus 로고
    • Requirements regarding dose rate and exposure time for killing of tumour cells in beta particle radionuclide therapy
    • Carlsson J, Eriksson V, Stenerlöw B and Lundqvist H: Requirements regarding dose rate and exposure time for killing of tumour cells in beta particle radionuclide therapy. Eur J Nucl Med Mol Imaging 33: 1185-1195, 2006.
    • (2006) Eur J Nucl Med Mol Imaging , vol.33 , pp. 1185-1195
    • Carlsson, J.1    Eriksson, V.2    Stenerlöw, B.3    Lundqvist, H.4
  • 15
    • 33750687269 scopus 로고    scopus 로고
    • Penetration of tumor therapy interesting substances in non-vasularized metastases: Review of studies in multicellular spheroids
    • Carlsson J and Gedda L: Penetration of tumor therapy interesting substances in non-vasularized metastases: review of studies in multicellular spheroids. Curr Cancer Ther Rev 2: 293-304, 2006.
    • (2006) Curr Cancer Ther Rev , vol.2 , pp. 293-304
    • Carlsson, J.1    Gedda, L.2
  • 16
    • 0032489520 scopus 로고    scopus 로고
    • DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
    • Rogakou EP, Pilch DR, Orr AH, Ivanova VS and Bonner WM: DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J Biol Chem 273: 5858-5868, 1998.
    • (1998) J Biol Chem , vol.273 , pp. 5858-5868
    • Rogakou, E.P.1    Pilch, D.R.2    Orr, A.H.3    Ivanova, V.S.4    Bonner, W.M.5
  • 17
    • 0034737439 scopus 로고    scopus 로고
    • Initiation of DNA fragmentation during apoptosis induces phosphorylation of H2AX histone at serine 139
    • Rogakou EP, Nieves-Neira W, Boon C, Pommier Y and Bonner WM: Initiation of DNA fragmentation during apoptosis induces phosphorylation of H2AX histone at serine 139. J Biol Chem 275: 9390-9395, 2000.
    • (2000) J Biol Chem , vol.275 , pp. 9390-9395
    • Rogakou, E.P.1    Nieves-Neira, W.2    Boon, C.3    Pommier, Y.4    Bonner, W.M.5
  • 20
    • 52249090889 scopus 로고    scopus 로고
    • Low-dose hypersensitive gammaH2AX response and infrequent apoptosis in epidermis from radiotherapy patients
    • Simonsson M, Qvarnstrom F, Nyman J, Johansson K, Garmo H and Turesson I: Low-dose hypersensitive gammaH2AX response and infrequent apoptosis in epidermis from radiotherapy patients. Radiother Oncol 88: 388-397, 2008.
    • (2008) Radiother Oncol , vol.88 , pp. 388-397
    • Simonsson, M.1    Qvarnstrom, F.2    Nyman, J.3    Johansson, K.4    Garmo, H.5    Turesson, I.6
  • 21
    • 19444374556 scopus 로고    scopus 로고
    • Mediation of cell death by poly(ADP-ribose) polymerase-1
    • Koh DW, Dawson TM and Dawson VL: Mediation of cell death by poly(ADP-ribose) polymerase-1. Pharmacol Res 52: 5-14, 2005.
    • (2005) Pharmacol Res , vol.52 , pp. 5-14
    • Koh, D.W.1    Dawson, T.M.2    Dawson, V.L.3
  • 22
    • 0033941791 scopus 로고    scopus 로고
    • Detection of apoptosis in tissue sections
    • Stadelmann C and Lassmann H. Detection of apoptosis in tissue sections. Cell Tissue Res: 301: 319-331, 2000.
    • (2000) Cell Tissue Res , vol.301 , pp. 319-331
    • Stadelmann, C.1    Lassmann, H.2
  • 23
    • 0038449141 scopus 로고    scopus 로고
    • PARP-1, a determinant of cell survival in response to DNA damage
    • Bouchard VJ, Rouleau M and Poirier GG: PARP-1, a determinant of cell survival in response to DNA damage. Exp Hematol 31: 446-454, 2003.
    • (2003) Exp Hematol , vol.31 , pp. 446-454
    • Bouchard, V.J.1    Rouleau, M.2    Poirier, G.G.3
  • 24
    • 0034760530 scopus 로고    scopus 로고
    • Gain-of-function of poly(ADP-ribose) polymerase-1 upon cleavage by apoptotic proteases: Implications for apoptosis
    • D'Amours D, Sallmann F, Dixit V and Poirier G: Gain-of-function of poly(ADP-ribose) polymerase-1 upon cleavage by apoptotic proteases: implications for apoptosis. J Cell Sci 114: 3771-3778, 2001.
    • (2001) J Cell Sci , vol.114 , pp. 3771-3778
    • D'Amours, D.1    Sallmann, F.2    Dixit, V.3    Poirier, G.4
  • 25
    • 84966192535 scopus 로고
    • The histological structure of some human lung cancers and the possible implications for radiotherapy
    • Thomlinson RH and Gray LH: The histological structure of some human lung cancers and the possible implications for radiotherapy. Br J Cancer 9: 539-549, 1955.
    • (1955) Br J Cancer , vol.9 , pp. 539-549
    • Thomlinson, R.H.1    Gray, L.H.2
  • 26
    • 0014292997 scopus 로고
    • The relation between cell proliferation and the vascular system in a transplanted mouse mammary tumour
    • Tannock IF: The relation between cell proliferation and the vascular system in a transplanted mouse mammary tumour. Br J Cancer 22: 258-273, 1968.
