MHC class I Dk locus and Ly49G2+ NK cells confer H-2k resistance to murine cytomegalovirus

Journal of Immunology

Volumn 182, Issue 11, 2009, Pages 7163-7171

  Xie, Xuefang ^a   Stadnisky, Michael D ^a   Brown, Michael G ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

H2 ANTIGEN; HLA D ANTIGEN; HLA ANTIGEN CLASS 1; KLRA7 PROTEIN, MOUSE; NATURAL KILLER CELL LECTIN LIKE RECEPTOR SUBFAMILY A;

ANIMAL CELL; ARTICLE; CELL EXPANSION; CELL SELECTION; CONGENIC RESISTANT STRAIN; CONTROLLED STUDY; CYTOLYSIS; CYTOMEGALOVIRUS; GENE LOCUS; GENETIC VARIABILITY; LYMPHOCYTE ACTIVATION; MOUSE; NATURAL KILLER CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; VIRUS RESISTANCE; ANIMAL; BETAHERPESVIRINAE; CELL PROLIFERATION; GENETIC RECOMBINATION; GENETICS; IMMUNITY; IMMUNOLOGY;

ANIMALS; CELL PROLIFERATION; H-2 ANTIGENS; HISTOCOMPATIBILITY ANTIGENS CLASS I; IMMUNITY; KILLER CELLS, NATURAL; LYMPHOCYTE ACTIVATION; MICE; MUROMEGALOVIRUS; NK CELL LECTIN-LIKE RECEPTOR SUBFAMILY A; RECOMBINATION, GENETIC;

EID: 67449152224     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0803933     Document Type: Article

References (37)

