Ligand switching in cell-permeable peptides: Manipulation of the α-integrin signature motif

ACS Chemical Biology

Volumn 4, Issue 6, 2009, Pages 457-471

  Bernard, Elise ^a   Parthasarathi, Laavanya ^a   Cho, Min Kyu ^b   Aylward, Kelly ^a   Raab, Markus ^a   Daxecker, Heide ^a   O'Dushlaine, Colm T ^b   Shields, Denis C ^c   Devocelle, Marc ^a   Keyes, Tia ^d   Cosgrave, Lynda ^d   O'Neill, Sarah ^a   Mok, Kenneth H ^b   Moran, Niamh ^a  

^a ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

^b TRINITY COLLEGE DUBLIN   (Ireland)

^c UNIVERSITY COLLEGE DUBLIN   (Ireland)

^d DUBLIN CITY UNIVERSITY   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE; ALANINE; ALPHA INTEGRIN; ANTITHROMBOCYTIC AGENT; GLYCINE; ISOLEUCINE; PHENYLALANINE; SERINE; SYNTHETIC PEPTIDE; THROMBOXANE; TRYPTOPHAN; TYROSINE;

AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; HUMAN; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN ENGINEERING; PROTEIN MOTIF; THROMBOCYTE ADHESION; THROMBOCYTE AGGREGATION INHIBITION;

CELL ADHESION; CELL MEMBRANE PERMEABILITY; HUMANS; INTEGRIN ALPHA CHAINS; LIGANDS; PEPTIDES; PLATELET AGGREGATION;

EID: 67649249772     PISSN: 15548929     EISSN: None     Source Type: Journal    
DOI: 10.1021/cb8002623     Document Type: Article

References (39)

