Antenatal glucocorticoid therapy increases glucose delivery to cerebral circulations during acute hypoxemia in fetal sheep during late gestation

American Journal of Obstetrics and Gynecology

Volumn 201, Issue 1, 2009, Pages 82.e1-82.e8

  Jellyman, Juanita K ^a   Gardner, David S ^a   McGarrigle, Hugh H ^b   Fowden, Abigail L ^a   Giussani, Dino A ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

dexamethasone; fetus; hypoxia

Indexed keywords

DEXAMETHASONE SODIUM PHOSPHATE; GLUCOSE; OXYGEN; SODIUM CHLORIDE; TRITIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD GAS ANALYSIS; BRAIN CIRCULATION; BRAIN HYPOXIA; CONTROLLED STUDY; CORTICOSTEROID THERAPY; DRUG BLOOD LEVEL; FEMALE; FETUS; GESTATION PERIOD; HYPOXIA; NONHUMAN; PRENATAL CARE; PRIORITY JOURNAL; SHEEP;

EID: 67649361961     PISSN: 00029378     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ajog.2009.01.012     Document Type: Article

References (48)

1. Liggins G.C. Premature delivery of foetal lambs infused with glucocorticoids. J. Endocrinol 45 (1969) 515-523
2. NIH Consensus Development Conference. Effect of corticosteroids for fetal maturation on perinatal outcomes. NIH Consensus Development Panel on the Effect of Corticosteroids for Fetal Maturation on Perinatal Outcomes. JAMA 273 (2005) 413-418
3. Crowley PA. Antenatal corticosteroid therapy: a meta-analysis of the randomized trials, 1972 to 1994. Am J Obstet Gynecol 195;173:322-35.
4. Bennet L., Kozuma S., McGarrigle H.H., and Hanson M.A. Temporal changes in fetal cardiovascular, behavioural, metabolic and endocrine responses to maternally administered dexamethasone in the late gestation fetal sheep. Br J Obstet Gynaecol 106 (1999) 331-339
5. Moss T.J.M., Nitsos I., Harding R., and Newnham J. The acute and longer-term differential effects of maternal and fetal betamethasone treatments in chronically catheterised fetal sheep. Am J Obstet Gynecol 189 (2003) 1751-1757
6. Samtani M.N., Loehle M., Grant A., Nathanielsz P.W., and Jusko W.J. Betamethasone pharmacokinetics after two prodrug formulations in sheep: implications for antenatal corticosteroid use. Drug Metab Dispos 33 (2005) 1124-1130
7. Schwab M., Coksaygan T., Samtani M.N., Jusko W.J., and Nathanielsz P.W. Kinetics of betamethasone and fetal cardiovacular adverse effects in pregnant sheep after different doses. Am J Obstet Gynecol 108 (2006) 617-625
8. Huch A., Huch R., Schneider H., and Rooth G. Continuous transcutaneous monitoring of fetal oxygen tension during labour. Br J Obstet Gynaecol 84 Suppl 1 (1997) 1-39
9. Giussani D.A., Spencer J.A.D., and Hanson M.A. Fetal cardiovascular reflex responses to hypoxaemia. Fetal Matern Med Rev 6 (1994) 17-37
10. Gudmundsson S., and Dubiel M. Doppler velocimetry in the evaluation of fetal hypoxia. J Perinat Med 29 (2001) 399-407
11. Scharf A., Seppelt M., and Sohn C. Doppler flow velocity to measure the redistribution of fetal cardiac output in fetal stress. Eur J Obstet Gynecol Reprod Biol 110 Suppl 1 (2003) S119-S126
12. Boddy K., Dawes G.S., Fisher R., Pinter S., and Robinson J.S. Foetal respiratory movements, electrocortical and cardiovascular responses to hypoxemia and hypercapnia in sheep. J Physiol 243 (1974) 599-618
13. Cohn H.E., Sacks E.J., Heymann M.A., and Rudolph A.M. Cardiovascular responses to hypoxemia and acidemia in fetal lambs. Am J Obstet Gynecol 120 (1974) 817-824
14. Giussani D.A., Spencer J.A., Moore P.J., Bennet L., and Hanson M.A. Afferent and efferent components of the cardiovascular reflex responses to acute hypoxia in term fetal sheep. J Physiol 461 (1993) 431-449
15. Jones C.T. The development of some metabolic responses to hypoxia in the foetal sheep. J Physiol 265 (1977) 743-762
16. Jones C.T., Ritchie J.W., and Walker D. The effects of hypoxia on glucose turnover in the fetal sheep. J Dev Physiol 5 (1983) 223-235
17. Hooper S.B. Fetal metabolic responses to hypoxia. Reprod Fertil Dev 7 (1995) 527-538
18. Jellyman J.K., Gardner D.S., Fowden A.L., and Giussani D.A. Effects of dexamethasone on the uterine and umbilical vascular beds during basal and hypoxemic conditions in sheep. Am J Obstet Gynecol 190 (2004) 825-835
19. Jellyman J.K., Gardner D.S., Fowden A.L., and Giussani D.A. Fetal cardiovascular, metabolic and endocrine responses to acute hypoxemia during and following maternal treatment with dexamethasone in sheep. J Physiol 567 (2005) 673-688
20. Owens J.A., Falconer J., and Robinson J.S. Effect of restriction of placental growth on oxygen delivery to and consumption by the pregnant uterus and fetus. J Dev Physiol 9 (1987) 137-150
21. Ballard P.L., and Ballard R.A. Scientific basis and therapeutic regimens for use of antenatal glucocorticoids. Am J Obstet Gynecol 173 (1995) 254-262