1. Lanier, L. L. 2005. NK cell recognition. Annu. Rev. Immunol. 23: 225-274.
2. Yokoyama, W. M., S. Kim, and A. R. French. 2004. The dynamic life of natural killer cells. Annu. Rev. Immunol. 22: 405-429.
3. Gasser, S., and D. H. Raulet. 2006. Activation and self-tolerance of natural killer cells. Immunol. Rev. 214: 130-142.
4. Brown, M. G., and A. A. Scalzo. 2008. NK gene complex dynamics and selection for NK cell receptors. Semin. Immunol. 20: 361-368.
5. Smith, H. R. C., J. W. Heusel, I. K. Mehta, S. Kim, B. G. Dorner, O. V. Naidenko, K. Iizuka, H. Furukawa, D. L. Beckman, J. T. Pingel et al. 2002. Recognition of a virus-encoded ligand by a natural killer cell activation receptor. Proc. Natl. Acad. Sci. USA 99: 8826-8831.
6. Arase, H., E. S. Mocarski, A. E. Campbell, A. B. Hill, and L. L. Lanier. 2002. Direct recognition of cytomegalovirus by activating and inhibitory NK cell receptors. Science 296: 1323-1326.
7. Scalzo, A. A., P. A. Lyons, N. A. Fitzgerald, C. A. Forbes, W. M. Yokoyama, and G. R. Shellam. 1995. Genetic mapping of Cmv1 in the region of mouse chromosome 6 encoding the NK gene complex-associated loci Ly49 and musNKR-P1. Genomics 27: 435-441.
8. Rodriguez, M., P. Sabastian, P. Clark, and M. G. Brown. 2004. Cmv1-independent antiviral role of NK cells revealed in murine cytomegalovirus infected New Zealand White mice. J. Immunol. 173: 6312-6318. (Pubitemid 39487790)
9. Desrosiers, M.-P., A. Kielczewska, J.-C. Loredo-Osti, S. G. Adam, A. P. Makrigiannis, S. Lemieux, T. Pham, M. Lodoen, K. Morgan, L. L. Lanier, and S. M. Vidal. 2005. Epistasis between mouse Klra and major histocompatibility complex class I loci is associated with a new mechanism of natural killer cell-mediated innate resistance to cytomegalovirus infection. Nat. Genet. 37: 593-599.
10. k role in NK cell-mediated resistance in acute murine cyto-megalovirus- infected MA/My mice. J. Immunol. 175: 6820-6828.
11. Adam, S. G., A. Caraux, N. Fodil-Cornu, J. C. Loredo-Osti, S. Lesjean-Pottier, J. Jaubert, I. Bubic, S. Jonjic, J.-L. Guenet, S. M. Vidal, and F. Colucci. 2006. Cmv4, a new locus linked to the NK cell gene complex, controls innate resistance to cytomegalovirus in wild-derived mice. J. Immunol. 176: 5478-5485.
12. k class I proteins. J. Virol. 81: 229-236.
13. Scalzo, A. A., R. Wheat, C. Dubbelde, L. R. Stone, P. Clark, C. A. Forbes, Y. Du, N. Dong, J. Stoll, W. M. Yokoyama, and M. G. Brown. 2003. Molecular genetic characterization of the distal NKC recombination hotspot and putative murine CMV resistance control locus. Immunogenetics 55: 370-378.
14. Polic, B., H. Hengel, A. Krmpotic, J. Trgovcich, I. Pavic, P. Lucin, S. Jonjic, and U. H. Koszinowski. 1998. Hierarchical and redundant lymphocyte subset control precludes cytomegalovirus replication during latent infection. J. Exp. Med. 188: 1047-1054.
15. Krmpotic, A., I. Bubic, B. Polic, P. Lucin, and S. Jonjic. 2003. Pathogenesis of murine cytomegalovirus infection. Microbes Infect. 5: 1263-1277.
16. Robbins, S. H., G. Bessou, A. Cornillon, N. Zucchini, B. Rupp, Z. Ruzsics, T. Sacher, E. Tomasello, E. Vivier, U. H. Koszinowski, and M. Dalod. 2007. Natural killer cells promote early CD8 T cell responses against cytomegalovirus. PLoS Pathog. 3: 1152-1164.
17. Brown, M. G., A. O. Dokun, J. W. Heusel, H. R. C. Smith, D. L. Beckman, E. A. Blattenberger, C. E. Dubbelde, L. R. Stone, A. A. Scalzo, and W. M. Yokoyama. 2001. Vital involvement of a natural killer cell activation receptor in resistance to viral infection. Science 292: 934-937.
18. Lee, S. H., S. Girard, D. Macina, M. Busa, A. Zafer, A. Belouchi, P. Gros, and S. M. Vidal. 2001. Susceptibility to mouse cytomegalovirus is associated with deletion of an activating natural killer cell receptor of the C-type lectin superfamily. Nat. Genet. 28: 42-45.
19. Daniels, K. A., G. Devora, W. C. Lai, C. L. O'Donnell, M. Bennett, and R. M. Welsh. 2001. Murine cytomegalovirus is regulated by a discrete subset of natural killer cells reactive with monoclonal antibody to Ly49H. J. Exp. Med. 194: 29-44.
