ΔFosB induction in orbitofrontal cortex potentiates locomotor sensitization despite attenuating the cognitive dysfunction caused by cocaine

Pharmacology Biochemistry and Behavior

Volumn 93, Issue 3, 2009, Pages 278-284

  Winstanley, Catharine A ^a   Green, Thomas A ^a   Theobald, David E H ^a   Renthal, William ^a   LaPlant, Quincey ^a   DiLeone, Ralph J ^a   Chakravarty, Sumana ^a   Nestler, Eric J ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Addiction; Frontal cortex; Impulsivity; Nucleus accumbens; Real time PCR; Viral mediated gene transfer

Indexed keywords

COCAINE; TRANSCRIPTION FACTOR DELTA FOSB; DOPAMINE UPTAKE INHIBITOR; FOSB PROTEIN, RAT; MESSENGER RNA; PROTEIN C FOS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHEMOSENSITIZATION; COCAINE DEPENDENCE; COGNITIVE DEFECT; CONTROLLED STUDY; GENE EXPRESSION; IMPULSIVENESS; LOCOMOTION; MALE; NONHUMAN; NUCLEUS ACCUMBENS; ORBITAL CORTEX; PRIORITY JOURNAL; RAT; ANIMAL; BIOSYNTHESIS; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; FRONTAL LOBE; GENETICS; LONG EVANS RAT; METABOLISM; MOTOR ACTIVITY; NEOSTRIATUM; PHYSIOLOGY; PSYCHOLOGICAL ASPECT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALIA; RATTUS;

ANIMALS; COCAINE; COGNITION DISORDERS; DOPAMINE UPTAKE INHIBITORS; FRONTAL LOBE; GENE EXPRESSION; MALE; MOTOR ACTIVITY; NEOSTRIATUM; PROTO-ONCOGENE PROTEINS C-FOS; RATS; RATS, LONG-EVANS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 67649427639     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbb.2008.12.007     Document Type: Article

References (61)

