The participation of the Na+-Ca2+ exchanger in primary cardiac myofibroblast migration, contraction, and proliferation

Journal of Cellular Physiology

Volumn 213, Issue 2, 2007, Pages 540-551

  Raizman, Joshua E ^a   Komljenovic, Jelena ^a   Chang, Rose ^a   Deng, Cicie ^a   Bedosky, Kristen M ^a   Rattan, Sunil G ^a   Cunnington, Ryan H ^a   Freed, Darren H ^a   Dixon, Ian M C ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

1 (5 IODO 1 NAPHTHALENESULFONYL)HEXAHYDRO 1H 1,4 DIAZEPINE; 2 [2 [4 (4 NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA METHANESULFONATE; 6,7 DIMETHOXY 2 PHENYLQUINOXALINE; ALPHA SMOOTH MUSCLE ACTIN; CATION CHANNEL; GADOLINIUM; MESSENGER RNA; MYOSIN HEAVY CHAIN; PLATELET DERIVED GROWTH FACTOR BB; SODIUM CALCIUM EXCHANGE PROTEIN; 2 (2 (4 (4 NITROBENZYLOXY)PHENYL)ETHYL)ISOTHIOUREA METHANESULFONATE; 2-(2-(4-(4-NITROBENZYLOXY)PHENYL)ETHYL)ISOTHIOUREA METHANESULFONATE; ACTIN; ANTIARRHYTHMIC AGENT; AZEPINE DERIVATIVE; CALCIUM CHANNEL L TYPE; DRUG DERIVATIVE; ENZYME INHIBITOR; MYOSIN LIGHT CHAIN KINASE; NAPHTHALENE DERIVATIVE; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PLATELET-DERIVED GROWTH FACTOR BB; THIOUREA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL MIGRATION; CELL MOTILITY; CELL PROLIFERATION; CHEMOTAXIS; CONTROLLED STUDY; HEART MUSCLE CELL; IMMUNOFLUORESCENCE; MALE; MOUSE; MUSCLE FIBER CONTRACTION; MYOFIBROBLAST; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SODIUM CALCIUM EXCHANGE; WESTERN BLOTTING; ANIMAL; CELL CULTURE; CELL MOTION; CYTOLOGY; DRUG ANTAGONISM; GENETICS; HEART CONTRACTION; METABOLISM; PHYSIOLOGY; RAT; SPRAGUE DAWLEY RAT;

ACTINS; ANIMALS; ANTI-ARRHYTHMIA AGENTS; AZEPINES; CALCIUM CHANNELS, L-TYPE; CELL MOVEMENT; CELL PROLIFERATION; CELLS, CULTURED; ENZYME INHIBITORS; GADOLINIUM; MALE; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; MYOSIN-LIGHT-CHAIN KINASE; NAPHTHALENES; PLATELET-DERIVED GROWTH FACTOR; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR BETA; SODIUM-CALCIUM EXCHANGER; THIOUREA;

EID: 34848893324     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.21134     Document Type: Article

References (85)

1. Arnon A, Hamlyn JM, Blaustein MP. 2000. Na(+) entry via store-operated channels modulates Ca(2+) signaling in arterial myocytes. Am J Physiol Cell Physiol 278:C163-C173.
2. Bhatt A, Kaverina I, Otey C, Huttenlocher A. 2002. Regulation of focal complex composition and disassembly by the calcium-dependent protease calpain. J Cell Sci 115:3415-3425.
3. Birukov KG, Csortos C, Marzilli L, Dudek S, Ma SF, Bresnick AR, Verin AD, Cotter RJ, Garcia JG. 2001. Differential regulation of alternatively spliced endothelial cell myosin light chain kinase isoforms by p60(Src). J Biol Chem 276:8567-8573.
4. Bonner JC. 2004. Regulation of PDGF and its receptors in fibrotic diseases. Cytokine Growth Factor Rev 15:255-273.
5. Brown RD, Ambler SK, Mitchell MD, Long CS. 2005. The cardiac fibroblast: Therapeutic target in myocardial remodeling and failure. Annu Rev Pharmacol Toxicol 45:657-687.
6. Burridge K. 1981. Are stress fibres contractile? Nature 294:691-692.
7. Burstein B, Libby E, Glass L. 2006. Atrial fibroblasts are different from ventricular: Explanation of atrial-ventricular remodeling differences in congestive heart failure? American Heart Association Scientific Sessions 2006 conference. McCormic Place Chicago, IL. Nov. 12-15.
