Identification of threonine 348 as a residue involved in aminopeptidase A substrate specificity

Journal of Biological Chemistry

Volumn 284, Issue 16, 2009, Pages 10618-10626

  Claperon, Cédric ^a,b,c   Banegas Font, Inmaculada ^a,b,c   Iturrioz, Xavier ^a,b,c   Rozenfeld, Raphael ^a,b,c   Maigret, Bernard ^d,e   Llorens Cortes, Catherine ^a,b,c  

^a INSERM   (France)

^b Centre de Recherche Interdisciplinaire en Biologie   (France)

^c SORBONNE UNIVERSITÉ   (France)

^d CNRS   (France)

^e LORIA   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACIDIC AMINO ACIDS; ACTIVE SITE; AMINO PEPTIDASE; ANGIOTENSIN II; ANGIOTENSIN III; ASPARTATE; CENTRAL CONTROL; MEMBRANE-BOUND; N-TERMINAL; OPTIMAL POSITIONING; PHOSPHONATE; RECOMBINANT ENZYMES; SERINE RESIDUES; SIDE CHAINS; STIMULATORY EFFECTS; SUBSTRATE SPECIFICITY; THREE-DIMENSIONAL MODEL; WATER MOLECULE;

AMINES; AMINO ACIDS; ANIMALS; BINDING SITES; BLOOD PRESSURE; CALCIUM; CARBOXYLATION; HYDROGEN; HYDROGEN BONDS; ORGANIC ACIDS; ORGANIC POLYMERS; PLANTS (BOTANY); PRESSURE EFFECTS; THREE DIMENSIONAL; ZINC;

SUBSTRATES;

ALCOHOL; ASPARTIC ACID; CALCIUM; CARBOXYLIC ACID; GLUTAMIC ACID; GLUTAMYL AMINOPEPTIDASE; RECOMBINANT ENZYME; SERINE; THREONINE; TYROSINE; WATER; ANGIOTENSIN III; GLUTAMATE PHOSPHONIC ACID; GLUTAMIC ACID DERIVATIVE; PHOSPHONIC ACID DERIVATIVE; RECOMBINANT PROTEIN;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CATALYSIS; CELL STRAIN; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; GENE MUTATION; HYDROGEN BOND; HYDROLYSIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN INTERACTION; RESIDUE ANALYSIS; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; DRUG ANTAGONISM; GENETICS; METABOLISM; SITE DIRECTED MUTAGENESIS;

ANIMALIA;

ANGIOTENSIN III; ANIMALS; CALCIUM; GLUTAMATES; GLUTAMYL AMINOPEPTIDASE; MICE; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; MUTAGENESIS, SITE-DIRECTED; PHOSPHONIC ACIDS; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY; THREONINE;

EID: 67449098153     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M806783200     Document Type: Article

References (35)

