Clinically relevant radioresistant cells efficiently repair DNA double-strand breaks induced by X-rays

Cancer Science

Volumn 100, Issue 4, 2009, Pages 747-752

  Kuwahara, Yoshikazu ^a   Li, Li ^b   Baba, Taisuke ^a   Nakagawa, Hironobu ^a   Shimura, Tsutomu ^a   Yamamoto, Yoichiro ^a   Ohkubo, Yasuhito ^c   Fukumoto, Manabu ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b GUANGDONG MEDICAL UNIVERSITY   (China)

^c TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE H2AX; DNA;

ARTICLE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CELL PROLIFERATION; CELL STRAIN HEPG2; CELL SURVIVAL; CONTROLLED STUDY; DNA REPAIR; DOUBLE STRANDED DNA BREAK; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MICRONUCLEUS; PRIORITY JOURNAL; RADIATION DOSE; RADIATION DOSE FRACTIONATION; RADIATION EXPOSURE; RADIOSENSITIVITY; X RAY; CELL CYCLE; CLONOGENIC ASSAY; DNA DAMAGE; GENETICS; KINETICS; LIVER CELL CARCINOMA; LIVER TUMOR; METABOLISM; PATHOLOGY; RADIATION RESPONSE; TUMOR CELL LINE;

CARCINOMA, HEPATOCELLULAR; CELL CYCLE; CELL LINE, TUMOR; CELL SURVIVAL; COLONY-FORMING UNITS ASSAY; DNA BREAKS, DOUBLE-STRANDED; DNA DAMAGE; DNA REPAIR; DNA, NEOPLASM; DOSE-RESPONSE RELATIONSHIP, RADIATION; HUMANS; KINETICS; LIVER NEOPLASMS; RADIATION TOLERANCE; X-RAYS;

EID: 67449090507     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2009.01082.x     Document Type: Article

References (46)

