Genetic deletion of faim reveals its role in modulating c-FLIP expression during CD95-mediated apoptosis of lymphocytes and hepatocytes

Cell Death and Differentiation

Volumn 16, Issue 7, 2009, Pages 1062-1070

  Huo, J ^a   Xu, S ^a   Guo, K ^b   Zeng, Q ^b   Lam, K P ^a  

^a AGENCY FOR SCIENCE   (Singapore)

^b INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CASPASE 8; FAS ANTIGEN; FAS APOPTOSIS INHIBITORY MOLECULE; FLICE INHIBITORY PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; B LYMPHOCYTE; CELL POPULATION; CELL VIABILITY; CHEMICAL ANALYSIS; ENZYME ACTIVATION; ENZYME BINDING; ENZYME REGULATION; GENE DELETION; IMMUNOSTIMULATION; IN VIVO STUDY; LIVER CELL; LIVER INJURY; MORTALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; T LYMPHOCYTE; THYMOCYTE;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD95; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; B-LYMPHOCYTES; CASP8 AND FADD-LIKE APOPTOSIS REGULATING PROTEIN; CASPASE 3; CASPASE 8; DEXAMETHASONE; FAS LIGAND PROTEIN; GENE DELETION; HEPATOCYTES; IMMUNOLOGIC FACTORS; LIVER; MICE; MICE, KNOCKOUT; T-LYMPHOCYTES; TUMOR NECROSIS FACTOR-ALPHA;

MUS;

EID: 67549146632     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2009.26     Document Type: Article

References (30)

