Effects of dexamethasone on the glucogenic capacity of fetal, pregnant, and non-pregnant adult sheep

Journal of Endocrinology

Volumn 192, Issue 1, 2007, Pages 67-73

  Franko, K L ^a   Giussani, D A ^a   Forhead, A J ^a   Fowden, A L ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; GLUCOSE; GLUCOSE 6 PHOSPHATASE; GLYCOGEN; HYDROCORTISONE; INSULIN; LIOTHYRONINE; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); SODIUM CHLORIDE; THYROXINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; FEMALE; FETUS; GLUCOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; GLYCOGEN ANALYSIS; GLYCOGEN LIVER LEVEL; GLYCOGEN METABOLISM; HYDROCORTISONE BLOOD LEVEL; INSULIN BLOOD LEVEL; KIDNEY PARENCHYMA; LIOTHYRONINE BLOOD LEVEL; LIVER PARENCHYMA; MATERNAL TREATMENT; NONHUMAN; PLACENTAL TRANSFER; PREGNANCY; PRIORITY JOURNAL; PROTEIN CONTENT; SHEEP; THYROXINE BLOOD LEVEL;

ANIMALS; BLOOD GLUCOSE; DEXAMETHASONE; FEMALE; GLUCOCORTICOIDS; GLUCONEOGENESIS; GLUCOSE-6-PHOSPHATASE; GLYCOGEN; HYDROCORTISONE; INSULIN; KIDNEY; LIVER; MATERNAL-FETAL EXCHANGE; MODELS, ANIMAL; PHOSPHOENOLPYRUVATE CARBOXYLASE; PREGNANCY; SHEEP; STIMULATION, CHEMICAL; THYROXINE; TRIIODOTHYRONINE;

EID: 33947381879     PISSN: 00220795     EISSN: None     Source Type: Journal    
DOI: 10.1677/joe.1.07063     Document Type: Article

References (40)

