First reported case of Cryptococcus gattii in the southeastern USA: Implications for travel-associated acquisition of an emerging pathogen

PLoS ONE

Volumn 4, Issue 6, 2009, Pages

  Byrnes III, Edmond J ^a   Li, Wenjun ^a   Lewit, Yonathan ^a   Perfect, John R ^a   Carter, Dee A ^b   Cox, Gary M ^a   Haitman, Joseph ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOTERICIN B; FLUCONAZOLE; FLUCYTOSINE;

ARTICLE; AUSTRALIA; BRAIN BIOPSY; CENTRAL NERVOUS SYSTEM TUMOR; COMPUTER ASSISTED TOMOGRAPHY; CRYPTOCOCCOSIS; CRYPTOCOCCUS; CRYPTOCOCCUS GATTII; DRUG MEGADOSE; DRUG SUBSTITUTION; DRUG WITHDRAWAL; EUCALYPTUS; FUNGAL VIRULENCE; FUNGUS CULTURE; FUNGUS ISOLATION; FUNGUS SPORE; HUMAN; INHALATION; KIDNEY DISEASE; LUNG NODULE; MATING; MOLECULAR TYPING; MULTILOCUS SEQUENCE TYPING; MUSCLE RESECTION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PERCUTANEOUS BIOPSY; PHENOTYPE; PLANT FUNGUS INTERACTION; SEIZURE; STRAIN DIFFERENCE; TRAVEL; TREATMENT DURATION; TREATMENT OUTCOME; UNITED STATES; UNIVERSITY HOSPITAL; BRAIN; CASE REPORT; EPIDEMIC; EPIDEMIOLOGY; GENETICS; GENOTYPE; MALE; MICROBIOLOGY; MIDDLE AGED; SEROTYPING; THIGH; VIRULENCE;

CRYPTOCOCCUS GATTII;

BRAIN; CALIFORNIA; CRYPTOCOCCOSIS; CRYPTOCOCCUS; DISEASE OUTBREAKS; EPIDEMIOLOGY, MOLECULAR; GENOTYPE; HUMANS; MALE; MIDDLE AGED; NORTH CAROLINA; SEROTYPING; SOUTHEASTERN UNITED STATES; THIGH; VIRULENCE;

EID: 67649215062     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0005851     Document Type: Article

References (60)

