Thiopyrophosphoantigens: Solid-phase synthesis and in vitro characterization of a new class of Vγ9 Vδ2 T cells activators

Journal of Medicinal Chemistry

Volumn 52, Issue 12, 2009, Pages 3716-3722

  Breccia, Perla ^a   Angeli, Francesca ^a   Cerbara, Ilaria ^a   Topai, Alessandra ^a   Auricchio, Giovanni ^a   Martino, Angelo ^b   Colizzi, Vittorio ^c   Poccia, Fabrizio ^b  

^a Colosseum Combinatorial Chemistry Centre for Technology ^*  (Italy)

^b NATIONAL INSTITUTE FOR INFECTIOUS DISEASES L SPALLANZANI   (Italy)

^c UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; GAMMA INTERFERON; ISOPENTENYL DIPHOSPHATE; MEVALONIC ACID; THIO 4 HYDROXY 3 METHYLBUT 2 ENYL PYROPHOSPHATE; THIOPYROPHOSPHOANTIGEN; TRISODIUM S (2 ETHYL 1,3 DIOXOLANYL)THIODIPHOSPHONATE; TRISODIUM S (3 METHYL 3 BUTENYL)THIODIPHOSPHONATE; TRISODIUM S (ETHYL 2 TETRAHYDRO 2H 2 PYRANYLOXY)THIODIPHOSPHONATE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; CELL PROLIFERATION; CYTOKINE RELEASE; CYTOTOXICITY; DRUG SCREENING; HUMAN; HUMAN CELL; IMMUNOREGULATION; IMMUNOSTIMULATION; IN VITRO STUDY; INNATE IMMUNITY; NORMAL HUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; SOLID PHASE SYNTHESIS; STRUCTURE ACTIVITY RELATION; T LYMPHOCYTE ACTIVATION;

HEMITERPENES; LYMPHOCYTE ACTIVATION; MOLECULAR STRUCTURE; MOLECULAR WEIGHT; ORGANOPHOSPHORUS COMPOUNDS; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; SMALL MOLECULE LIBRARIES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SULFHYDRYL COMPOUNDS; T-LYMPHOCYTES;

EID: 67549150600     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm900054u     Document Type: Article

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