8. Calabrese EJ. 2001. Cell migration/chemotaxis: Biphasic dose responses. Crit Rev Toxicol 31:615-624.
9. Carafoli E. 2002. Calcium signaling: A tale for all seasons. Proc Natl Acad Sci USA 99:1115-1122.
10. Chilton L, Ohya S, Freed D, George E, Drobic V, Shibukawa Y, Maccannell KA, Imaizumi Y, Clark RB, Dixon IM, Giles WR. 2005. K+ currents regulate the resting membrane potential, proliferation, and contractile responses in ventricular fibroblasts and myofibroblasts. Am J Physiol Heart Circ Physiol 288:H2931-H2939.
11. Cirillo M, Quinn SJ, Romero JR, Canessa ML. 1993. Regulation of Ca2+ transport by platelet-derived growth factor-BB in rat vascular smooth muscle cells. Circ Res 72:847-856.
12. Clapham DE. 1995. Calcium signaling. Cell 80:259-268.
13. Cleutjens JP, Verluyten MJ, Smiths JF, Daemen MJ. 1995. Collagen remodeling after myocardial infarction in the rat heart. Am J Pathol 147:325-338.
14. Desmouliere A, Geinoz A, Gabbiani F, Gabbiani G. 1993. Transforming growth factor-beta I induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts. J Cell Biol 122:103-111.
15. Diez C, Nestler M, Friedrich U, Vieth M, Stolte M, Hu K, Hoppe J, Simm A. 2001. Down-regulation of Akt/PKB in senescent cardiac fibroblasts impairs PDGF-induced cell proliferation. Cardiovasc Res 49:731-740.
16. Downey GP, Chan CK, Trudel S, Grinstein S. 1990. Actin assembly in electropermeabilized neutrophils: Role of intracellular calcium. J Cell Biol 110:1975-1982.
17. Dreval V, Dieterich P, Stock C, Schwab A. 2005. The role of Ca2+ transport across the plasma membrane for cell migration. Cell Physiol Biochem 16:119-126.
18. Fan J, Guan S, Cheng CF, Cho M, Fields JW, Chen M, Denning MF, Woodley DT, Li W. 2006. PKCdelta clustering at the leading edge and mediating growth factor-enhanced, but not ecm-initiated, dermal fibroblast migration. J Invest Dermatol 126:1233-1243.
19. Frangogiannis NG, Michael LH, Entman ML. 2000. Myofibroblasts in reperfused myocardial infarcts express the embryonic form of smooth muscle myosin heavy chain (SMemb). Cardiovasc Res 48:89-100.
20. Freed DH, Cunnington RH, Dangerfield AL, Sutton JS, Dixon IM. 2005. Emerging evidence for the role of cardiotrophin-1 in cardiac repair in the infarcted heart. Cardiovasc Res 65:782-792.
21. Fresu M, Bianchi M, Parsons JT, Villa-Moruzzi E. 2001. Cell-cycle-dependent association of protein phosphatase I and focal adhesion kinase. Biochem J 358:407-414.
22. Gabbiani G. 2003. The myofibroblast in wound healing and fibrocontractive diseases. J Pathol 200:500-503.
23. Ganitkevich V, Hasse V, Pfitzer G. 2002. Ca2+-dependent and Ca2+-independent regulation of smooth muscle contraction. J Muscle Res Cell Motil 23:47-52.
24. Glading A, Lauffenburger DA, Wells A. 2002. Cutting to the chase: Calpain proteases in cell motility. Trends Cell Biol 12:46-54.
25. Grotendorst GR, Chang T, Seppa HE, Kleinman HK, Martin GR. 1982. Platelet-derived growth factor is a chemoattractant for vascular smooth muscle cells. J Cell Physiol 113:261-266.
26. Gullberg D, Tingstrom A, Thuresson AC, Olsson L, Terracio L, Borg TK, Rubin K. 1990. Beta I integrin-mediated collagen gel contraction is stimulated by PDGF. Exp Cell Res 186:264-272.
27. Halaszovich CR, Zitt C, Jungling E, Luckhoff A. 2000. Inhibition of TRP3 channels by lanthanides. Block from the cytosolic side of the plasma membrane. J Biol Chem 275:37423-37428.