1. King DA, Peckham C, Waage JK, Brownlie J, Woolhouse ME (2006) Epidemiology. Infectious diseases: preparing for the future. Science 313: 1392-1393.
2. Morens DM, Folkers GK, Fauci AS (2004) The challenge of emerging and reemerging infectious diseases. Nature 430: 242-249.
3. Jones KE, Patel NG, Levy MA, Storeygard A, Balk D, et al. (2008) Global trends in emerging infectious diseases. Nature 451: 990-993.
4. Cohen ML (2000) Changing patterns of infectious disease. Nature 406: 762-767.
5. Perfect JR, Casadevall A (2006) Fungal molecular pathogenesis: What can it do and why do we need it? In: Heitman J, Filler S, Edwards J, Mitchell A, eds. Molecular Principals of Fungal Pathogenesis ASM Press.
6. Maiden MC, Bygraves JA, Feil E, Morelli G, Russell JE, et al. (1998) Multilocus sequence typing: a portable approach to the identification of clones within populations of pathogenic microorganisms. Proc Natl Acad Sci U S A 95: 3140-3145.
7. Frothingham R, Meeker-O'Connell WA (1998) Genetic diversity in the Mycobacterium tuberculosis complex based on variable numbers of tandem DNA repeats. Microbiology 144 (Pt 5): 1189-1196.
8. Kidd SE, Guo H, Bartlett KH, Xu J, Kronstad JW (2005) Comparative gene genealogies indicate that two clonal lineages of Cryptococcus gattii in British Columbia resemble strains from other geographical areas. Eukaryot Cell 4: 1629-1638.
9. Litvintseva AP, Thakur R, Vilgalys R, Mitchell TG (2006) Multilocus sequence typing reveals three genetic subpopulations of Cryptococcus neoformans var. grubii (serotype A), including a unique population in Botswana. Genetics 172: 2223-2238.
10. Fraser JA, Giles SS, Wenink EC, Geunes-Boyer SG, Wright JR, et al. (2005) Same-sex mating and the origin of the Vancouver Island Cryptococcus gattii outbreak. Nature 437: 1360-1364.
11. Bovers M, Hagen F, Kuramae EE, Boekhout T (2008) Six monophyletic lineages identified within Cryptococcus neoformans and Cryptococcus gattii by multi-locus sequence typing. Fungal Genet Biol 45: 400-421.
12. Li W, Fenollar F, Rolain JM, Fournier PE, Feurle GE, et al. (2008) Genotyping reveals a wide heterogeneity of Tropheryma whipplei. Microbiology 154: 521-527.
13. Li W, Raoult D, Fournier PE (2007) Genetic diversity of Bartonella henselae in human infection detected with multispacer typing. Emerg Infect Dis 13: 1178-1183.
14. Brisse S, Pannier C, Angoulvant A, de Meeus T, Diancourt L, et al. (2009) Uneven distribution of mating types among genotypes of Candida glabrata from clinical samples. Eukaryot Cell, Online ahead of print Jan 16, 2009.
15. Casadevall A, Perfect J (1998) Cryptococcus neoformans. Washington DC: ASM Press.
16. Kwon-Chung KJ, Boekhout T, Fell JW, Diaz M (2002) Proposal to conserve the name Cryptococcus gattii against C. hondurianus and C. bacillisporus (Basidiomycota, Hymenomycetes, Tremellomycetidae). Taxon 51: 804-806.
17. Sorrell TC (2001) Cryptococcus neoformans variety gattii. Med Mycol 39: 155-168.
18. Upton A, Fraser JA, Kidd SE, Bretz C, Bartlett KH, et al. (2007) First contemporary case of human infection with Cryptococcus gattii in Puget Sound: evidence for spread of the Vancouver Island outbreak. J Clin Microbiol 45: 3086-3088.
19. Kidd SE, Hagen F, Tscharke RL, Huynh M, Bartlett KH, et al. (2004) A rare genotype of Cryptococcus gattii caused the cryptococcosis outbreak on Vancouver Island (British Columbia, Canada). Proc Natl Acad Sci U S A 101: 17258-17263.
20. MacDougall L, Kidd SE, Galanis E, Mak S, Leslie MJ, et al. (2007) Spread of Cryptococcus gattii in British Columbia, Canada, and detection in the Pacific Northwest, USA. Emerg Infect Dis 13: 42-50.
21. Bartlett KH, Kidd SE, Kronstad JW (2008) The emergence of Cryptococcus gattii in British Columbia and the Pacific Northwest. Curr Infect Dis Rep 10: 58-65.
22. Byrnes EJ 3rd, Bildfell R, Frank SA, Mitchell TG, Marr KA, et al. (2009) Molecular evidence that the Vancouver Island Cryptococcus gattii outbreak has expanded into the United States Pacific Northwest. J Inf Dis; Published online Feb 16, 2009.
23. Byrnes EJ 3rd, Bildfell RJ, Dearing PL, Valentine BA, Heitman J (2009) Cryptococcus gattii with bimorphic colony types in a dog in western Oregon: additional evidence for expansion of the Vancouver Island outbreak. J Vet Diagn Invest 21: 133-136.
24. Kwon-Chung KJ, Varma A (2006) Do major species concepts support one, two or more species within Cryptococcus neoformans? FEMS Yeast Res 6: 574-587.
25. Kwon-Chung KJ (1976) A new species of Filobasidiella, the sexual state of Cryptococcus neoformans B and C serotypes. Mycologia 68: 943-946.
26. Boekhout T, Theelen B, Diaz M, Fell JW, Hop WC, et al. (2001) Hybrid genotypes in the pathogenic yeast Cryptococcus neoformans. Microbiology 147: 891-907.
27. Perfect JR (1989) Cryptococcosis. Infect Dis Clin North Am 3: 77-102.
28. Kwon-Chung KJ, Bennett JE (1984) Epidemiologic differences between the two varieties of Cryptococcus neoformans. Am J Epidemiol 120: 123-130.
29. Stephen C, Lester S, Black W, Fyfe M, Raverty S (2002) Multispecies outbreak of cryptococcosis on southern Vancouver Island, British Columbia. Can Vet J 43: 792-794.
30. Litvintseva AP, Thakur R, Reller LB, Mitchell TG (2005) Prevalence of clinical isolates of Cryptococcus gattii serotype C among patients with AIDS in Sub-Saharan Africa. J Infect Dis 192: 888-892.
