Expression of porcine Toll-like receptor 2, 4 and 9 gene transcripts in the presence of lipopolysaccharide and Salmonella enterica serovars Typhimurium and Choleraesuis

Veterinary Immunology and Immunopathology

Volumn 130, Issue 1-2, 2009, Pages 96-101

  Burkey, T E ^a   Skjolaas, K A ^b   Dritz, S S ^b   Minton, J E ^b  

^a UNIVERSITY OF NEBRASKA LINCOLN   (United States)

^b KANSAS STATE UNIVERSITY   (United States)

Author keywords

Salmonella enterica; Swine; Toll like receptors

Indexed keywords

LIPOPOLYSACCHARIDE; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 9;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL SALMONELLOSIS; ARTICLE; BACTERIAL IMMUNITY; CONTROLLED STUDY; GENE EXPRESSION; GENETIC TRANSCRIPTION; ILEUM; IMMUNOGENETICS; IN VITRO STUDY; IN VIVO STUDY; INTESTINE EPITHELIUM CELL; JEJUNUM MUCOSA; MONONUCLEAR PHAGOCYTE; NEWBORN; NONHUMAN; SALMONELLA CHOLERAESUIS; SALMONELLA TYPHIMURIUM; SWINE;

ANIMALS; ANIMALS, NEWBORN; CELL LINE; EPITHELIAL CELLS; GASTROINTESTINAL DISEASES; GENE EXPRESSION PROFILING; ILEUM; LIPOPOLYSACCHARIDES; MALE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SALMONELLA INFECTIONS, ANIMAL; SALMONELLA TYPHIMURIUM; SWINE; SWINE DISEASES; TOLL-LIKE RECEPTORS;

ANIMALIA; SALMONELLA ENTERICA; SALMONELLA ENTERICA SUBSP. ENTERICA SEROVAR TYPHIMURIUM; SUIDAE; SUS;

EID: 67349243869     PISSN: 01652427     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vetimm.2008.12.027     Document Type: Article

References (50)

