Thyroid hormone levels of pregnant inuit women and their infants exposed to environmental contaminants

Environmental Health Perspectives

Volumn 117, Issue 6, 2009, Pages 1014-1020

  Dallaire, Renée ^a,b   Muckle, Gina ^a,b   Dewailly, Éric ^a,b   Jacobson, Sandra W ^c   Jacobson, Joseph L ^c   Sandanger, Torkjel M ^d   Sandau, Courtney D ^e   Ayotte, Pierre ^a,b  

^a LAVAL UNIVERSITY   (Canada)

^b UNIVERSITÉ LAVAL   (Canada)

^c WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d NORWEGIAN INSTITUTE FOR AIR RESEARCH   (Norway)

^e Trium Environmental Solutions Inc   (Canada)

Author keywords

Cohort; Cord blood; Inuit; Metabolites; Organochlorines; Pentachlorophenol; Polychlorinated biphenyls; Pregnant women; Prenatal exposure; Thyroid hormones

Indexed keywords

ENVIRONMENTAL CHEMICAL; HEXACHLOROBENZENE; LIOTHYRONINE; PENTACHLOROPHENOL; POLYCHLORINATED BIPHENYL; THYROID HORMONE; THYROTROPIN; THYROXINE; THYROXINE BINDING GLOBULIN;

ADULT; AGE; ARTICLE; BRAIN DEVELOPMENT; BREAST FEEDING; DEVELOPMENTAL DISORDER; DISEASE ASSOCIATION; ENVIRONMENTAL EXPOSURE; ESKIMO; FEMALE; HORMONE DETERMINATION; HUMAN; INFANT; MAJOR CLINICAL STUDY; MALE; MATERNAL PLASMA; PLACENTAL TRANSFER; POLLUTION; PREGNANT WOMAN; PRENATAL EXPOSURE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; THYROID HORMONE BLOOD LEVEL; UMBILICAL CORD BLOOD;

ADULT; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL POLLUTANTS; FEMALE; HEXACHLOROBENZENE; HUMANS; INFANT; INFANT, NEWBORN; INUITS; POLYCHLORINATED BIPHENYLS; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; THYROID HORMONES; THYROTROPIN; THYROXINE; THYROXINE-BINDING PROTEINS; TRIIODOTHYRONINE; YOUNG ADULT;

EID: 67549150885     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.0800219     Document Type: Article

References (49)

