Aspirin in recurrent miscarriage: Is there an indication?

Israel Medical Association Journal

Volumn 11, Issue 3, 2009, Pages 178-182

  Carp, Howard J A ^a,b  

^a SHEBA MEDICAL CENTER   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

Author keywords

Antiphospholipid syndrome; Aspirin; Pregnancy loss; Recurrent miscarriage; Thrombophilias

Indexed keywords

ACETYLSALICYLIC ACID; ENOXAPARIN; HEPARIN; PLACEBO; SALICYLIC ACID DERIVATIVE; STEROID;

ANTIPHOSPHOLIPID SYNDROME; CHROMOSOME ABERRATION; CLINICAL TRIAL; CONGENITAL MALFORMATION; DRUG EFFICACY; DRUG INDICATION; DRUG MECHANISM; DRUG PENETRATION; DRUG SAFETY; DUCTUS ARTERIOSUS OBLITERATION; EVIDENCE BASED MEDICINE; FETOTOXICITY; FETUS DEATH; GASTROINTESTINAL HEMORRHAGE; HEART REINFARCTION; HUMAN; KIDNEY FUNCTION; LIVE BIRTH; LOW DRUG DOSE; MISSED ABORTION; PREGNANCY OUTCOME; PREGNANT WOMAN; PRENATAL DRUG EXPOSURE; RECURRENT ABORTION; REVIEW; RISK BENEFIT ANALYSIS; SIDE EFFECT; SPONTANEOUS ABORTION; TERATOGENICITY; THROMBOPHILIA; TRICUSPID VALVE REGURGITATION; VEIN THROMBOSIS;

ABORTION, HABITUAL; ASPIRIN; CYCLOOXYGENASE INHIBITORS; FEMALE; HUMANS; PREGNANCY;

EID: 67549149104     PISSN: 15651088     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (40)

