Metabolic background determines the importance of NOS3 polymorphisms in restenosis after percutaneous coronary intervention: A study in patients with and without the metabolic syndrome

Disease Markers

Volumn 26, Issue 2, 2009, Pages 75-83

  Pons, Douwe ^a,b   Monraats, Pascalle S ^a,b   Zwinderman, Aeilko H ^c   De Maat, Moniek P M ^d   Doevendans, Pieter A F M ^e   De Winter, Robbert J ^c   Tio, René A ^f   Waltenberger, Johannes ^g   Jukema, J Wouter ^a,b,g  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b ROYAL NETHERLANDS ACADEMY OF ARTS AND SCIENCES   (Netherlands)

^c ACADEMIC MEDICAL CENTER   (Netherlands)

^d ERASMUS MEDICAL CENTER   (Netherlands)

^e UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^f UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^g Durrer Center for Cardiogenetic Research   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; NOS3 PROTEIN, HUMAN;

ADULT; ALLELE; ARTICLE; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; PERCUTANEOUS CORONARY INTERVENTION; PRIORITY JOURNAL; RESTENOSIS; ANGIOCARDIOGRAPHY; CLINICAL TRIAL; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; MIDDLE AGED; MULTICENTER STUDY; PROSPECTIVE STUDY; RADIOGRAPHY; RISK FACTOR; TRANSLUMINAL CORONARY ANGIOPLASTY;

ANGIOPLASTY, TRANSLUMINAL, PERCUTANEOUS CORONARY; CORONARY ANGIOGRAPHY; CORONARY RESTENOSIS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; METABOLIC SYNDROME X; MIDDLE AGED; NITRIC OXIDE SYNTHASE TYPE III; POLYMORPHISM, GENETIC; PROSPECTIVE STUDIES; RISK FACTORS;

EID: 67449087545     PISSN: 02780240     EISSN: None     Source Type: Journal    
DOI: 10.1155/2009/520653     Document Type: Article

References (43)

1. Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III), JAMA 285 (2001), 2486-2497.
2. W.R. Agema, M.P. De Maat, A.H. Zwinderman, J.J. Kastelein, T.J. Rabelink, A.J. van Boven, E.J. Feskens, J.M. Boer, E.E. van der Wall and J.W. Jukema, An integrated evaluation of endothelial constitutive nitric oxide synthasepolymorphisms and coronary artery disease in men, Clin Sci (Lond) 107 (2004), 255-261.
3. W.R. Agema, J.W. Jukema, S.N. Pimstone and J.J. Kastelein, Genetic aspects of restenosis after percutaneous coronary interventions: towards more tailored therapy, Eur Heart J 22 (2001), 2058-2074.
4. W.R.P. Agema, P.S. Monraats, A.H. Zwinderman, R.J.deWinter, R.A. Tio, P.A.F.M. Doevendans, J. Waltenberger, M.P.M. de Maat, R.R. Frants, D.E. Atsma, A. van der Laarse, E.E. van der Wall and J.W. Jukema, Current PTCA practice and clinical outcomes in The Netherlands: the real world in the pre-drug-eluting stent era, Eur Heart J 25 (2004), 1163-1170.
5. C. Boulanger and T.F. Luscher, Release of endothelin from the porcine aorta. Inhibition by endothelium-derived nitric oxide, J Clin Invest 85 (1990), 587-590.
6. S. Cheng, M.A. Grow, C. Pallaud, W. Klitz, H.A. Erlich, S. Visvikis, J.J. Chen, C.R. Pullinger, M.J. Malloy, G. Siest and J.P. Kane, A multilocus genotyping assay for candidate markers of cardiovascular disease risk, Genome Res 9 (1999), 936-949.
7. P. Desantis, M.O. Babaoglu, J.C. Pezzullo, D.R. Abernethy and J.E.Freedman, Impaired production of platelet-derived nitric oxide in human subjects with a polymorphic variant of endothelial nitric oxide synthase, Circulation 102 (2000), S61.
8. T.A. Fairchild, D. Fulton, J.T. Fontana, J.P. Gratton, T.J. McCabe and W.C. Sessa, Acidic hydrolysis as a mechanism for the cleavage of the Glu(298)→ Asp variant of human endothelial nitric-oxide synthase, J Biol Chem 276 (2001), 26674-26679.
9. U.C. Garg and A. Hassid, Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells, J Clin Invest 83 (1989), 1774-1777.
10. S. Genuth, K.G. Alberti, P. Bennett, J. Buse, R. Defronzo, R. Kahn, J. Kitzmiller, W.C. Knowler, H. Lebovitz, A. Lernmark, D. Nathan, J. Palmer, R. Rizza, C. Saudek, J. Shaw, M. Steffes, M. Stern, J. Tuomilehto and P. Zimmet, Follow-up report on the diagnosis of diabetes mellitus, Diabetes Care 26 (2003), 3160-3167.
11. R. Golser, A.C. Gorren, B. Mayer and K. Schmidt, Functional characterization of Glu298Asp mutant human endothelial nitric oxide synthase purified from a yeast expression system, Nitric Oxide 8 (2003), 7-14.
12. A.H. Gomma, M.A. Elrayess, C.J. Knight, E. Hawe, K.M. Fox and S.E. Humphries, The endothelial nitric oxide synthase (Glu298Asp and -786T>C) gene polymorphisms are associated with coronary in-stent restenosis, Eur Heart J 23 (2002), 1955-1962.
13. O. Gorchakova, W. Koch, N. von Beckerath, J. Mehilli, A. Schomig and A. Kastrati, Association of a genetic variant of endothelial nitric oxide synthase with the 1 year clinical outcome after coronary stent placement, Eur Heart J 24 (2003), 820-827.
14. S.M. Grundy, H.B. Brewer, Jr., J.I. Cleeman, S.C. Smith, Jr. and C. Lenfant, Definition of metabolic syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition, Circulation 109 (2004), 433-438.
15. T.D. Howard, W.H. Giles, J. Xu, M.A. Wozniak, A.M. Malarcher, L.A. Lange, R.F. Macko, M.J. Basehore, D.A. Meyers, J.W. Cole and S.J. Kittner, Promoter polymorphisms in the nitric oxide synthase 3gene are associated with ischemic stroke susceptibility in young black women, Stroke 36 (2005), 1848-1851.
16. P. Kubes, M. Suzuki and D.N. Granger, Nitric oxide: an endogenous modulator of leukocyte adhesion, Proc Natl Acad Sci U S A 88 (1991), 4651-4655.
17. T. Le Tourneau, E. Van Belle, D. Corseaux, B. Vallet, G. Lebuffe, B. Dupuis, J.M. Lablanche, E. McFadden, C. Bauters and M.E. Bertrand, Role of nitric oxide in restenosis after experimental balloon angioplasty in the hypercholesterolemic rabbit: effects on neointimal hyperplasia and vascular remodeling, J Am Coll Cardiol 33 (1999), 876-882.
18. M.E. Lean, T.S. Han and C.E. Morrison, Waist circumference as a measure for indicating need for weight management, BMJ 311 (1995), 158-161.
19. C.R. Lee, K.E. North, M.S. Bray, C.L. Avery, M.J. Mosher, D.J. Couper, J. Coresh, A.R. Folsom, E. Boerwinkle, G. Heiss and D.C. Zeldin, NOS3 polymorphisms, cigarette smoking, and cardiovascular disease risk: the Atherosclerosis Risk in Communities study, Pharmacogenet Genomics 16 (2006), 891-899.
20. C.P. Leeson, A.D. Hingorani, M.J. Mullen, N. Jeerooburkhan, M. Kattenhorn, T.J. Cole, D.P. Muller, A. Lucas, S.E. Humphries and J.E. Deanfield, Glu298Asp endothelial nitric oxide synthase gene polymorphism interacts with environmental and dietary factors to influence endothelial function, Circ Res 90 (2002), 1153-1158.
21. A.A. Lteif, K. Han and K.J. Mather, Obesity, insulin resistance, and the metabolic syndrome: determinants of endothelial dysfunction in whites and blacks, Circulation 112 (2005), 32-38.
22. D.M. McDonald, N.J. Alp and K.M. Channon, Functional comparison of the endothelial nitric oxide synthase Glu298Asp polymorphic variants in human endothelial cells, Pharmacogenetics 14 (2004), 831-839.
23. D.M. McNamara, R. Holubkov, J.J. Wang, A. Palmer, N.B. Merz and B.L. Sharaf, The eNOS Asp298 variant is not associated with atherosclerosis or endothelial dysfunction. Results from the NHLBI WISE study, Circulation 100 (1999), S718.
