Expression of TNF-α leader sequence renders MCF-7 tumor cells resistant to the cytotoxicity of soluble TNF-α

Breast Cancer Research and Treatment

Volumn 116, Issue 1, 2009, Pages 91-102

  Yan, Dan ^a   Qin, Nalin ^a   Zhang, Hailong ^a   Liu, Tao ^a   Yu, Mingxia ^a   Jiang, Xiaodan ^a   Feng, Wei ^a   Wang, Jing ^a   Yin, Bingjiao ^a   Zhang, Tao ^a   Zhou, Muxiang ^b   Li, Zhuoya ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Breast cancer; Cytotoxicity; NF B; TNF leader sequence; Transmembrane TNF

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PEPTIDE HYDROLASE INHIBITOR; PYRROLIDINE DITHIOCARBAMATE; SIGNAL PEPTIDE; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR ALPHA;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER RESISTANCE; CELL PROTECTION; CELL STRAIN MCF 7; CYTOTOXICITY; DRUG SENSITIVITY; GENE OVEREXPRESSION; GENETIC TRANSFECTION; PRIORITY JOURNAL; WILD TYPE;

BLOTTING, WESTERN; BREAST NEOPLASMS; CELL DEATH; CELL LINE, TUMOR; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; MICROSCOPY, CONFOCAL; NF-KAPPA B; PROTEIN SORTING SIGNALS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSFECTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 67649418389     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-008-0111-5     Document Type: Article

References (40)

