Genetic differences between primary larynx and pharynx carcinomas and their matched lymph node metastases by multiplex ligation-dependent probe amplification

Oral Oncology

Volumn 45, Issue 7, 2009, Pages 600-604

  Alonso Guervós, Marta ^a   Álvarez Marcos, César ^b   LLorente, José Luis ^a   Sampedro Nuño, Andrés ^c   Suárez, Carlos ^a   Hermsen, Mario ^a  

^a HOSPITAL UNIVERSITARIO CENTRAL DE ASTURIAS   (Spain)

^b HOSPITAL VALLE DEL NALÓN   (Spain)

^c UNIVERSIDAD DE OVIEDO   (Spain)

Author keywords

DNA copy number changes; Larynx and pharynx tumors; Lymph node metastasis; Squamous cell carcinomas

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A; CYCLIN DEPENDENT KINASE INHIBITOR 2D; DNA; PROTEIN P53;

ADULT; AGED; ARTICLE; CHROMOSOME 17P; CHROMOSOME 8P; CHROMOSOME 8Q; CHROMOSOME LOSS; CLINICAL ARTICLE; CONTROLLED STUDY; COPY NUMBER VARIATION; GENETIC DIFFERENCE; GENETIC VARIABILITY; HUMAN; HUMAN TISSUE; LARYNX CARCINOMA; LMNA GENE; LYMPH NODE METASTASIS; MALE; MFHAS1 GENE; MULTIPLEX LIGATION DEPENDENT PROBE AMPLIFICATION; N33 GENE; NUMERICAL CHROMOSOME ABERRATION; PHARYNX CARCINOMA; PRIMARY TUMOR; PRIORITY JOURNAL; RECQL4 GENE; SQUAMOUS CELL CARCINOMA; TUMOR SUPPRESSOR GENE;

AGED; CARCINOMA, SQUAMOUS CELL; DNA COPY NUMBER VARIATIONS; HUMANS; LARYNGEAL NEOPLASMS; LARYNX; LYMPH NODES; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; PHARYNGEAL NEOPLASMS; PHARYNX;

EID: 67449101575     PISSN: 13688375     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.oraloncology.2008.08.005     Document Type: Article

References (30)

