Use of platelet-rich plasma in periodontal surgery - A prospective randomised double blind clinical trial

Clinical Oral Investigations

Volumn 13, Issue 2, 2009, Pages 179-187

  Harnack, L ^a   Boedeker, R H ^a   Kurtulus, I ^a   Boehm, S ^a   Gonzales, J ^a   Meyle, Joerg ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

Tricalcium phosphate; Early healing; Periodontal surgery; Platelet rich plasma; Wound healing

Indexed keywords

BETA-TRICALCIUM PHOSPHATE; CALCIUM PHOSPHATE;

ARTICLE; BONE PROSTHESIS; BONE REGENERATION; CHRONIC PERIODONTITIS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; HUMAN; METHODOLOGY; ORAL SURGERY; OSTEOLYSIS; PERIODONTAL DISEASE; PERIODONTITIS; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; THROMBOCYTE RICH PLASMA; TREATMENT OUTCOME;

ALVEOLAR BONE LOSS; BONE REGENERATION; BONE SUBSTITUTES; CALCIUM PHOSPHATES; CHRONIC PERIODONTITIS; DOUBLE-BLIND METHOD; HUMANS; ORAL SURGICAL PROCEDURES; PERIODONTAL ATTACHMENT LOSS; PERIODONTAL POCKET; PLATELET-RICH PLASMA; PROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 67649414446     PISSN: 14326981     EISSN: 14363771     Source Type: Journal    
DOI: 10.1007/s00784-008-0223-7     Document Type: Article

References (49)

