Effects of prednisone alone or prednisone with ultralow-dose aspirin on the gastroduodenal mucosa of healthy dogs

Journal of Veterinary Internal Medicine

Volumn 23, Issue 3, 2009, Pages 482-487

  Graham, A Heather ^a   Leib, Michael S ^a  

^a VIRGINIA MARYLAND REGIONAL COLLEGE OF VETERINARY MEDICINE   (United States)

Author keywords

Corticosteroids; Diarrhea; Endoscopy; Erosion; Nonsteroidal antiinflammatory drugs; Ulcer; Vomiting

Indexed keywords

ACETYLSALICYLIC ACID; PREDNISONE;

ANIMAL; ANIMAL DISEASE; ARTICLE; CHEMICALLY INDUCED DISORDER; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOG; DRUG EFFECT; FEMALE; GASTROINTESTINAL DISEASE; INTESTINE MUCOSA; MALE; PATHOLOGY; RANDOMIZED CONTROLLED TRIAL; STOMACH MUCOSA;

ANIMALS; ASPIRIN; DOGS; FEMALE; GASTRIC MUCOSA; GASTROINTESTINAL DISEASES; INTESTINAL MUCOSA; MALE; PREDNISONE;

ANIMALIA; CANIS FAMILIARIS;

EID: 67449106401     PISSN: 08916640     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1939-1676.2009.0312.x     Document Type: Article

References (57)