20. Dokun, A. O., S. Kim, H. R. Smith, H. S. Kang, D. T. Chu, and W. M. Yokoyama. 2001. Specific and nonspecific NK cell activation during virus infection. Nat. Immunol. 2: 951-956.
21. Silver, E. T., K. J. Lavender, D. E. Gong, B. Hazes, and K. P. Kane. 2002. Allelic variation in the ectodomain of the inhibitory Ly-49G2 receptor alters its specificity for allogeneic and xenogeneic ligands. J. Immunol. 169: 4752-4760.
22. Makrigiannis, A. P., A. T. Pau, A. Saleh, R. Winkler-Pickett, J. R. Ortaldo, and S. K. Anderson. 2001. Class I MHC-binding characteristics of the 129/J Ly49 repertoire. J. Immunol. 166: 5034-5043. (Pubitemid 32280716)
23. Tay, C. H., L. Y. Yu, V. Kumar, L. Mason, J. R. Ortaldo, and R. M. Welsh. 1999. The role of LY49 NK cell subsets in the regulation of murine cytomegalovirus infections. J. Immunol. 162: 718-726.
24. Depatie, C., A. Chalifour, C. Pare, S. H. Lee, S. M. Vidal, and S. Lemieux. 1999. Assessment of Cmv1 candidates by genetic mapping and in vivo antibody depletion of NK cell subsets. Int. Immunol. 11: 1541-1551.
25. Grundy, J. E., J. S. Mackenzie, and N. F. Stanley. 1981. Influence of H-2 and non-H-2 genes on resistance to murine cytomegalovirus infection. Infect. Immun. 32: 277-286.
26. Hollyoake, M., R. D. Campbell, and B. Aguado. 2005. NKp30 (NCR3) is a pseudogene in 12 inbred and wild mouse strains, but an expressed gene in Mus caroli. Mol. Biol. Evol. 22: 1661-1672.
27. Orange, J. S., and C. A. Biron. 1996. Characterization of early IL-12, IFN-αβ, and TNF effects on antiviral state and NK cell responses during murine cytomegalovirus infection. J. Immunol. 156: 4746-4756.
28. Yerkovich, S. T., S. D. Olver, J. C. Lenzo, C. D. Peacock, and P. Price. 1997. The roles of tumour necrosis factor-α, interleukin-1 and interleukin-12 in murine cytomegalovirus infection. Immunology 91: 45-52.
29. Schneider, K., A. Loewendorf, C. De Trez, J. Fulton, A. Rhode, H. Shumway, S. Ha, G. Patterson, K. Pfeffer, S. A. Nedospasov, et al. 2008. Lymphotoxinmediated crosstalk between B cells and splenic stroma promotes the initial type I interferon response to cytomegalovirus. Cell Host Microbe 3: 67-76.
30. Hengel, H., U. Reusch, A. Gutermann, H. Ziegler, S. Jonjic, P. Lucin, and U. H. Koszinowski. 1999. Cytomegaloviral control of MHC class I function in the mouse. Immunol. Rev. 168: 167-176.
31. Brown, M. G., A. A. Scalzo, L. R. Stone, P. Clark, Y. Du, B. Palanca, and W. M. Yokoyama. 2001. Nkc allelic variability among inbred mouse strains: evidence for Nkc haplotypes. Immunogenetics 53: 584-591.
32. Ortaldo, J. R., A. T. Mason, R. Winkler-Pickett, A. Raziuddin, W. J. Murphy, and L. H. Mason. 1999. Ly-49 receptor expression and functional analysis in multiple mouse strains. J. Leukocyte Biol. 66: 512-520.
33. Makrigiannis, A. P., E. Rousselle, and S. K. Anderson. 2004. Independent control of Ly49g alleles: implications for NK cell repertoire selection and tumor cell killing. J. Immunol. 172: 1414-1425.
34. Fehniger, T. A., S. F. Cai, X. Cao, A. J. Bredemeyer, R. M. Presti, A. R. French, and T. J. Ley. 2007. Acquisition of murine NK cell cytotoxicity requires the translation of a pre-existing pool of granzyme B and perforin mRNAs. Immunity 26: 798-811.
35. Kim, S., J. Poursine-Laurent, S. M. Truscott, L. Lybarger, Y. Song, L. Yang, A. R. French, J. B. Sunwoo, S. Lemieux, T. H. Hansen, and W. M. Yokoyama. 2005. Licensing of natural killer cells by host major histocompatibility complex class I molecules. Nature 436: 709-713.
36. Fernandez, N. C., E. Treiner, R. E. Vance, A. M. Jamieson, S. Lemieux, and D. H. Raulet. 2005. A subset of natural killer cells achieves self-tolerance without expressing inhibitory receptors specific for self-MHC molecules. Blood 105: 4416-4423.
37. Bashirova, A. A., M. P. Martin, D. W. McVicar, and M. Carrington. 2006. The killer immunoglobulin-like receptor gene cluster: tuning the genome for defense. Annu. Rev. Genomics Hum. Genet. 7: 277-300.