1. Akins JR, Waldrep K, Bernert JT Jr. 1989. The estimation of total serum lipids by a completely enzymatic "summation" method. Clin Chim Acta 184(3):219-226.
2. Brouwer A, Ahlborg UG, Van den Berg M, Birnbaum LS, Boersma ER, Bosveld B, et al. 1995. Functional aspects of developmental toxicity of polyhalogenated aromatic hydrocarbons in experimental animals and human infants. Eur J Pharmacol 293(1):1-40.
3. Brouwer A, Morse DC, Lans MC, Schuur AG, Murk AJ, Klasson-Wehler E, et al. 1998. Interactions of persistent environmental organohalogens with the thyroid hormone system: mechanisms and possible consequences for animal and human health. Toxicol Ind Health 14(1-2):59-84.
4. Calvo RM, Jauniaux E, Gulbis B, Asuncion M, Gervy C, Contempre B, et al. 2002. Fetal tissues are exposed to biologically relevant free thyroxine concentrations during early phases of development. J Clin Endocrinol Metab 87(4):1768-1777.
5. Chevrier J, Eskenazi B, Bradman A, Fenster L, Barr DB. 2007. Associations between prenatal exposure to polychlorinated biphenyls and neonatal thyroid-stimulating hormone levels in a Mexican-American population, Salinas Valley, California. Environ Health Perspect 115:1490-1416.
6. Chevrier J, Eskenazi B, Holland N, Bradman A, Barr DB. 2008. Effects of exposure to polychlorinated biphenyls and organochlorine pesticides on thyroid function during pregnancy. Am J Epidemiol 168(3):298-310.
7. Dallaire R, Dewailly É, Ayotte P, Muckle G, Laliberte C, Bruneau S. 2008. Effects of prenatal exposure to organochlorines on thyroid hormone status in newborns from two remoate coastal regions in Québec, Canada. Environ Res 108(3):387-392.
8. Darras VM, Hume R, Visser TJ. 1999. Regulation of thyroid hormone metabolism during fetal development. Mol Cell Endocrinol 151(1-2):37-47.
9. Demers LM, Spencer CA. 2002. Laboratory Medicine Practice Guidelines. Laboratory Support for The Diagnosis and Monitoring of Thyroid Disease. Washington, DC:National Academy of Clinical Biochemistry.
10. Dowling AL, Zoeller RT. 2000. Thyroid hormone of maternal origin regulates the expression of RC3/neurogranin mRNA in the fetal rat brain. Brain Res Mol Brain Res 82(1-2):126-132.
11. Fisher DA. 1998. Thyroid function in premature infants. The hypothyroxinemia of prematurity. Clin Perinatol 25(4):999-1014.
12. Goldey ES, Kehn LS, Lau C, Rehnberg GL, Crofton KM. 1995. Developmental exposure to polychlorinated biphenyls (Aroclor 1254) reduces circulating thyroid hormone concentrations and causes hearing deficits in rats. Toxicol Appl Pharmacol 135(1):77-88.
13. Hume R, Simpson J, Delahunty C, van Toor H, Wu SY, Williams FL, et al. 2004. Human fetal and cord serum thyroid hormones: developmental trends and interrelationships. J Clin Endocrinol Metab 89(8):4097-4103.
14. Jacobson JL, Jacobson SW. 1996. Intellectual impairment in children exposed to polychlorinated biphenyls in utero. N Engl J Med 335(11):783-789.
15. Koopman-Esseboom C, Morse DC, Weisglas-Kuperus N, Lutkeschipholt IJ, Van der Paauw CG, Tuinstra LG, et al. 1994. Effects of dioxins and polychlorinated biphenyls on thyroid hormone status of pregnant women and their infants. Pediatr Res 36(4):468-473.
16. Maervoet J, Vermeir G, Covaci A, Van Larebeke N, Koppen G, Schoeters G, et al. 2007. Association of thyroid hormone concentrations with levels of organochlorine compounds in cord blood of neonates. Environ Health Perspect 115:1780-1786.
17. McKinnon B, Li H, Richard K, Mortimer R. 2005. Synthesis of thyroid hormone binding proteins transthyretin and albumin by human trophoblast. J Clin Endocrinol Metab 90(12):6714-6720.
18. Morreale de Escobar G, Obregon MJ, Escobar del Rey F. 2000. Is neuropsychological development related to maternal hypothyroidism or to maternal hypothyroxinemia? J Clin Endocrinol Metab 85(11):3975-3987.
19. Morse DC, Wehler EK, Wesseling W, Koeman JH, Brouwer A. 1996. Alterations in rat brain thyroid hormone status following pre- and postnatal exposure to polychlorinated biphenyls (Aroclor 1254). Toxicol Appl Pharmacol 136(2):269-279.
20. Muckle G, Ayotte P, Dewailly É, Jacobson SW, Jacobson JL. 2001. Prenatal exposure of the northern Quebec Inuit infants to environmental contaminants. Environ Health Perspect 109:1291-1299.
21. Otake T, Yoshinaga J, Enomoto T, Matsuda M, Wakimoto T, Ikegami M, et al. 2007. Thyroid hormone status of newborns in relation to in utero exposure to PCBs and hydroxylated PCB metabolites. Environ Res 105(2):240-246.
22. Palha JA. 2002. Transthyretin as a thyroid hormone carrier: function revisited. Clin Chem Lab Med 40(12):1292-1300.
23. Pop VJ, Brouwers EP, Vader HL, Vulsma T, van Baar AL, de Vijlder JJ. 2003. Maternal hypothyroxinaemia during early pregnancy and subsequent child development: a 3-year follow-up study. Clin Endocrinol (Oxf) 59(3):282-288.
24. Pop VJ, Kuijpens JL, van Baar AL, Verkerk G, van Son MM, de Vijlder JJ, et al. 1999. Low maternal free thyroxine concentrations during early pregnancy are associated with impaired psychomotor development in infancy. Clin Endocrinol (Oxf) 50(2):149-155.
