Exploring the genetic link between RLS and ADHD

Journal of Psychiatric Research

Volumn 43, Issue 10, 2009, Pages 941-945

  Schimmelmann, B G ^a   Friedel, S ^a   Nguyen, T T ^b   Sauer, S ^c   Vogel, C I Ganz ^a   Konrad, K ^d   Wilhelm, C ^d   Sinzig, J ^e   Renner, T J ^f   Romanos, M ^f   Palmason, H ^h   Dempfle, A ^b   Walitza, S ^f,g   Freitag, C ⁱ   Meyer, J ^h   Linder, M ^j   Schafer H ^b   Warnke, A ^f   Lesch, K P ^f   Herpertz Dahlman, B ^d   Hinney, A ^a   Hebebrand, J ^a   more..

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

^c MAX PLANCK INSTITUTE FOR MOLECULAR GENETICS   (Germany)

^d RWTH AACHEN UNIVERSITY   (Germany)

^e UNIVERSITY OF COLOGNE   (Germany)

^f UNIVERSITY OF WÜRZBURG   (Germany)

^g UNIVERSITY OF ZURICH   (Switzerland)

^h UNIVERSITY OF TRIER   (Germany)

ⁱ SAARLAND UNIVERSITY   (Germany)

^j Bezirksklinik Regensburg ^*  (Germany)

more..

Author keywords

Attention deficit hyperactivity disorder; Genome wide association study; RLS

Indexed keywords

IRON;

ALLELE; ARTICLE; ATTENTION DEFICIT DISORDER; CHILD; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DISEASE ASSOCIATION; FAMILY; FEMALE; GENETIC HETEROGENEITY; GENETIC LINKAGE; GENOME; GENOTYPE; GERMANY; HAPLOTYPE; HUMAN; MALE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RESTLESS LEGS SYNDROME; SIBLING; SINGLE NUCLEOTIDE POLYMORPHISM;

ADOLESCENT; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; CHILD; FAMILY HEALTH; FEMALE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HOMEODOMAIN PROTEINS; HUMANS; MALE; MAP KINASE KINASE 5; NEOPLASM PROTEINS; POLYMORPHISM, SINGLE NUCLEOTIDE; RESTLESS LEGS SYNDROME; TRANSCRIPTION FACTORS;

EID: 67349258896     PISSN: 00223956     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpsychires.2009.01.003     Document Type: Article

References (36)

