Toughening of porous bioceramic scaffolds by bioresorbable polymeric coatings

Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine

Volumn 223, Issue 4, 2009, Pages 459-470

  Dorozhkin, S ^a   Ajaal, T ^b  

^a Kudrinskaja Square ^*  (Russian Federation)

^b QUEEN S UNIVERSITY   (Canada)

Author keywords

Bioceramics; Calcium phosphates; Mechanical properties; Poly( caprolactone); Porous scaffolds; Statistical experimental design; Taguchi methods; Toughening

Indexed keywords

ANALYSIS OF MEANS; BIORESORBABLE; BIORESORBABLE SCAFFOLDS; CAPROLACTONE; CONCENTRATION OF; FLEXURAL STRENGTH; HEAT TREATMENT TEMPERATURE; HIGH QUALITY; OPTIMAL CONDITIONS; ORTHOGONAL ARRAY; POLYMERIC COATINGS; POROUS BIOCERAMIC; POROUS SCAFFOLDS; PROCESSING VARIABLES; STATISTICAL EXPERIMENTAL DESIGN;

BENDING STRENGTH; BIOCERAMICS; CALCIUM; CALCIUM ALLOYS; DESIGN; MECHANICAL PROPERTIES; PHOSPHATES; PLASTIC COATINGS; POLYMER SOLUTIONS; POLYMERS; SCAFFOLDS; STATISTICS; TAGUCHI METHODS;

CALCIUM PHOSPHATE;

BIOMATERIAL; CALCIUM PHOSPHATE; POLYCAPROLACTONE; POLYESTER;

ABSORPTION; ARTICLE; BIODEGRADABLE IMPLANT; CERAMICS; CHEMICAL MODEL; CHEMISTRY; COMPUTER SIMULATION; EQUIPMENT; EQUIPMENT DESIGN; HARDNESS; MATERIALS TESTING; MECHANICAL STRESS; POROSITY; YOUNG MODULUS;

ABSORBABLE IMPLANTS; ABSORPTION; CALCIUM PHOSPHATES; CERAMICS; COATED MATERIALS, BIOCOMPATIBLE; COMPUTER SIMULATION; ELASTIC MODULUS; EQUIPMENT DESIGN; EQUIPMENT FAILURE ANALYSIS; HARDNESS; MATERIALS TESTING; MODELS, CHEMICAL; POLYESTERS; POROSITY; STRESS, MECHANICAL;

EID: 67449158188     PISSN: 09544119     EISSN: None     Source Type: Journal    
DOI: 10.1243/09544119JEIM513     Document Type: Article

References (37)

