Delirium Prevention and Treatment

Critical Care Clinics

Volumn 25, Issue 3, 2009, Pages 585-591

  Skrobik, Yoanna ^a,b  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b MAISONNEUVE ROSEMONT HOSPITAL   (Canada)

Author keywords

Critical care; Delirum; Non pharmacologic management; Pharmacology; Prevention

Indexed keywords

ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; BENZODIAZEPINE; CHOLINESTERASE INHIBITOR; DEXMEDETOMIDINE; DIAZEPAM; DONEPEZIL; FLUNITRAZEPAM; HALOPERIDOL; MIDAZOLAM; NEUROLEPTIC AGENT; OLANZAPINE; OPIATE; PETHIDINE; PHENOBARBITAL; PLACEBO; PROPOFOL; QUETIAPINE; SEDATIVE AGENT;

ALCOHOL ABUSE; ALCOHOL WITHDRAWAL; ALCOHOLISM; BRADYCARDIA; CAREGIVER; CLINICAL TRIAL; CONTINUOUS INFUSION; CRITICALLY ILL PATIENT; DELIRIUM; DRUG DOSE REDUCTION; DRUG DOSE TITRATION; EXTRAPYRAMIDAL SYNDROME; HEARING AID; HOSPITAL PATIENT; HUMAN; INTENSIVE CARE; INTERPERSONAL COMMUNICATION; MOBILIZATION; ORIENTATION; PRIORITY JOURNAL; REVIEW; RISK ASSESSMENT; SLEEP; SPECTACLES; TREATMENT OUTCOME; WITHDRAWAL SYNDROME;

AGED; ANALGESICS, OPIOID; CRITICAL CARE; CRITICAL ILLNESS; DELIRIUM; HUMANS;

EID: 67649304471     PISSN: 07490704     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ccc.2009.05.003     Document Type: Review

References (37)

