Asp 218 participates with Asp 213 to bind a Ca 2+ atom into the S1 subsite of aminopeptidase A: A key element for substrate specificity

Biochemical Journal

Volumn 416, Issue 1, 2008, Pages 37-46

  Claperon, Cédric ^a,b,c   Rozenfeld, Raphael ^a,b,c   Iturrioz, Xavier ^a,b,c   Inguimbert, Nicolas ^a,d   Okada, Mayumi ^a,b,c   Roques, Bernard ^a,d   Maigret, Bernard ^e   Llorens Cortes, Catherine ^a,b,c  

^a INSERM   (France)

^b l'alimentation et l'Environnement   (France)

^c SORBONNE UNIVERSITÉ   (France)

^d UNIVERSITÉ PARIS DESCARTES   (France)

^e LORIA   (France)

Author keywords

Calcium binding site; Hypertension; Inhibitor design; Molecular modelling; Monozinc aminopeptidase; Site directed mutagenesis

Indexed keywords

CALCIUM-BINDING SITE; HYPERTENSION; INHIBITOR DESIGN; MOLECULAR MODELLING; MONOZINC AMINOPEPTIDASE; SITE-DIRECTED MUTAGENESIS;

ANIMALS; ATOMS; BINDING ENERGY; BLOOD PRESSURE; CALCIUM; CALCIUM ALLOYS; CARBOXYLATION; DESIGN; HYDROGEN; HYDROGEN BONDS; MOLECULAR MODELING; MUTAGENESIS; SUBSTRATES; ZINC;

BINDING SITES;

4 AMINO 5 MERCAPTO N (2 AMINOETHYL)PENTANAMIDE; 4 AMINO 5 MERCAPTOPENTANOYLAMINO ACETIC ACID; ANTIHYPERTENSIVE AGENT; ASPARTIC ACID; CALCIUM ION; CARBONYL DERIVATIVE; GLUTAMIC ACID; GLUTAMYL AMINOPEPTIDASE; GLUTAMYL AMINOPEPTIDASE INHIBITOR; HYDROGEN; NI 926; NI 955; UNCLASSIFIED DRUG; (4 AMINO 5 MERCAPTOPENTANOYLAMINO)ACETIC ACID; (4-AMINO-5-MERCAPTOPENTANOYLAMINO)ACETIC ACID; 4-AMINO-5-MERCAPTO-N-(2-AMINOETHYL)PENTANAMIDE; AMINO ACID; CALCIUM; ENZYME INHIBITOR; GLUTAMATE PHOSPHONIC ACID; GLUTAMATE THIOL; GLUTAMIC ACID DERIVATIVE; PHOSPHONIC ACID DERIVATIVE; THIOL DERIVATIVE;

ACIDITY; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; CALCIUM BINDING; CHO CELL; CONTROLLED STUDY; DRUG DESIGN; ENZYME INHIBITION; ENZYME SPECIFICITY; ENZYME STRUCTURE; FEMALE; HYDROGEN BOND; HYDROPHILICITY; MOUSE; NONHUMAN; PHARMACOPHORE; PRIORITY JOURNAL; PROTEIN DOMAIN; THREE DIMENSIONAL IMAGING; AMINO ACID SEQUENCE; ANIMAL; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; CRICETULUS; DRUG ANTAGONISM; GENETICS; HAMSTER; KINETICS; METABOLISM; SITE DIRECTED MUTAGENESIS;

ANIMALIA;

AMINO ACID SEQUENCE; AMINO ACIDS; ANIMALS; ASPARTIC ACID; BINDING SITES; CALCIUM; CHO CELLS; CRICETINAE; CRICETULUS; ENZYME INHIBITORS; GLUTAMATES; GLUTAMYL AMINOPEPTIDASE; KINETICS; MICE; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PHOSPHONIC ACIDS; SUBSTRATE SPECIFICITY; SULFHYDRYL COMPOUNDS;

EID: 56049102830     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20080471     Document Type: Article

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