Cytokines in recurrent miscarriage

Lupus

Volumn 13, Issue 9, 2004, Pages 630-634

  Carp, H ^a  

^a SHEBA MEDICAL CENTER   (Israel)

Author keywords

Cytokines; Fetal anomalies; Habitual abortion; hCG; NK cells; Pregnancy loss; Progesterone; Recurrent miscarriage; Thrombosis

Indexed keywords

ACETYLSALICYLIC ACID; CHORIONIC GONADOTROPIN; CYCLOPHOSPHAMIDE; CYTOKINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HEPARIN; INTERLEUKIN 3; INTERLEUKIN 6; LOW MOLECULAR WEIGHT HEPARIN; PHOSPHOLIPID ANTIBODY; PROGESTERONE; TUMOR NECROSIS FACTOR ALPHA;

ANTIPHOSPHOLIPID SYNDROME; APOPTOSIS; BLOOD CLOTTING; CHROMOSOME ABERRATION; CONFERENCE PAPER; DRUG INHIBITION; DRUG MECHANISM; EMBRYOTOXICITY; FETOPLACENTAL UNIT; FETOSCOPY; FETUS ECHOGRAPHY; FETUS KARYOTYPING; FETUS MALFORMATION; HORMONAL THERAPY; HUMAN; IMMUNOMODULATION; IMMUNOSURVEILLANCE; MISSED ABORTION; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; RECURRENT ABORTION; TERATOGENESIS; TH1 CELL; TH2 CELL; THROMBOSIS; TROPHOBLAST;

ABNORMALITIES; ABORTION, HABITUAL; ANIMALS; CYTOKINES; FEMALE; FETAL DEATH; HUMANS; KILLER CELLS, NATURAL; PREGNANCY; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 4644354630     PISSN: 09612033     EISSN: None     Source Type: Journal    
DOI: 10.1191/09612033043lu1091oa     Document Type: Conference Paper

References (60)

