Thick silicon double-sided strip detectors for low-energy small-animal SPECT

IEEE Transactions on Nuclear Science

Volumn 56, Issue 3, 2009, Pages 557-564

  Shokouhi, Sepideh ^a   McDonald, Benjamin S ^a   Durko, Heather L ^b   Fritz, Mark A ^a   Furenlid, Lars R ^b   Peterson, Todd E ^a  

^a VANDERBILT UNIVERSITY   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

Author keywords

Low energy radiation detectors; Silicon DSSD; SPECT

Indexed keywords

CHARACTERIZATION STUDIES; HIGH POTENTIAL; HIGH RESOLUTION; LOW ENERGIES; LOW ENERGY RADIATION DETECTORS; PHOTON INTERACTIONS; SMALL-ANIMAL; SPATIAL RESOLUTION; SPECT; STRIP DETECTORS; TRIGGER THRESHOLD;

APPLICATION SPECIFIC INTEGRATED CIRCUITS; ELECTRIC POWER SUPPLIES TO APPARATUS; RADIATION DAMAGE; SILICON DETECTORS;

RADIATION DETECTORS;

EID: 67649213850     PISSN: 00189499     EISSN: None     Source Type: Journal    
DOI: 10.1109/TNS.2009.2019106     Document Type: Article

References (36)

