The anti-arrhythmic peptide AAP10 remodels Cx43 and Cx40 expression and function

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 380, Issue 1, 2009, Pages 11-24

  Easton, Jennifer A ^a,c   Petersen, Jorgen S ^b,d   Martin, Patricia E M ^a  

^a GLASGOW CALEDONIAN UNIVERSITY   (United Kingdom)

^b Zealand Pharma AS   (Denmark)

^c UNIVERSITY OF LIVERPOOL   (United Kingdom)

^d Serono International SA   (Switzerland)

Author keywords

AAP10, protein kinase C; Anti arrhythmic peptide; Connexin; Gap junction; Intercellular communication

Indexed keywords

ANTIARRHYTHMIC PEPTIDE; CHELERYTHRINE; CONNEXIN 26; CONNEXIN 40; CONNEXIN 43; MESSENGER RNA; PROTEIN AAP10; PROTEIN KINASE C; UNCLASSIFIED DRUG;

ANTIARRHYTHMIC ACTIVITY; ARTICLE; CELL TRANSFER; CONTROLLED STUDY; DRUG EFFECT; ENZYME INHIBITION; ENZYME LOCALIZATION; ENZYME REGULATION; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TRANSPORT;

ANTI-ARRHYTHMIA AGENTS; BENZOPHENANTHRIDINES; BLOTTING, WESTERN; CELL MEMBRANE; CONNEXIN 43; CONNEXINS; FLUORESCENT DYES; GAP JUNCTIONS; GENE EXPRESSION REGULATION; HELA CELLS; HUMANS; OLIGOPEPTIDES; PROTEIN KINASE C; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TIME FACTORS;

EID: 67349277678     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-009-0411-2     Document Type: Article

References (44)