28. Hao J, Wang B, Jones SC, Jassal DS, Dixon IM. 2000. Interaction between angiotensin II and Smad proteins in fibroblasts in failing heart and in vitro. Am J Physiol Heart Circ Physiol 279:H3020-H3030.
29. Heldin CH, Westermark B. 1999. Mechanism of action and in vivo role of patelet-derived growth factor. Physiol Rev 79:1283-1316.
30. Hinz B. 2006. Masters and servants of the force: The role of matrix adhesions in myofibroblast force perception and transmission. Eur J Cell Biol 8S:175-181.
31. Hinz B, Gabbiani G. 2003. Mechanisms of force generation and transmission by myofibroblasts. Curr Opin Biotechnol 14:538-546.
32. Hinz B, Celetta G, Tomasek JJ, Gabbiani G, Chaponnier C. 2001. Alpha-smooth muscle actin expression upregulates fibroblast contractile activity. Mol Biol Cell 12:2730-2741.
33. Iwamoto T, Kita S. 2004. Development and application of Na+/Ca2+ exchange inhibitors. Mol Cell Biochem 259:157-161.
34. Iwamoto T, Watano T, Shigekawa M. 1996. A novel isothiourea derivative selectively inhibits the reverse mode of Na+/Ca2+ exchange in cells expressing N CX1. J Biol Chem 271:22391-22397.
35. Iwamoto T, Wakabayashi S, Imagawa T, Shigekawa M. 1998. Na+/Ca2+ exchanger overexpression impairs calcium signaling in fibroblasts: Inhibition of the [Ca2+] increase at the cell periphery and retardation of cell adhesion. Eur J Cell Biol 76:228-236.
36. Iwamoto T, Kita S, Uehara A, Inoue Y, Taniguchi Y, Imanaga I, Shigekawa M. 2001. Structural domains influencing sensitivity to isothiourea derivative inhibitor KB-R7943 in cardiac Nna(+)/Ca(2+) exchanger. Mol Pharmacol 59:524-531.
37. Jo DY, Rafii S, Hamada T, Moore MA. 2000. Chemotaxis of primitive hematopoietic cells in response to stromal cell-derived factor-1. J Clin Invest 105:101-111.
38. Ju H, Hao J, Zhao S, Dixon IM. 1998. Antiproliferative and antifibrotic effects of mimosine on adult cardiac fibroblasts. Biochim Biophys Acta 1448:51-60.
39. Juhaszova M, Ambesi A, Lindenmayer GE, Bloch RJ, Blaustein MP. 1994. Na(+)-Ca2+ exchanger in arteries: Identification by immunoblotting and immunofluorescence microscopy. Am J Physiol 266:C234-C242.
40. Kamkin A, Kiseleva I, Wagner KD, Scholz H, Theres H, Kazanski V, Lozinsky I, Gunther J, Isenberg G. 2001. Mechanically induced potentials in rat atrial fibroblasts depend on actin and tubulin polymerisation. Pflugers Arch 442:487-497.
41. Kamkin A, Kiseleva I, Isenberg G. 2003a. Activation and inactivation of a non-selective cation conductance by local mechanical deformation of acutely isolated cardiac fibroblasts. Cardiovasc Res 57:793-803.
42. Kamkin A, Kiseleva I, Wagner KD, Lozinsky I, Gunther J, Scholz H. 2003b. Mechanically induced potemials in atrial fibroblasts from rat hearts are sensitive to hypoxia/reoxygenation. Pflugers Arch 446:169-174.
43. Kamm KE, Stull JT. 2001. Dedicated myosin light chain kinases with diverse cellular functions. J Biol Chem 276:4527-4530.
44. Krendel M, Mooseker MS. 2005. Myosins: Tails (and heads) of functional diversity. Physiology (Bethesda) 20:239-251.
45. Lauffenburger DA, Horwitz AF. 1996. Cell migration: A physically integrated molecular process. Cell 84:359-369.
46. Lee SL, Yu AS, Lytton J. 1994. Tissue-specific expression of Na(+)-Ca2+ exchanger isoforms. J Biol Chem 269:14849-14852.
47. Lee J, Ishihara A, Oxford G, Johnson B, Jacobson K. 1999. Regulation of cell movement is mediated by stretch-activated calcium channels. Nature 400:382-386.
48. Lee CH, Poburko D, Sahota P, Sandhu J, Ruehlmann DO, van Breemen C. 2001. The mechanism of phenylephrine-mediated [Ca(2+)](i) oscillations underlying tonic contraction in the rabbit inferior vena cava. J Physiol 534:641-650.