1. Imura H, Fukata J, Mori T. Cytokines and endocrine function: interaction between the immune and neuroendocrine systems. Clin Endocrinol 1991; 25: 107-115.
2. Carp HJA. Pitfalls in interpreting therapy for early pregnancy. Early Pregnancy 1996; 2: 96-101.
3. Saito S. Cytokine network at the feto-maternal interface. J Reprod Immunol 2000; 47: 87-103.
4. Wegmann TG. The cytokine basis for cross-talk between the maternal immune and reproductive systems. Curr Opin Immunol 1990; 2: 765-769.
5. Schäfer-Somi S. Cytokines during early pregnancy of mammals: a review. Animal Reprod Sci 2003; 75: 73-94.
6. Torchinsky A, Shepshelovich J, Orenstein H et al. TNFα protects embryos exposed to developmental toxicants Am J Reprod Immunol 2003; 49: 159-168.
7. Chaouat G, Zourbas S, Ostojic S et al. A brief review of recent data on some cytokine expressions at the materno-foetal interface that might challenge the classical Th-1/Th-2 dichotomy. J Reprod Immunol 2002; 53: 241-256.
8. Zigril M, Fein A, Carp HJA, Toder V. Immunopotentiation reverses the embryotoxic effect of serum from women with pregnancy loss. Fertil Steril 1991; 56: 653-659.
9. Abir R, Ornoy A, Ben Hur H, Jaffe, P, Pinus H. The effects of sera from women with spontaneous abortions on the in vitro development of early somite stage rat embryos. Am J Reprod Immunol 1994; 32: 73-81.
10. Carp HJA, Toder V, Mashiach S, Nebel L, Serr DM. Early Pregnancy Loss: Current Concepts of Research and Treatment. Obstet Gynecol Surv 1990; 45: 657-669.
11. Carp HJA, Torchinsky A, Fein A, Toder V. Hormones, Cytokines and Fetal Anomalies In Habitual Abortion. J Gynec Endocrinol 2002; 15: 472-483.
12. Philipp T, Kalousek DK. Transcervical embryoscopy in missed abortion. J Assist Reprod Genet 2001; 18: 285-290.
13. Philipp T, Philipp K, Reiner A, Beer F, Kalousek DK. Embryoscopic and cytogenetic analysis of 233 missed abortions: factors involved in the pathogenesis of developmental defects of early failed pregnancies. Hum Reprod 2003; 18: 1724-1732.
14. Beck TW, Magnuson NS, Rapp UR. Growth factor regulation of cell cycle progression and cell fate determination. Curr Top Microbiol Immunol 1995; 194: 291-303.
15. Force T, Bonventre JV. Growth factors and mitogen-activated protein kinases. Hypertension 1998; 31: 152-161.
16. Mirkes, P.E. Cyclophosphamide teratogenesis: a review. Teratog Carcinog Mutagen 1985; 5: 75-88.
17. Hartwell LH, Kastan MB. Cell cycle control and cancer. Science 1994; 266: 1821-1828.
18. Bursh W, Oberhammer F, Shulte-Herman R. Cell death by apoptosis and its protective role against disease. Trends Pharmacol Sci 1992; 12: 245-251.
19. Jaskoll TH, Choy HA, Chen H, Melnick M. Developmental expression and CORT-regulation of TGF-β and EGE receptor mRNA during mouse palatal morphogenesis: correlation between CORT-induced cleft palate and TGF-β2 mRNA expression. Teratology 1996; 54: 34-44.
20. Torchinsky A, Savion S, Gorivodsky M et al. Cyclophosphamide-induced teratogenesis in ICR mice: the role of apoptosis. Teratog Mutagen Carcinog 1995; 15: 179-190.
21. Ivnitsky I, Torchinsky A, Gorivodsky M et al. Tnf-α Expression In embryos exposed to a teratogen. Am J Reprod Immunol 1998; 40: 431-440.
22. Savion S, Brengauz-Breitmann M, Torchinsky A, Toder V. A possible role for granulocyte macrophage-colony stimulating factor in modulating teratogen-induced effects. Teratog Carcinog Mutagen 1999; 19: 171-182.
23. Wells PG, Kim PM, Nicol CJ, Parman T, Winn LM. Reactive itermediates. In Kavlock RJ, Daston GP eds. Drug toxicity in embryonic development I. Berlin, Heidelberg, NewYork: Springer-Verlag, 1997: 453-518.
24. Morgan ET. Regulation of cytochromes P450 during inflammation and infection. Drug Metab Rev 1997; 29: 1129-1188.
25. Clark DA, Lea RG, Flanders KC, Banwatt D, Chaouat G. Role of a unique species of TGF-β in preventing rejection of the conceptus during pregnancy. In Gergely J, Benczur M, Erdei N eds. Progress in immunology VIII. Budapest: Springer-Verlag, 1992: 841-852.
26. Chaouat G, Menu E, Wegmann TG. Role of lymphokines of the CSF family and of TNF, gamma interferon and IL-2 in placental growth and fetal survival studied in two murine models of spontaneous resorptions. In Chaouat G, Mowbray JF eds. Cellular and molecular biology of the maternal-fetal relationship. Paris: INSERM/John Libbey Eurotext, 1191: 91.
27. King A, Jokhi PP, Burrows TD, Gardner L, Sharkey AM, Loke YW. Functions of human decidual NK cells. Am J Reprod Immunol 1996; 35: 258-260.
28. Yui J, Garcia-Lloret M, Wegmann TG, Guilbert LJ. Cytotoxicity of tumor necrosis factor -alpha and gamma-interferon against primary human placental trophoblast. Placenta 1994; 15: 819-835.
29. Arck PC, Merali FS, Stanisz AM et al. Stress-induced murine abortion associated with substance P-dependent alteration in cytokines in maternal uterine decidua. Biol Reprod 1995; 53: 814-819.
30. Emmer PM, Nelen WL, Steegers EA, Hendriks JC, Veerhoek M, Joosten I. Peripheral natural killer cytotoxicity and CD56(pos)CD16(pos) cells increase during early pregnancy in women with a history of recurrent spontaneous abortion. Hum Reprod 2000; 15: 1163-1169.
31. Shakhar K, Ben-Eliyahu S, Rosen E, Loewenthal R, Carp HJA. Primary versus secondary recurrent miscarriage: differences in number and activity of peripheral NK cells. Fertil Steril 2003; 80: 368-375.
32. Clifford K, Flanagan AM, Regan L. Endometrial CD56+ natural killer cells in women with recurrent miscarriage: a histomorphometric study. Hum Reprod 1999; 14: 2727-2730.