1. Weiss D, Brazzell J. Detection of activated platelets in dogs with primary immune-mediated hemolytic anemia. J Vet Intern Med 2006;20:682-686.
2. Bunch S, Metcalf M, Crane S, et al. Idiopathic pleural effusion and pulmonary thromboembolism in a dog with autoimmune hemolytic anemia. J Am Vet Med Assoc 1989;195:1748-1753.
3. Carr AP, Panciera DL, Kidd L. Prognostic factors for mortality and thromboembolism in canine immune-mediated hemolytic anemia: A retrospective study of 72 dogs. J Vet Intern Med 2002; 16:504-509.
4. Grundy SA, Barton C. Influence of drug treatment on survival of dogs with immune-mediated hemolytic anemia: 88 cases (1989-1999). J Am Vet Med Assoc 2001;218:543-546.
5. Klein MK, Dow SW, Rosychuk RA. Pulmonary thromboembolism associated with immune-mediated hemolytic anemia in dogs: Ten cases (1982-1987). J Am Vet Med Assoc 1989;195:246-250.
6. Stone MS, Johnstone IB, Brooks M, et al. Lupus-type "anticoagulant" in a dog with hemolysis and thrombosis. J Vet Intern Med 1994;8:57-61.
7. Weinkle TK, Center SA, Randolph JF, et al. Evaluation of prognostic factors, survival rates, and treatment protocols for immune-mediated hemolytic anemia in dogs: 151 cases (1993-2002). J Am Vet Med Assoc 2005;226:1869-1880.
8. Lunsford KV, Mackin AJ. Thromboembolic therapies in dogs and cats: An evidence-based approach. Vet Clin North Am Small Anim Pract 2007;37:579-609.
9. Dow SW, Rosychuk RA, McChesney AE, et al. Effects of flunixin and flunixin plus prednisone on the gastrointestinal tract of dogs. Am J Vet Res 1990;51:1131-1138.
10. Boulay JP, Lipowitz AJ, Klausner JS. Effect of cimetidine on aspirin-induced gastric hemorrhage in dogs. Am J Vet Res 1986;47: 1744-1746.
11. Jenkins CC, DeNovo RC, Patton CS, et al. Comparison of effects of cimetidine and omeprazole on mechanically created gastric ulceration and on aspirin-induced gastritis in dogs. Am J Vet Res 1991;52:658-661.
12. Johnston SA, Leib MS, Forrester SD, et al. The effect of misoprostol on aspirin-induced gastroduodenal lesions in dogs. J Vet Intern Med 1995;9:32-38.
13. Lipowitz AJ, Boulay JP, Klausner JS. Serum salicylate concentrations and endoscopic evaluation of the gastric mucosa in dogs after oral administration of aspirin-containing products. Am J Vet Res 1986;47:1586-1589.
14. Reimer ME, Johnston SA, Leib MS, et al. The gastroduodenal effects of buffered aspirin, carprofen, and etodolac in healthy dogs. J Vet Intern Med 1999;13:472-477.
15. Sennello KA, Leib MS. Effects of deracoxib or buffered aspirin on the gastric mucosa of healthy dogs. J Vet Intern Med 2006;20:1291-1296.
16. Fox PR, Petrie J-P, Hohenhaus AE. Peripheral vascular disease. In: Ettinger SJ, Feldman EC, eds. Textbook of Veterinary Internal Medicine: Diseases of the Dog and Cat, 6th ed. St. Louis, MO: Elsevier Saunders; 2005:1145-1165.
17. Rackear D, Feldman B, Farver T, et al. The effect of three different dosages of acetylsalicyclic acid on canine platelet aggregation. J Am Anim Hosp Assoc 1988;24:23-26.
18. Narita T, Tomiza Wa N, Sato R, et al. Effects of long-term oral administration of ketoprofen in clinically healthy beagle dogs. J Vet Med Sci 2005;67:847-853.
19. Mealey KL, Bentjen SA, Gay JM, et al. Ivermectin sensitivity in collies is associated with a deletion mutation of the mdr1 gene. Pharmacogenetics 2001;11:727-733.
20. Ward DM, Leib MS, Johnston SA, et al. The effect of dosing interval on the efficacy of misoprostol in the prevention of aspirininduced gastric injury. J Vet Intern Med 2003;17:282-290.
21. Leib M, Duncan R. Diagnosing gastric helicobacter infections in dogs and cats. Compend Cont Educ Pract Vet 2005;27: 221-228.
22. Marks S, Melli A, Kass P, et al. Evaluation of methods to diagnose Clostridium perfringens-associated diarrhea in dogs. J Am Vet Med Assoc 1999;214:357-360.
23. Wallace JL, Keenan CM, Granger DN. Gastric ulceration induced by nonsteroidal anti-inflammatory drugs is a neutrophil-dependent process. Am J Physiol 1990;259:G462-G467.
24. Lascelles BDX, Blikslager AT, Fox SM, et al. Gastrointestinal perforation in dogs treated with a selective cyclooxygenase-2 inhbitor: 29 cases (2002-2003). J Am Vet Med Assoc 2005;227: 1112-1117.
25. Boston SE, Moens NM, Kruth SA, et al. Endoscopic evaluation of the gastroduodenal mucosa to determine the safety of short-term concurrent administration of meloxicam and dexamethasone in healthy dogs. Am J Vet Res 2003;64:1369-1375.
26. Forsyth SF, Guilford WG, Lawoko CR. Endoscopic evaluation of the gastroduodenal mucosa following non-steroidal anti-inflammatory drug administration in the dog. N Z Vet J 1996;44: 179-181.
27. Neiger R, Gaschen F, Jaggy A. Gastric mucosal lesions in dogs with acute intervertebral disc disease: Characterization and effects of omeprazole or misoprostol. J Vet Intern Med 2000;14:33-36.