1. Nagata S. Apoptosis regulated by a death factor and its receptor: Fas ligand. and Fas. Philos Trans R Soc Lond B Biol Sci 1994; 345 281-287.
2. Krammer PH. CD95's deadly mission in the immune system. Nature 2000; 407: 789-795.
3. Takahashi T, Tanaka M, Brannan CI, Jenkins NA, Cobeland NG, Suda T et al. Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell 1994; 76: 969-976.
4. Watanabe-Fukunaga R, Brannan CI, Copeland NG, Jenkins NA, Negata S. Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis, Nature 1992; 356: 314-317.
5. Kischkel FC, Hellbardt S, Behrmann I, Germer M, Pawlita M, Krammer PH et al. Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor. EMBO J 1995; 14: 5579-5588.
6. Scaffidi C, Schmitz I, Krammer PH, Peter ME. The role of c-FLIP in modulation of CD95-induced apoptosis. J Biol Chem 1999; 274: 1541-1548.
7. Schneider TJ, Fischer GM, Donohoe TJ, Colarusso TP, Rothstein TL. A novel gene coding for a Fas apoptosis inhibitory molecule (FAIM) isolated from inducibly Fas-resistant B lymphocytes. J Exp Med 1999; 189: 949-956.
8. Sole C, Dolcet X, Segura MF, Gutierrez H, Diaz-Meco MT, Gozzelino R et al. The death receptor antagonist FAIM promotes neurite outgrowth by a mechanism that depends on ERK and NF-kapp B signaling. J Cell Biol 2004; 167: 479-492.
9. Segura MF, SoLe C, Pascual M, Moubarak RS, Perez-Garcia MJ, Gozzelino R et al. The long form of Fas apoptotic inhibitory molecule is expressed specifically in neurons and protects them against death receptor-triggered apoptosis. J Neurosci 2007; 27: 11228--11241.
10. Jaluria P, Chu C, Betenbaugh M, Shiloach J. Cells by design: A mini-review of targeting cell. engineering using DNA microarrays. Mol Biotechnol 2008; 39: 105-111.
11. Wong DC, Wong KT, Nissom PM, Hong CK, Yap MG. Targeting early apoptotic genes in batch and fed-batch CHO cell cultures. Biotechnol Bioeng 2006; 95: 350-361.
12. Rothstein TL, Wang JK, Panka DJ, Foote LC, Wang Z, Stanger B et al Protection against Fas-depandent Th1-mediated apoptosis by antigen receptor engagement in B cells. Nature 1995; 374: 163-165.
13. Lagresle C, Mondiere P, Bella C, Krammer PH, Defrance T. Concurrent engagement of CD40 and the antigen receptor protects naive and memory human B cells from APO-1/Fas-mediated apoptosis. J Exp Med 1996; 183: 1377-1388.
14. Ogasawara J, Suda T, Nagata S. Selective apoptosis of CD4+CD8+ thymocytes by the anti-Fas antibody. J Exp Med 1995; 181: 485-491.
15. Hernandez-Caselles T, Stutman 0. Immune functions of tumor necrosis factor. I. Tumor necrosis factor induces apoptosis of mouse thymocytes and can also stimulate or inhibit IL-6-induced proliferation depending on the concentration of mitogenic costimulation. J Immunol 1993; 151: 3999-4012.
16. Matylevich NP, Korol BA, Nelipovich PA, Afanas'ev VN, Umanskii SR. D20 inhibition of interphase thymocyte death. Radiobiologiia 1991; 31: 27-32.
17. Fernandes-Alnemri T, Armstrong RC, Krebs J, Srinivasula SM, Wang L, Bullrich F et al. In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains. Proc Natl Acad Sci USA 1996; 93: 7464-7469.
18. Ueffing N, Keil E, Freund C, Kuhne R, Schulze-Osthoff K, Schmitz I. Mutational analyses of c-FLIPR, the only murine short FLIP isoform, reveal requirements for DISC recruitment. Cell Death Differ 2008; 15: 773-782.
19. Wang X, Zhang J, Kim HP, Wang Y, Choi AM, Ryter SW. Bcl-XL disrupts death-inducing signal complex formation in plasma membrane induced by hypoxia/reoxygenation. FASEB J 2004; 18: 1826-1833.
20. Lavrik IN, Mock T, Golks A, Hoffmann,JG, Baumann S, Krammer PH. CD95 stimulation results in the formation of a novel death effector domain protein-containing complex. J Biol Chem 2008; 283: 26401-26408.
21. Ogasawara J, Watanabe-Fukunaga R, Adachi M, Matsuzawa A, Kasugai T, Kitamura Y et al. Lethal effect of the anti-Fas antibody in mice. Nature 1993; 364: 806-809.
22. Kitada S, Zapata JM, Andreeff M, Read JC. Bryostatin and CD40-ligand enhance apoptosis resistance and induce expression of cell survival genes in B-cell chronic lymphocytic leukaemia. Br J Haematol 1999, 106: 995-1004.
23. Rothstein TL, Zhong X, Schram BR, Negm RS, Donohoe TJ, Cabral DS et al. Reseptor-specific regulation of B-cell susceptibility to Fas-mediated apoptosis and a novel Fas apoptosis inhibitory molecule. Immunol Rev 2000; 176: 116-133.
24. Zazzeroni F, Papa S, Algeciras-Schimnich A, Alvarez K, Melis T, Bubici C et al. Gadd45 beta mediates the projective effects of CD40 costimulation against Fas-induced apoptosis. Blood 2003; 102 3270-3279.
25. Zhang J, Cado D, Chen A, Kabra NH, Winoto A. Fas-mediated apoptosis and activation-induced T-cell proliferation are detective in mice lacking FADD/Mort1. Nature 1998, 392: 296-300.
26. Yeh WC, Pompa JL, McCurrach ME, Shu HB, Elia AJ, Shahinian A et al FADD: Essential for embryo development and signaling from some, but not all, inducers of apoptosis. Science 1998; 279: 1954-1958.
27. Yeh WC, Itie A, Elia AJ, Ng M, Shu HB, Wakeham A et al. Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development. Immunity 2000; 12: 633-642.
28. Varfolomeev EE, Schuchmann M, Luria V, Chiannikulchai N, Beckmann JS, Mett IL et al. Targeted disruption of the Mouse Caspase 8 gene ablates Cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally. lmmunity 1998; 9: 267-276.
29. Xu S, Huo J, Tan JE, Lam KP. Mol deficiency afters Csk localization in lipid rafts but does not effect T-cell development. Mol Cell Biol 2005; 25: 8486-8495.
30. Nicoletti I, Migliorati G, Pagliacci MC, Grignani F, Riccardi C. A rapid and simple method for measuring thymocyte apoptosis by'propidium iodide staining and flow cytometry. J immmol Methods 1991; 139: 271-279.