33. Aoki K, Kajiura S, Matsumoto Y et al. Preconceptional natural-killer-cell activity as a predictor of miscarriage. Lancet 1995; 345: 1340-1342.
34. Coulam CB, Beaman KD. Reciprocal alteration in circulating TJ6+ CD19+ and TJ6+ CD56+ leukocytes in early pregnancy predicts success or miscarriage. Am J Reprod Immunol 1995; 34: 219-224.
35. Tong S, Marjono B, Brown DA et al. Macrophage inhibitory cytokine 1 (MIC 1) as a predictor of miscarriage. Lancet 2004; 363: 129-130.
36. Levi M, Ten Cate H. Disseminated intravascular coagulation. N Engl J Med 1999; 341: 586-592.
37. Yan SB, Helterbrand J, Hartman DL, Wright TJ, Bernard GR. Low levels of protein C are associated with poor outcome in severe sepsis. Chest 2001; 120: 915-922.
38. Knackstedt MK, Zenclussen AC, Hertwig K et al. Th1 cytokines and the prothrombinase fg12 in stress-triggered and inflammatory abortion. Am J Reprod Immunol 2003; 49: 210-220.
39. Emofsson M, Tenno T, Siegbahn A. Inhibition of tissue factor surface expression in human peripheral blood monocytes exposed to cytokines. Br J Haematol 1996; 95: 249-257.
40. Scholz M, Vogel JU, Hover G et al. Thrombin stimulates IL-6 and IL-8 expression in cytomegalovirus-infected human retinal pigment epithelial cells. Int J Mol Med 2004; 13: 327-331.
41. Schraufstatter IU, Trieu K, Zhao M, Rose DM, Terkeltaub RA, Burger M. IL-8-mediated cell migration in endothelial cells depends on cathepsin B activity and transactivation of the epidermal growth factor receptor. J Immunol 2003; 171: 6714-6722.
42. Blank M, Cohen J, Toder V, Shoenfeld Y. Induction of anti-phospholipid syndrome in naive mice with mouse lupus monoclonal and human polyclonal anti-cardiolipin antibodies. Proc Natl Acad Sci USA 1991; 88: 3069-3073.
43. Bakimer R, Fishman P, Blank M, Sredni B, Djaldetti M, Shoenfeld Y. Induction of primary antiphospholipid syndrome in mice by immunization with a human monoclonal anticardiolipin antibody (H-3). J Clin Invest 1992; 89: 1558-1563.
44. Cowchock S, Reece EA. Do low-risk pregnant women with antiphospholipid antibodies need to be treated? Organizing Group of the Antiphospholipid Antibody Treatment Trial. Am J Obstet Gynecol 1997; 176: 1099-1100.
45. Tulppala M, Marttunen M, Soderstrom-Anttila V et al. Low-dose aspirin in prevention of miscarriage in women with unexplained or autoimmune related recurrent miscarriage: effect on prostacyclin and thromboxane A2 production. Hum Reprod 1997; 12: 1567-1572.
46. Pattison NS, Chamley LW, Birdsall M, Zanderigo AM, Liddell HS, McDougall J. Does aspirin have a role in improving pregnancy outcome for women with the antiphospholipid syndrome? A randomized controlled trial. Am J Obstet Gynecol 2000; 183: 1008-1012.
47. Rand JH. The antiphospholipid syndrome. Annu Rev Med 2003; 54: 409-424.
48. Shoenfeld Y, Sherer Y, Fishman P. Interleukin-3 and pregnancy loss in antiphospholipid syndrome. Scand J Rheumatol Suppl 1998; 107: 19-22.
49. Fishman P, Falach-Vaknine E, Zigelman R et al. Prevention of fetal loss in experimental antiphospholipid syndrome by in vivo administration of recombinant interleukin-3. J Clin Invest 1993; 91: 1834-1837.
50. Bertolaccini ML, Atsumi T, Lanchbury JS et al. Plasma tumor necrosis factor alpha levels and the 238A promoter polymorphism in patients with antiphospholipid syndrome. Thromb Haemost 2001; 85: 198-203.
51. Tincani A, Branch DW, Levy RA et al. Treatment of pregnant patients with antiphospholipid syndrome. Lupus 2003; 12: 524-529.
52. Kutten WH. Antiphospholipid antibody-associated recurrent pregnancy loss: treatment with heparin and low-dose aspirin is superior to low-dose aspirin alone. Am J Obstet Gynecol 1996; 174: 1584-1589.
53. Rai R, Cohen H, Dave M, Regan L. Randomised controlled trial of aspirin and aspirin plus heparin in pregnant women with recurrent miscarriage associated with phospholipid antibodies (or antiphospholipid antibodies). Br Med J 1997; 314: 253-257.
54. Lantz M, Thysell H, Nilsson E, Olsson I. On the binding of tumor necrosis factor (TNF) to heparin and the release in vivo of the TNF-binding protein I by heparin. J Clin Invest 1991; 88: 2026-2031.
55. Baram D, Rashkovsky M, Hershkoviz R et al. Inhibitory effects of low molecular weight heparin on mediator release by mast cells: preferential inhibition of cytokine production and mast cell-dependent cutaneous inflammation. Clin Exp Immunol 1997; 110: 485-491.
56. Downing LJ, Strieter RM, Kadell AM, Wilke CA, Greenfield LJ, Wakefield TW. Low-dose low-molecular-weight heparin is anti-inflammatory during venous thrombosis. J Vasc Surg 1998; 28: 848-854.
57. Garcia-Lloret MI, Morrish DW, Wegmann TG, Honore L, Turner AR, Guilbert LJ. Demonstration of functional cytokine-placental interactions: CSF-1 and GM-CSF stimulate human cytotrophoblast differentiation and peptide hormone secretion. Exp Cell Res 1994; 214: 46-54.
58. Piccinni MP, Scaletti C, Maggi E, Romagnani S. Role of hormone-controlled Th1- and Th2-type cytokines in successful pregnancy. J Neuroimmunol 2000; 109: 30-33.
59. Gafter U, Sredni B, Segal J, Kalechman Y. Suppressed cell-mediated immunity and monocyte and natural killer cell activity following allogeneic immunization of women with spontaneous recurrent abortion. J Clin Immunol 1997; 17: 408-419.
60. Graphou O, Chioti A, Pantazi A et al. Effect of intravenous immunoglobulin treatment on the Th1/Th2 balance in women with recurrent spontaneous abortions. Am J Reprod Immunol 2003; 49: 21-29.