Cytotoxic activity and cellular processing in human ovarian carcinoma cell lines of a new platinum(II) compound containing a fluorescent substituted propylene diamine ligand

Biochemical Pharmacology

Volumn 78, Issue 4, 2009, Pages 365-373

  Marqués Gallego, Patricia ^a   den Dulk, Hans ^a   Brouwer, Jaap ^a   Tanase, Stefania ^a   Mutikainen, Ilpo ^b   Turpeinen, Urho ^b   Reedijk, Jan ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Cytotoxic activity; Fluorescence microscopy; Glutathione; Nucleobases; Platinum resistance

Indexed keywords

CISPLATIN; CYTOTOXIC AGENT; DNA; GLUTATHIONE; PLATINUM DERIVATIVE; PLATINUM N,N' BIS(ANTHRACEN 9 YLMETHYL)PROPANE 1,3 DIAMINE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BASE PAIRING; CALF (BOVINE); CANCER CELL CULTURE; CELL NUCLEUS; CONTROLLED STUDY; CROSS RESISTANCE; CYTOTOXICITY; DRUG DESIGN; DRUG DISTRIBUTION; DRUG DNA INTERACTION; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; FLUORESCENCE ANALYSIS; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; IN VITRO STUDY; INCUBATION TIME; INTERCALATION COMPLEX; LYSOSOME; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OVARY CARCINOMA; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; THYMUS;

ALKENES; CISPLATIN; CRYSTALLOGRAPHY, X-RAY; DIAMINES; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; FLUORESCENCE; HUMANS; OVARIAN NEOPLASMS; PHOTOCHEMICAL PROCESSES; PLATINUM; TUMOR CELLS, CULTURED;

EID: 67349271738     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2009.04.027     Document Type: Article

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