1. Allen R.P., and Earley C.J. Restless legs syndrome: a review of clinical and pathophysiologic features. Clinical Neurophysiology 18 2 (2001) 128-147
2. Allen Institute for Brain Science. Allen Brain Atlas. 2004.
3. Allen R.P., Walters A.S., Montplaisir J., Hening W., Myers A., Bell T.J., et al. Restless legs syndrome prevalence and impact: REST general population study. Archives of Internal Medicine 165 11 (2005) 1286-1292
4. Albayrak O., Friedel S., Schimmelmann B.G., Hinney A., and Hebebrand J. Genetic aspects in attention-deficit/hyperactivity disorder. Journal of Neural Transmission 115 2 (2008) 305-315
5. American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 4th ed. Washington, DC: American Psychiatric Association; 1994.
6. Cavanaugh J.E., Jaumotte J.D., Lakoski J.M., and Zigmond M.J. Neuroprotective role of ERK1/2 and ERK5 in a dopaminergic cell line under basal conditions and in response to oxidative stress. Journal of Neuroscience Research 84 6 (2006) 1367-1375
7. Cortese S., Konofal E., Lecendreux M., Arnulf I., Mouren M.C., Darra F., et al. Restless legs syndrome and attention-deficit/hyperactivity disorder: a review of the literature. Sleep 28 8 (2005) 1007-1013
8. Cortese S., Lecendreux M., Bernardina B.D., Mouren M.C., Sbarbati A., and Konofal E. Attention-deficit/hyperactivity disorder, tourette's syndrome, and restless legs syndrome: the iron hypothesis. Medical Hypotheses 70 6 (2008) 1128-1132
9. Desai A.V., Cherkas L.F., Spector T.D., and Williams A.J. Genetic influences in self-reported symptoms of obstructive sleep apnoea and restless legs: a twin study. Twin Research 7 6 (2004) 589-595
10. Dudbridge F. Likelihood-based association analysis for nuclear families and unrelated subjects with missing genotype data. Human Heredity 66 (2008) 87-98
11. Erickson K.M., Jones B.C., and Hess E.J. Iron deficiency decreases dopamine D1 and D2 receptors in rat brain. Pharmacology Biochemistry Behaviour 69 (2001) 409-418
12. Faraone S.V., and Biederman J. Neurobiology of attention-deficit hyperactivity disorder. Biological Psychiatry 44 10 (1998) 951-958
13. Friedel S., Saar K., Sauer S., Dempfle A., Walitza S., Renner T., et al. Association and linkage of allelic variants of the dopamine transporter gene in ADHD. Molecular Psychiatry 12 10 (2007) 923-933
14. Gross M.K., Dottori M., and Goulding M. Lbx1 specifies somatosensory association interneurons in the dorsal spinal cord. Neuron 34 (2002) 535-549
15. Hoban T.F., and Chervin R.D. Pediatric sleep-related breathing disorders and restless legs syndrome: how children are different. Neurologist 11 6 (2005) 325-337
16. Konofal E., Cortese S., Marchand M., Mouren M.C., Arnulf I., and Lecendreux M. Impact of restless legs syndrome and iron deficiency on attention-deficit/hyperactivity disorder in children. Sleep Medicine 8 7-8 (2007) 693-694
17. Konofal E., Lecendreux M., Deron J., Marchand M., Cortese S., Zaim M., et al. Effects of iron supplementation on attention deficit hyperactivity disorder in children. Pediatric Neurology 38 1 (2008) 20-26
18. Li D., Sham P.C., Owen M.J., and He L. Meta-analysis shows significant association between dopamine system genes and attention deficit hyperactivity disorder (ADHD). Human Molecular Genetics 15 14 (2006) 2276-2284
19. Maeda R., Mood K., Jones T.L., Aruga J., Buchberg A.M., and Daar I.O. Xme is 1, a protooncogene involved in specifying neural crest cell fate in Xenopus embryos. Oncogene 20 11 (2001) 1329-1342
20. Martin E.R., Monks S.A., Warren L.L., and Kaplan N.L. A test for linkage and association in general pedigrees: the pedigree disequilibrium test. American Journal of Human Genetics 67 (2000) 146-154
21. Milligan S.A., and Chesson A.L. Restless legs syndrome in the older adult: diagnosis and management. Drugs Aging 19 10 (2002) 741-751
22. O'Connell J.R., and Weeks D.E. Pedcheck: a program for identification of genotype incompatibilities in linkage analysis. American Journal of Human Genetics 63 (1998) 259-266
23. Oner P., Dirik E.B., Taner Y., Caykoylu A., and Anlar O. Association between low serum ferritin and restless legs syndrome in patients with attention deficit hyperactivity disorder. Tohoku Journal of Expert Medicine 213 3 (2007) 269-276
24. Oner P., and Oner O. Relationship of ferritin to symptom ratings children with attention deficit hyperactivity disorder: effect of comorbidity. Child Psychiatry and Human Development 39 3 (2008) 323-330
25. Oner O., Alkar O.Y., and Oner P. Relation of ferritin levels with symptom ratings and cognitive performance in children with attention deficit-hyperactivity disorder. Pediatrics International 50 1 (2008) 40-44
26. Picchietti DL, Stevens HE. Early manifestations of restless legs syndrome in childhood and adolescence. Sleep Medicine 2007;[ Epub ahead of print Nov. 15].
27. Sauer S., Reinhardt R., Lehrach H., and Gut I.G. Single-nucleotide polymorphisms: analysis by mass spectrometry. Nature Protocols 1 4 (2006) 1761-1771
28. Schimmelmann B.G., Friedel S., Dempfle A., Warnke A., Lesch K.P., Walitza S., et al. No evidence for preferential transmission of common valine allele of the val66met polymorphism of the brain-derived neurotrophic factor gene (BDNF) in ADHD. Journal of Neural Transmission 114 4 (2007) 523-526
29. Schormair B., Kemlink D., Roeske D., Eckstein G., Xiong L., Lichtner P., et al. PTPRD (protein tyrosine phosphatase receptor type delta) is associated with restless legs syndrome. Nature Genetics 40 (2008) 946-948
30. Stefansson H., Rye D.B., Hicks A., Petursson H., Ingason A., Thorgeirsson T.E., et al. A genetic risk factor for periodic limb movements in sleep. New England Journal of Medicine 357 7 (2007) 639-647
31. Swanson J.M., Sergeant J.A., Taylor E., Sonuga-Barke E.J., Jensen P.S., and Cantwell D.P. Attention-deficit hyperactivity disorder and hyperkinetic disorder. Lancet 351 9100 (1998) 429-433
32. Swanson J.M., Kinsbourne M., Nigg J., Lanphear B., Stefanatos G.A., Volkow N., et al. Etiologic subtypes of attention-deficit/hyperactivity disorder: brain imaging, molecular genetic and environmental factors and the dopamine hypothesis. Neuropsychology Reviews 17 1 (2007) 39-59
33. Trotti L.M., Bhadriraju S., and Rye D.B. An update of the pathophysiology and genetics of restless legs syndrome. Current Neurology and Neuroscience Reports 8 4 (2008) 281-287
34. Wagner M.L., Walters A.S., and Fisher B.C. Symptoms of attention-deficit/hyperactivity disorder in adults with restless legs syndrome. Sleep 27 8 (2004) 1499-1504
35. Winkelmann J., Schormair B., Lichtner P., Ripke S., Xiong L., Jalilzadeh S., Fulda S., Pütz B., Eckstein G., Hauk S., Trenkwalder C., Zimprich A., Stiasny-Kolster K., Oertel W., Bachmann C.G., Paulus W., Peglau I., Eisensehr I., Montplaisir J., Turecki G., Rouleau G., Gieger C., Illig T., Wichmann H.E., Holsboer F., Müller-Myhsok B., and Meitinger T. Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions. Nature Genetics 39 8 (2007) 1000-1006
36. Yang B., Chan R.C., Jing J., Li T., Sham P., and Chen R.Y. A meta-analysis of association studies between the 10-repeat allele of a VNTR polymorphism in the 3́UTR of dopamine transporter gene and attention deficit hyperactivity disorder. American Journal of Medical Genetics Part B 144B (2007) 541-550