49. Leslie KO, Taatjes DJ, Schwarz J, vonTurkovich M, Low RB. 1991. Cardiac myofibroblasts express alpha smooth muscle actin during right ventricular pressure overload in the rabbit. Am J Pathol 139:207-216.
50. Levinson H, Moyer KE, Saggers GC, Ehrlich HP. 2004. Calmodulin-myosin light chain kinase inhibition changes fibroblast-populated collagen lattice contraction, cell migration, focal adhesion formation, and wound contraction. Wound Repair Regen 12:505-511.
51. Liang W, McDonald P, McManus B, van Breemen C, Wang X. 2003. Histamine-induced Ca(2+) signaling in human valvular myofibroblasts. J Mol Cell Cardiol 35:379-388.
52. Lijnen P, Petrov V, Fagard R. 2003a. Transforming growth factor-beta 1-mediated collagen gel contraction by cardiac fibroblasts. J Renin Angiotensin Aldosterone Syst 4:113-118.
53. Lijnen P, Petrov V, Rumilla K, Fagard R. 2003b. Transforming growth factor-beta 1 promotes contraction of collagen gel by cardiac fibroblasts through their differentiation into myofibroblasts. Methods Find Exp Clin Pharmacol 25:79-86.
54. Masur SK, Dewal HS, Dinh TT, Erenburg I, Petridou S. 1996. Myofibroblasts differentiate from fibroblasts when plated at low density. Proc Natl Acad Sci USA 93:4219-4223.
55. McDonald TF, Peizer S, Trautwein W, Pelzer DJ. 1994. Regulation and modulation of calcium channels in cardiac, skeletal, and smooth muscle cells. Physiol Rev 74:365-507.
56. Munevar S, Wang YL, Dembo M. 2004. Regulation of mechanical interactions between fibroblasts and the substratum by stretch-activated Ca2+ entry. J Cell Sci 117:85-92.
57. Parekh AB, Penner R. 1997. Store depletion and calcium influx. Physiol Rev 77:901-930.
58. Pfitzer G. 2001. Invited review: Regulation of myosin phosphorylation in smooth muscle. J Appl Physiol 91:497-503.
59. Philipson KD, Nicoll DA. 2000. Sodium-calcium exchange: A molecular perspective. Annu Rev Physiol 62:111-133.
60. Pintado AJ, Herrero CJ, Garcia AG, Montiel C. 2000. The novel Na(+)/Ca(2+) exchange inhibitor KB-R7943 also blocks native and expressed neuronal nicotinic receptors. Br J Pharmacol 130:1893-1902.
61. Reuter H, Henderson SA, Han T, Matsuda T, Baba A, Ross RS, Goldhaber JI, Philipson KD. 2002. Knockout mice for pharmacological screening: Testing the specificity of Na+-Ca2+ exchange inhibitors. Circ Res 91:90-92.
62. Romero JR, Rivera A, Lanca V, Bicho MD, Conlin PR, Ricupero DA. 2005. Na+/Ca2+ exchanger activity modulates connective tissue growth factor mRNA expression in transforming growth factor beta1- and Des-Arg10-kallidin- stimulated myofibroblasts. J Biol Chem 280:14378-14384.
63. Ronnov-Jessen L, Petersen OW. 1993. Induction of alpha-smooth muscle actin by transforming growth factor-beta 1 in quiescent human breast gland fibroblasts. Implications for myofibroblast generation in breast neoplasia. Lab Invest 68:696-707.
64. Rook MB, van Ginneken AC, De Jonge B, El Aoumari A, Gros D, Jongsma HJ. 1992. Differences in gap junction channels between cardiac myocytes, fibroblasts, and heterologous pairs. Am J Physiol 263:C959-C977.
65. Rosker C, Graziani A, Lukas M, Eder P, Zhu MX, Romanin C, Groschner K. 2004. Ca(2+) signaling by TRPC3 involves Na(+) entry and local coupling to the Na(+)/Ca(2+) exchanger. J Biol Chem 279:13696-13704.
66. Scherberich A, Campos-Toimil M, Ronde P, Takeda K, Beretz A. 2000. Migration of human vascular smooth muscle cells involves serum-dependent repeated cytosolic calcium transients. J Cell Sci 113:653-662.