    • (1968) Br J Cancer , vol.22 , pp. 258-273
    • Tannock, I.F.1
  • 27
    • 0025881615 scopus 로고
    • Morphometric studies in intraductal breast carcinoma using computerized image analysis
    • Mayr NA, Staples JJ, Robinson RA, Vanmetre JE and Hussey DH: Morphometric studies in intraductal breast carcinoma using computerized image analysis. Cancer 67: 2805-2812, 1991.
    • (1991) Cancer , vol.67 , pp. 2805-2812
    • Mayr, N.A.1    Staples, J.J.2    Robinson, R.A.3    Vanmetre, J.E.4    Hussey, D.H.5
  • 28
    • 0033805101 scopus 로고    scopus 로고
    • Effect of therapeutic macromolecules in spheroids
    • Fracasso G and Colombatti M: Effect of therapeutic macromolecules in spheroids. Crit Rev Oncol Hematol 36: 159-178, 2000.
    • (2000) Crit Rev Oncol Hematol , vol.36 , pp. 159-178
    • Fracasso, G.1    Colombatti, M.2
  • 29
    • 0016875214 scopus 로고
    • Radiation response of multicell spheroids - an in vitro tumour model
    • Sutherland RM and Durand RE: Radiation response of multicell spheroids - an in vitro tumour model. Curr Top Radiat Res Q 11: 87-139, 1976.
    • (1976) Curr Top Radiat Res Q , vol.11 , pp. 87-139
    • Sutherland, R.M.1    Durand, R.E.2
  • 30
    • 0021693130 scopus 로고
    • Liquid-overlay culture of cellular spheroids
    • Carlsson J and Yuhas JM: Liquid-overlay culture of cellular spheroids. Recent Results Cancer Res 95: 1-23, 1984.
    • (1984) Recent Results Cancer Res , vol.95 , pp. 1-23
    • Carlsson, J.1    Yuhas, J.M.2
  • 31
    • 0023093713 scopus 로고
    • Multicellular spheroids. A review on cellular aggregates in cancer research
    • Mueller-Klieser W: Multicellular spheroids. A review on cellular aggregates in cancer research. J Cancer Res Clin Oncol 113: 101-122, 1987.
    • (1987) J Cancer Res Clin Oncol , vol.113 , pp. 101-122
    • Mueller-Klieser, W.1
  • 32
    • 0024281372 scopus 로고
    • Cell and environment interactions in tumor microregions: The multicell spheroid model
    • Sutherland RM: Cell and environment interactions in tumor microregions: the multicell spheroid model. Science 240: 177-184, 1988.
    • (1988) Science , vol.240 , pp. 177-184
    • Sutherland, R.M.1
  • 33
    • 0033804913 scopus 로고    scopus 로고
    • Apoptosis, cell adhesion and the extracellular matrix in the three-dimensional growth of multicellular tumor spheroids
    • Santini MT, Rainaldi G and Indovina PL: Apoptosis, cell adhesion and the extracellular matrix in the three-dimensional growth of multicellular tumor spheroids. Crit Rev Oncol Hematol 36: 75-87, 2000.
    • (2000) Crit Rev Oncol Hematol , vol.36 , pp. 75-87
    • Santini, M.T.1    Rainaldi, G.2    Indovina, P.L.3
  • 34
    • 38449099723 scopus 로고    scopus 로고
    • Three-dimensional cell organization leads to a different type of ionizing radiationinduced cell death: MG-63 monolayer cells undergo mitotic catastrophe while spheroids die of apoptosis
    • Indovina P, Rainaldi G and Santini MT: Three-dimensional cell organization leads to a different type of ionizing radiationinduced cell death: MG-63 monolayer cells undergo mitotic catastrophe while spheroids die of apoptosis. Int J Oncol 31: 1473-1483, 2007.
    • (2007) Int J Oncol , vol.31 , pp. 1473-1483
    • Indovina, P.1    Rainaldi, G.2    Santini, M.T.3
  • 35
    • 0024261272 scopus 로고
    • Relations between pH, oxygen partial pressure and growth in cultured cell spheroids
    • Carlsson J and Acker H: Relations between pH, oxygen partial pressure and growth in cultured cell spheroids. Int J Cancer 42: 715-720, 1988.
    • (1988) Int J Cancer , vol.42 , pp. 715-720
    • Carlsson, J.1    Acker, H.2
  • 37
    • 0029294613 scopus 로고
    • In situ detection of fragmented DNA (tunel assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: A cautionary note
    • Grasl-Kraupp B, Ruttkay-Nedecky B, Koudelka H, Bukowska K, Bursch W and Schulte-Hermann R: In situ detection of fragmented DNA (tunel assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: A cautionary note. Hepatology 21: 1465-1468, 1995.
    • (1995) Hepatology , vol.21 , pp. 1465-1468
    • Grasl-Kraupp, B.1    Ruttkay-Nedecky, B.2    Koudelka, H.3    Bukowska, K.4    Bursch, W.5    Schulte-Hermann, R.6
  • 38
    • 29644443047 scopus 로고    scopus 로고
    • Computational Methods for analysis of foci: Validation for radiation-induced gamma-H2AX foci in human cells
    • Böcker W and Iliakis G: Computational Methods for analysis of foci: validation for radiation-induced gamma-H2AX foci in human cells. Radiat Res 165: 113-124, 2006.
    • (2006) Radiat Res , vol.165 , pp. 113-124
    • Böcker, W.1    Iliakis, G.2


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