1. Ahlquist JAO, Franklyn JA, Ramsden DP & Sheppard MC 1989 The influence of dexamethasone on serum thyrotrophin and thyrotrophin synthesis in the rat. Molecular and Cellular Endocrinology 64 55-61.
2. Barnes RJ, Comline RS & Silver M 1978 Effect of cortisol on liver glycogen concentrations in hypophysectomized, adrenalectomized and normal foetal lambs during late or prolonged gestation. Journal of Physiology 275 567-579.
3. Bell ME, Wood CE & Keller-Wood M 1991 Influence of reproductive state on pituitary-adrenal activity in the ewe. Domestic Animal Endocrinology 8 245-254.
4. Bennett L, Kozuma S, McGarrigle HH & Hanson MA 1999 Temporal changes in fetal cardiovascular, behavioural, metabolic and endocrine responses to maternally administered dexamethasone in the late gestation fetal sheep. British Journal of Obstetrics and Gynaecology 106 331-339.
5. Bergman EN, Brockman RP & Kaufman CF 1974 Glucose metabolism in ruminants: comparison of whole body turnover with production in the gut, liver and kidney. Federation Proceedings 33 1849-1854.
6. Bollen M & Stalmans W 1988 The effect of the thyroid status on the activation of glycogen synthase in liver cells. Endocrinology 122 2915-2919.
7. Dancis J, Jansen V & Levitz M 1980 Placental transfer of steroids: effects of binding to serum albumin and to placenta. American Journal of Physiology 238 E208-E213.
8. Dawkins MJR 1966 Biochemical aspects of developing function in newborn mammalian liver. British Medical Bulletin 22 27-33.
9. 4. Journal of Clinical Endocrinology and Metabolism 42 976-978.
10. Epstein ME, Farrell PM, Sparks JW, Pepe G, Driscoll GG & Chez RA 1977 Maternal betamethasone and fetal growth and development in the monkey. American Journal of Obstetrics and Gynecology 127 261-263.
11. Fletcher AJW, Goodfellow MR, Forhead AJ, Gardner DS, McGarrigle HHG, Fowden AL & Giussani DA 2000 Low doses of dexamethasone suppress pituitary adrenal function but augment the glycaemic response to acute hypoxia in fetal sheep during late gestation. Pediatric Research 47 684-691.
12. Forhead AJ, Poore KR, Mapstone J & Fowden AL 2003 Developmental regulation of hepatic and renal gluconeogenic enzymes by thyroid hormones in fetal sheep during late gestation. Journal of Physiology 548 941-947.
13. Forhead AJ, Curtis K, Kaptein E, Visser TJ & Fowden AL 2006 Developmental control of iodothyronine deiodinases by cortisol in the ovine fetus and placenta near term. Endocrinology 142 12.
14. Forhead AJ, Jellyman JK, Gardner DS, Giussani DA, Kaptein E, Visser TJ & Fowden AL 2007 Differential effects of maternal dexamethasone treatment on circulating thyroid hormone concentrations and tissue deiodinase activity in the pregnant ewe and fetus. Endocrinology In Press.
15. Fowden AL & Silver M 1995 The effects of thyroid hormones on oxygen and glucose metabolism in the sheep fetus during late gestation. Journal of Physiology 482 203-213.
16. Fowden AL & Forhead AJ 2004 Endocrine mechanisms of intrauterine programming. Reproduction 127 515-526.
17. Fowden AL, Mijovic J & Silver M 1993 The effects of cortisol on hepatic and renal gluconeogenic enzyme activities in the sheep fetus during late gestation. Journal of Endocrinology 137 213-222.
18. Fowden AL, Li J & Forhead AJ 1998 Glucocortiocids and the preparation for life after birth; are there long term consequences of the life insurance? Proceedings of the Nutrition Society 57 113-122.
19. Fowden AL, Ousey JC & Forhead AJ 2001 Comparative aspects of prepartum maturation; provision of nutrients. Pferdeheilkunde 17 653-658.
20. Jellyman JK, Gardner DS, Edwards CMB, Fowden AL & Giussani DA 2005a Fetal cardiovascular, metabolic and endocrine responses to acute hypoxaemia during and following maternal treatment with dexamethasone in sheep. Journal of Physiology 567 673-688.
21. Jellyman JK, Gardner DS, Edwards CMB, Fowden AL & Giussani DA 2005b The effects of pregnancy on the cardiovascular response to acute systemic isocapnic hypoxia in conscious sheep. British Journal of Obstetrics and Gynaecology 112 889-896.
22. Keller-Wood ME, Silbiger J & Wood CE 1988 Progesterone attenuates the inhibition of adrenocorticotropin responses by cortisol in non pregnant ewes. Endocrinology 123 647-651.
23. Klepac R 1985 Effect of dexamethasone on glycogen deposition in pregnant rats and their fetuses. Experimental and Clinical Endocrinology 86 305-309.
24. Kream J, Mulay S, Fukushima DK & Solomon S 1983 Determination of plasma dexamethasone in the mother and the newborn after administration of the hormone in a clinical trial. Journal of Clinical Endocrinology and Metabolism 56 127-133.
25. Levitsky LL, Paton JB & Fisher DE 1988 Precursors to glycogen in ovine fetuses. American Journal of Physiology 255 E743-E747.
26. Liggins GC 1994 The role of cortisol in preparing the fetus for birth. Reproduction, Fertility, and Development 6 141-150.
27. Lisboa PC, Curty FH, Moreira RM, Oliveira KJ & Pazos-Moura CC 2001 Sex steroids and rat anterior pituitary and liver iodothyronine deiodinase activities. Hormone and Metabolism Research 33 532-535.
28. Malbon CC & Campbell R 1984 Thyroid hormones regulate hepatic glycogen synthase. Endocrinology 115 681-686.
29. Matthews PA, Fowden AL & Forhead AJ 2006 Role of thyroid hormones in the deposition of hepatic glycogen in fetal sheep near term. Early Human Development 82 633-634.
30. Mitsuma T & Nogimori T 1982 Effects of dexamethasone on the hypothalamic-pituitary-thyroid axis in rats. Acta Endocrinologica 100 51-56.
31. NIH Consensus Development Conference 1995 Effects of corticosteroid for fetal maturation on perinatal outcomes. Journal of the American Medical Association 273 413-418.
32. Osathanondh R, Chopra IJ & Tulchinsky D 1978 Effects of dexamethasone on fetal and maternal thyroxine, triiodothyronine, reverse triiodothyronine and thyrotropin levels. Journal of Clinical Endocrinology and Metabolism 47 1236-1249.
33. Robinson PM, Comline RS, Fowden AL & Silver M 1983 Adrenal cortex of fetal lamb: changes after hypophysectomy and effects of synacthen on cytoarchitecture and secretory activity. Quarterly Journal of Experimental Physiology 68 15-27.
34. Roehrig KL & Allred JB 1974 Direct enzymatic procedure for the determination of liver glycogen. Analytical Biochemistry 58 414-421.
35. Schwartz AL & Rall TW 1973 Hormonal regulation of glycogen metabolism in neonatal rat liver. Biochemical Journal 134 985-993.
36. Shelley HJ 1961 Glycogen reserves and their changes at birth and in anoxia. British Medical Bulletin 17 137-143.
37. Stolte EH, Kemenade BM, Savelkoul HF & Flik G 2006 Evolution of glucocorticoid receptors with different glucocorticoid sensitivity. Journal of Endocrinology 190 17-28.
38. Thomas AL, Krane EJ & Nathanielsz PW 1978 Changes in the fetal thyroid axis after induction of premature parturition by low dose continuous intravascular cortisol infusion to fetal sheep at 130 days of gestation. Endocrinology 103 17-23.
39. Trahair JT & Sangild P 1997 Systemic and luminal influences on the perinatal development of the gut. Equine Veterinary Journal 24 40-50.
40. Tye LM & Burton AP 1980 Glycogen deposition in fetal mouse tissues and the effect of dexamethasone. Biology of the Neonate 38 265-269.