1. Deschavanne PJ, Fertil B. A review of human cell radiosensitivity in vitro. Int J Radiat Oncol Biol Phys 1996; 34: 251-66.
2. Jameel JK, Rao VS, Cawkwell L, Drew PJ. Radioresistance in carcinoma of the breast. Breast 2004; 13: 452-60.
3. Tanio Y, Watanabe M, Inoue T et al. Chemo-radioresistance of small cell lung cancer cell lines derived from untreated primary tumors obtained by diagnostic bronchofiberscopy. Jpn J Cancer Res 1990; 81: 289-97.
4. Tang WY, Chau SP, Tsang WP, Kong SK, Kwok TT. The role of Raf-1 in radiation resistance of human hepatocellular carcinoma HepG2 cells. Oncol Rep 2004; 12: 1349-54.
5. Wei K, Kodym R, Jin C. Radioresistant cell strain of human fibrosarcoma cells obtained after long-term exposure to X-rays. Radiat Environ Biophys 1998; 37: 133-7.
6. Mirzayans R, Scott A, Cameron M, Murray D. Induction of accelerated senescence by gamma radiation in human solid tumor-derived cell lines expressing wild-type TP53. Radiat Res 2005; 163: 53-62.
7. Oh CW, Bump EA, Kim JS, Janigro D, Mayberg MR. Induction of a senescence-like phenotype in bovine aortic endothelial cells by ionizing radiation. Radiat Res 2001; 156: 232-40.
8. Suzuki K, Mori I, Nakayama Y, Miyakoda M, Kodama S, Watanabe M. Radiation-induced senescence-like growth arrest requires TP53 function but not telomere shortening. Radiat Res 2001; 155: 248-53.
9. Bergqvist M, Brattstrom D, Stalberg M, Vaghef H, Brodin O, Hellman B. Evaluation of radiation-induced DNA damage and DNA repair in human lung cancer cell lines with different radiosensitivity using alkaline and neutral single cell gel electrophoresis. Cancer Lett 1998; 133: 9-18.
10. Olive PL, Banath JP, MacPhail HS. Lack of a correlation between radiosensitivity and DNA double-strand break induction or rejoining in six human tumor cell lines. Cancer Res 1994; 54: 3939-46.
11. Sakata K, Someya M, Matsumoto Y, Hareyama M. Ability to repair DNA double-strand breaks related to cancer susceptibility and radiosensitivity. Radiat Med 2007; 25: 433-8.
12. Tannock I. The Basic Science of Oncology, 4th edn. New York: McGraw-Hill, Medical Publications, 2005.
13. Fenech M. The in vitro micronucleus technique. Mutat Res 2000; 455: 81-95.
14. Rothkamm K, Lobrich M. Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses. Proc Natl Acad Sci USA 2003; 100: 5057-62.
15. Clingen PH, Wu JY, Miller J et al. Histone H2AX phosphorylation as a molecular pharmacological marker for DNA interstrand crosslink cancer chemotherapy. Biochem Pharmacol 2008; 76: 19-27.
16. Harasawa R, Mizusawa H, Nozawa K, Nakagawa T, Asada K, Kato I. Detection and tentative identification of dominant mycoplasma species in cell cultures by restriction analysis of the 16S-23S rRNA intergenic spacer regions. Res Microbiol 1993; 144: 489-93.
17. Taneja N, Davis M, Choy JS et al. Histone H2AX phosphorylation as a predictor of radiosensitivity and target for radiotherapy. J Biol Chem 2004; 279: 2273-80.
18. Iwasaki I, Sugiyama H, Kanazawa S, Hemmi H. Establishment of cisplatin-resistant variants of human neuroblastoma cell lines, TGW and GOTO, and their drug cross-resistance profiles. Cancer Chemother Pharmacol 2002; 49: 438-44.
19. Landmark H, Nahas SA, Aaroe J, Gatti R, Borresen-Dale AL, Rodningen OK. Transcriptional response to ionizing radiation in human radiation sensitive cell lines. Radiother Oncol 2007; 83: 256-60.
20. Saga Y, Suzuki M, Machida S, Ohwada M, Sato I. Establishment of a new cell line (TAYA) of clear cell adenocarcinoma of the ovary and its radiosensitivity. Oncology 2002; 62: 180-4.
21. Slijepcevic P. Is there a link between telomere maintenance and radiosensitivity? Radiat Res 2004; 161: 82-6.
22. Uchiyama-Kokubu N, Watanabe T. Establishment and characterization of adriamycin-resistant human colorectal adenocarcinoma HCT-15 cell lines with multidrug resistance. Anticancer Drugs 2001; 12: 769-79.
23. Hait WNE. Drug Resistance (Cancer Treatment and Research). Holland, Springer Verl.: Kluwer Academic Pub, 1996.
24. An J, Chervin AS, Nie A, Ducoff HS, Huang Z. Overcoming the radioresistance of prostate cancer cells with a novel Bcl-2 inhibitor. Oncogene 2007; 26: 652-61.
25. Bao S, Wu Q, McLendon RE et al. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 2006; 444: 756-60.
26. Lee HC, Kim DW, Jung KY et al. Increased expression of antioxidant enzymes in radioresistant variant from U251 human glioblastoma cell line. Int J Mol Med 2004; 13: 883-7.
27. Wang T, Tamae D, LeBon T, Shively JE, Yen Y, Li JJ. The role of peroxiredoxin II in radiation-resistant MCF-7 breast cancer cells. Cancer Res 2005; 65: 10338-46.
28. Weichselbaum RR, Beckett MA, Hallahan DE, Kufe DW, Vokes EE. Molecular targets to overcome radioresistance. Semin Oncol 1992; 19: 14-20.
29. Puck TT, Marcus PI. Action of x-rays on mammalian cells. J Exp Med 1956; 103: 653-66.
30. Vistica DT, Skehan P, Scudiero D, Monks A, Pittman A, Boyd MR. Tetrazolium-based assays for cellular viability: A critical examination of selected parameters affecting formazan production. Cancer Res 1991; 51: 2515-20.
31. Hellman B, Brodin D, Andersson M et al. Radiation-induced DNA-damage and gene expression profiles in human lung cancer cells with different radiosensitivity. Exp Oncol 2005; 27: 102-7.
32. Schwartz JL, Rotmensch J, Giovanazzi S, Cohen MB, Weichselbaum RR. Faster repair of DNA double-strand breaks in radioresistant human tumor cells. Int J Radiat Oncol Biol Phys 1988; 15: 907-12.
33. Olive PL, Banath JP. Phosphorylation of histone H2AX as a measure of radiosensitivity. Int J Radiat Oncol Biol Phys 2004; 58: 331-5.
34. Mahrhofer H, Burger S, Oppitz U, Flentje M, Djuzenova CS. Radiation induced DNA damage and damage repair in human tumor and fibroblast cell lines assessed by histone H2AX phosphorylation. Int J Radiat Oncol Biol Phys 2006; 64: 573-80.
35. Shrivastav M, De Haro LP, Nickoloff JA. Regulation of DNA double-strand break repair pathway choice. Cell Res 2008; 18: 134-47.
36. Delacote F, Han M, Stamato TD, Jasin M, Lopez BS. An xrcc4 defect or Wortmannin stimulates homologous recombination specifically induced by double-strand breaks in mammalian cells. Nucl Acids Res 2002; 30: 3454-63.
37. Frank-Vaillant M, Marcand S. Transient stability of DNA ends allows nonhomologous end joining to precede homologous recombination. Mol Cell 2002; 10: 1189-99.
38. Kim JS, Krasieva TB, Kurumizaka H, Chen DJ, Taylor AM, Yokomori K. Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells. J Cell Biol 2005; 170: 341-7.
39. Akudugu JM, Slabbert JP, Serafin A, Bohm L. Frequency of radiation-induced micronuclei in neuronal cells does not correlate with clonogenic survival. Radiat Res 2000; 153: 62-7.
40. Gourabi H, Mozdarani H. A cytokinesis-blocked micronucleus study of the radioadaptive response of lymphocytes of individuals occupationally exposed to chronic doses of radiation. Mutagenesis 1998; 13: 475-80.
41. Ismail IH, Wadhra TI, Hammarsten O. An optimized method for detecting gamma-H2AX in blood cells reveals a significant interindividual variation in the gamma-H2AX response among humans. Nucleic acids Res 2007; 35: E36.
42. Hendrickson EA. Cell-cycle regulation of mammalian DNA double-strand-break repair. Am J Hum Genet 1997; 61: 795-800.
43. Rothkamm K, Kruger I, Thompson LH, Lobrich M. Pathways of DNA double-strand break repair during the mammalian cell cycle. Mol Cell Biol 2003; 23: 5706-15.
44. Hall EJ, Giaccia AJ. Radiobiology for the Radiologist, 6th edn. Philadelphia, London: Lippincott Williams & Wilkins, 2006.
45. Ivanov A, Cragg MS, Erenpreisa J, Emzinsh D, Lukman H, Illidge TM. Endopolyploid cells produced after severe genotoxic damage have the potential to repair DNA double strand breaks. J Cell Sci 2003; 116: 4095-106.
46. Mothersill C, Seymour C. Lethal mutations and genomic instability. Int J Radiat Biol 1997; 71: 751-8.