1. S. R. Cherry, "In vivo molecular and genomic imaging: New challenges for imaging physics," Phys. Med. Biol., vol. 49, pp. R13-R48, 2004.
2. S. D. Metzler, R. Accorsi, J. R. Novak, A. S. Ayan, and R. J. Jaszczak, "On-axis sensitivity and resolution of a slit-slat collimator," J. Nucl. Med., vol. 47, pp. 1884-1890, 2006.
3. R. Accorsi, F. Gasparini, and R. C. Lanza, "A coded aperture for highresolution nuclear medicine planar imaging with a conventional anger camera: Experimental results," IEEE Trans. Nucl. Sci., vol. 48, pp. 2411-2417, 2001.
4. F. J. Beekman, D. P. McElroy, F. Berger, S. S. Gambhir, E. J. Hoffman, and S. R. Cherry, "Toward in vivo nuclear microscopy: Iodine-125 imaging in mice using micro-pinholes," Eur. J. Nucl. Med. Mol. Imag., vol. 29, pp. 933-938, 2002.
5. N. U. Schram, G. Ebel, U. Egeland, T. Schurrat, M. Behe, and T. M. Behr, "High-resolution SPECT using multi-pinhole collimation," IEEE Trans. Nucl. Sci., vol. 50, pp. 315-320, 2003.
6. Z. Cao, G. Bal, R. Accorsi, and P. D. Acton, "Optimal number of pin-holes in multi-pinhole SPECT for mouse brain imaging-a simulation study," Phys. Med. Biol., vol. 50, pp. 4609-4624, 2005.
7. G. Bal, G. L. Zeng, M. R. Lewitt, Z. Cao, and P. D. Acton, "Study of different pinhole configurations for small animal tumor imaging," in IEEE Nucl. Sci. Symp. Conf. Rec., 2004, vol. 5, pp. 16-22.
8. Z. Liu, G. A. Kastis, G. D. Stevenson, H. H. Barrett, L. R. Furenlid, M. A. Kupinski, D. D. Patton, and D. W. Wilson, "Quantitative analysis of acute myocardial infarct in rat hearts with ischemia-reperfusion using a high-resolution stationary SPECT system," J. Nucl. Med., vol. 43, pp. 933-939, 2002.
9. S. R. Meikle, P. Kench, A. G. Weisenberger, R. Wojcik, M. F. Smith, S. Majewski, S. Eberl, R. R. Fulton, A. B. Rosenfeld, and M. J. Fulham, "A prototype coded aperture detector for small animal SPECT," IEEE Trans. Nucl. Sci., vol. 49, pp. 2139-2147, 2002.
10. M. B. Williams, A. V. Stolin, and B. K. Kundu, "Investigation of efficiency and spatial resolution using pinhole with small pinhole angle," IEEE Trans. Nucl. Sci., vol. 50, pp. 1562-1568, 2003.
11. Molecular Imaging. Bioscan, Inc., Washington, DC, 2008 [Online]. Available: www.bioscan.com
12. F. J. Beekman, F. van der Have, B. Vastenhouv, A. J. A. Van der Linden, P. P. van Rijk, J. P. H. Burbach, and M. P. Smidt, "U-SPECT-I: A stationary molecular imaging system for small animal with 0.1 microlitre resolution," J. Nucl. Med., vol. 46, pp. 1194-1200, 2005.
13. L. R. Furenlid, D. W. Wilson, Y. Chen, K. Hyunki, P. J. Pietraski, M. J. Crawford, and H. H. Barrett, "FastSPECT II: A second-generation high-resolution dynamic SPECT imager," IEEE Trans. Nucl. Sci., vol. 51, pp. 631-635, 2004.
14. A. G. Weisenberger, B. Kross, S. Majewski, V. Popov, M. F. Smith, V. H. Tran, B. Welch, J. Baba, J. Goddard, M. Pomper, and B. Tsui, "Instrumentation development of a SPECT-CT system to image awake ice," in IEEE Nucl. Sci. Conf. Rec., 2006, vol. 5, pp. 3000-3003.
15. D. P. McElroy, L. R. MacDonald, F. J. Beekman, Y. Wang, B. E. Patt, J. S. Iwanczyk, B. M. W. Tsui, and E. J. Hoffman, "Performance evaluation of A-SPECT: A high resolution desktop pinhole SPECT system for imaging small animals," IEEE Trans. Nucl. Sci., vol. 49, pp. 2139-2147, 2002.
16. B. M. W. Tsui, Y. Wang, G. S. P. Mok, A. G. Weisenberger, and S. Majewski, "Design and development of high performance stationary full ring SPECT based on high resolution detector modules for small animal imaging," in IEEE Nucl. Sci. Conf. Rec., 2007, p. M11-6.
17. V. V. Nagarkar, I. Shestakova, V. Gaysinskiy, S. V. Tipnis, B. Singh, W. Barber, B. Hasegawa, and G. Entine, "A CCD-based detector for SPECT," IEEE Trans. Nucl. Sci., vol. 53, pp. 54-58, 2006.
18. J. W. Heemskerk, A. H. Westra, P. M. Linotte, K. M. Ligtvoet, W. Zbijewski, and F. J. Beekman, "Front-illuminated versus back-illuminated photon-counting CCD-based gamma camera: Important consequences for spatial resolution and energy resolution," Phys. Med. Biol., vol. 52, pp. N149-N162, 2007.
