Protective effect of glycyrrhizin on nephrotic syndrome induced by adriamycin in rats

Clinical and Investigative Medicine

Volumn 32, Issue 3, 2009, Pages

  Yu, Li ^a   Bi, XueCheng ^b   Zhu, Gang ^d   Han, ZhaoDong ^a   Ye, YongKang ^a   Liang, YuXiang ^a   Zhang, Lei ^a   Hao, ZhiHong ^a   Zeng, GuoHua ^c   He, HuiChan ^a   Zhong, WeiDe ^a,b  

^a GUANGZHOU FIRST PEOPLE'S HOSPITAL   (China)

^b SOUTHERN MEDICAL UNIVERSITY   (China)

^c GUANGZHOU MEDICAL UNIVERSITY   (China)

^d BEIJING HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; COLLAGEN; CONNECTIVE TISSUE GROWTH FACTOR; CREATININE; DOXORUBICIN; FIBRONECTIN; GLYCYRRHIZIC ACID; LAMININ; PEROXIDASE; SODIUM CHLORIDE; TRANSFORMING GROWTH FACTOR BETA1;

ALBUMIN BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DISEASE SEVERITY; ELECTRON MICROSCOPY; HISTOPATHOLOGY; KIDNEY FUNCTION TEST; MACROPHAGE ACTIVATION; MALE; MEAN ARTERIAL PRESSURE; NEPHROTIC SYNDROME; NONHUMAN; PRIORITY JOURNAL; PROTEIN URINE LEVEL; QUANTITATIVE ASSAY; RAT; RENAL PROTECTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TREATMENT OUTCOME; UREA NITROGEN BLOOD LEVEL;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIBIOTICS, ANTINEOPLASTIC; DOXORUBICIN; GLYCYRRHIZIC ACID; IMMUNOHISTOCHEMISTRY; KIDNEY CORTEX; MALE; NEPHROTIC SYNDROME; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 67649383590     PISSN: 0147958X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Hendrik Bos, Gozewijn D Laverman, Robert H Henning, et al. Involvement of renal ACE activity in proteinuriaassociated renal damage in untreated and treated adriamycin nephrotic rats. J Renin Angiotensin Aldosterone Syst 2003; 4:106-12
2. Bruno Vogt, Bernhard Dick, Hans peter Marti, Felix J Frey, Brigitte M Frey. Reduced 11β -hydroxysteroid-dehydrogenase acticity in experimental nephritic syndrome. Nephrol Dial Transplant 2002; 17:753-8
3. Tomas Zima, Vladimir Tesar, Jirina Crkovska. ICRF 187 (dexrazoxan) protects from adriamycin induced nephritic syndrome in rats. Nephrol Dial Transplant 1998; 13:1975-9
4. Rubin Wang, John Kong, Dali Wang, Lin min, Eric Jung. A survey of Chinese herbal ingredients with liver protection activities. Chin Med 2007; 2: 5-13
5. Sohn EJ, Kang DG, Lee HS. Protective effects of glycyrrhizin on gentamicin induced acute renal failure in rats. Pharmacol Toxicol 2003; 93: 116-22
6. Gumpricht E, Dahl R, Devereaux MW, Sokol RJ. Licorice Compounds Glycyrrhizin and 18-Glycyrrhetinic Acid Are Potent Modulators of Bile Acid-induced Cytotoxicity in Rat Hepatocytes. J Biol Chem 2005; 280: 10556-63
7. Yoshida T, Tsuda Y, Takeuchi D, Kobayashi M, Pollard RB, Suzuki F. Glycyrrhizin inhibits neutrophil-associated generation of alternatively activated macrophages. Cytokine. 2006; 33:317-22.
8. Tamaki K, Okuda S, Ando T. TGFβ1 in glomerulosclerosis and interstitial fibrosis of adriamycin nephropathy. Kidney Int 1994; 45:525-32.
9. Remuzzi G, Zoja C, Remuzzi A. Low protein diet prevents glomerular damage in adriamycin treated rats. Kidney Int 1985; 28: 21-7
10. Deschenes G, Doucet A. Collecting duct ATPase activity is correlated with urinary sodium excretion in rat nephritic syndromes. J Am Soc Nephrol 2000;11:604-15
11. Seza Ozen, Yusuf Usta, Inci Sahin Erdemli, Dicle Orhan. Association of nitric oxide production and apoptosis in a model of experimental nephropathy. Nephrol Dial Transplant 2001; 16:32-8
12. Sato H, Goto W, Yamamura J, Kurokawa M, Kageyama S, Takahara T. Therapeutic basis of glycyrrhizin on chronic hepatitis B. Antiviral Res 1996; 30:171-7.
13. Kim DH, Hong SW, Kim BT, Bae EA, Park HY, Han MJ. Biotransformation of glycyrrhizin by human intestinal bacteria and its relation to biological activities. Arch Pharm Res 2000; 23:172-7.
14. Toshiaki Makino, Nobuhiro Ohtake, Akito Watanabe, Naoko Tsuchiya, Sachiko Imamura, Seiichi Iizuka. Down-regulation of a hepatic transporter Mrp2 is involved in alteration of pharmacokinetics of glycyrrhizin and its metabolites in a rat model of chronic liver injury. DMD Fast Forward. 2008; doi:10.1124/dmd.108.021089
15. Morimoto Y, Nakajima C. Pseudoaldosteronism induced by licorice derivatives in Japan. J. Trad. Med 1991; 8:1-22.
16. Cinatl J, Morgenstern B. Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus. Lancet 2003; 361: 2045-6.
17. Homma M, Ishihara M, Qian W, Kohda Y. Effects of long term administration of Shakuyaku-kanzo-To and Shosaiko-To on serum potassium levels. Yakugaku Zasshi 2006; 126:973-8.
18. Vladimír Tesař, Tomáš Zima, Milan Jirsa, Jiřina Crkovská, Stanislav Štípek, Zdena Vernerov. Influence of losartan and enalapril on urinary excretion of 8 isoprostane in experimental nephritic syndrome. Med Sci Monit 2002; 8: BR69-74
19. Comporti M. Lipid peroxidation. Biopathological significance. Mol Aspects Med. 1993; 14:199-207.
20. Krag S, Danielsen CC, Carmeliet P. Plasminogen activator inhibitor 1 gene deficiency attenuates TGF beta1 induced kidney disease. Kidney Int 2005; 68:2651-66.
21. Crean JKG, Finlay D, MurphyM. The role of p42/ p44 MAPK and protein kinase B in connective tissue growth factor induced extracellular matrix protein production, cell migration and actin cytoskeletal rearrangement in human mesangial cells. J Biol Chem 2002; 277: 44187-94.
22. Zhang ZG, Liu XG, Chen GP. Significance of MMP 2 and TIMP 2 mRNA expressions on glomerular cells in the development of glomerulosclerosis. Chin Med Sci J 2004; 19:84-8.
23. Ma LJ, Jha S, Ling H. Divergent effects of low versus high dose anti TGF beta antibody in puromycin aminonucleoside nephropathy in rats. Kidney Int 2004; 65:106-15.
24. Zhang C, Meng X, Zhu Z. Role of connective tissue growth factor in renal tubular epithelial myofibroblast transdifferentiation and extracellular matrix accumulation in vitro. Life Sci 2004; 75:367-79.