67. Seppa H, Grotendorst G, Seppa S, Schiffmann E, Martin GR. 1982. Platelet-derived growth factor in chemotactic for fibroblasts. J Cell Biol 92:584-588.
68. Serini G, Bochaton-Piallat ML, Ropraz P, Geinoz A, Borsi L, Zardi L, Gabbiani G. 1998. The fibronectin domain ED-A is crucial for myofibroblastic phenotype induction by transforming growth factor-beta1. J Cell Biol 142:873-881.
69. Skalli O, Ropraz P, Trzeciak A, Benzonana G, Gillessen D, Gabbiani G. 1986. A monoclonal antibody against alpha-smooth muscle actin: A new probe for smooth muscle differentiation. J Cell Biol 103:2787-2796.
70. Sobolevsky AI, Khodorov BI. 1999. Blockade of NMDA channels in acutely isolated rat hippocampal neurons by the Na+/Ca2+ exchange inhibitor KB- R7943. Neuropharmacology 38:1235-1242.
71. Somlyo AP, Wu X, Walker LA, Somlyo AV. 1999. Pharmacomechanical coupling: The role of calcium, G-proteins, kinases and phosphatases. Rev Physiol Biochem Pharmacol 134:201-234.
72. Takayama Y, Mizumachi K. 2001. Effects of lactoferrin on collagen gel contractile activity and myosin light chain phosphorylation in human fibroblasts. FEBS Lett 508:111-116.
73. Tomasek JJ, Gabbiani G, Hinz B, Chaponnier C, Brown RA. 2002. Myofibroblasts and mechano-regulation of connective tissue remodelling. Nat Rev Mol Cell Biol 3:349-363.
74. Tsubakimoto K, Matsumoto K, Abe H, Ishii J, Amano M, Kaibuchi K, Endo T. 1999. Small GTPase RhoD suppresses cell migration and cytokinesis. Oncogene 18:2431-2440.
75. Van Erk MJ, Teuling E, Staal YC, Huybers S, Van Bladeren PJ, Aarts JM, Van OB. 2004. Time-and dose-dependent effects of curcumin on gene expression in human colon cancer cells. J Carcinog 3:8.
76. Venkatachalam K, Zheng F, Gill DL. 2004. Control of TRPC and store-operated channels by protein kinase C. Novartis Found Symp 258:172-185.
77. Wallace JM, Freeburn JC, Gilmore WS, Sinnamon DG, Craig BM, McNally RJ, Strain JJ. 1998. The assessment of platelet derived growth factor concentration in post myocardial infarction and stable angina patients. Ann Clin Biochem 35:236-241.
78. Wang J, Chen H, Seth A, McCulloch CA. 2003. Mechanical force regulation of myofibroblast differentiation in cardiac fibroblasts. Am J Physiol Heart Circ Physiol 285:H1871-H1881.
79. Willems IE, Havenith MG, De Mey JG, Daemen MJ. 1994. The alpha-smooth muscle actin-positive cells in healing human myocardial scars. Am J Pathol 145:868-875.
80. Wu H, Reynolds AB, Kanner SB, Vines RR, Parsons JT. 1991. Identification and characterization of a novel cytoskeleton-associated pp60src substrate. Mol Cell Biol 11:5113-5124.
81. Wu Z, Wong K, Glogauer M, Ellen RP, McCulloch CA. 1999. Regulation of stretch-activated intracellular calcium transients by actin filaments. Biochem Biophys Res Commun 261:419-425.
82. Yang S, Huang XY. 2005. Ca2+ influx through L-type Ca2+ channels controls the trailing tail contraction in growth factor-induced fibroblast cell migration. J Biol Chem 280:27130-27137.
83. Yang XC, Sachs F. 1989. Block of stretch-activated ion channels in Xenopus oocytes by gadolinium and calcium ions. Science 243:1068-1071.
84. Yano T, Miura T, Ikeda Y, Matsuda E, Saito K, Miki T, Kobayashi H, Nishino Y, Ohtani S, Shimamoto K. 2005. Intracardiac fibroblasts, but not bone marrow derived cells, are the origin of myofibroblasts in myocardial infarct repair. Cardiovasc Pathol 14:241-246.
85. Zhang S, Yuan JX, Barrett KE, Dong H. 2005. Role of Na+/Ca2+ exchange in regulating cytosolic Ca2+ in cultured human pulmonary artery smooth muscle cells. Am J Physiol Cell Physiol 288:C245-C252.