1. Stirling Y, Woolf L, North WR, Seghatchian MJ, Meade TW. Haemostasis in normal pregnancy. Thromb Haemost 1984; 52: 176-82.
2. Comp PC, Thurnau GR, Welsh J, Esmon CT. Functional and immunologic protein S levels are decreased during pregnancy. Blood 1986; 68: 881-5.
3. Rushton DI. Placental pathology in spontaneous miscarriage. In: Beard RW, Sharp F, eds. Early Pregnancy Loss: Mechanisms and Treatment. London: Royal College of Obstetricians and Gynaecologists, 1988: 149-58.
4. Tulppala M, Marttunen M, Soderstrom-Anttila V, Ailus K, Palosuo T, Ylikorkala O. Low dose aspirin in the prevention of miscarriage in women with unexplained or autoimmune related recurrent miscarriage: effect on prostacyclin and thromboxane A2 production. Hum Reprod 1997; 12: 1567-72.
5. DeWitt DL. Cox-2-selective inhibitors: the new super aspirins. Mol Pharmacol 1999; 55: 625-31.
6. Al-Bahrani A, Taha S, Shaath H, Bakhiet M. TNF-alpha and IL-8 in acute stroke and the modulation of these cytokines by antiplatelet agents. Curr Neurovasc Res 2007; 4: 31-7.
7. Levi M, Ten Cate H. Disseminated intravascular coagulation. N Engl J Med 1999; 341: 586-92.
8. Schraufstatter IU, Trieu K, Zhao M, Rose DM, Terkeltaub RA, Burger M. IL-8-mediated cell migration in endothelial cells depends on cathepsin B activity and transactivation of the epidermal growth factor receptor. J Immunol 2003; 171: 6714-22.
9. Fishman P, Falach-Vaknin E, Sredni B, et al. Aspirin-interleukin-3 interrelationships in patients with anti-phospholipid syndrome. Am J Reprod Immunol 1996; 35: 80-4.
10. Carp HJA. Cytokines in recurrent miscarriage. Lupus 2004; 13: 630-4.
11. Out HJ, Kooijman CD, Bruinse HW, et al. Histo-pathological findings from patients with intrauterine fetal death and antiphospholipid antibodies. Eur J Obstet Gynaecol 1991; 41: 179-86.
12. Rai R, Backos M, Baxter N, Chilcott I, Regan L. Recurrent miscarriage - an aspirin a day? Hum Reprod 2000; 15: 2220-3.
13. Tincani A, Branch DW, Levy RA, et al. Treatment of pregnant patients with antiphospholipid syndrome. Lupus 2003; 12: 524-9.
14. Cowchock S, Reece EA. Do low-risk pregnant women with antiphospholipid antibodies need to be treated? Organizing Group of the Antiphospholipid Antibody Treatment Trial. Am J Obstet Gynecol 1997; 176: 1099-100.
15. Pattison NS, Chamley LW, Birdsall M, et al. Does aspirin have a role in improving pregnancy outcome for women with the antiphospholipid syndrome? A randomized controlled trial. Am J Obstet Gynecol 2000; 183: 1008-12.
16. Empson M, Lassere M, Craig J, et al. Prevention of recurrent miscarriage for women with antiphospholipid antibody or lupus anticoagulant. Cochrane Database Syst Rev 2005: D002859.
17. Gris JC, Mercier E, Quere I, et al. Low-molecular-weight heparin versus low-dose aspirin in women with one fetal loss and a constitutional thrombophilic disorder. Blood 2004; 103: 3695-9.
18. Phillipp T, Phillipp K, Reiner A, Beer F, Kalousek DK. Embryoscopic and cytogenetic analysis of 233 missed abortions: factors involved in the pathogenesis of developmental defects of early failed pregnancies. Hum Reprod 2003; 18: 1724-32.
19. Carp HJA. Obstetric outcomes after recurrent pregnancy loss. In: Carp HJA, ed. Recurrent Pregnancy Loss, Causes, Controversies and Treatment. London: Informa Healthcare Ltd., 2007: 231-42.
20. Carp HJA, Toder V, Orgad S, et al. Karyotype of the abortus in recurrent miscarriage. Fertil Steril 2001; 5: 678-82.
21. Ogasawara M, Aoki K, Okada S, Suzumori K. Embryonic karyotype of abortuses in relation to the number of previous miscarriages. Fertil Steril 2000; 73: 300-4.
22. Takakuwa K, Asano K, Arakawa M, Yasuda M, Hasegawa I, Tanaka K. Chromosome analysis of aborted conceptuses of recurrent aborters positive for anticardiolipin antibody. Fertil Steril 1997; 68: 54-8.
23. Carp HJA, Dolitzky M, Inbal A. Thromboprophylaxis improves the live birth rate in women with consecutive recurrent miscarriages and hereditary thrombophilia. J Thromb Hemost 2003; 1: 433-8.
24. Beigel R, Matetzky S, Fefer P, Dvir D, Hod H. Aspirin - issues in daily practice: an update. IMAJ 2007; 9: 221-6.
25. Derry S, Loke YK. Risk of gastrointestinal haemorrhage with long term use of aspirin: meta-analysis. BMJ 2000; 321: 1183-7.
26. Segal R, Lubart E, Leibovitz A, Iaina A, Caspi D. Renal effects of low dose aspirin in elderly patients. IMAJ 2006; 8: 679-82.
27. Nielsen GL, Sorensen HT, Larsen H, Pedersen I. Risk of adverse birth outcome and miscarriage in pregnant users of non-steroidal anti-inflammatory drugs: population based observational study and case control study. BMJ 2001; 322: 266-70.
28. Li DK, Liu L, Odouli R. Exposure to non-steroidal anti-inflammatory drugs during pregnancy and risk of miscarriage: population-based cohort study. BMJ 2003; 327: 8-72.
29. Kozer E, Moldovan Costei A, Boskovic R, Nulman I, Nikfar S, Koren G. Effects of aspirin consumption during pregnancy on pregnancy outcomes: meta-analysis. Birth Defects Res B Dev Reprod Toxicol 2003; 68: 70-84.
30. Golding JA. A randomized trial of low dose aspirin for primiparae in pregnancy. Br J Obstet Gynaecol 1998; 105: 293-9.
31. Ylikorkala O, Makila UM, Kaapa P, Viinikka L. Maternal ingestion of acetylsalicylic acid inhibits fetal and neonatal prostacyclin and thromboxane in humans. Am J Obstet GynecoI 1986; 55: 345-9.
32. Hertz-Picciotto I, Hopenhayn-Rich R, Golub M, Hooper K. The risks and benefits of taking aspirin during pregnancy. Epidemiol Rev 1990; 12: 108-48.
33. Cappon GD, Cook JC, Hurtt ME. Relationship between cyclooxygenase 1 and 2 selective inhibitors and fetal development when administered to rats and rabbits during the sensitive periods for heart development and midline closure. Birth Defects Res B Dev Reprod Toxicol 2003; 68: 47-56.
34. De Wolf F, Carreras LO, Moerman P, Vermylen J, Van Assche A, Renaer M. Decidual vasculopathy and extensive placenta 1 infarction in a patient with repeated thromboembolic accidents, recurrent fetal loss, and a lupus anticoagulant. Am J Obstet Gynecol 1982; 142: 829-34.
35. Dolitzky M, Inbal A, Segal Y, Weiss A, Brenner B, Carp HJA. A randomized study of thromboprophylaxis in women with unexplained consecutive recurrent miscarriages. Fertil Steril 2006; 86: 362-6.
36. Klebanoff MA, Berendes HW. Aspirin exposure during the first 20 weeks of gestation and IQ at four years of age. Teratology 1988; 37: 249-55.
37. Heymann MA, Randolph AM. Effects of acetyl salicylic acid on the ductus arteriosus and circulation in fetal lambs in utero. Circ Res 1976; 38: 418-22.
38. Kozer E, Shekoufeh N, Costei A, Boskovic R, Nulman I, Koren G. Aspirin consumption during the first trimester of pregnancy and congenital anomalies: a meta-analysis. Am J Obstet Gynecol 2002; 187: 1623-30.
39. Martinez-Frias ML, Rodriguez-Pinilla E, Prieto L. Prenatal exposure to salicylates and gastroschisis: a case-control study. Teratology 1997; 56: 241-3.
40. Chan LY, Yuen PM. Risk of miscarriage in pregnant users of NSAIDs. More information is needed to be able to interpret study's results. BMJ 2001; 322: 1365-6.