1. Newby, L. K., Califf, R. M., White, H. D., Harrington, R. A., Van de Werf, F., Granger, C. B., Simes, R. J., Hasselblad, V., and Armstrong, P. W. (2002) The failure of orally administered glycoprotein IIb/IIIa inhibitors to prevent recurrent cardiac events, Am. J. Med. 112, (8), 647-658. (Pubitemid 34597166)
2. Bassler, N., Loeffler, C., Mangin, P., Yuan, Y., Schwarz, M., Hagemeyer, C. E., Eisenhardt, S. U., Ahrens, I., Bode, C., Jackson, S. P., and Peter, K. (2007) A mechanistic model for paradoxical platelet activation by ligand-mimetic alphaIIb beta3 (GPIIb/IIIa) antagonists, Arterioscler., Thromb., Vasc. Biol. 27, (3), e9-e15. (Pubitemid 46263418)
3. O'Toole, T. E., Katagiri, Y., Faull, R. J., Peter, K., Tamura, R., Quaranta, V., Loftus, J. C., Shattil, S. J., and Ginsberg, M. H. (1994) Integrin cytoplasmic domains mediate inside-out signal transduction, J. Cell Biol. 124, (6), 1047-1059. (Pubitemid 24109406)
4. Peter, K., and Bode, C. (1996) A deletion in the alpha subunit locks platelet integrin alpha IIb beta 3 into a high affinity state, Blood Coagulation Fibrinolysis 7, (2), 233-236. (Pubitemid 26171538)
5. Hughes, P. E., and Pfaff, M. (1998) Integrin affinity modulation, Trends Cell Biol. 8, (9), 359-364. (Pubitemid 28398427)
6. Lu, C., Takagi, J., and Springer, T. A. (2001) Association of the membrane proximal regions of the alpha and beta subunit cytoplasmic domains constrains an integrin in the inactive state, J. Biol. Chem. 276, (18), 14642-14648. (Pubitemid 37373336)
7. Kim, M., Carman, C. V., and Springer, T. A. (2003) Bidirectional transmembrane signaling by cytoplasmic domain separation in integrins, Science 301, (5640), 1720-1725. (Pubitemid 37174365)
8. Ma, Y. Q., Yang, J., Pesho, M. M., Vinogradova, O., Qin, J., and Plow, E. F. (2006) Regulation of integrin alphaIIbbeta3 activation by distinct regions of its cytoplasmic tails, Biochemistry 45, (21), 6656-6662.
9. Ginsberg, M. H., Partridge, A., and Shattil, S. J. (2005) Integrin regulation, Curr. Opin. Cell Biol. 17, (5), 509-516. (Pubitemid 41267165)
10. Aylward, K., Meade, G., Ahrens, I., Devocelle, M., and Moran, N. (2006) A novel functional role for the highly conserved alphasubunit KVGFFKR motif distinct from integrin alphaIIbbeta3 activation processes, J. Thromb. Haemostasis 4, (8), 1804-1812. (Pubitemid 44144809)
11. Naik, U. P., Patel, P. M., and Parise, L. V. (1997) Identification of a novel calcium-binding protein that interacts with the integrin alphaIIb cytoplasmic domain, J. Biol. Chem. 272, (8), 4651-4654. (Pubitemid 27090004)
12. Kato, A., Kawamata, N., Tamayose, K., Egashira, M., Miura, R., Fujimura, T., Murayama, K., and Oshimi, K. (2002) Ancient ubiquitous protein 1 binds to the conserved membrane-proximal sequence of the cytoplasmic tail of the integrin alpha subunits that plays a crucial role in the inside-out signaling of alpha IIbbeta 3, J. Biol. Chem. 277, (32), 28934-28941.
13. Vijayan, K. V., Liu, Y., Li, T. T., and Bray, P. F. (2004) Protein phosphatase 1 associates with the integrin alphaIIb subunit and regulates signaling, J. Biol. Chem. 279, (32), 33039-33042. (Pubitemid 39062944)
14. Gushiken, F. C., Patel, V., Liu, Y., Pradhan, S., Bergeron, A. L., Peng, Y., and Vijayan, K. V. (2008) Protein phosphatase 2A negatively regulates integrin alpha IIb beta 3 signaling, J. Biol. Chem. 283, (19), 12862-12869.
15. Larkin, D., Murphy, D., Reilly, D. F., Cahill, M., Sattler, E., Harriott, P., Cahill, D. J., and Moran, N. (2004) ICln, a novel integrin alphaIIbbeta3-associated protein, functionally regulates platelet activation, J. Biol. Chem. 279, (26), 27286-27293.
16. Brophy, T. M., Raab, M., Daxecker, H., Culligan, K. G., Lehmann, I., Chubb, A. J., Treumann, A., and Moran, N. (2008) RN181, a novel ubiquitin E3 ligase that interacts with the KVGFFKR motif of platelet integrin alpha(IIb)beta3, Biochem. Biophys. Res. Commun. 369, (4), 1088-1093.
17. Liu, Q. Y., Corjay, M., Feuerstein, G. Z., and Nambi, P. (2006) Identi- fication and characterization of triosephosphate isomerase that specifically interacts with the integrin alphaIIb cytoplasmic domain, Biochem. Pharmacol. 72, (5), 551-557. (Pubitemid 44163300)
18. Stephens, G., O'Luanaigh, N., Reilly, D., Harriott, P., Walker, B., Fitzgerald, D., and Moran, N. (1998) A sequence within the cytoplasmic tail of GpIIb independently activates platelet aggregation and thromboxane synthesis, J. Biol. Chem. 273, (32), 20317-20322. (Pubitemid 28377595)