28. Narita T, Sato R, Tomizawa N, et al. Safety of reduced-dosage ketoprofen for long-term oral administration in healthy dogs. Am J Vet Res 2006;67:1115-1120.
29. Luo JC, Shin VY, Liu ES, et al. Non-ulcerogenic dose of dexamethasone delays gastric ulcer healing in rats. J Pharmacol Exp Ther 2003;307:692-698.
30. Luo JC, Shin VY, Liu ES, et al. Dexamethasone delays ulcer helaing by inhibition of angiogenesis in rat stomachs. Eur J Pharmacol 2004;485:275-281.
31. Graham D, Smith J, Spjut H. Gastric adaptation. Gastroenterology 1988;95:327-333.
32. Rohrer CR, Hill RC, Fischer A, et al. Gastric hemorrhage in dogs given high doses of methylprednisolone sodium succinate. Am J Vet Res 1999;60:977-981.
33. Rohrer CR, Hill RC, Fischer A, et al. Efficacy of misoprostol in prevention of gastric hemorrhage in dogs treated with high doses of methylprednisolone sodium succinate. Am J Vet Res 1999;60: 982-985.
34. Sorjonen DC, Dillon AR, Powers RD, et al. Effects of dexamethasone and surgical hypotension on the stomach of dogs: Clinical, endoscopic, and pathologic evaluations. Am J Vet Res 1983;44:1233-1237.
35. Carpani de Kaski M, Rentsch R, Levi S, et al. Corticosteroids reduce regenerative repair of epithelium in experimental gastric ulcers. Gut 1995;37:613-616.
36. Narita T, Sato R, Motoishi K, et al. The interaction between orally administered non-steroidal anti-inflammatory drugs and prednisolone in healthy dogs. Surgery 2007;69:353-363.
37. Jones CJ, Budsberg SC. Physiologic characteristics and clinical importance of the cyclooxygenase isoforms in dogs and cats. J Am Vet Med Assoc 2000;217:721-729.
38. Tizzard IR. Veterinary Immunology: An Introduction, 7th ed. Philapdelphia, PA: Elsevier; 2004:441-443.
39. Webb C, Twedt D. Canine gastritis. Vet Clin Sm Anim Pract 2003;33:969-985.
40. Taylor L, Crawford L. Aspirin-induced gastrointestinal lesions in dogs. J Am Vet Med Assoc 1968;152:617-619.
41. Nakashima S, Arai S, Mizuno Y, et al. A clinical study of Japanese patients with ulcer induced by low-dose aspirin and other non-steroidal anti-inflammatory drugs. Aliment Pharmacol Ther 2005;21:60-66.
42. Taha A, Angerson W, Prasad R, et al. The incidence and early mortality after peptic ulcer perforation, and the use of low-dose aspirin and non-steroidal anti-inflammatory drugs. Aliment Pharmacol Ther 2008;28:878-885.
43. Toombs J, Caywood D, Lipowitz A, et al. Colonic perforation following neurosurgical procedures and corticosteroid therapy in four dogs. J Am Vet Med Assoc 1980;177:68-72.
44. Toombs JP, Collins LG, Graves GM, et al. Colonic perforation in corticosteroid-treated dogs. J Am Vet Med Assoc 1986; 188:145-150.
45. Vane JR, Botting RM. Mechanism of action of nonsteroidal anti-inflammatory drugs. Am J Med 1998;104:2S-8S.
46. Davies N. Non-steroidal anti-inflammatory drug-induced gastrointestinal permeability. Aliment Pharmacol Therap 1998; 12:303-320.
47. Roth L, Leib M, Davenport D, et al. Comparisons between endoscopic and histologic evaluation of the gastrointestinal tract in dogs and cats: 75 cases (1984-1987). J Am Vet Med Assoc 1990; 196:635-638.
48. Craven M, Chandler M, Steiner J, et al. Acute effects of carprofen and meloxicam on canine gastrointestinal permeability and mucosal absorptive capacity. J Vet Intern Med 2007;21: 917-923.
49. Meddings J, Gibbons I. Discrimination of site-specific alterations in gastrointestinal permeability in the rat. Gastroenterology 1998;114:83-92.
50. Meddings J, Kirk D, Olson M. Noninvasive detecton of non-steroidal anti-inflammatory drug-induced gastropathy in dogs. Am J Vet Res 1995;56:977-981.
51. Steiner J, Williams D, Moeller E. Development and validation of a method for simultaneous separation and quantification of 5 different sugars in canine urine. Can J Vet Res 2000;64:164-170.
52. Steiner J, Williams D, Moeller E. Kinetics of urinary recovery of five sugars after orogastric administration in healthy dogs. Am J Vet Res 2002;63:845-848.
53. Gilson S, Parker B, Twedt D. Evaluation of two commercial test kits for detection of occult blood in feces of dogs. Am J Vet Res 1990;51:1385-1387.
54. Cook A, Gilson S, Fischer W, et al. Effect of diet on result obtained by use of two commercial test kits for detection of occult blood in feces of dogs. Am J Vet Res 1992;53:1749-1751.
55. Rahman A, Isenberg D. Systemic lupus erythematosis. N Eng J Med 2008;358:929-939.
56. Cook A, Cowgill L. Clinical and pathological features of protein-losing glomerular disease in the dog: A review of 137 cases (1985-1992). J Am Anim Hosp Assoc 1996;31:313-322.
57. Monier J, Fournel C, Lapras M, et al. Systemic lupus in a colony of dogs. Am J Vet Res 1988;49:46-51.