25. Porterfield SP, Hendrich CE. 1993. The role of thyroid hormones in prenatal and neonatal neurological development - current perspectives. Endocr Rev 14(1):94-106.
26. Rhainds M, Levallois P, Dewailly É, Ayotte P. 1999. Lead, mercury, and organochlorine compound levels in cord blood in Quebec, Canada. Arch Environ Health 54(1):40-47.
27. Ribas-Fito N, Sala M, Cardo E, Mazon C, De Muga ME, Verdu A, et al. 2003. Organochlorine compounds and concentrations of thyroid stimulating hormone in newborns. Occup Environ Med 60(4):301-303.
28. Richardson VM, Staskal DF, Ross DG, Diliberto JJ, DeVito MJ, Birnbaum LS. 2008. Possible mechanisms of thyroid hormone disruption in mice by BDE 47, a major polybrominated diphenyl ether congener. Toxicol Appl Pharmacol 226(3):244-250.
29. Sandau CD. 2000. Analytical Chemistry of Hydroxylated Metabolites of PCBs and Other Halogenated Phenolic Compounds in Blood and Their Relationship to Thyroid Hormone and Retinol Homeostasis in Humans and Polar Bears [PhD thesis]. Carleton, Ontario, Canada:Carleton University.
30. Sandau CD, Ayotte P, Dewailly É, Duffe J, Norstrom RJ. 2000. Analysis of hydroxylated metabolites of PCBs (OH-PCBs) and other chlorinated phenolic compounds in whole blood from Canadian Inuit. Environ Health Perspect 108:611-616.
31. Sandau CD, Ayotte P, Dewailly É, Duffe J, Norstrom RJ. 2002. Pentachlorophenol and hydroxylated polychlorinated biphenyl metabolites in umbilical cord plasma of neonates from coastal populations in Quebec. Environ Health Perspect 110:411-417.
32. Sandau CD, Sjodin A, Davis MD, Barr JR, Maggio VL, Waterman AL, et al. 2003. Comprehensive solid-phase extraction method for persistent organic pollutants. Validation and application to the analysis of persistent chlorinated pesticides. Anal Chem 75(1):71-77.
33. Schantz SL, Seo BW, Wong PW, Pessah IN. 1997. Long-term effects of developmental exposure to 2,2′,3,5′,6-pentachlorobiphenyl (PCB 95) on locomotor activity, spatial learning and memory and brain ryanodine binding. Neurotoxicology 18(2):457-467.
34. Schantz SL, Widholm JJ. 2001. Cognitive effects of endocrine-disrupting chemicals in animals. Environ Health Perspect 109:1197-1206.
35. Schisterman EF, Whitcomb BW, Louis GM, Louis TA. 2005. Lipid adjustment in the analysis of environmental contaminants and human health risks. Environ Health Perspect 113:853-857.
36. Schreiber G, Southwell BR, Richardson SJ. 1995. Hormone delivery systems to the brain-transthyretin. Exp Clin Endocrinol Diabetes 103(2):75-80.
37. Schuur AG, Legger FF, van Meeteren ME, Moonen MJ, van Leeuwen-Bol I, Bergman A, et al. 1998. In vitro inhibition of thyroid hormone sulfation by hydroxylated metabolites of halogenated aromatic hydrocarbons. Chem Res Toxicol 11(9):1075-1081.
38. Southwell BR, Duan W, Alcorn D, Brack C, Richardson SJ, Kohrle J, et al. 1993. Thyroxine transport to the brain: role of protein synthesis by the choroid plexus. Endocrinology 133(5):2116-2126.
39. Stagnaro-Green A. 2004. Postpartum thyroiditis. Best Pract Res Clin Endocrinol Metab 18(2):303-316.
40. Steuerwald U, Weihe P, Jorgensen PJ, Bjerve K, Brock J, Heinzow B, et al. 2000. Maternal seafood diet, methylmercury exposure, and neonatal neurologic function. J Pediatr 136(5):599-605.
41. Stewart P, Lonky E, Reihman J, Pagano J, Gump B, Darvill T. 2008. The relationship between prenatal PCB exposure and intelligence (IQ) in 9-year-old children. Environ Health Perspect 116:1416-1422.
42. Takayama M, Itoh S, Nagasaki T, Tanimizu I. 1977. A new enzymatic method for determination of serum choline-containing phospholipids. Clin Chim Acta 79(1):93-98.
43. Takser L, Mergler D, Baldwin M, de Grosbois S, Smargiassi A, Lafond J. 2005. Thyroid hormones in pregnancy in relation to environmental exposure to organochlorine compounds and mercury. Environ Health Perspect 113:1039-1045.
44. van den Berg KJ. 1990. Interaction of chlorinated phenols with thyroxine binding sites of human transthyretin, albumin and thyroid binding globulin. Chem Biol Interact 76(1):63-75.
45. van Raaij JA, Frijters CM, van den Berg KJ. 1993. Hexa-chlorobenzene-induced hypothyroidism. Involvement of different mechanisms by parent compound and metabolite. Biochem Pharmacol 46(8):1385-1391.
46. van Raaij JA, Frijters CM, Kong LW, van den Berg KJ, Notten WR. 1994. Reduction of thyroxine uptake into cerebrospinal fluid and rat brain by hexachlorobenzene and pentachlorophenol. Toxicology 94(1-3):197-208.
47. Visser TJ. 1996. Pathways of thyroid hormone metabolism. Acta Med Austriaca 23(1-2):10-16.
48. Vulsma T, Gons MH, de Vijlder JJ. 1989. Maternal-fetal transfer of thyroxine in congenital hypothyroidism due to a total organification defect or thyroid agenesis. N Engl J Med 321(1):13-16.
49. Wolff MS, Camann D, Gammon M, Stellman SD. 1997. Proposed PCB congener groupings for epidemiological studies. Environ Health Perspect 105:13-14.