31. Chaturvedi S, Dyavaiah M, Larsen RA, Chaturvedi V (2005) Cryptococcus gattii in AIDS patients, southern California. Emerg Infect Dis 11: 1686-1692.
32. Blankenship JR, Singh N, Alexander BD, Heitman J (2005) Cryptococcus neoformans isolates from transplant recipients are not selected for resistance to calcineurin inhibitors by current immunosuppressive regimens. J Clin Microbiol 43: 464-467.
33. Miller WG, Padhye AA, van Bonn W, Jensen E, Brandt ME, et al. (2002) Cryptococcosis in a bottlenose dolphin (Tursiops truncatus) caused by Cryptococcus neoformans var. gattii. J Clin Microbiol 40: 721-724.
34. Pfeiffer T, Ellis D (1991) Environmental isolation of Cryptococcus gattii from California. J Infect Dis 163: 929-930.
35. Litvintseva AP, Kestenbaum L, Vilgalys R, Mitchell TG (2005) Comparative analysis of environmental and clinical populations of Cryptococcus neoformans. J Clin Microbiol 43: 556-564.
36. Chambers C, MacDougall L, Li M, Galanis E (2008) Tourism and specific risk areas for Cryptococcus gattii, Vancouver Island, Canada. Emerg Infect Dis 14: 1781-1783.
37. Lindberg J, Hagen F, Laursen A, Stenderup J, Boekhout T (2007) Cryptococcus gattii risk for tourists visiting Vancouver Island, Canada. Emerg Infect Dis 13: 178-179.
38. Lim S, Notley-McRobb L, Lim M, Carter DA (2004) A comparison of the nature and abundance of microsatellites in 14 fungal genomes. Fungal Genet Biol 41: 1025-1036.
39. Benson G (1999) Tandem repeats finder: a program to analyze DNA sequences. Nucleic Acids Res 27: 573-580.
40. Larkin MA, Blackshields G, Brown NP, Chenna R, McGettigan PA, et al. (2007) Clustal W and Clustal X version 2.0. Bioinformatics 23: 2947-2948.
41. Xue C, Tada Y, Dong X, Heitman J (2007) The human fungal pathogen Cryptococcus can complete its sexual cycle during a pathogenic association with plants. Cell Host Microbe 1: 263-273.
42. Mylonakis E, Moreno R, El Khoury JB, Idnurm A, Heitman J, et al. (2005) Galleria mellonella as a model system to study Cryptococcus neoformans pathogenesis. Infect Immun 73: 3842-3850.
43. Halliday CL, Carter DA (2003) Clonal reproduction and limited dispersal in an environmental population of Cryptococcus neoformans var gattii isolates from Australia. J Clin Microbiol 41: 703-711.
44. London R, Orozco BS, Mylonakis E (2006) The pursuit of cryptococcal pathogenesis: heterologous hosts and the study of cryptococcal host-pathogen interactions. FEMS Yeast Res 6: 567-573.
45. Fuchs BB, Mylonakis E (2006) Using non-mammalian hosts to study fungal virulence and host defense. Curr Opin Microbiol 9: 346-351.
46. Idnurm A, Walton FJ, Floyd A, Reedy JL, Heitman J (2009) Identification of ENA1 as a virulence gene of the human pathogenic fungus Cryptococcus neoformans through signature-tagged insertional mutagenesis. Eukaryot Cell;Online ahead of print Jan 16, 2009.
47. 2+-ATPase, is involved in stress tolerance and virulence in Cryptococcus neoformans. Infect Immun 75: 3394-3405.
48. Datta K, Bartlett K, Baer R, Byrnes E, Galanis E, et al. (2009) Cryptococcus gattii: an emerging pathogenic fungus in Western North America. Emerg Infect Dis; Submitted.
49. Sorrell TC, Chen SC, Ruma P, Meyer W, Pfeiffer TJ, et al. (1996) Concordance of clinical and environmental isolates of Cryptococcus neoformans var. gattii by random amplification of polymorphic DNA analysis and PCR fingerprinting. J Clin Microbiol 34: 1253-1260.
50. Campbell LT, Currie BJ, Krockenberger M, Malik R, Meyer W, et al. (2005) Clonality and recombination in genetically differentiated subgroups of Cryptococcus gattii. Eukaryot Cell 4: 1403-1409.
51. Kidd SE, Sorrell TC, Meyer W (2003) Isolation of two molecular types of Cryptococcus neoformans var. gattii from insect frass. Med Mycol 41: 171-176.
52. Raboin LM, Selvi A, Oliveira KM, Paulet F, Calatayud C, et al. (2007) Evidence for the dispersal of a unique lineage from Asia to America and Africa in the sugarcane fungal pathogen Ustilago scitaminea. Fungal Genet Biol 44: 64-76.
53. Fraser JA, Subaran RL, Nichols CB, Heitman J (2003) Recapitulation of the sexual cycle of the primary fungal pathogen Cryptococcus neoformans var. gattii: implications for an outbreak on Vancouver Island, Canada. Eukaryot Cell 2: 1036-1045.
54. Saul N, Krockenberger M, Carter D (2008) Evidence of recombination in mixed-mating-type and alpha-only populations of Cryptococcus gattii sourced from single eucalyptus tree hollows. Eukaryot Cell 7: 727-734.
55. Heitman J (2006) Sexual reproduction and the evolution of microbial pathogens. Curr Biol 16: R711-725.
56. Nielsen K, Heitman J (2007) Sex and virulence of human pathogenic fungi. Adv Genet 57: 143-173.
57. Campbell LT, Carter DA (2006) Looking for sex in the fungal pathogens Cryptococcus neoformans and Cryptococcus gattii. FEMS Yeast Res 6: 588-598.
58. Carter D, Saul N, Campbell LT, Tien B, Krockenberger M (2007) Sex in natural populations of C. gattii. Sex in Fungi: Molecular Determination and Evolutionary Implications. In: Heitman J, Kronstad JW, Taylor J, Casselton L, eds. ASM Press. pp 477-488.
59. Grigg ME, Bonnefoy S, Hehl AB, Suzuki Y, Boothroyd JC (2001) Success and virulence in Toxoplasma as the result of sexual recombination between two distinct ancestries. Science 294: 161-165.
60. Su C, Evans D, Cole RH, Kissinger JC, Ajioka JW, et al. (2003) Recent expansion of Toxoplasma through enhanced oral transmission. Science 299: 414-416.