1. V Akoyev DJ Takemoto 2007 ZO-1 is required for protein kinase C gamma-driven disassembly of connexin 43 Cell Signal 19 958 967 (Pubitemid 46436436)
2. LN Axelsen M Stahlhut S Mohammed BD Larsen MS Nielsen NH Holstein-Rathlou S Andersen ON Jensen JK Hennan AL Kjolbye 2006 Identification of ischemia-regulated phosphorylation sites in connexin43: a possible target for the antiarrhythmic peptide analogue rotigaptide (ZP123) J Mol Cell Cardiol 40 790 798 (Pubitemid 43817040)
3. LN Axelsen K Haugan M Stahlhut AL Kjolbye JK Hennan NH Holstein-Rathlou JS Petersen MS Nielsen 2007 Increasing gap junctional coupling: a tool for dissecting the role of gap junctions J Membr Biol 216 23 35 (Pubitemid 350194812)
4. WA Ayad D Locke IV Koreen AL Harris 2006 Heteromeric, but not homomeric, connexin channels are selectively permeable to inositol phosphates J Biol Chem 281 16727 16739 (Pubitemid 43909628)
5. MA Beardslee DL Lerner PN Tadros JG Laing EC Beyer KA Yamada AG Kleber RB Schuessler JE Saffitz 2000 Dephosphorylation and intracellular redistribution of ventricular connexin43 during electrical uncoupling induced by ischemia Circ Res 87 656 662
6. JP Blackburn NS Peters HI Yeh S Rothery CR Green NJ Severs 1995 Upregulation of connexin43 gap junctions during early stages of human coronary atherosclerosis Arterioscler Thromb Vasc Biol 15 1219 1228
7. JM Brandner P Houdek B Husing C Kaiser I Moll 2004 Connexins 26, 30, and 43: differences among spontaneous, chronic, and accelerated human wound healing J Invest Dermatol 122 1310 1320 (Pubitemid 38651108)
8. CE Chadjichristos JP Derouette BR Kwak 2006 Connexins in atherosclerosis Adv Cardiol 42 255 267
9. SL Chan MC Lee KO Tan LK Yang AS Lee H Flotow NY Fu MS Butler DD Soejarto AD Buss VC Yu 2003 Identification of chelerythrine as an inhibitor of BclXL function J Biol Chem 278 20453 20456 (Pubitemid 36806340)
10. M Chanson JP Derouette I Roth B Foglia I Scerri T Dudez BR Kwak 2005 Gap junctional communication in tissue inflammation and repair Biochem Biophys Acta 1711 197 207 (Pubitemid 40799294)
11. AT Chaytor PE Martin DH Edwards TM Griffith 2001 Gap junctional communication underpins EDHF-type relaxations evoked by ACh in the rat hepatic artery Am J Physiol Heart Circ Physiol 280 H2441 H2450 (Pubitemid 32553282)
12. TC Clarke D Thomas JS Petersen WH Evans PE Martin 2006 The antiarrhythmic peptide rotigaptide (ZP123) increases gap junction intercellular communication in cardiac myocytes and HeLa cells expressing connexin 43 Br J Pharmacol 147 486 495 (Pubitemid 43355046)
13. S Dhein S Weng R Grover T Tudyka M Gottwald T Schaefer L Polontchouk 2001 Protein kinase C alpha mediates the effect of antiarrhythmic peptide on gap junction conductance Cell Commun Adhes 8 257 264 (Pubitemid 135749808)
14. BW Doble X Dang P Ping RR Fandrich BE Nickel Y Jin PA Cattini E Kardami 2004 Phosphorylation of serine 262 in the gap junction protein connexin-43 regulates DNA synthesis in cell-cell contact forming cardiomyocytes J Cell Sci 117 507 514 (Pubitemid 38181211)
15. S Dolan JG Kelly AM Monteiro AM Nolan 2004 Differential expression of central metabotropic glutamate receptor (mGluR) subtypes in a clinical model of post-surgical pain Pain 110 369 377 (Pubitemid 38953302)
16. WH Evans E De Vuyst L Leybaert 2006 The gap junction cellular internet: connexin hemichannels enter the signalling limelight Biochem J 397 1 14 (Pubitemid 44032830)
17. GS Goldberg AP Moreno PD Lampe 2002 Gap junctions between cells expressing connexin 43 or 32 show inverse permselectivity to adenosine and ATP J Biol Chem 277 36725 36730
18. DE Gutstein GE Morley H Tamaddon D Vaidya MD Schneider J Chen KR Chien H Stuhlmann GI Fishman 2001 Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of connexin43 Circ Res 88 333 339 (Pubitemid 32173758)
19. D Harris PE Martin WH Evans DA Kendall TM Griffith MD Randall 2000 Role of gap junctions in endothelium-derived hyperpolarizing factor responses and mechanisms of K(+)-relaxation Eur J Pharmacol 402 119 128 (Pubitemid 30625318)
20. NR Jorgensen SC Teilmann Z Henriksen E Meier SS Hansen JE Jensen OH Sorensen JS Petersen 2005 The antiarrhythmic peptide analog rotigaptide (ZP123) stimulates gap junction intercellular communication in human osteoblasts and prevents decrease in femoral trabecular bone strength in ovariectomized rats Endocrinology 146 4745 4754 (Pubitemid 41446612)
21. J Jozwiak S Dhein 2008 Local effects and mechanisms of antiarrhythmic peptide AAP10 in acute regional myocardial ischemia: electrophysiological and molecular findings Nauyn-Schmiedeberg's Arch Pharmacol 378 459 470 10.1007/s00210-008-0317-4