24. P.R. Myers, R. Webel, V. Thondapu, X.P. Xu, J. Amann, M.A. Tanner, J.S. Jenkins, J.S. Pollock and M.H. Laughlin, Restenosis is associated with decreased coronary artery nitric oxide synthase, Int J Cardiol 55 (1996), 183-191.
25. C.K. Naber, D. Baumgart, C. Altmann, W. Siffert, R. Erbel and G. Heusch, eNOS 894T allele and coronary blood flow at rest and during adenosine-induced hyperemia, Am J Physiol Heart Circ Physiol 281 (2001), H1908-H1912.
26. P. Piatti, C. Di Mario, L.D. Monti, G. Fragasso, F. Sgura, A. Caumo, E. Setola, P. Lucotti, E. Galluccio, C. Ronchi, A. Origgi, I. Zavaroni, A. Margonato and A. Colombo, Association of insulin resistance, hyperleptinemia, and impaired nitric oxide release with in-stent restenosis in patients undergoing coronary stenting, Circulation 108 (2003), 2074-2081.
27. M.W. Radomski, R.M. Palmer and S. Moncada, Endogenous nitric oxide inhibits human platelet adhesion to vascular endothelium, Lancet 2 (1987), 1057-1058.
28. J.S. Rana, P.S. Monraats, A.H. Zwinderman, M.P. De Maat, J.J. Kastelein, P.A. Doevendans, R.J. de Winter, R.A. Tio, R.R. Frants, L.A. van der, E.E. van der Wall and J.W. Jukema, Metabolic syndrome and risk of restenosis in patients undergoing percutaneous coronary intervention, Diabetes Care 28 (2005), 873-877.
29. L.J. Rosenberg, P. Desantis, M.O. Babaoglu and D.R. Abernethy, Polymorphic variant endothelial nitric oxide synthase impairs endothelium-dependent vascular relaxation in both heterozygotes and homozygotes, Clin Pharmacol Ther 69 (2001), 89.
30. N. Sattar, A. Gaw, O. Scherbakova, I. Ford, D.S. O'Reilly, S.M. Haffner, C. Isles, P.W. Macfarlane, C.J. Packard, S.M. Cobbe and J. Shepherd, Metabolic syndrome with and without C-reactive protein as a predictor of coronary heart disease and diabetes in the West of Scotland Coronary Prevention Study, Circulation 108 (2003), 414-419.
31. M.P. Schneider, J. Erdmann, C. Delles, E. Fleck, V. Regitz-Zagrosek and R.E. Schmieder, Functional gene testing of the Glu298Asp polymorphism of the endothelial NO synthase, J Hypertens 18 (2000), 1767-1773.
32. G. Sofowora, V. Dishy, H.G. Xie, H. Imamura, Y. Nishimi, C.R. Morales, J.D. Morrow, R.B. Kim, C.M. Stein and A.J. Wood, In-vivo effects of Glu298Asp endothelial nitric oxide synthase polymorphism, Pharmacogenetics 11 (2001), 809-814.
33. S. Srinivasan, M.E. Hatley, D.T. Bolick, L.A. Palmer, D. Edelstein, M. Brownlee and C.C. Hedrick, Hyperglycaemiainduced superoxide production decreases eNOS expression via AP-1 activation in aortic endothelial cells, Diabetologia 47 (2004), 1727-1734.
34. T. Suzuki, M. Hayase, K. Hibi, H. Hosokawa, K. Yokoya, P.J. Fitzgerald, P.G. Yock, J.P. Cooke, T. Suzuki and A.C. Yeung, Effect of local delivery of L-arginine on in-stent restenosis in humans, Am J Cardiol 89 (2002), 363-367.
35. T. Suzuki, K. Okumura, T. Sone, T. Kosokabe, H. Tsuboi, J. Kondo, H. Mukawa, H. Kamiya, T. Tomida, H. Imai, H. Matsui and T. Hayakawa, The Glu298Asp polymorphism in endothelial nitric oxide synthase gene is associated with coronary in-stent restenosis, Int J Cardiol 86 (2002), 71-76.
36. M. Takemoto, K. Egashira, M. Usui, K. Numaguchi, H. Tomita, H. Tsutsui, H. Shimokawa, K. Sueishi and A. Takeshita, Important role of tissue angiotensin-converting enzyme activity in the pathogenesis of coronary vascular and myocardial structural changes induced by long-term blockade of nitric oxide synthesis in rats, J Clin Invest 99 (1997), 278-287.
37. M. Tesauro, W.C. Thompson, P. Rogliani, L. Qi, P.P. Chaudhary and J. Moss, Intracellular processing of endothelial nitric oxide synthase isoforms associated with differences in severity of cardiopulmonary diseases: cleavage of proteins with aspartate vs. glutamate at position 298, Proc Natl Acad Sci USA 97 (2000), 2832-2835.
38. D.A. Tregouet and L. Tiret, Cox proportional hazards survival regression in haplotype-based association analysis using the Stochastic-EM algorithm, Eur J Hum Genet 12 (2004), 971-974.
39. T.J. Tunny, K.A. Richardson and C.V. Clark, Association study of the 5' flanking regions of endothelial-nitric oxide synthase and endothelin-1 genes in familial primary open-angle glaucoma, Clin Exp Pharmacol Physiol 25 (1998), 26-29.
40. B.A. Veldman, W. Spiering, P.A. Doevendans, G. Vervoort, A.A. Kroon, P.W. de Leeuw and P. Smits, The Glu298Asp polymorphism of the NOS3 gene as a determinant of the baseline production of nitric oxide, J Hypertens 20 (2002), 2023-2027.
41. P. Vermeersch, Z. Nong, E. Stabile, O. Varenne, H. Gillijns, M. Pellens, N. Van Pelt, M. Hoylaerts, S. De, I, D. Collen and S. Janssens, L-arginine administration reduces neointima formation after stent injury in rats by a nitric oxide-mediated mechanism, Arterioscler Thromb Vasc Biol 21 (2001), 1604-1609.
42. X.L. Wang, A.S. Sim, M.X. Wang, G.A. Murrell, B. Trudinger and J. Wang, Genotype dependent and cigarette specific effects on endothelial nitric oxide synthase gene expression and enzyme activity, FEBS Lett 471 (2000), 45-50.
43. T.C. Wu, Y.H. Chen, J.W. Chen, L.C. Chen, S.J. Lin, P.Y. Ding, S.P. Wang and M.S. Chang, Impaired forearm reactive hyperemia is related to late restenosis after coronary stenting, Am J Cardiol 85 (2000), 1071-1076.