RNA interference targeting leucine aminopeptidase blocks hatching of Schistosoma mansoni eggs

Molecular and Biochemical Parasitology

Volumn 167, Issue 2, 2009, Pages 118-126

  Rinaldi, Gabriel ^a,b,c   Morales, Maria E ^c   Alrefaei, Yousef N ^a,c   Cancela, Martín ^b   Castillo, Estela ^d   Dalton, John P ^e   Tort, José F ^b   Brindley, Paul J ^a,c  

^a GEORGE WASHINGTON UNIVERSITY MEDICAL CENTER   (United States)

^b DEPARTAMENTO DE BIOQUÍMICA   (Uruguay)

^c TULANE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^d UNIVERSIDAD DE LA REPÚBLICA   (Uruguay)

^e MCGILL UNIVERSITY   (Canada)

Author keywords

Bestatin; EC 3.4.11.1; Eggs; Hatching; LAP; Leucine aminopeptidase; Leucyl aminopeptidase; MEROPS family M17; Phylogeny; RNA interference; Schistosome

Indexed keywords

COUMARIN DERIVATIVE; CYTOSOL AMINOPEPTIDASE; EXOPEPTIDASE; SMALL INTERFERING RNA;

ARTICLE; CONTROLLED STUDY; DEVELOPMENTAL STAGE; DRUG TARGETING; ENZYME ACTIVITY; EXON; FUNCTIONAL GENOMICS; GENE DUPLICATION; GENE EXPRESSION PROFILING; GENE STRUCTURE; GENETIC ANALYSIS; HATCHING; HELMINTH; INHIBITION KINETICS; INTRON; LIFE CYCLE; MIRACIDIUM; NONHUMAN; NUCLEOTIDE SEQUENCE; ORTHOLOGY; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTOZOAL GENETICS; RNA INTERFERENCE; SCHISTOSOMA JAPONICUM; SCHISTOSOMA MANSONI; SCHISTOSOMULUM; SEQUENCE HOMOLOGY; SPECIES DIFFERENTIATION; SPOROCYST;

AMINO ACID SEQUENCE; ANIMALS; GENE DUPLICATION; GENE KNOCKDOWN TECHNIQUES; GENES, ESSENTIAL; HELMINTH PROTEINS; LEUCYL AMINOPEPTIDASE; MOLECULAR SEQUENCE DATA; PHYLOGENY; RNA INTERFERENCE; SCHISTOSOMA JAPONICUM; SCHISTOSOMA MANSONI; SEQUENCE HOMOLOGY, AMINO ACID;

GASTROPODA; SCHISTOSOMA; SCHISTOSOMA MANSONI; VERMES;

EID: 67649361330     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molbiopara.2009.05.002     Document Type: Article

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