1. Abreu M.T., Thomas L.S., Arnold E.T., Lukasek K., Michelsen K.S., and Arditi M. TLR signaling at the intestinal epithelial interface. J. Endotoxin. Res. 9 (2003) 322-330
2. Abreu M.T., Vora P., Faure E., Thomas L.S., Arnold E.T., and Arditi M. Decreased expression of Toll-like receptor-4 and MD-2 correlates with intestinal epithelial cell protection against dysregulated proinflammatory gene expression in response to bacterial lipopolysaccharide. J. Immunol. 167 (2001) 1609-1616
3. Akira S., and Takeda K. Toll-like receptor signalling. Nat. Rev. Immunol. 4 (2004) 499-511
4. Alvarez B., Revilla C., Chamorro S., Lopez-Fraga M., Alonso F., Dominguez J., and Ezquerra A. Molecular cloning, characterization and tissue expression of porcine Toll-like receptor 4. Dev. Comp. Immunol. 30 (2006) 345-355
5. Balaji R., Wright K.J., Hill C.M., Dritz S.S., Knoppel E.L., and Minton J.E. Acute phase responses of pigs challenged orally with Salmonella typhimurium. J. Anim. Sci. 78 (2000) 1885-1891
6. Barton G.M., and Medzhitov R. Toll-like receptors and their ligands. Curr. Top. Microbiol. Immunol. 270 (2002) 81-92
7. Bogunovic M.S., Reka S., Evans K.N., Mayer L.F., Sperber K., and Plevy S.E. Functional Toll-like receptors (TLR) are expressed on intestinal epithelial cells (IEC). Gastroenterology 118 (2000) A804
8. Burkey T.E., Dritz S.S., Nietfeld J.C., Johnson B.J., and Minton J.E. Effect of dietary mannanoligosaccharide and sodium chlorate on the growth performance, acute-phase response, and bacterial shedding of weaned pigs challenged with Salmonella enterica serotype Typhimurium. J. Anim. Sci. 82 (2004) 397-404
9. Burkey T.E., Skjolaas K.A., Dritz S.S., and Minton J.E. Expression of Toll-like receptors, interleukin 8, macrophage migration inhibitory factor, and osteopontin in tissues from pigs challenged with Salmonella enterica serovar Typhimurium or serovar Choleraesuis. Vet. Immunol. Immunopathol. 115 (2007) 309-319
10. Callaway T.R., Edrington T.S., Anderson R.C., Byrd J.A., and Nisbet D.J. Gastrointestinal microbial ecology and the safety of our food supply as related to Salmonella. J. Anim. Sci. 86 (2008) E163-E172
11. Cario E., Rosenberg I.M., Brandwein S.L., Beck P.L., Reinecker H.C., and Podolsky D.K. Lipopolysaccharide activates distinct signaling pathways in intestinal epithelial cell lines expressing Toll-like receptors. J. Immunol. 164 (2000) 966-972
12. Cho W.S., and Chae C. Expression of inflammatory cytokines (TNF-alpha, IL-1, IL-6 and IL-8) in colon of pigs naturally infected with Salmonella typhimurium and S. choleraesuis. J. Vet. Med. A 50 (2003) 484-487
13. Fraser J.N., Davis B.L., Skjolaas-Wilson K., Burkey T.E., Dritz S.S., Johnson B.J., and Minton J.E. Effects of feeding Salmonella enterica serovar Typhimurium or serovar Choleraesuis on growth performance and circulating insulin-like growth factor-I, tumor necrosis factor-alpha, and interleukin-1beta in weaned pigs. J. Anim. Sci. 85 (2007) 1161-1167
14. Gewirtz A.T., Siber A.M., Madara J.L., and McCormick B.A. Orchestration of neutrophil movement by intestinal epithelial cells in response to Salmonella typhimurium can be uncoupled from bacterial internalization. Infect. Immun. 67 (1999) 608-617
15. Ghosh S., May M.J., and Kopp E.B. NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. Annu. Rev. Immunol. 16 (1998) 225-260
16. Goff W.L., Johnson W.C., Wyatt C.R., and Cluff C.W. Assessment of bovine mononuclear phagocytes and neutrophils for induced l-arginine-dependent nitric oxide production. Vet. Immunol. Immunopathol. 55 (1996) 45-62
17. Hemmi H., Takeuchi O., Kawai T., Kaisho T., Sato S., Sanjo H., Matsumoto M., Hoshino K., Wagner H., Takeda K., and Akira S. A Toll-like receptor recognizes bacterial DNA. Nature 408 (2000) 740-745
18. Hoshino K., Takeuchi O., Kawai T., Sanjo H., Ogawa T., Takeda Y., Takeda K., and Akira S. Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J. Immunol. 162 (1999) 3749-3752
19. Hyland K.A., Brown D.R., and Murtaugh M.P. Salmonella enterica serovar Choleraesuis infection of the porcine jejunal Peyer's patch rapidly induces IL-1β and IL-8 expression. Vet. Immunol. Immunopathol. 109 (2006) 1-11
20. Hyland K.A., Kohrt L., Vulchanova L., and Murtaugh M.P. Mucosal innate immune response to intragastric infection by Salmonella enterica serovar Choleraesuis. Vet. Immunol. Immunopathol. 43 (2006) 1890-1899
21. Jenkins N.L., Turner J.L., Dritz S.S., Durham S.K., and Minton J.E. Changes in circulating insulin-like growth factor-I, insulin-like growth factor binding proteins, and leptin in weaned pigs infected with Salmonella enterica serovar Typhimurium. Domest. Anim. Endocrinol. 26 (2004) 49-60
22. Jiang Z., Georgel P., Du X., Shamel L., Sovath S., Mudd S., Huber M., Kalis C., Keck S., Glanos C., Freudenber M., and Beutler B. CD14 is required for MyD88-independent LPS signaling. Nat. Immunol. 6 (2005) 565-570
23. Medzhitov R. Toll-like receptors and innate immunity. Nat. Rev. Immunol. 1 (2001) 135-145
24. Medzhitov R., Preston-Hurlburt P., and Janeway Jr. C.A. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388 (1997) 394-397
25. Muneta Y., Uenishi H., Kikuma R., Yoshihara K., Shimoji Y., Yamamoto R., Hamashima N., Yokomizo Y., and Mori Y. Porcine TLR2 and TLR6: identification and their involvement in Mycoplasma hyopneumoniae infection. J. Interferon Cytokine Res. 23 (2003) 583-590