1. Alibhai I.N., Green T.A., Potashkin J.A., and Nestler E.J. Regulation of fosB and DeltafosB mRNA expression: in vivo and in vitro studies. Brain Res 1143 (2007) 22-33
2. American Psychiatric Association. Diagnostic and Statistical Manual IV", Washington D.C.: American Psychiatric Association (1994)
3. Bachtell R.K., Whisler K., Karanian D., and Self D.W. Effects of intra-nucleus accumbens shell administration of dopamine agonists and antagonists on cocaine-taking and cocaine-seeking behaviors in the rat. Psychopharmacology (Berl) 183 (2005) 41-53
4. Baunez C., and Robbins T.W. Bilateral lesions of the subthalamic nucleus induce multiple deficits in an attentional task in rats. Eur J Neurosci 9 (1997) 2086-2099
5. Bechara A. Decision making, impulse control and loss of willpower to resist drugs: a neurocognitive perspective. Nat Neurosci 8 (2005) 1458-1463
6. Berendse H.W., Galis-de Graaf Y., and Groenewegen H.J. Topographical organization and relationship with ventral striatal compartments of prefrontal corticostriatal projections in the rat. J Comp Neurol 316 (1992) 314-347
7. Carlezon Jr. W.A., et al. Regulation of cocaine reward by CREB. Science 282 (1998) 2272-2275
8. Chen J., Kelz M.B., Hope B.T., Nakabeppu Y., and Nestler E.J. Chronic Fos-related antigens: stable variants of deltaFosB induced in brain by chronic treatments. J Neurosci 17 (1997) 4933-4941
9. Chudasama Y., et al. Dissociable aspects of performance on the 5 choice serial reaction time task following lesions of the dorsal anterior cingulate, infralimbic and orbitofrontal cortex in the rat: differential effects on selectivity, impulsivity and compulsivity. Behav Brain Res 146 (2003) 105-119
10. Churchill L., Swanson C.J., Urbina M., and Kalivas P.W. Repeated cocaine alters glutamate receptor subunit levels in the nucleus accumbens and ventral tegmental area of rats that develop behavioral sensitization. J Neurochem 72 (1999) 2397-2403
11. Colby C.R., Whisler K., Steffen C., Nestler E.J., and Self D.W. Striatal cell type-specific overexpression of DeltaFosB enhances incentive for cocaine. J Neurosci 23 (2003) 2488-2493
12. Costall B., Domeney A.M., and Naylor R.J. Locomotor hyperactivity caused by dopamine infusion into the nucleus accumbens of rat brain: specificity of action. Psychopharmacology (Berl) 82 (1984) 174-180.
13. Deutch A.Y., Clark W.A., and Roth R.H. Prefrontal cortical dopamine depletion enhances the responsiveness of mesolimbic dopamine neurons to stress. Brain Res 521 (1990) 311-315
14. Fitzgerald L.W., Ortiz J., Hamedani A.G., and Nestler E.J. Drugs of abuse and stress increase the expression of GluR1 and NMDAR1 glutamate receptor subunits in the rat ventral tegmental area: common adaptations among cross-sensitizing agents. J Neurosci 16 (1996) 274-282
15. Garavan H., and Hester R. The role of cognitive control in cocaine dependence. Neuropsychol Rev 17 (2007) 337-345
16. Geisler S., Derst C., Veh R.W., and Zahm D.S. Glutamatergic afferents of the ventral tegmental area in the rat. J Neurosci 27 (2007) 5730-5743
17. Green T.A., et al. Induction of ICER expression in nucleus accumbens by stress or amphetamine increases behavioral responses to emotional stimuli. J Neurosci 26 (2006) 8235-8242
18. Hanson K.L., Luciana M., Sullwold K.,. Reward-related decision-making deficits and elevated impulsivity among MDMA and other drug users. Drug Alcohol Depend (2008)
19. Hommel J.D., Sears R.M., Georgescu D., Simmons D.L., and DiLeone R.J. Local gene knockdown in the brain using viral-mediated RNA interference. Nat Med 9 (2003) 1539-1544
20. Hope B., Kosofsky B., Hyman S.E., and Nestler E.J. Regulation of immediate early gene expression and AP-1 binding in the rat nucleus accumbens by chronic cocaine. Proc Natl Acad Sci U S A 89 (1992) 5764-5768
21. Jentsch J.D., and Taylor J.R. Impulsivity resulting from frontostriatal dysfunction in drug abuse: implications for the control of behavior by reward-related stimuli. Psychopharmacology 146 (1999) 373-390
22. Kalivas P.W., and Stewart J. Dopamine transmission in the initiation and expression of drug- and stress-induced sensitization of motor activity. Brain Res Brain Res Rev 16 (1991) 223-244
23. Kalivas P.W., and Volkow N.D. The neural basis of addiction: a pathology of motivation and choice. Am J Psychiatry 162 (2005) 1403-1413
24. Kano T., Suzuki Y., Shibuya M., Kiuchi K., and Hagiwara M. Cocaine-induced CREB phosphorylation and c-Fos expression are suppressed in Parkinsonism model mice. NeuroReport 6 (1995) 2197-2200
25. Karler R., Calder L.D., and Bedingfield J.B. Cocaine behavioral sensitization and the excitatory amino acids. Psychopharmacology (Berl) 115 (1994) 305-310
26. Kelz M.B., et al. Expression of the transcription factor deltaFosB in the brain controls sensitivity to cocaine. Nature 401 (1999) 272-276
27. Klebaur J.E., et al. The ability of amphetamine to evoke arc (Arg 3.1) mRNA expression in the caudate, nucleus accumbens and neocortex is modulated by environmental context. Brain Res 930 (2002) 30-36
28. Konradi C., Cole R.L., Heckers S., and Hyman S.E. Amphetamine regulates gene expression in rat striatum via transcription factor CREB. J Neurosci 14 (1994) 5623-5634
29. Larsen M.H., Rosenbrock H., Sams-Dodd F., and Mikkelsen J.D. Expression of brain derived neurotrophic factor, activity-regulated cytoskeleton protein mRNA, and enhancement of adult hippocampal neurogenesis in rats after sub-chronic and chronic treatment with the triple monoamine re-uptake inhibitor tesofensine. Eur J Pharmacol 555 (2007) 115-121
30. Lejuez C.W., Bornovalova M.A., Daughters S.B., and Curtin J.J. Differences in impulsivity and sexual risk behavior among inner-city crack/cocaine users and heroin users. Drug Alcohol Depend 77 (2005) 169-175
