Role of CCL5 in invasion, proliferation and proportion of CD44+/CD24- phenotype of MCF-7 cells and correlation of CCL5 and CCR5 expression with breast cancer progression

Oncology Reports

Volumn 21, Issue 4, 2009, Pages 1113-1121

  Zhang, Yimin ^a   Yao, Feng ^a   Yao, Xiaoli ^a   Yi, Changhong ^a   Tan, Cheng ^a   Wei, Lei ^b   Sun, Shengrong ^a  

^a WUHAN UNIVERSITY   (China)

^b WUHAN UNIVERSITY   (China)

Author keywords

Breast cancer; CC chemokine ligand 5; CD44+ CD24 cells; Invasion; Proliferation

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; CD24 ANTIGEN; CHEMOKINE RECEPTOR CCR1; CHEMOKINE RECEPTOR CCR3; CHEMOKINE RECEPTOR CCR5; HERMES ANTIGEN; MESSENGER RNA; MONOCLONAL ANTIBODY; RANTES; CCL5 PROTEIN, HUMAN; CD24 PROTEIN, HUMAN; CD44 PROTEIN, HUMAN;

ADULT; AGED; ARTICLE; BREAST CANCER; BREAST CARCINOGENESIS; CANCER GROWTH; CANCER STAGING; CELL INVASION; CELL PROLIFERATION; CELL STRAIN MCF 7; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION FUNCTION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN TISSUE; LYMPHOCYTE SUBPOPULATION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; BREAST; BREAST TUMOR; CANCER INVASION; CHEMISTRY; FEMALE; IMMUNOLOGY; MIDDLE AGED; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE;

ADULT; AGED; ANTIBODIES, MONOCLONAL; ANTIGENS, CD24; ANTIGENS, CD44; BREAST; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; CHEMOKINE CCL5; FEMALE; HUMANS; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM STAGING; PHENOTYPE; RECEPTORS, CCR5;

EID: 67449088106     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or_00000331     Document Type: Article

References (38)