22. P Kanagaratnam E Dupont S Rothery S Coppen NJ Severs NS Peters 2006 Human atrial conduction and arrhythmogenesis correlates with conformational exposure of specific epitopes on the connexin40 carboxyl tail J Mol Cell Cardiol 40 675 687
23. AL Kjolbye CB Knudsen T Jepsen BD Larsen JS Petersen 2003 Pharmacological characterization of the new stable antiarrhythmic peptide analog Ac-D-Tyr-D-Pro-D-Hyp-Gly-D-Ala-Gly-NH2 (ZP123): in vivo and in vitro studies J Pharmacol Exp Ther 306 1191 1199 (Pubitemid 37028306)
24. AL Kjolbye K Haugan JK Hennan JS Petersen 2007 Pharmacological modulation of gap junction function with the novel compound rotigaptide: a promising new principle for prevention of arrhythmias Basic Clin Pharmacol Toxicol 101 215 230 (Pubitemid 350194808)
25. IE Lai-Cheong L Arita JA McGrath 2007 Genetic diseases of junctions J Invest Dermatol 127 2713 2725 (Pubitemid 350134810)
26. DW Laird 2006 Life cycle of connexins in health and disease Biochem J 394 527 543
27. PD Lampe AF Lau 2004 The effects of connexin phosphorylation on gap junctional communication Int J Biochem Cell Biol 36 1171 1186 (Pubitemid 38515659)
28. PE Martin C Wall TM Griffith 2005 Effects of connexin-mimetic peptides on gap junction functionality and connexin expression in cultured vascular cells Br J Pharmacol 144 617 627 (Pubitemid 40445609)
29. G Mese G Richard T White 2007 Gap junctions: basic structure and function J Invest Dermatol 127 2516 2524 (Pubitemid 47585051)
30. M Mesnil V Krutovskikh C Piccoli C Elfgang O Traub K Willecke H Yamasaki 1995 Negative growth control of HeLa cells by connexin genes: connexin species specificity Cancer Res 55 629 639
31. M Mesnil S Crespin J Avanzo M Zaidan-Dagli 2005 Defective gap junctional communication in the carcinogenic process Biochim Biophys Acta 1719 125 145 (Pubitemid 41785641)
32. A Muller M Gottwald T Tudyka W Linke W Klaus S Dhein 1997 Increase in gap junction conductance by an antiarrhythmic peptide Eur J Pharmacol 327 65 72 (Pubitemid 27220222)
33. BJ Nicholson PA Weber F Cao H Chang P Lampe G Goldberg 2000 The molecular basis of selective permeability of connexins is complex and includes both size and charge Braz J Med Biol Res 33 369 378
34. H Niessen H Harz P Bedner K Kramer K Willecke 2000 Selective permeability of different connexin channels to the second messenger inositol 1, 4,5-trisphosphate J Cell Sci 113 1365 1372 (Pubitemid 30240555)
35. M Rackauskas MM Kreuzberg M Pranevicius K Willecke VK Verselis FF Bukauskas 2007 Gating properties of heterotypic gap junction channels formed of connexins 40, 43, and 45 Biophys J 92 1952 1965 (Pubitemid 46495259)
36. TS Richards CA Dunn WG Carter ML Usui JE Olerud PD Lampe 2004 Protein kinase C spatially and temporally regulates gap junctional communication during human wound repair via phosphorylation of connexin43 on serine368 J Cell Biol 167 555 562 (Pubitemid 39489062)
37. E Rivedal E Leithe 2005 Connexin43 synthesis, phosphorylation, and degradation in regulation of transient inhibition of gap junction intercellular communication by the phorbol ester TPA in rat liver epithelial cells Exp Cell Res 302 143 152 (Pubitemid 39550457)
38. M Stahlhut JS Petersen JK Hennan MT Ramirez 2006 The antiarrhythmic peptide rotigaptide (ZP123) increases connexin 43 protein expression in neonatal rat ventricular cardiomyocytes Cell Commun Adhes 13 21 27 (Pubitemid 43355046)
39. MS Turner GA Haywood P Andreka L You PE Martin WH Evans KA Webster NH Bishopric 2004 Reversible connexin 43 dephosphorylation during hypoxia and reoxygenation is linked to cellular ATP levels Circ Res 95 726 733 (Pubitemid 39331933)
40. M Urban R Rozental DC Spray 1999 A simple RT-PCR-based strategy for screening connexin identity Braz J Med Biol Res 32 1029 1037 (Pubitemid 129539720)
41. V Valiunas EC Beyer PR Brink 2002 Cardiac gap junction channels show quantitative differences in selectivity Circ Res 91 104 111
42. PA Weber HC Chang KE Spaeth JM Nitsche BJ Nicholson 2004 The permeability of gap junction channels to probes of different size is dependent on connexin composition and permeant-pore affinities Biophys J 87 958 973 (Pubitemid 39095076)
43. S Weng M Lauven T Schaefer L Polontchouk R Grover S Dhein 2002 Pharmacological modification of gap junction coupling by an antiarrhythmic peptide via protein kinase C activation Faseb J 16 1114 1116
44. R Yu S Mandlekar T Tan AN Kong 2000 Activation of p38 and c-Jun N-terminal kinase pathways and induction of apoptosis by chelerythrine do not require inhibition of protein kinase C J Biol Chem 275 9612 9619 (Pubitemid 30185193)