31. Livak K.J., and Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25 (2001) 402-408 (San Diego, Calif
32. McClung C.A., and Nestler E.J. Regulation of gene expression and cocaine reward by CREB and deltaFosB. Nat Neurosci 6 (2003) 1208-1215
33. Mitchell J.B., and Gratton A. Partial dopamine depletion of the prefrontal cortex leads to enhanced mesolimbic dopamine release elicited by repeated exposure to naturally reinforcing stimuli. J Neurosci 12 (1992) 3609-3618
34. Moeller F.G., et al. Reduced anterior corpus callosum white matter integrity is related to increased impulsivity and reduced discriminability in cocaine-dependent subjects: diffusion tensor imaging. Neuropsychopharmacology 30 (2005) 610-617
35. Nestler E.J. Transcriptional mechanisms of addiction: role of deltaFosB. Philos Trans R Soc London, B Biol Sci 363 (2008) 3245-3255
36. Nye H.E., Hope B.T., Kelz M.B., Iadarola M., and Nestler E.J. Pharmacological studies of the regulation of chronic FOS-related antigen induction by cocaine in the striatum and nucleus accumbens. J Pharmacol Exp Ther 275 (1995) 1671-1680
37. Parkinson J.A., et al. Nucleus accumbens dopamine depletion impairs both acquisition and performance of appetitive Pavlovian approach behaviour: implications for mesoaccumbens dopamine function. Behav Brain Res 137 (2002) 149-163
38. Paxinos G., and Watson C. The rat brain in stereotaxic co-ordinates (1998), Academic Press, Sydney
39. Peakman M.C., et al. Inducible, brain region-specific expression of a dominant negative mutant of c-Jun in transgenic mice decreases sensitivity to cocaine. Brain Res 970 (2003) 73-86
40. Pierce R.C., and Kalivas P.W. A circuitry model of the expression of behavioral sensitization to amphetamine-like psychostimulants. Brain Res Brain Res Rev 25 (1997) 192-216
41. Robinson T.E., and Berridge K.C. The neural basis of drug craving: an incentive-sensitization theory of addiction. Brain Res Brain Res Rev 18 (1993) 247-291
42. Rogers R.D., et al. Dissociable deficits in the decision-making cognition of chronic amphetamine abusers, opiate abusers, patients with focal damage to prefrontal cortex, and tryptophan-depleted normal volunteers: Evidence for monoaminergic mechanisms. Neuropsychopharmacology 20 (1999) 322-339
43. Schilman E.A., Uylings H.B., Galis-de Graaf Y., Joel D., and Groenewegen H.J. The orbital cortex in rats topographically projects to central parts of the caudate-putamen complex. Neurosci Lett 432 (2008) 40-45
44. Schoenbaum G., Roesch M.R., and Stalnaker T.A. Orbitofrontal cortex, decision-making and drug addiction. Trends Neurosci 29 (2006) 116-124
45. Self D.W., et al. Involvement of cAMP-dependent protein kinase in the nucleus accumbens in cocaine self-administration and relapse of cocaine-seeking behavior. J Neurosci 18 (1998) 1848-1859
46. Stalnaker T.A., Franz T.M., Singh T., and Schoenbaum G. Basolateral amygdala lesions abolish orbitofrontal-dependent reversal impairments. Neuron 54 (2007) 51-58
47. Steketee J.D. Neurotransmitter systems of the medial prefrontal c006Frtex: potential role in sensitization to psychostimulants. Brain Res Brain Res Rev 41 (2003) 203-228
48. Steketee J.D., and Walsh T.J. Repeated injections of sulpiride into the medial prefrontal cortex induces sensitization to cocaine in rats. Psychopharmacology (Berl) 179 (2005) 753-760
49. Ujike H., Takaki M., Kodama M., and Kuroda S. Gene expression related to synaptogenesis, neuritogenesis, and MAP kinase in behavioral sensitization to psychostimulants. Ann N Y Acad Sci 965 (2002) 55-67
50. Uslaner J.M., Crombag H.S., Ferguson S.M., and Robinson T.E. Cocaine-induced psychomotor activity is associated with its ability to induce c-fos mRNA expression in the subthalamic nucleus: effects of dose and repeated treatment. Eur J Neurosci 17 (2003) 2180-2186
51. Uslaner J.M., and Robinson T.E. Subthalamic nucleus lesions increase impulsive action and decrease impulsive choice - mediation by enhanced incentive motivation?. Eur J Neurosci 24 (2006) 2345-2354
52. van Zundert B., Yoshii A., and Constantine-Paton M. Receptor compartmentalization and trafficking at glutamate synapses: a developmental proposal. Trends Neurosci 27 (2004) 428-437
53. Verdejo-Garcia A.J., Perales J.C., and Perez-Garcia M. Cognitive impulsivity in cocaine and heroin polysubstance abusers. Addict Behav 32 (2007) 950-966
54. Volkow N.D., and Fowler J.S. Addiction, a disease of compulsion and drive: involvement of the orbitofrontal cortex. Cereb. Cortex 10 (2000) 318-325
55. Winstanley C.A., et al. Increased impulsivity during withdrawal from cocaine self-administration: role for DeltaFosB in the orbitofrontal cortex. Cereb. Cortex (Jun 6 2008) Electronic publication ahead of print
56. Winstanley C.A., Baunez C., Theobald D.E., and Robbins T.W. Lesions to the subthalamic nucleus decrease impulsive choice but impair autoshaping in rats: the importance of the basal ganglia in Pavlovian conditioning and impulse control. Eur J Neurosci 21 (2005) 3107-3116
57. Winstanley C.A., Theobald D.E., Dalley J.W., and Robbins T.W. Interactions between serotonin and dopamine in the control of impulsive choice in rats: Therapeutic implications for impulse control disorders. Neuropsychopharmacology 30 (2005) 669-682
58. Winstanley C.A., et al. DeltaFosB induction in orbitofrontal cortex mediates tolerance to cocaine-induced cognitive dysfunction. J Neurosci 27 (2007) 10497-10507
59. Wolf M.E. The role of excitatory amino acids in behavioral sensitization to psychomotor stimulants. Prog Neurobiol 54 (1998) 679-720
60. Yao W.D., et al. Identification of PSD-95 as a regulator of dopamine-mediated synaptic and behavioral plasticity. Neuron 41 (2004) 625-638
61. Zachariou V., et al. An essential role for DeltaFosB in the nucleus accumbens in morphine action. Nat Neurosci 9 (2006) 205-211