Solid state chemistry of proteins IV. What is the meaning of thermal denaturation in freeze dried proteins?

Journal of Pharmaceutical Sciences

Volumn 98, Issue 4, 2009, Pages 1387-1399

  Pikal, Michael J ^a,b   Rigsbee, Daniel ^b   Akers, Michael J ^b  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b ELI LILLY AND COMPANY   (United States)

Author keywords

Cold denaturation in dry proteins; Freeze dried proteins; Protein denaturation in solids; Thermodynamics of denaturation

Indexed keywords

CARBOHYDRATE; HUMAN GROWTH HORMONE; PROTEIN;

ARTICLE; CHEMISTRY; DENATURATION; DIFFERENTIAL SCANNING CALORIMETRY; FREEZE DRYING; MEDICAL RESEARCH; SOLID STATE; TEMPERATURE; THERMAL ANALYSIS; THERMODYNAMICS; TRANSITION TEMPERATURE;

EID: 67449138534     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21517     Document Type: Article

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