19. L. J. Meng, "An intensified EMCCD camera for low energy gamma ray imaging application," IEEE Trans. Nucl. Sci., vol. 53, pp. 2376-2384, 2006.
20. M. M. Rogulski, H. B. Barber, H. H. Barrett, R. L. Shoemaker, and J. M. Woolfenden, "Ultra-high-resolution brain SPECT imaging: Simulation results," IEEE Trans. Nucl. Sci., vol. 40, pp. 1123-1129, 1993.
21. G. A. Kastis, M. C. Wu, S. J. Balzer, D. W. Wilson, L. R. Furenlid, G. Stevenson, H. B. Barber, H. H. Barrett, J. M. Woolfenden, P. Kelly, and M. Appleby, "Tomographic small-animal imaging using a high-resolution semiconductor camera," IEEE Trans. Nucl. Sci., vol. 49, pp. 172-175, 2002.
22. T. E. Peterson, D. W. Wilson, and H. H. Barrett, "Application of silicon strip detectors tosmall-animal imaging," Nucl. Instr. Methods, vol. 505, pp. 608-611, 2003.
23. C. Fiorini, A. Longoni, M. Porro, F. Perotti, P. Lechner, and L. Struder, "Monolithic arrays of silicon drift detectors for medical imaging applications and related CMOS readout electronics," Nucl. Instr. Methods, vol. 560, pp. 148-152, 2006.
24. A. H. Wuosmaa et al., "Instrumentation of double-sided silicon strip detectors for multi-particle detection," Nucl. Instr. Methods Phys. Research A, vol. 345, pp. 482-491, 1994.
25. H. Tajima, "Low noise double-sided silicon strip detector for multiplecompton gamma-ray telescope," SLAC-PUB-9493-ISAS-RN-754, 2002.
26. S. Shokouhi, H. L. Durko, M. A. Fritz, L. R. Furenlid, and T. E. Peterson, "Thick silicon strip detectors for small-animal SPECT imaging," in IEEE Nucl. Sci. Symp. Conf. Rec., 2006, vol. 6, pp. 3562-3566.
27. Radiation Detection and Imaging Technology. Gamma Medica -Ideas (Norway) AS, Snarøya, Norway, 2006 [Online]. Available: www.ideas.no
28. N. Clinthorne, D. Burdette, A. Studen, K. Honscheid, H. Kagan, E. Chesi, S. Huh, C. Lacastá, G. Liosa, M. Mikuž, D. S. Smith, and P. Weilhammer, "Timing in silicon pad detectors for compton cameras and high resolution PET," in IEEE Nucl. Sci. Symp. Conf. Rec., 2005, vol. 5, pp. 2868-2870.
29. S. Shokouhi, M. A. Fritz, B. S. McDonald, H. L. Durko, L. R. Furenlid, D. W. Wilson, and T. E. Peterson, "A silicon SPECT system for molecular imaging of mouse brain," in IEEE Nucl. Sci. Symp. Conf. Rec., 2007, vol. 4, pp. 2782-2784.
30. D. M. Petterson, S. Mikkelsen, J. Talebi, and D. Meier, "A readout ASIC for SPECT," IEEE Trans. Nucl. Sci., vol. 52, pp. 764-771, 2005.
31. D. W. Wilson, H. H. Barrett, and E. W. Clarkson, "Reconstruction of two- and three-dimensional images from synthetic-collimator data," IEEE Trans. Med. Imag., vol. 9, pp. 412-422, 2000.
32. B. W. Miller, H. B. Barber, H. H. Barrett, D. W. Wilson, and L. Chen, "A low-cost approach to high-resolution, single-photon imaging using columnar scintillators and image intensifiers," in IEEE Nucl. Sci. Symp. Conf. Rec., 2006, vol. 6, pp. 3540-3545.
33. W.Qu, M.P.Kung,C.Hou, L. W. Jin, and H. F.Kung, "Radioiodinated aza-diphenylacetylenes as potential SPECT imaging agents for [beta]-amyloid plaque detection," Bioorgan. Medicin. Chem. Lett., vol. 17, pp. 3581-3584, 2007.
34. G. Tamagnan, D.Alagille, A. Koren, B. Ciliax, K. Marek, and J. Seibyl, "Development of a new class of compounds with very high affinity for the amyloid plaques," presented at the Alzheimer's and Parkinson's Disease: Progress and New Perspectives Conf., Salzburg, Austria, Mar. 14-18, 2007.
35. G. Muehllehner, "Effect of resolution improvement on required count density in ECT imaging: A computer simulation," Phys. Med. Biol., vol. 30, pp. 163-173, 1985.
36. L. Pacciani, O. Uberti, E. del Monte, A. Argan, M. Feroci, P. Soffitta, A. Trois, E. Costa, I. Donnarumma, Y. Evangelista, F. Lazzarotto, M. Rapisarda, E. Morelli, M. Mastropietro, and A. Rubini, "Threshold equalization algorithm for the XAA1.2 ASICs and its application to Su-perAGILE X-ray imager," Nuclear Instrum. Methods Phys. Res. Sec. A, vol. 593, pp. 367-375, 2008.