1. Danielsen, E. M., Noren, O., Sjostrom, H., Ingram, J., and Kenny, A. J. (1980) Biochem. J. 189, 591-603
2. Glenner, G. G., Mc, M. P., and Folk, J. E. (1962) Nature 194, 867
3. Nagatsu, I., Nagatsu, T., Yamamoto, T., Glenner, G. G., and Mehl, J. W. (1970) Biochim. Biophys. Acta 198, 255-270
4. Wilk, S., and Healy, D. (1993) Adv. Neuroimmunol. 3, 195-207
5. Lodja, Z., and Gossrau, R. (1980) Histochemistry 67, 267-290
6. de Mota, N., Iturrioz, X., Claperon, C., Bodineau, L., Fassot, C., Roques, B. P., Palkovits, M., and Llorens-Cortes, C. (2008) J. Neurochem. 106, 416-428
7. Zini, S., Masdehors, P., Lenkei, Z., Fournie-Zaluski, M. C., Roques, B. P., Corvol, P., and Llorens-Cortes, C. (1997) Neuroscience 78, 1187-1193
8. Chauvel, E. N., Llorens-Cortès, C., Coric, P., Wilk, S., Roques, B., and Fournié-Zaluski, M. C. (1994) J. Med. Chem. 37, 2950-2956
9. Zini, S., Fournie-Zaluski, M. C., Chauvel, E., Roques, B. P., Corvol, P., and Llorens-Cortes, C. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 11968-11973
10. Fournie-Zaluski, M. C., Fassot, C., Valentin, B., Djordjijevic, D., Reaux-Le Goazigo, A., Corvol, P., Roques, B. P., and Llorens-Cortes, C. (2004) Proc. Natl. Acad. Sci. U. S. A. 101, 7775-7780
11. Reaux, A., Fournie-Zaluski, M. C., David, C., Zini, S., Roques, B. P., Corvol, P., and Llorens-Cortes, C. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 13415-13420
12. Bodineau, L., Frugiere, A., Marc, Y., Inguimbert, N., Fassot, C., Balavoine, F., Roques, B., and Llorens-Cortes, C. (2008) Hypertension 51, 1318-1325
13. Ferreira, A. J., and Raizada, M. K. (2008) Hypertension 51, 1273-1274
14. Iturrioz, X., Reaux-Le Goazigo, A., and Llorens-Cortes, C. (2004) Aminopeptidase Inhibitor as Anti-Hypertensive Drugs, Kluwer Academic/Plenum Publishers
15. Reaux, A., Iturrioz, X., Vazeux, G., Fournie-Zaluski, M. C., David, C., Roques, B. P., Corvol, P., and Llorens-Cortes, C. (2000) Biochem. Soc. Trans. 28, 435-440
16. Thunnissen, M. M., Nordlund, P., and Haeggstrom, J. Z. (2001) Nat. Struct. Biol. 8, 131-135
17. Iturrioz, X., Rozenfeld, R., Michaud, A., Corvol, P., and Llorens-Cortes, C. (2001) Biochemistry 40, 14440-14448
18. Iturrioz, X., Vazeux, G., Celerier, J., Corvol, P., and Llorens-Cortes, C. (2000) Biochemistry 39, 3061-3068
19. Vazeux, G., Iturrioz, X., Corvol, P., and Llorens-Cortes, C. (1997) Biochem. J. 327, 883-889
20. Vazeux, G., Iturrioz, X., Corvol, P., and Llorens-Cortes, C. (1998) Biochem. J. 334, 407-413
21. Vazeux, G., Wang, J., Corvol, P., and Llorens-Cortes, C. (1996) J. Biol. Chem. 271, 9069-9074
22. Wang, J. Y., and Cooper, M. D. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 1222-1226
23. Rozenfeld, R., Iturrioz, X., Maigret, B., and Llorens-Cortes, C. (2002) J. Biol. Chem. 277, 29242-29252
24. Lejczak, B., De Choszczak, M. P., and Kafarski, P. (1993) J. Enzyme Inhib. 7, 97-103
25. Rozenfeld, R., Iturrioz, X., Okada, M., Maigret, B., and Llorens-Cortes, C. (2003) Biochemistry 42, 14785-14793
26. Goto, Y., Hattori, A., Mizutani, S., and Tsujimoto, M. (2007) J. Biol. Chem. 282, 37074-37081
27. Claperon, C., Rozenfeld, R., Iturrioz, X., Inguimbert, N., Okada, M., Roques, B., Maigret, B., and Llorens-Cortes, C. (2008) Biochem. J. 416, 37-46
28. Herlitze, S., and Koenen, M. (1990) Gene (Amst.) 91, 143-147
29. Wu, Q., Lahti, J. M., Air, G. M., Burrows, P. D., and Cooper, M. D. (1990) Proc. Natl. Acad. Sci. U. S. A. 87, 993-997
30. Laemmli, U. K. (1970) Nature 227, 680-685
31. Song, L., Ye, M., Troyanovskaya, M., Wilk, E., Wilk, S., and Healy, D. P. (1994) Am. J. Physiol. 267, F546-F557
32. Schottel, B. L., Chifotides, H. T., and Dunbar, K. R. (2008) Chem. Soc. Rev. 37, 68-83
33. Matthews, B. W. (1988) Acc. Chem. Res. 21, 333-340
34. Rozenfeld, R., Muller, L., El Messari, S., and Llorens-Cortes, C. (2004) J. Biol. Chem. 279, 43285-43295
35. Ito, K., Nakajima, Y., Onohara, Y., Takeo, M., Nakashima, K., Matsubara, F., Ito, T., and Yoshimoto, T. (2006) J. Biol. Chem. 281, 33664-33676