1. Steeg P.S. Tumor metastasis: mechanistic insights and clinical challenges. Nat Med 12 (2006) 895-904
2. Leon X., de Juan J., Costey M., Orus C., del Prado Venegas M., and Quer M. Selective neck dissection in patients presenting clinical node metastases. Acta Otorrinolaringol Esp 55 (2004) 73-80
3. Ransom D.T., Leonard J.H., Kearsley J.H., et al. Loss of heterozygosity studies in squamous cell carcinomas of the head and neck. Head Neck 18 (1996) 248-253
4. Hardisson D., Álvarez-Marcos C., Salas Bustamante A., Alonso-Guervós M., Sastre N., and Sampedro A. Numerical aberrations of chromosomes 8, 9, 11, and 17 in squamous cell carcinoma of the pharynx and larynx: a flourescence in situ hybridization and DNA flow cytometric analysis of 50 cases. Oral Oncol 40 (2004) 409-417
5. Hermsen M., Guervós M.A., Meijer G., et al. New chromosomal regions with high-level amplifications in squamous cell carcinomas of the larynx and pharynx, identified by comparative genomic hybridization. J Pathol 194 (2001) 177-182
6. Snijders A.M., Schmidt B.L., Fridlyand J., et al. Rare amplicons implicate frequent deregulation of cell fate specification pathways in oral squamous cell carcinoma. Oncogene 24 (2005) 4232-4242
7. Singh B., Gogineni S.K., Sacks P.G., et al. Molecular cytogenetic characterization of head and neck squamous cell carcinoma and refinement of 3q amplification. Cancer Res 61 (2001) 4506-4513
8. Roepman P., Wessels L.F., Kettelarij N., et al. An expression profile for diagnosis of lymph node metastases from primary head and neck squamous cell carcinomas. Nat Genet 37 (2005) 182-186
9. Tremmel S.C., Gotte K., Popp S., et al. Intratumoral genomic heterogeneity in advanced head and neck cancer detected by comparative genomic hybridization. Cancer Genet Cytogenet 144 (2003) 165-174
10. Patmore H.S., Ashman J.N.E., Cawkwell L., MacDonald A., Stafford N.D., and Greenman J. Can a genetic signature for metastatic head and neck squamous cell carcinoma be characterised by comparative genomic hybridisation?. Br J Cancer 90 (2004) 1976-1982
11. Welkoborsky H.J., Bernauer H.S., Riazimand H.S., Jacob R., Mann W.J., and Hinni M.L. Patterns of chromosomal aberrations in metastasizing and nonmetastasizing squamous cell carcinomas of the oropharynx and hypopharynx. Ann Otol Rhinol Laryngol 109 (2000) 401-410
12. Bockmuhl U., Schluns K., Schmidt S., Matthias S., and Petersen I. Chromosomal alterations during metastasis formation of head and neck squamous cell carcinoma. Genes Chromosomes Cancer 33 (2002) 29-35
13. Gotte K., Riedel F., Schafer C., Coy J.F., and Hormann K. Genetic discordance between primary tumours and metastases of head and neck cancer detected by microsatellite analysis. Oncol Rep 9 (2002) 829-834
14. Worsham M.J., Pals G., Schouten J.P., et al. Delineating genetic pathways of disease progression in head and neck squamous cell carcinoma. Arch Otolaryngol Head Neck Surg 129 (2003) 702-708
15. Schouten J.P., McElgunn C.J., Waaijer R., Zwijnenburg D., Diepvens F., and Pals G. Relative quantification of 40 nucleic acid sequences by multiplex ligation-dependent probe amplification. Nucleid Acids Res 30 12 (2002) e57
16. Weiss M.M., Hermsen M.A.J.A., Meijer G.A., et al. Comparative genomic hybridization. Mol Pathol 52 (1999) 243-251
17. Moerland E., van Hezik R.L., van der Aa T.C., van Beek M.W., and van den Brule A.J. Detection of HER2 amplification in breast carcinomas: comparison of multiplex ligation-dependent probe amplification (MLPA) and fluorescence in situ hybridization (FISH) combined with automated spot counting. Cell Oncol 28 (2006) 151-159
18. Álvarez Marcos C.A., Llorente Pendás J.L., Franco Gutiérrez V., et al. Distant metastases in head and neck cancer. Acta Otorrinolaringol Esp 57 (2006) 369-372
19. Almandori G., Bussu F., Cadoni G., et al. Multistep laryngeal carcinogenesis helps our understanding of the field cancerisation phenomenon: a review. Eur J Cancer 40 (2004) 2383-2388
20. Hunter K.D., Parkinson E.K., and Harrison P.R. Prolifering early head and neck cancer. Nat Rev Cancer 5 (2005) 127-135
21. Begum S., Cao D., Gillison M., Zahurak M., and Westra W.H. Tissue distribution of human papillomavirus 16 DNA integration in patients with tonsillar carcinoma. Clin Cancer Res 11 (2005) 5694-5699
22. Bockmuhl U., Petersen S., Schmidt S., et al. Patterns of chromosomal alterations in metastasizing and nonmetastasizing primary head and neck carcinomas. Cancer Res 57 (1997) 5213-5216
23. Kujawski M., Aalto Y., Jaskula-Sztul R., et al. DNA copy number losses are more frequent in primary larynx tumors with lymph node metastases than in tumors without metastases. Cancer Genet Cytogenet 114 (1999) 31-34
24. Hermsen M., Alonso Guervós M., Meijer G., van Diest P., Suárez Nieto C., Marcos C.A., et al. Chromosomal changes in relation to clinical outcome in larynx and pharynx squamous cell carcinoma. Cell Oncol 27 (2005) 191-198
25. Lammerding J., Schulze P.C., Takahashi T., et al. Lamin A/C deficiency causes defective nuclear mechanics and mechanotransduction. J Clin Invest 113 (2004) 370-378
26. Liu B., Wang J., Chan K.M., et al. Genomic instability in laminopathy-based premature aging. Nat Med 11 (2005) 780-785
27. Braakhuis B.J.M., Tabor M.P., Kummer J.A., Leemars C.R., and Brakenhoff R.H. A genetic explanation of Slaughter's concept of field cancerization: evidence and clinical implications. Cancer Res 63 (2003) 1727-1730
28. Bockmühl U., Ishwad C.S., Ferrell R.E., and Gollin S.M. Association of 8p23 deletions with poor survival in head and neck cancer. Otolaryngol Head Neck Surg 124 (2001) 451-455
29. Ishwad C.S., Shuster M., Bockmuhl U., et al. Frequent allelic loss and homozygous deletion in chromosome band 8p23 in oral cancer. Int J Cancer 80 (1999) 25-31
30. Mohaghegh P., and Hickson I.D. DNA helicase deficiencies associated with cancer predisposition and premature ageing disorders. Human Mol Genet 10 (2001) 741-746