1. Anitua E (2001) The use of plasma-rich growth factors (PRGF) in oral surgery. Pract Proced Aesthet Dent 13:487-493
2. Bowers GM, Vargo JW, Levy B, Emerson JR, Bergquist JJ (1986) Histologic observations following the placement of tricalcium phosphate implants in human intrabony defects. J Periodontol 57:286-287
3. Camargo PM, Lekovic V, Weinlaender M, Vasilic N, Madzarevic M, Kenney EB (2002) Platelet-rich plasma and bovine porous bone mineral combined with guided tissue regeneration in the treatment of intrabony defects in humans. J Periodontal Res 37:300-306
4. Camargo PM, Lekovic V, Weinlaender M, Vasilic N, Madzarevic M, Kenney EB (2005) A reentry study on the use of bovine porous bone mineral, GTR, and platelet-rich plasma in the regenerative treatment of intrabony defects in humans. Int J Periodontics Restor Dent 25:49-59
5. Cameron HU (1992) Tricalcium phosphate as a bone graft substitute. Contemp Orthop 25:506-508
6. Christgau M, Moder D, Hiller KA, Dada A, Schmitz G, Schmalz G (2006) Growth factors and cytokines in autologous platelet concentrate and their correlation to periodontal regeneration outcomes. J Clin Periodontol 33:837-845
7. Christgau M, Moder D, Wagner J, Glassl M, Hiller KA, Wenzel A, Schmalz G (2006) Influence of autologous platelet concentrate on healing in intra-bony defects following guided tissue regeneration therapy: A randomized prospective clinical split-mouth study. J Clin Periodontol 33:908-921
8. Cortellini P, Pini PG, Tonetti MS (1996) The modified papilla preservation technique with bioresorbable barrier membranes in the treatment of intrabony defects. Case reports. Int J Periodontics Restor Dent 16:546-559
9. Daculsi G, Passuti N (1990) Effect of the macroporosity for osseous substitution of calcium phosphate ceramics. Biomaterials 11:86-87
10. Daculsi G, Passuti N, Martin S, Deudon C, Legeros RZ, Raher S (1990) Macroporous calcium phosphate ceramic for long bone surgery in humans and dogs. Clinical and histological study. J Biomed Mater Res 24:379-396
11. Damien CJ, Parsons JR (1991) Bone graft and bone graft substitutes: A review of current technology and applications. J Appl Biomater 2:187-208
12. Delecrin J, Takahashi S, Gouin F, Passuti N (2000) A synthetic porous ceramic as a bone graft substitute in the surgical management of scoliosis: A prospective, randomized study. Spine 25:563-569
13. Ducheyne P (1988) Titanium and calcium phosphate ceramic dental implants, surfaces, coatings and interfaces. J Oral Implantol 14:325-340
14. Ducheyne P, Radin S, Heughebaert M, Heughebaert JC (1990) Calcium phosphate ceramic coatings on porous titanium: Effect of structure and composition on electrophoretic deposition, vacuum sintering and in vitro dissolution. Biomaterials 11:244-254
15. Ducheyne P, Radin S, King L (1993) The effect of calcium phosphate ceramic composition and structure on in vitro behavior. I. Dissolution. J Biomed Mater Res 27:25-34
16. Dupraz A, Delecrin J, Moreau A, Pilet P, Passuti N (1998) Long-term bone response to particulate injectable ceramic. J Biomed Mater Res 42:368-375
17. Erbe EM, Marx JG, Clineff TD, Bellincampi LD (2001) Potential of an ultraporous beta-tricalcium phosphate synthetic cancellous bone void filler and bone marrow aspirate composite graft. Eur Spine J 10(Suppl 2):S141-S146
18. Hamadouche M, Sedel L (2000) Ceramics in orthopaedics. J Bone Joint Surg Br 82:1095-1099
19. Hollinger JO, Brekke J, Gruskin E, Lee D (1996) Role of bone substitutes. Clin Orthop Relat Res 324:55-65
20. Hossain MZ, Yamada T, Yamauchi K (1989) [Biodegradable ceramic as a bone graft substitute followed by orthodontic tooth movement]. Nippon Kyosei Shika Gakkai Zasshi 48:483-495
21. Kawase T, Okuda K, Wolff LF, Yoshie H (2003) Platelet-rich plasma-derived fibrin clot formation stimulates collagen synthesis in periodontal ligament and osteoblastic cells in vitro. J Periodontol 74:858-864
22. Kovacs K, Velich N, Huszar T, Fenyves B, Suba Z, Szabo G (2005) Histomorphometric and densitometric evaluation of the effects of platelet-rich plasma on the remodeling of beta-tricalcium phosphate in beagle dogs. J Craniofac Surg 16:150-154
23. Kovacs K, Velich N, Huszar T, Szabo G, Semjen G, Reiczigel J, Suba Z (2003) Comparative study of beta-tricalcium phosphate mixed with platelet-rich plasma versus beta-tricalcium phosphate, a bone substitute material in dentistry. Acta Vet Hung 51:475-484
24. Legeros RZ (1991) Calcium phosphates in oral biology and medicine. Monogr Oral Sci 15:1-201
25. Legeros RZ (1993) Biodegradation and bioresorption of calcium phosphate ceramics. Clin Mater 14:65-88
26. Lekovic V, Camargo PM, Weinlaender M, Kenney EB, Vasilic N (2001) Combination use of bovine porous bone mineral, enamel matrix proteins, and a bioabsorbable membrane in intrabony periodontal defects in humans. J Periodontol 72:583-589