1. Beaman, F. D., Bancroft, L. W., Peterson, J. J., and Kransdorf, M. J. Bone graft materials and synthetic substitutes. Radiologic Clinics North Am., 2006, 44, 451-461.
2. Rezwan, K., Chen, Q. Z., Blaker, J. J., and Boccaccini, A. R. Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering. Biomaterials, 2006, 27, 3413-3431.
3. Schlichting, K., Dahne, M., and Weiler, A. Biodegradable composite implants. Sports Medicine Arthroscopy Rev., 2006, 14, 169-176.
4. Weiler, A., Hoffmann, R. F. G., Stähelin, A. C., Helling, H. J., and Südkamp, N. P. Biodegradable implants in sports medicine: the biological base. Arthroscopy, 2000, 16, 305-321.
5. Daniels, A. V., Chang, M. K. O., Andias, K. P., and Heller, J. Mechanical properties of biodegradable polymers and composites proposed for internal fixation of bone. J. Appl. Biomater., 1990, 1, 57-78.
6. Gupta, N., Kishore, E., Bet, W., and Sankaran, S. Studies on compressive failure features in synthetic foam material. J. Mater. Sci., 2001, 36, 4485-4491.
7. Dorozhkin, S. V. Calcium orthophosphates. J. Mater. Sci., 2007, 42, 1061-1095.
8. Park, J. B. and Bronzino, J. D. (Eds) Biomaterials. Principles and applications, 2003, p. 246 (CRC Press, Boca Raton, Florida).
9. Hench, L. L. Bioceramics. J. Am. Ceram. Soc., 1998, 81, 1705-1728.
10. Suchanek, W. and Yoshimura, M. Processing and properties of hydroxyapatite-based biomaterials for use as hard tissue replacement implants. J. Mater. Res., 1998, 13, 94-117.
11. Tian, J. and Tian, J. Preparation of porous hydroxyapatite. J. Mater. Sci., 2001, 36, 3061-3066.
12. Miao, X., Hu, Y., Liu, J., and Wong, A. P. Porous calcium phosphate ceramics prepared by coating polyurethane foams with calcium phosphate cements. Mater. Lett., 2004, 58, 397-402.
13. Luyten, J., Thijs, I., Vandermeulen, W., Mullens, S., Wallaeys, B., and Mortelmans, R. Strong ceramic foams from polyurethane templates. Adv. Appl. Ceram., 2005, 104, 4-8.
14. Robinson, J. H., Best, S. M., Ahmad, Z., and Edirisinghe, M. J. The effect of reaction conditions on hydroxyapatite particle morphology and applications to the reticulated foam method of scaffold production. Key Engng. Mater., 2008, 361-363, 3-6.
15. Peroglio, M., Gremillard, L., Chevalier, J., Chazeau, L., Gauthier, C., and Hamaide, T. Toughening of bio-ceramics scaffolds by polymer coating. J. Eur. Ceram. Soc., 2007, 27, 2679-2685.
16. Kim, H. W., Knowles, J. C., and Kim, H. E. Hydroxyapatite /poly(e-caprolactone) composite coatings on hydroxyapatite porous bone scaffold for drug delivery. Biomaterials, 2004, 25, 1279-1287.
17. Kim, H. W., Knowles, J. C., and Kim, H. E. Hydroxyapatite porous scaffold engineered with biological polymer hybrid coating for antibiotic vancomycin release. J. Mater. Sci.: Mater. Medicino, 2005, 16, 189-195.
18. Elfick, A. P. D. Poly(e-caprolactone) as a potential material for a temporary joint spacer. Biomaterials, 2002, 23, 4463-4467.
19. Sinha, V. R., Bansal, K., Kaushik, R., Kumria, R., and Trehan, A. Poly-e-caprolactone microspheres and nanospheres: an overview. Int. J. Pharmaceutics, 2004, 278, 1-23.
20. Ikada, Y. and Tsuji, H. Biodegradable polyesters for medical and ecological applications. Macromolecular Rapid Commun., 2000, 21, 117-132.
21. Tencer, A. F., Mooney, V., Brown, K. L., and Silva, P. A. Compressive properties of polymer coated synthetic hydroxyapatite for bone grafting. J. Biomed. Mater. Res., 1985, 19, 957-969.
22. Wu, C., Ramaswamy, Y., Boughton, P., and Zreiqat, H. Improvement of mechanical and biological properties of porous CaSiO3 scaffolds by poly(D,L-lactic acid) modification. Acta Biomaterialia, 2008, 4, 343-353.
23. Miao, X., Tan, D. M., Li, J., Xiao, Y., and Crawford, R. Mechanical and biological properties of hydroxyapatite/ tricalcium phosphate scaffolds coated with poly(lactic-co-glycolic acid). Acta Biomaterialia, 2008, 4, 638-645.
24. Charles-Harris, M., del Valle, S., Hentges, E., Bleuet, P., Lacroix, D., and Planell, J. A. Mechanical and structural characterisation of completely degradable polylactic acid/calcium phosphate glass scaffolds. Biomaterials, 2007, 28, 4429-4438.
25. Blaker, J. J., Maquet, V., Jéröme, R., Boccaccini, A. R., and Nazhat, S. N. Mechanical properties of highly porous PDLLA/BioglassH composite foams as scaffolds for bone tissue engineering. Acta Biomaterialia, 2005, 1, 643-652.
26. Peter, S. J., Miller, M. J., Yasko, A. W., Yaszemski, M. J., and Mikos, A. G. Polymer concepts in tissue engineering. J. Biomed. Mater. Res., Appl. Biomater., 1998, 43, 422-427.
27. Hutmacher, D. W., Schautz, T., Zein, I., Kee Woeig, N. G., Teoh, S. H., and Tan, K. C. Mechanical properties and cell cultural response of polycaprolactone scaffolds designed and fabricated via fused deposition modeling. J. Biomed. Mater. Res., 2001, 55, 203-216.
28. Ha, C. S. and Gardella Jr, J. A. Surface chemistry of biodegradable polymers for drug delivery systems. Chem. Rev., 2005, 105, 4205-4232.
29. Rizzi, S. C., Heath, D. J., Coombes, A. G. A., Bocvk, N., Textor, M., and Downes, S. Biodegradable polymer / hydroxyapatite composites: surface analysis and initial attachment of human osteoblast. J. Biomed. Mater. Res., 2001, 55, 575-586.
30. Saito, N., Murakami, N., Takahashi, J., Horiuchi, H., Ota, H., Kato, H., Okada, T., Nozaki, K., and Takaoka, K. Synthetic biodegradable polymers as drug delivery systems for bone morphogenetic proteins. Adv. Drug Delivery Rev., 2005, 57, 1037-1048.
31. Rao, R. S., Kumar, C. G., Prakasham, R. S., and Hobbs, P. J. The Taguchi methodology as a statistical tool for biotechnological applications: a critical appraisal. Biotechnol. J., 2008, 3, 510-523.
32. Ranito, C. M. S., Nogueira, C. A., Domingues, J., Pedrosa, F., Costa Oliveira, F. A., and Borges, J. P. Optimization of the synthesis of hydroxyapatite powders for biomedical applications using Taguchi's method. Mater. Sci. Forum, 2006, 514-516(2), 1025-1028.
33. Kumar, S., Kumar, P., and Shan, H. S. Optimization of tensile properties of evaporative pattern casting process through Taguchi's method. J. Mater. Processing Technol., 2008, 204, 59-69.
34. Langstaff, S., Sayer, M., Smith, T. J. N., Pugh, S. M., Hesp, S. A. M., and Thompson, W. T. Resorbable bioceramics based on stabilized calcium phosphates. Part I: rational design, sample preparation and material characterization. Biomaterials, 1999, 20, 1727-1741.
35. Langstaff, S., Sayer, M., Smith, T. J. N., and Pugh, S. M. Resorbable bioceramics based on stabilized calcium phosphates. Part II: evaluation of biological response. Biomaterials, 2001, 22, 135-150.
36. Nair, V. N. (Ed.) Taguchi's parameter design: a panel discussion. Technometrics, 1992, 34, 127-161.
37. León, R. V., Shoemaker, A. C., and Kacker, R. N. Performance measures independent of adjustment: an explanation and extension of Taguchi's signalto-noise ratios. Technometrics, 1987, 29, 253-285.