1. M Kriegler C Perez K DeFay I Albert SD Lu 1988 A novel form of TNF/cachectin is a cell surface cytotoxic transmembrane protein: ramifications for the complex physiology of TNF Cell 53 1 45 53 10.1016/0092-8674(88)90486-2
2. E Friedmann E Hauben K Maylandt 2006 SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production Nat Cell Biol 8 8 843 848 10.1038/ncb1440
3. R Fluhrer G Grammer L Israel 2006 A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b Nat Cell Biol 8 8 894 896 10.1038/ncb1450
4. M Yamaguchi T Murakami T Tomimatsu 1998 Autocrine inhibition of leptin production by tumor necrosis factor-alpha (TNF-alpha) through TNF-alpha type-I receptor in vitro Biochem Biophys Res Commun 244 1 30 34 10.1006/bbrc.1998.8199
5. E Haas M Grell H Wajant P Scheurich 1999 Continuous autotropic signaling by membrane-expressed tumor necrosis factor J Biol Chem 274 25 18107 18112 10.1074/jbc.274.25.18107
6. A Domonkos A Udvardy L Laszlo T Nagy E Duda 2001 Receptor-like properties of the 26 kDa transmembrane form of TNF Eur Cytokine Netw 12 3 411 419 (Pubitemid 32905259)
7. M Cayabyab JH Phillips LL Lanier 1994 CD40 preferentially costimulates activation of CD4 + T lymphocytes J Immunol 152 4 1523 1531 (Pubitemid 24075682)
8. KE Pollok YJ Kim J Hurtado Z Zhou KK Kim BS Kwon 1994 4-1BB T-cell antigen binds to mature B cells and macrophages, and costimulates anti-mu-primed splenic B cells Eur J Immunol 24 2 367 374 10.1002/eji.1830240215 (Pubitemid 24041126)
9. E Stuber M Neurath D Calderhead HP Fell W Strober 1995 Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells Immunity 2 5 507 521 10.1016/1074-7613(95)90031-4
10. D van Essen H Kikutani D Gray 1995 CD40 ligand-transduced co-stimulation of T cells in the development of helper function Nature 378 6557 620 623 10.1038/378620a0
11. SR Wiley RG Goodwin CA Smith 1996 Reverse signaling via CD30 ligand J Immunol 157 8 3635 3639 (Pubitemid 126449178)
12. S Harashima T Horiuchi N Hatta 2001 Outside-to-inside signal through the membrane TNF-alpha induces E-selectin (CD62E) expression on activated human CD4 + T cells J Immunol 166 1 130 136 (Pubitemid 32038425)
13. H Mitoma T Horiuchi N Hatta 2005 Infliximab induces potent anti-inflammatory responses by outside-to-inside signals through transmembrane TNF-alpha Gastroenterology 128 2 376 392 10.1053/j.gastro.2004.11.060
14. M Higuchi K Nagasawa T Horiuchi 1997 Membrane tumor necrosis factor-alpha (TNF-alpha) expressed on HTLV-I-infected T cells mediates a costimulatory signal for B cell activation-characterization of membrane TNF-alpha Clin Immunol Immunopathol 82 2 133 140 10.1006/clin.1996.4291
15. M Rossol U Meusch M Pierer 2007 Interaction between transmembrane TNF and TNFR1/2 mediates the activation of monocytes by contact with T cells J Immunol 179 6 4239 4248
16. L Xin J Wang H Zhang 2006 Dual regulation of soluble tumor necrosis factor-alpha induced activation of human monocytic cells via modulating transmembrane TNF-alpha-mediated 'reverse signaling' Int J Mol Med 18 5 885 892
17. A Lugering M Schmidt N Lugering HG Pauels W Domschke T Kucharzik 2001 Infliximab induces apoptosis in monocytes from patients with chronic active Crohn's disease by using a caspase-dependent pathway Gastroenterology 121 5 1145 1157 10.1053/gast.2001.28702 (Pubitemid 33022095)
18. T ten Hove C van Montfrans MP Peppelenbosch SJ van Deventer 2002 Infliximab treatment induces apoptosis of lamina propria T lymphocytes in Crohn's disease Gut 50 2 206 211 10.1136/gut.50.2.206 (Pubitemid 34087933)
19. GH Waetzig P Rosenstiel A Arlt 2005 Soluble tumor necrosis factor (TNF) receptor-1 induces apoptosis via reverse TNF signaling and autocrine transforming growth factor-beta1 FASEB J 19 1 91 93 (Pubitemid 40069928)
20. FT Stevenson SL Bursten RM Locksley DH Lovett 1992 Myristyl acylation of the tumor necrosis factor alpha precursor on specific lysine residues J Exp Med 176 4 1053 1062 10.1084/jem.176.4.1053
21. T Utsumi T Takeshige K Tanaka 2001 Transmembrane TNF (pro-TNF) is palmitoylated FEBS Lett 500 1-2 1 6 10.1016/S0014-5793(01)02576-5
22. E Pocsik E Duda D Wallach 1995 Phosphorylation of the 26 kDa TNF precursor in monocytic cells and in transfected HeLa cells J Inflamm 45 3 152 160
23. AD Watts NH Hunt Y Wanigasekara 1999 A casein kinase I motif present in the cytoplasmic domain of members of the tumour necrosis factor ligand family is implicated in 'reverse signalling' EMBO J 18 8 2119 2126 10.1093/emboj/18.8. 2119 (Pubitemid 29179169)
24. S Jin D Lu S Ye 2005 A simplified probe preparation for ELISA-based NF-kappaB activity assay J Biochem Biophys Methods 65 1 20 29 10.1016/j.jbbm.2005.08.006
25. T Hasegawa K Suzuki C Sakamoto 2003 Expression of the inhibitor of apoptosis (IAP) family members in human neutrophils: up-regulation of cIAP2 by granulocyte colony-stimulating factor and overexpression of cIAP2 in chronic neutrophilic leukemia Blood 101 3 1164 1171 10.1182/blood-2002-05-1505
26. KJ Livak TD Schmittgen 2001 Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method Methods (San Diego, Calif) 25 4 402 408 (Pubitemid 34164012)
27. T Himeno N Watanabe N Yamauchi 1990 Expression of endogenous tumor necrosis factor as a protective protein against the cytotoxicity of exogenous tumor necrosis factor Cancer Res 50 16 4941 4945 (Pubitemid 20257915)
28. C Dollbaum AA Creasey SH Dairkee 1988 Specificity of tumor necrosis factor toxicity for human mammary carcinomas relative to normal mammary epithelium and correlation with response to doxorubicin Proc Natl Acad Sci USA 85 13 4740 4744 10.1073/pnas.85.13.4740
29. Z Cai A Bettaieb NE Mahdani 1997 Alteration of the sphingomyelin/ceramide pathway is associated with resistance of human breast carcinoma MCF7 cells to tumor necrosis factor-alpha-mediated cytotoxicity J Biol Chem 272 11 6918 6926 10.1074/jbc.272.11.6918
30. C Luberto DF Hassler P Signorelli 2002 Inhibition of tumor necrosis factor-induced cell death in MCF7 by a novel inhibitor of neutral sphingomyelinase J Biol Chem 277 43 41128 41139 10.1074/jbc.M206747200
31. Z Cai C Capoulade C Moyret-Lalle 1997 Resistance of MCF7 human breast carcinoma cells to TNF-induced cell death is associated with loss of p53 function Oncogene 15 23 2817 2826 10.1038/sj.onc.1201445 (Pubitemid 28004570)
32. AM Stall FG Kroese FT Gadus DG Sieckmann LA Herzenberg LA Herzenberg 1988 Rearrangement and expression of endogenous immunoglobulin genes occur in many murine B cells expressing transgenic membrane IgM Proc Natl Acad Sci USA 85 10 3546 3550 10.1073/pnas.85.10.3546
33. N Roy QL Deveraux R Takahashi GS Salvesen JC Reed 1997 The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases EMBO J 16 23 6914 6925 10.1093/emboj/16.23.6914 (Pubitemid 27520792)
34. CY Wang MW Mayo RG Korneluk DV Goeddel AS Baldwin Jr 1998 NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation Science 281 5383 1680 1683 10.1126/science.281.5383.1680
35. B Benayoun S Baghdiguian A Lajmanovich 2007 NF-{kappa}B-dependent expression of the antiapoptotic factor c-FLIP is regulated by calpain 3, the protein involved in limb-girdle muscular dystrophy type 2A FASEB J 22 5 1521 1529 (Pubitemid 351656792)
36. T Lwin LA Hazlehurst Z Li 2007 Bone marrow stromal cells prevent apoptosis of lymphoma cells by upregulation of anti-apoptotic proteins associated with activation of NF-kappaB (RelB/p52) in non-Hodgkin's lymphoma cells Leukemia 21 7 1521 1531 10.1038/sj.leu.2404723
37. S Schutze T Machleidt D Adam 1999 Inhibition of receptor internalization by monodansylcadaverine selectively blocks p55 tumor necrosis factor receptor death domain signaling J Biol Chem 274 15 10203 10212 10.1074/jbc.274.15.10203
38. CH Woo TH Kim JA Choi 2006 Inhibition of receptor internalization attenuates the TNFalpha-induced ROS generation in non-phagocytic cells Biochem Biophys Res Commun 351 4 972 978 10.1016/j.bbrc.2006.10.154
39. R Forster E Kremmer A Schubel 1998 Intracellular and surface expression of the HIV-1 coreceptor CXCR4/fusin on various leukocyte subsets: rapid internalization and recycling upon activation J Immunol 160 3 1522 1531 (Pubitemid 28093457)
40. O Micheau J Tschopp 2003 Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes Cell 114 2 181 190 10.1016/S0092-8674(03) 00521-X