19. Vinogradova, O., Velyvis, A., Velyviene, A., Hu, B., Haas, T., Plow, E., and Qin, J. (2002) A structural mechanism of integrin alpha(IIb) beta(3) "inside-out" activation as regulated by its cytoplasmic face, Cell 110, (5), 587-597.
20. Weljie, A. M., Hwang, P. M., and Vogel, H. J. (2002) Solution structures of the cytoplasmic tail complex from platelet integrin alpha IIband beta 3-subunits, Proc. Natl. Acad. Sci. U.S.A. 99, (9), 5878-5883. (Pubitemid 34493233)
21. De Melker, A. A., Kramer, D., Kuikman, I., and Sonnenberg, A. (1997) The two phenylalanines in the GFFKR motif of the integrin alpha6A subunit are essential for heterodimerization, Biochem. J. 328, (Pt 2), 529-537. (Pubitemid 27515597)
22. 3 involves a novel allosteric regulation of its thiol isomerase activity, Biochemistry 43, (2), 473-480.
23. Edwards, R. J., Moran, N., Devocelle, M., Kiernan, A., Meade, G., Signac, W., Foy, M., Park, S. D., Dunne, E., Kenny, D., and Shields, D. C. (2007) Bioinformatic discovery of novel bioactive peptides, Nat. Chem. Biol. 3, (2), 108-112. (Pubitemid 46134997)
24. Fullard, J. F. (2004) The role of the platelet glycoprotein IIb/IIIa in thrombosis and haemostasis, Curr. Pharm. Des. 10, (14), 1567-1576. (Pubitemid 38559768)
25. Zhang, X., Jiang, G., Cai, Y., Monkley, S. J., Critchley, D. R., and Sheetz, M. P. (2008) Talin depletion reveals independence of initial cell spreading from integrin activation and traction, Nat. Cell Biol. 10, 1062-1068.
26. Izaguirre, G., Aguirre, L., Hu, Y. P., Lee, H. Y., Schlaepfer, D. D., Aneskievich, B. J., and Haimovich, B. (2001) The cytoskeletal/nonmuscle isoform of alpha-actinin is phosphorylated on its actinbinding domain by the focal adhesion kinase, J. Biol. Chem. 276, (31), 28676-28685. (Pubitemid 37451942)
27. Daxecker, H., Raab, M., Bernard, E., Devocelle, M., Treumann, A., and Moran, N. (2008) A peptide affinity column for the identification of integrin alpha IIb-binding proteins, Anal. Biochem. 374, (1), 203-212.
28. Barry, W. T., Boudignon-Proudhon, C., Shock, D. D., McFadden, A., Weiss, J. M., Sondek, J., and Parise, L. V. (2002) Molecular basis of CIB binding to the integrin alpha IIb cytoplasmic domain, J. Biol. Chem. 277, (32), 28877-28883.
29. Vinogradova, O., Haas, T., Plow, E. F., and Qin, J. (2000) A structural basis for integrin activation by the cytoplasmic tail of the alpha IIbsubunit, Proc. Natl. Acad. Sci. U.S.A. 97, (4), 1450-1455. (Pubitemid 30118461)
30. Rice, P., Longden, I., and Bleasby, A. (2000) EMBOSS: the European Molecular Biology Open Software Suite, Trends Genet. 16, (6), 276-277.
31. Gasteiger, E., Hoogland, C., Gattiker, A., Duvaud, S., Wilkins, M. R., Appel, R. D., and Bairoch, A. (2005) Protein Identification and Analysis Tools on the ExPASy Server, in The Proteomics Protocols Handbook (Walker, J. M., Ed.) pp 571-607, Humana Press, Totowa, NJ.
32. Cornette, J. L., Cease, K. B., Margalit, H., Spouge, J. L., Berzofsky, J. A., and DeLisi, C. (1987) Hydrophobicity scales and computational techniques for detecting amphipathic structures in proteins, J. Mol. Biol. 195, (3), 659-685.
33. Maiti, R., Van Domselaar, G. H., Zhang, H., and Wishart, D. S. (2004) SuperPose: a simple server for sophisticated structural superposition, Nucleic Acids Res. 32, (Web Server issue), W590-W594. (Pubitemid 38997404)
34. Dosztanyi, Z., Csizmok, V., Tompa, P., and Simon, I. (2005) IUPred: web server for the prediction of intrinsically unstructured regions of proteins based on estimated energy content, Bioinformatics 21, (16), 3433-3434. (Pubitemid 41222453)
35. Lambert, C., Leonard, N., De Bolle, X., and Depiereux, E. (2002) ESyPred3D: prediction of proteins 3D structures, Bioinformatics 18, (9), 1250-1256.
36. Comeau, S. R., Gatchell, D. W., Vajda, S., and Camacho, C. J. (2004) ClusPro: a fully automated algorithm for protein-protein docking, Nucleic Acids Res. 32, (Web Server issue), W96-W99. (Pubitemid 38997307)
37. Comeau, S. R., Gatchell, D. W., Vajda, S., and Camacho, C. J. (2004) ClusPro: an automated docking and discrimination method for the prediction of protein complexes, Bioinformatics 20, (1), 45-50. (Pubitemid 38088339)
38. Sayle, R. A., and Milner-White, E. J. (1995) RASMOL: biomolecular graphics for all, Trends Biochem. Sci. 20, (9), 374.
39. Humphrey, W., Dalke, A., and Schulten, K. (1996) VMD: visual molecular dynamics, J. Mol. Graphics Modell. 14, (1), 27-28; 33-38. (Pubitemid 26152973)