22. Fletcher A.J., Gardner D.S., Edwards C.M., Fowden A.L., and Giussani D.A. Cardiovascular and endocrine responses to acute hypoxemia during and following dexamethasone infusion in the ovine fetus. J Physiol 549 (2003) 271-287
23. Derks J.B., Giussani D.A., Jenkins S.L., et al. A comparative study of cardiovascular, endocrine and behavioural effects of betamethasone and dexamethasone administration to fetal sheep. J Physiol 499 Pt 1 (1997) 217-226
24. Kream J., Mulay S., Fukushima D.K., and Solomon S. Determination of plasma dexamethasone in the mother and the newborn after administration of the hormone in a clinical trial. J Clin Endocrinol Metab 56 (1983) 127-133
25. Petersen M.C., Nation R.L., Ashley J.J., and McBride W.G. The placental transfer of betamethasone. Eur J Clin Pharmacol 18 (1980) 245-247
26. Jobe A.H., Newnham J., Willet K., Sly P., and Ikegami M. Fetal versus maternal and gestational age effects of repetitive antenatal glucocorticoids. Pediatrics 102 (1998) 1116-1125
27. Newnham J.P., Evans S.F., Godfrey M., Huang W., Ikegami M., and Jobe A. Maternal, but not fetal, administration of corticosteroids restricts fetal growth. J Matern Fetal Med 8 (1999) 81-87
28. Nathanielsz P.W., and Hanson M.A. The fetal dilemma: spare the brain and spoil the liver. J Physiol 548 (2003) 2 33
29. Parer J.T. Effects of fetal asphyxia on brain cell structure and function: limits of tolerance. Comp Biochem Physiol 119 (1998) 711-716
30. Richardson B.S., Rurak D., Patrick J.E., Homan J., and Carmichael L. Cerebral oxidative metabolism during sustained hypoxaemia in fetal sheep. J Dev Physiol 11 (1989) 37-43
31. Richardson B.S., Carmichael L., Homan J., and Patrick J.E. Cerebral oxidative metabolism in fetal sheep with prolonged and graded hypoxemia. J Dev Physiol 19 (1993) 77-83
32. Richardson B.S. The fetal brain: metabolic and circulatory responses to asphyxia. Clin Invest Med 16 (1993) 103-114
33. Blood A.B., Hunter C.J., and Power G.G. Adenosine mediates decreased cerebral metabolic rate and increased cerebral blood flow during acute moderate hypoxia in the near-term fetal sheep. J Physiol 553 Pt 3 (2003) 935-945
34. Blood A.B., Hunter C.J., and Power G.G. The role of adenosine in regulation of cerebral blood flow during hypoxia in the near-term fetal sheep. J Physiol 543 Pt 3 (2002) 1015-1023
35. Pearce W. Hypoxic regulation of the fetal cerebral circulation. J Appl Physiol 100 (2006) 731-738
36. Armstead W.M. Role of nitric oxide and cAMP in prostaglandin-induced pial arterial vasodilation. Am J Physiol 268 4 Pt 2 (1995) H1436-H1440
37. Wilderman M.J., and Armstead W.M. Role of neuronal NO synthase in relationship between NO and opioids in hypoxia-induced pial artery dilation. Am J Physiol 273 4 Pt 2 (1997) H1807-H1815
38. Herrera E.A., Riquelme R.A., Sanhueza E.M., Gajardo C., Parer J.T., and Llanos A.J. Cardiovascular responses to arginine vasopressin blockade during acute hypoxemia in the llama fetus. High Alt Med Biol 1 (2000) 175-184
39. Schwab M., Roedel M., Anwar M.A., et al. Effects of betamethasone administration to the fetal sheep in late gestation on fetal cerebral blood flow. J Physiol 528 Pt 3 (2000) 619-632
40. McCallum J., Smith N., Schwab M., et al. Effects of antenatal glucocorticoids on cerebral substrate metabolism in the preterm ovine fetus. Am J Obstet Gynecol 198 (2008) 105.e1-105.e9
41. Barnes R.J., Comline R.S., and Silver M. Effect of cortisol on liver glycogen concentrations in hypophysectomized, adrenalectomized and normal foetal lambs during late or prolonged gestation. J Physiol 275 (1978) 567-569
42. Fowden A.L., Mijovic J., and Silver M. The effects of cortisol on hepatic and renal gluconeogenic enzyme activities in the sheep fetus during late gestation. J Endocrinol 137 (1993) 213-222
43. Epstein M.F., Farrell P.M., Sparks J.W., Pepe G., Driscoll G.G., and Chez R.A. Maternal betamethasone and fetal growth and development in the monkey. Am J Obstet Gynecol 127 (1997) 261-263
44. Franko K.L., Giussani D.A., Forhead A.J., and Fowden A.L. Effects of dexamethasone on the glucogenic capacity of fetal, pregnant, and non-pregnant adult sheep. J Endocrinol 192 (2007) 67-73
45. Tye L.M., and Burton A.P. Glycogen deposition in fetal mouse tissues and the effect of dexamethasone. Biol Neonate 38 (1980) 265-269
46. Klepac R. Effect of dexamethasone on glycogen deposition in pregnant rats and their fetuses. Exp Clin Endocrinol 86 (1985) 305-309
47. Parer J.T. Fetal cerebral metabolism: the influence of asphyxia and other factors. J Perinatol 14 (1994) 376-385
48. Myers R.E., de Courten-Myers G.M., and Wagner K.R. The effects of asphyxia on the fetal brain. In: Beard R.W., and Nathanielz P. (Eds). Fetal physiology and medicine (1984), Marcel Dekker, New York 419-458