Tissue-specific mRNA expression profiles of drug-metabolizing enzymes and transporters in the cynomolgus monkey

Drug Metabolism and Pharmacokinetics

Volumn 24, Issue 2, 2009, Pages 139-144

  Nishimura, Masuhiro ^a   Koeda, Akiko ^b   Morikawa, Hiroshi ^b   Satoh, Tetsuo ^b,c   Narimatsu, Shizuo ^d   Naito, Shinsaku ^a  

^a OTSUKA PHARMACEUTICAL CO LTD   (Japan)

^b N   (Japan)

^c BUILDING RESEARCH INSTITUTE   (Japan)

^d OKAYAMA UNIVERSITY   (Japan)

Author keywords

Cynomolgus monkey; Drug metabolizing enzymes; MRNA expression; Quantification; Tissue distribution

Indexed keywords

ABC TRANSPORTER; CARRIER PROTEIN; CYTOCHROME P450; CYTOCHROME P450 1A8; CYTOCHROME P450 2B9; CYTOCHROME P450 2D17; CYTOCHROME P450 2E1; CYTOCHROME P450 2J2; CYTOCHROME P450 3A5; DRUG METABOLIZING ENZYME; GLUCURONOSYLTRANSFERASE; GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE M1; GLUTATHIONE TRANSFERASE M2; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; ORGANIC CATION TRANSPORTER; ORGANIC CATION TRANSPORTER 8; PEPTIDE TRANSPORTER 1; SULFOTRANSFERASE; UNCLASSIFIED DRUG;

ADRENAL GLAND; ANIMAL TISSUE; ARTICLE; BRAIN TISSUE; CONTROLLED STUDY; DRUG METABOLISM; DRUG RESEARCH; DRUG SCREENING; DRUG TRANSPORT; GENE EXPRESSION PROFILING; HEART; KIDNEY PARENCHYMA; LARGE INTESTINE; LIVER PARENCHYMA; LUNG PARENCHYMA; MOLECULAR PROBE; MONKEY; NONHUMAN; NUCLEOTIDE SEQUENCE; PANCREAS; PROSTATE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMALL INTESTINE; SPLEEN; TESTIS; THYMUS; TISSUE SPECIFICITY;

EID: 67649336984     PISSN: 13474367     EISSN: 18800920     Source Type: Journal    
DOI: 10.2133/dmpk.24.139     Document Type: Article

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