The α5(H105R) mutation impairs α5 selective binding properties by altered positioning of the α5 subunit in GABAA receptors containing two distinct types of α subunits

Journal of Neurochemistry

Volumn 110, Issue 1, 2009, Pages 244-254

  Balic, Ela ^a   Rudolph, Uwe ^b   Fritschy, Jean Marc ^a   Mohler, Hanns ^a   Benke, Dietmar ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b MCLEAN HOSPITAL   (United States)

Author keywords

5 subunit; Assembly; GABAA receptor; Knock in mice; Mutation; Targeting

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; DIAZEPAM; MUTANT PROTEIN; RECEPTOR SUBUNIT; 4 AMINOBUTYRIC ACID; BENZODIAZEPINE RECEPTOR AFFECTING AGENT; GABAA RECEPTOR GAMMA2 SUBUNIT, RAT; GABRA5 PROTEIN, MOUSE; HISTIDINE; LIGAND; PROTEIN SUBUNIT;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; EMBRYO; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; LIGAND BINDING; MOUSE; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; RAT; ANIMAL; BINDING SITE; BRAIN; CELL CULTURE; CELL FRACTIONATION; CELL LINE; CHEMISTRY; GENETICS; METABOLISM; MUTATION; PROTEIN BINDING; SYNAPTIC TRANSMISSION; TRANSGENIC MOUSE;

MUS;

ANIMALS; BINDING SITES; BRAIN; CELL LINE; CELLS, CULTURED; DIAZEPAM; GABA MODULATORS; GAMMA-AMINOBUTYRIC ACID; HISTIDINE; HUMANS; LIGANDS; MICE; MICE, TRANSGENIC; MUTATION; PROTEIN BINDING; PROTEIN SUBUNITS; RATS; RECEPTORS, GABA-A; SUBCELLULAR FRACTIONS; SYNAPTIC TRANSMISSION;

EID: 67449149935     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2009.06119.x     Document Type: Article

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