Mutational analysis of Smad7 in human cervical cancer

Oncology Reports

Volumn 21, Issue 4, 2009, Pages 1001-1004

  Hariharan, Ramkumar ^a   Babu, Janki Mohan ^a   Rema, P ^b   Pillai, M Radhakrishna ^a  

^a RAJIV GANDHI CENTRE FOR BIOTECHNOLOGY   (India)

^b REGIONAL CANCER CENTRE   (India)

Author keywords

Cervical cancer; Human papillomavirus; Mutation; Smad7

Indexed keywords

CYTOSINE; GUANOSINE; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; SMAD7 PROTEIN, HUMAN;

ARTICLE; CANCER SCREENING; CANCER TISSUE; CODON; CONDYLOMA ACUMINATUM; EXON; FEMALE; GENE MUTATION; GENE SEQUENCE; GENETIC VARIABILITY; HETEROZYGOSITY; HIGH RISK PATIENT; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; INFECTION RISK; MAJOR CLINICAL STUDY; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; SQUAMOUS CELL CARCINOMA; UTERINE CERVIX CARCINOMA; WART VIRUS; CHEMISTRY; GENETICS; ISOLATION AND PURIFICATION; MUTATION; PAPILLOMA VIRUS; PROTEIN TERTIARY STRUCTURE; UTERINE CERVIX TUMOR; VIROLOGY;

EXONS; FEMALE; HUMANS; MUTATION; PAPILLOMAVIRIDAE; PROTEIN STRUCTURE, TERTIARY; SMAD7 PROTEIN; UTERINE CERVICAL NEOPLASMS;

EID: 67449147322     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or_00000315     Document Type: Article

References (29)

1. Nair S and Pillai MR: Human papillomavirus and disease mechanisms: relevance to oral and cervical cancers. Oral Dis 11: 350-359, 2005.
2. Schiffman M, Castle PE, Jeronimo J, Rodriguez AC and Wacholder S: Human papillomavirus and cervical cancer. Lancet 370: 890-907, 2007.
3. Bosch FX and de Sanjosé S: The epidemiology of human papillomavirus infection and cervical cancer. Dis Markers 23: 213-227, 2007.
4. Tsunokawa Y, Takebe N, Kasamatsu T, Terada M and Sugimura T: Transforming activity of human papillomavirus type 16 DNA sequence in a cervical cancer. Proc Natl Acad Sci USA 83: 2200-2203, 1986.
5. González Martín A: Molecular biology of cervical cancer. Clin Transl Oncol 9: 347-354, 2007.
6. Sakaguchi J, Kyo S, Kanaya T, et al: Aberrant expression and mutations of TGF-beta receptor type II gene in endometrial cancer. Gynecol Oncol 98: 427-433, 2005.
7. Musch A, Rabe C, Paik MD, et al: Altered expression of TGF-beta receptors in hepatocellular carcinoma - effects of a constitutively active TGF-beta type I receptor mutant. Digestion 71: 781-791, 2005.
8. Lazzereschi D, Nardi F, Turco A, et al: A complex pattern of mutations and abnormal splicing of Smad4 is present in thyroid tumours. Oncogene 24: 5344-5354, 2005.
9. Chen T, Jackson CR, Link A, et al: Int7G24A variant of transforming growth factor-beta receptor type I is associated with invasive breast cancer. Clin Cancer Res 12: 392-397, 2007.
10. Chen T, Jackson C, Costello B, et al: An intronic variant of the TGFBR1 gene is associated with carcinomas of the kidney and bladder. Int J Cancer 112: 420-425, 2004.
11. Baldus SE, Schwarz E, Lohrey C, et al: Smad4 deficiency in cervical carcinoma cells. Oncogene 24: 810-819, 2005.
12. Maliekal TT, Anto RJ and Karunagaran D: Differential activation of Smads in HeLa and SiHa cells that differ in their response to transforming growth factor-beta. J Biol Chem 279: 36287-36292, 2004.
13. Maliekal TT, Antony ML, Nair A, Paulmurugan R and Karunagaran D: Loss of expression, and mutations of Smad 2 and Smad 4 in human cervical cancer. Oncogene 22: 4889-4897, 2003.
14. Attisano L and Wrana JL: Smads as transcriptional co-modulators. Curr Opin Cell 24: 235-243, 2000.
15. Massague J, Blain SW and Lo RS: TGF beta signaling in growth control, cancer and heritable disorders. Cell 103: 295-309, 2000.
16. Wrana JL: Regulation of Smad activity. Cell 100: 189-192, 2000.
17. Ten Dijke P, Miyazono K and Heldin CH: Signaling inputs converge on nuclear effectors in TGF-beta signaling. Trends Biochem Sci 25: 64-70, 2000.
18. Imamura T, Takase M, Nishihara A, et al: Smad6 inhibits signaling by the TGF-beta superfamily. Nature 389: 622-626, 1997.
19. Hayashi H, Abdollah S, Qiu Y, et al: The MAD-related protein Smad7 associates with the TGF-beta receptor and functions as an antagonist of TGF-beta signaling. Cell 89: 1165-1173, 1997.
20. Ishisaki A, Yamato K, Hashimoto S, et al: Differential inhibition of Smad6 and Smad7 on bone morphogenetic protein - and activin-mediated growth arrest and apoptosis in B cells. J Biol Chem 274: 13637-13642, 1999.
21. Itoh S, Landström M, Hermansson A, et al: Transforming growth factor 1 induces nuclear export of inhibitory Smad7. J Biol Chem 273: 29195-29201, 1998.
22. Nakayama T, Berg LK and Christian JL: Dissection of inhibitory Smad proteins: both N- and C-terminal domains are necessary for full activities of Xenopus Smad6 and Smad7. Mech Dev 100: 251-262, 2001.
23. Mochizuki T, Miyazaki H, Hara T, et al: Roles for the MH2 domain of Smad7 in the specific inhibition of transforming growth factor-beta superfamily signaling. J Biol Chem 279: 31568-31574, 2004.
24. Hu L, Guo M, He Z, Thornton J, McDaniel LS and Hughson MD: Human papillomavirus genotyping and p16INK4a expression in cervical intraepithelial neoplasia of adolescents. Mod Pathol 18: 267-273, 2005.
25. Fukushima T, Mashiko M, Takita K, et al: Mutational analysis of TGF-beta type II receptor, Smad2, Smad3, Smad4, Smad6 and Smad7 genes in colorectal cancer. J Exp Clin Cancer Res 22: 315-320, 2003.
26. Kawate S, Ohwada S, Hamada K, et al: Mutational analysis of the Smad6 and Smad7 genes in hepatocellular carcinoma. Int J Mol Med 8: 49-52, 2001.
27. Wang D, Kanuma T, Mizumuma H, Ibuki Y and Takenoshita S: Mutation analysis of the Smad6 and Smad7 gene in human ovarian cancers. Int J Oncol 17: 1087-1091, 2000.
28. Jonson T, Gorunova L, Dawiskiba S, et al: Molecular analyses of the 15q and 18q SMAD genes in pancreatic cancer. Genes Chromosomes Cancer 24: 62-71, 1999.
29. Broderick P, Carvajal-Carmona L, Pittman AM, et al: A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk. Nat Genet 39: 1315-1317, 2007.