1. Ely E.W., Shintani A., Truman B., et al. Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit. JAMA 291 (2004) 1753-1762
2. Ouimet S., Kavanagh B.P., Gottfried S.B., et al. Incidence, risk factors and consequences of ICU delirium. Intensive Care Med 33 (2007) 66-73
3. Thomason J.W., Shintani A., Peterson J.F., et al. Intensive care unit delirium is an independent predictor of longer hospital stay: a prospective analysis of 261 non-ventilated patients. Crit Care 9 (2005) R375-R381
4. Ely E.W., Inouye S.K., Bernard G.R., et al. Delirium in mechanically ventilated patients: validity and reliability of the confusion assessment method for the intensive care unit (CAM-ICU). JAMA 286 (2001) 2703-2710
5. Bergeron N., Dubois M.J., Dumont M., et al. Intensive care delirium screening checklist: evaluation of a new screening tool. Intensive Care Med 27 (2001) 859-864
6. Marquis F., Ouimet S., Riker R., et al. Individual delirium symptoms: do they matter?. Crit Care Med 35 (2007) 2533-2537
7. Ouimet S., Riker R., Bergeon N., et al. Subsyndromal delirium in the ICU: evidence for a disease spectrum. Intensive Care Med 33 (2007) 1007-1013
8. Inouye S.K., Bogardus Jr. S.T., Charpentier P.A., et al. A multicomponent intervention to prevent delirium in hospitalized older patients. N Engl J Med 340 (1999) 669-676
9. Marcantonio E.R., Flacker J.M., Wright R.J., et al. Reducing delirium after hip fracture: a randomized trial. J Am Geriatr Soc 49 (2001) 516-522
10. Schweickert W.D., Pohlman M.C., Pawlik A., et al. The impact of early mobilization on ICU delirium in mechanically ventilated (MV) patients. Lancet 373 (2009) 1874-1882
11. Cooper A.B., Thornley K.S., Young G.B., et al. Sleep in critically ill patients requiring mechanical ventilation. Chest 117 (2000) 809-818
12. Aizawa K., Kanai T., Saikawa Y., et al. A novel approach to the prevention of postoperative delirium in the elderly after gastrointestinal surgery. Surg Today 32 (2002) 310-314
13. Kalisvaart K.J., de Jonghe J.F., Bogaards M.J., et al. Haloperidol prophylaxis for elderly hip-surgery patients at risk for delirium: a randomized placebo-controlled study. J Am Geriatr Soc 53 (2005) 1658-1666
14. Liptzin B., Laki A., Garb J.L., et al. Donepezil in the prevention and treatment of post-surgical delirium. Am J Geriatr Psychiatry 13 (2005) 1100-1106
15. Riker R.R., Shehabi Y., Bokesch P.M., et al. Dexmedetomidine vs midazolam for sedation of critically ill patients: a randomized trial. JAMA 301 (2009) 489-499
16. Pandharipande P., Shintani A., Peterson J., et al. Lorazepam is an independent risk factor for transitioning to delirium in intensive care unit patients. Anesthesiology 104 (2006) 21-26
17. Pandharipande P., Cotton B., Shintani A., et al. Prevalence and risk factors for development of delirium in surgical and trauma intensive care unit patients. J Trauma 65 (2008) 34-41
18. Marcantonio E.R., Juarez G., Goldman L., et al. The relationship of postoperative delirium with psychoactive medications. JAMA 272 (1994) 1518-1522
19. Ouimet, et al. Delirium prevention strategies: targeting and improving outcomes. ICM 32 Suppl 1 (2006) S141
20. de Wit M., Wan S.Y., Gill S., et al. Prevalence and impact of alcohol and other drug use disorders on sedation and mechanical ventilation: a retrospective study. BMC Anesthesiol 7 (2007) 3
21. Moss M., and Burnham E.L. Alcohol abuse in the critically ill patient. Lancet 368 (2006) 2231-2242
22. Blondell R.D., Powell G.E., Dodds H.N., et al. Admission characteristics of trauma patients in whom delirium develops. Am J Surg 187 (2004) 332-337
23. Marcantonio E.R., Goldman L., Mangione C.M., et al. A clinical prediction rule for delirium after elective noncardiac surgery. JAMA 271 (1994) 134-139
24. Devlin J.W., Marquis F., Riker R.R., et al. Combined didactic and scenario-based education improves the ability of intensive care unit staff to recognize delirium at the bedside. Crit Care 12 (2008) R19
25. Cheung C.Z., Alibhai S.M., Robinson M., et al. Recognition and labeling of delirium symptoms by intensivists: does it matter?. Intensive Care Med 34 (2008) 437-446
26. Jacobi J., Fraser G.L., Coursin D.B., et al. Clinical practice guidelines for the sustained use of sedatives and analgesics in the critically ill adult. Crit Care Med 30 (2002) 119-141
27. Seitz D.P., Gill S.S., and van Zyl L.T. Antipsychotics in the treatment of delirium: a systematic review. J Clin Psychiatry 68 (2007) 11-21
28. Kapur S., and Seeman P. Antipsychotic agents differ in how fast they come off the dopamine D2 receptors. Implications for atypical antipsychotic action. J Psychiatry Neurosci 25 (2000) 161-166
29. Nordstrom A.L., Farde L., Wiesel F.A., et al. Central D2-dopamine receptor occupancy in relation to antipsychotic drug effects: a double-blind PET study of schizophrenic patients. Biol Psychiatry 33 (1993) 227-235
30. Skrobik Y.K., Bergeron N., Dumont M., et al. Olanzapine vs haloperidol: treating delirium in a critical care setting. Intensive Care Med 30 (2004) 444-449
31. Devlin, et al. Crit Care Med 36 12 (2008) A17
32. Ely E.W., Truman B., Shintani A., et al. Monitoring sedation status over time in ICU patients: reliability and validity of the Richmond Agitation-Sedation Scale (RASS). JAMA 289 (2003) 2983-2991
33. Spies C.D., Otter H.E., Huske B., et al. Alcohol withdrawal severity is decreased by symptom-orientated adjusted bolus therapy in the ICU. Intensive Care Med 29 (2003) 2230-2238
34. Hodges B., and Mazur J.E. Intravenous ethanol for the treatment of alcohol withdrawal syndrome in critically ill patients. Pharmacotherapy 24 (2004) 1578-1585
35. Gold J.A., Rimal B., Nolan A., et al. A strategy of escalating doses of benzodiazepines and phenobarbital administration reduces the need for mechanical ventilation in delirium tremens. Crit Care Med 35 (2007) 724-730
36. Kress J.P., Vinayak A.G., Levitt J., et al. Daily sedative interruption in mechanically ventilated patients at risk for coronary artery disease. Crit Care Med 35 (2007) 365-371
37. Girard T.D., Kress J.P., Fuchs B.D., et al. Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (awakening and breathing controlled trial): a randomised controlled trial. Lancet 371 (2008) 126-134