1. Lu X and Kang Y: Organotropism of breast cancer metastasis. J Mammary Gland Biol Neoplasia 12: 153-162, 2007.
2. Chambers AF, Groom AC and MacDonald IC: Dissemination and growth of cancer cells in metastatic sites. Nat Rev Cancer 2: 563-572, 2002.
3. Azenshtein E, Luboshits G, Shina S, Neumark E, Shahbazian D, Weil M, Wigler N, Keydar I and Ben Baruch A: The CC chemokine RANTES in breast carcinoma progression: regulation of expression and potential mechanisms of promalignant activity. Cancer Res 62: 1093-1102, 2002.
4. Hillyer P and Male D: Expression of chemokines on the surface of different human endothelia. Immunol Cell Biol 83: 375-382, 2005.
5. Karnoub AE, Dash AB, Vo AP, Sullivan A, Brooks MW, Bell GW, Richardson AL, Polyak K, Tubo R and Weinberg RA: Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature 449: 557-563, 2007.
6. Balkwill F and Mantovani A: Inflammation and cancer: back to Virchow? Lancet 357: 539-545, 2001.
7. Coussens LM and Werb Z: Inflammation and cancer. Nature 420: 860-867, 2002.
8. Manes S, Mira E, Colomer R, Montero S, Real LM, Gomez-Mouton C, Jimenez-Baranda S, Garzon A, Lacalle RA, Harshman K, Ruiz A and Martinez A: CCR5 expression influences the progression of human breast cancer in a p53-dependent manner. J Exp Med 198: 1381-1389, 2003.
9. John AE, Berlin AA and Lukacs NW: Respiratory syncytial virus-induced CCL5/RANTES contributes to exacerbation of allergic airway inflammation. Eur J Immunol 33: 1677-1685, 2003.
10. Niwa Y, Akamatsu H, Niwa H, Sumi H, Ozaki Y and Abe A: Correlation of tissue and plasma RANTES levels with disease course in patients with breast or cervical cancer. Clin Cancer Res 7: 285-289, 2001.
11. Luboshits G, Shina S, Kaplan O, Engelberg S, Nass D, Lifshitz-Mercer B, Chaitchik S, Keydar I and Ben Baruch A: Elevated expression of the CC chemokine regulated on activation, normal T cell expressed and secreted (RANTES) in advanced breast carcinoma. Cancer Res 59: 4681-4687, 1999.
12. Robinson SC, Scott KA, Wilson JL, Thompson RG, Proudfoot AE and Balkwill FR: A chemokine receptor antagonist inhibits experimental breast tumor growth. Cancer Res 63: 8360-8365, 2003.
13. Reya T, Morrison SJ, Clarke MF and Weissman IL: Stem cells, cancer and cancer stem cells. Nature 414: 105-111, 2001.
14. Behbod F and Rosen JM: Will cancer stem cells provide new therapeutic targets? Carcinogenesis 26: 703-711, 2005.
15. Smalley M and Ashworth A: Stem cells and breast cancer: a field in transit. Nat Rev Cancer 3: 832-844, 2003.
16. Dontu G, El Ashry D and Wicha MS: Breast cancer, stem/progenitor cells and the estrogen receptor. Trends Endocrinol Metab 15: 193-197, 2004.
17. Clarke MF and Fuller M: Stem cells and cancer: two faces of eve. Cell 124: 1111-1115, 2006.
18. Lynch MD, Cariati M and Purushotham AD: Breast cancer, stem cells and prospects for therapy. Breast Cancer Res 8: 211, 2006.
19. Polyak K and Hahn WC: Roots and stems: stem cells in cancer. Nat Med 12: 296-300, 2006.
20. Wicha MS, Liu S and Dontu G: Cancer stem cells: an old ideaa paradigm shift. Cancer Res 66: 1883-1890, 2006.
21. Al Hajj M, Wicha MS, Benito-Hernandez A, Morrison SJ and Clarke MF: Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci USA 100: 3983-3988, 2003.
22. Singh SK, Clarke ID, Terasaki M, Bonn VE, Hawkins C, Squire J and Dirks PB: Identification of a cancer stem cell in human brain tumors. Cancer Res 63: 5821-5828, 2003.
23. Collins AT, Berry PA, Hyde C, Stower MJ and Maitland NJ: Prospective identification of tumorigenic prostate cancer stem cells. Cancer Res 65: 10946-10951, 2005.
24. O'Brien CA, Pollett A, Gallinger S and Dick JE: A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature 445: 106-110, 2007.
25. Li C, Heidt DG, Dalerba P, Burant CF, Zhang L, Adsay V, Wicha M, Clarke MF and Simeone DM: Identification of pancreatic cancer stem cells. Cancer Res 67: 1030-1037, 2007.
26. Shipitsin M, Campbell LL, Argani P, Weremowicz S, Bloushtain-Qimron N, Yao J, Nikolskaya T, Serebryiskaya T, Beroukhim R, Hu M, Halushka MK, Sukumar S, Parker LM, Anderson KS, Harris LN, Garber JE, Richardson AL, Schnitt SJ, Nikolsky Y, Gelman RS and Polyak K: Molecular definition of breast tumor heterogeneity. Cancer Cell 11: 259-273, 2007.
27. - phenotype is enriched in basal-like breast tumors. Breast Cancer Res 10: R53, 2008.
28. Li HZ, Yi TB and Wu ZY: Suspension culture combined with chemotherapeutic agents for sorting of breast cancer stem cells. BMC Cancer 8: 135, 2008.
29. - breast cancer cells exhibit enhanced invasive properties: an early step necessary for metastasis. Breast Cancer Res 8: R59, 2006.
30. Liu R, Wang X, Chen GY, Dalerba P, Gurney A, Hoey T, Sherlock G, Lewicki J, Shedden K and Clarke MF: The prognostic role of a gene signature from tumorigenic breast-cancer cells. N Engl J Med 356: 217-226, 2007.
31. Hiratsuka S, Watanabe A, Aburatani H and Maru Y: Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis. Nat Cell Biol 8: 1369-1375, 2006.
32. Tysnes BB and Bjerkvig R: Cancer initiation and progression: involvement of stem cells and the microenvironment. Biochim Biophys Acta 1775: 283-297, 2007.
33. Mrowietz U, Schwenk U, Maune S, Bartels J, Kupper M, Fichtner I, Schroder JM and Schadendorf D: The chemokine RANTES is secreted by human melanoma cells and is associated with enhanced tumuor formation in nude mice. Br J Cancer 79: 1025-1031, 1999.
34. Fischer M, Juremalm M, Olsson N, Backlin C, Sundstrom C, Nilsson K, Enblad G and Nilsson G: Expression of CCL5/RANTES by Hodgkin and Reed-Sternberg cells and its possible role in the recruitment of mast cells into lymphomatous tissue. Int J Cancer 107: 197-201, 2003.
35. Ben Baruch A: The multifaceted roles of chemokines in malignancy. Cancer Metastasis Rev 25: 357-371, 2006.
36. Bieche I, Lerebours F, Tozlu S, Espie M, Marty M and Lidereau R: Molecular profiling of inflammatory breast cancer: identification of a poor-prognosis gene expression signature. Clin Cancer Res 10: 6789-6795, 2004.
37. Adler EP, Lemken CA, Katchen NS and Kurt RA: A dual role for tumor-derived chemokine RANTES (CCL5). Immunol Lett 90: 187-194, 2003.
38. Azenshtein E, Meshel T, Shina S, Barak N, Keydar I and Ben Baruch A: The angiogenic factors CXCL8 and VEGF in breast cancer: regulation by an array of pro-malignancy factors. Cancer Lett 217: 73-86, 2005.