27. Lekovic V, Camargo PM, Weinlaender M, Vasilic N, Aleksic Z, Kenney EB (2003) Effectiveness of a combination of platelet-rich plasma, bovine porous bone mineral and guided tissue regeneration in the treatment of mandibular grade II molar furcations in humans. J Clin Periodontol 30:746-751
28. Lekovic V, Camargo PM, Weinlaender M, Vasilic N, Kenney EB (2002) Comparison of platelet-rich plasma, bovine porous bone mineral, and guided tissue regeneration versus platelet-rich plasma and bovine porous bone mineral in the treatment of intrabony defects: A reentry study. J Periodontol 73:198-205
29. Marx RE, Carlson ER, Eichstaedt RM, Schimmele SR, Strauss JE, Georgeff KR (1998) Platelet-rich plasma: Growth factor enhancement for bone grafts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 85:638-646
30. Miranda SR, Nary FH, Padovan LE, Ribeiro DA, Nicolielo D, Matsumoto MA (2006) Use of platelet-rich plasma under autogenous onlay bone grafts. Clin Oral Implants Res 17:694-699
31. Moore WR, Graves SE, Bain GI (2001) Synthetic bone graft substitutes. ANZ J Surg 71:354-361
32. Nagase M, Chen RB, Araya Y, Nakajima T (1991) Evaluation of a bone substitute prepared from alpha-tricalcium phosphate and an acid polysaccharide solution. J Oral Maxillofac Surg 49:1305-1309
33. Okuda K, Kawase T, Momose M, Murata M, Saito Y, Suzuki H, Wolff LF, Yoshie H (2003) Platelet-rich plasma contains high levels of platelet-derived growth factor and transforming growth factor-beta and modulates the proliferation of periodontally related cells in vitro. J Periodontol 74:849-857
34. Palti A, Hoch T (2002) A concept for the treatment of various dental bone defects. Implant Dent 11:73-78
35. Radin S, Ducheyne P, Berthold P, Decker S (1998) Effect of serum proteins and osteoblasts on the surface transformation of a calcium phosphate coating: A physicochemical and ultrastructural study. J Biomed Mater Res 39:234-243
36. Saffar JL, Colombier ML, Detienville R (1990) Bone formation in tricalcium phosphate-filled periodontal intrabony lesions. Histological observations in humans. J Periodontol 61:209-216
37. Snyder AJ, Levin MP, Cutright DE (1984) Alloplastic implants of tricalcium phosphate ceramic in human periodontal osseous defects. J Periodontol 55:273-277
38. Stahl SS, Froum S (1986) Histological evaluation of human intraosseous healing responses to the placement of tricalcium phosphate ceramic implants. I. Three to eight months. J Periodontol 57:211-217
39. Sugaya A, Minabe M, Hori T, Tatsumi J, Watanabe Y, Ikeda K, Numabe Y, Hayashi H, Kamoi K (1990) Effects on wound healing of tricalcium phosphate-collagen complex implants in periodontal osseous defects in the dog. J Periodontal Res 25:60-63
40. Tamura K, Sato S, Kishida M, Asano S, Murai M, Ito K (2007) The use of porous beta-tricalcium phosphate blocks with platelet-rich plasma as an onlay bone graft biomaterial. J Periodontol 78:315-321
41. Trisi P, Rao W, Rebaudi A, Fiore P (2003) Histologic effect of pure-phase beta-tricalcium phosphate on bone regeneration in human artificial jawbone defects. Int J Periodontics Restor Dent 23:69-77
42. Van Winkelhoff AJ, Rodenburg JP, Goene RJ, Abbas F, Winkel EG, de Graaff J (1989) Metronidazole plus amoxycillin in the treatment of Actinobacillus actinomycetemcomitans associated periodontitis. J Clin Periodontol 16:128-131
43. Velich N, Nemeth Z, Hrabak K, Suba Z, Szabo G (2004) Repair of bony defect with combination biomaterials. J Craniofac Surg 15:11-15
44. Velich N, Nemeth Z, Toth C, Szabo G (2004) Long-term results with different bone substitutes used for sinus floor elevation. J Craniofac Surg 15:38-41
45. Wachtel H, Schenk G, Bohm S, Weng D, Zuhr O, Hurzeler MB (2003) Microsurgical access flap and enamel matrix derivative for the treatment of periodontal intrabony defects: A controlled clinical study. J Clin Periodontol 30:496-504
46. Weibrich G, Kleis WK, Hafner G (2002) Growth factor levels in the platelet-rich plasma produced by 2 different methods: Curasan-type PRP kit versus PCCS PRP system. Int J Oral Maxillofac Surg 17:184-190
47. Whitman DH, Berry RL, Green DM (1997) Platelet gel: An autologous alternative to fibrin glue with applications in oral and maxillofacial surgery. J Oral Maxillofac Surg 55:1294-1299
48. Wiltfang J, Schlegel KA, Schultze-Mosgau S, Nkenke E, Zimmermann R, Kessler P (2003) Sinus floor augmentation with beta-tricalciumphosphate (beta-TCP): Does platelet-rich plasma promote its osseous integration and degradation? Clin Oral Impl Res 14:213-218
49. Zerbo IR, Zijderveld SA, de Boer A, Bronckers AL, de Lange G, ten Bruggenkate CM, Burger EH (2004) Histomorphometry of human sinus floor augmentation using a porous beta-tricalcium phosphate: A prospective study. Clin Oral Implants Res 15:724-732