26. Nishi S.M., Dawson H.D., Kuhar D.J., Dubey J.P., Urban Jr. J.F., and Lunney J.K. Up-regulation of inflammatory, regulatory and Th1-immune markers in swine responding to acute Toxoplasma gondii infection. Proceedings of the American Association of Veterinary Parasitologists, 50th Annual Meeting. 15-18 July 2005 Abstract No. 10 (2005)
27. Otte J.M., Cario E., and Podolsky D.K. Mechanisms of cross hyporesponsiveness to Toll-like receptor bacterial ligands in intestinal epithelial cells. Gastroenterology 126 (2004) 1054-1070
28. Ozato K., Tsujimura H., and Tamura T. Toll-like receptor signaling and regulation of cytokine gene expression in the immune system. Biotechniques Suppl. (2002) 66-68 70, 72, passim
29. Philpott D.J., Girardin S.E., and Sansonetti P.J. Innate immune responses of epithelial cells following infection with bacterial pathogens. Curr. Opin. Immunol. 13 (2001) 410-416
30. Pugin J., Schurer-Maly C.C., Leturcq D., Moriarty A., Ulevitch R.J., and Tobias P.S. Lipopolysaccharide activation of human endothelial and epithelial cells is mediated by lipopolysaccharide-binding protein and soluble CD14. Proc. Natl. Acad. Sci. U.S.A. 90 (1993) 2744-2748
31. Raymond C.R., and Wilkie B.N. Toll-like receptor, MHC II, B7 and cytokine expression by porcine monocytes and monocyte-derived dendritic cells in response to microbial pathogen-associated molecular patterns. Vet. Immunol. Immunopathol. 107 (2005) 235-247
32. + exchange in porcine jejunal enterocytes. Am. J. Physiol. 266 (1994) G828-G838
33. Schierack P., Nordhoff M., Pollmann M., Weyrauch K.D., Amasheh S., Lodemann U., Jores J., Tachu B., Kleta S., Blikslager A., Tedin K., and Wieler L.H. Characterization of a porcine intestinal epithelial cell line for in vitro studies of microbial pathogenesis in swine. Histochem. Cell Biol. 125 (2005) 293-305
34. Schwandner R., Dziarski R., Wesche H., Rothe M., and Kirschning C.J. Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2. J. Biol. Chem. 274 (1999) 17406-17409
35. Shimazu R., Akashi S., Ogata H., Nagai Y., Fukudome K., Miyake K., and Kimoto M. MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. J. Exp. Med. 189 (1999) 1777-1782
36. Shimosato T., Kitazawa H., Katoh S., Tomioka Y., Karima R., Ueha S., Kawai Y., Hishinuma T., Matsushima K., and Saito T. Swine Toll-like receptor 9(1) recognizes CpG motifs of human cell stimulant. Biochim. Biophys. Acta 1627 (2003) 56-61
37. Shimosato T., Tohno M., Kitazawa H., Katoh S., Watanabe K., Kawai Y., Aso H., Yamaguchi T., and Saito T. Toll-like receptor 9 is expressed on follicle-associated epithelia containing M cells in swine Peyer's patches. Immunol. Lett. 98 (2005) 83-89
38. Suzuki M., Hisamatsu T., and Podolsky D.K. Gamma interferon augments the intracellular pathway for lipopolysaccharide (LPS) recognition in human intestinal epithelial cells through coordinated up-regulation of LPS uptake and expression of the intracellular Toll-like receptor 4-MD-2 complex. Infect. Immun. 71 (2003) 3503-3511
39. Skjolaas K.A., Burkey T.E., Dritz S.S., and Minton J.E. Effects of Salmonella enterica serovars Typhimurium (ST) and Choleraesusis (SC) on chemokine and cytokine expression in swine ileum and jejunal epithelial cells. Vet. Immunol. Immunopathol. 111 (2006) 199-209
40. Skjolaas K.A., Burkey T.E., Dritz S.S., and Minton J.E. Effects of Salmonella enterica serovar Typhimurium, or serovar Choleraesuis, Lactobacillus reuteri and Bacillus licheniformis on chemokine and cytokine expression in the swine jejunal epithelial cell line, IPEC-J2. Vet. Immunol. Immunopathol. 115 (2007) 299-308
41. Splichal I., Trebichavsky I., Muneta Y., and Mori Y. Early cytokine response of gnotobiotic piglets to Salmonella enterica serotype Typhimurium. Vet. Res. 33 (2002) 197-291
42. Takeda K., and Akira S. Toll receptors and pathogen resistance. Cell Microbiol. 5 (2003) 143-153
43. Thomas A.V., Broers A.D., Vandegaart H.F., and Desmecht D.J. Genomic structure, promoter analysis and expression of the porcine (Sus scrofa) TLR4 gene. Mol. Immunol. 43 (2006) 653-659
44. Tohno M., Shimosato T., Kitazawa H., Katoh S., Iliev I.D., Kimura T., Kawai Y., Watanabe K., Aso H., Yamaguchi T., and Saito T. Toll-like receptor 2 is expressed on the intestinal M cells in swine. Biochem. Biophys. Res. Commun. 330 (2005) 547-554
45. Tötemeyer S., Foster N., Kaiser P., Maskell D.J., and Bryant C.E. Toll-like receptor expression in C3H/HeN and C3H/HeJ mice during Salmonella enterica serovar Typhimurium infection. Infect. Immun. 71 (2003) 6653-6657
46. Turner J.L., Dritz S.S., Higgins J.J., Herkelman K.L., and Minton J.E. Effects of a Quillaja saponaria extract on growth performance and immune function of weanling pigs challenged with Salmonella typhimurium. J. Anim. Sci. 80 (2002) 1939-1946
47. Turner J.L., Dritz S.S., Higgins J.J., and Minton J.E. Effects of Ascophyllum nodosum extract on growth performance and immune function of young pigs challenged with Salmonella typhimurium. J. Anim. Sci. 80 (2002) 1947-1953
48. Uenishi, H., Shinkai, H. Porcine Toll-like receptors: the front line of pathogen monitoring and possible implications for disease resistance. Dev. Comp. Immunol., in press.
49. Watson P.R., Paulin S.M., Jones P.W., and Wallis T.S. Interaction of Salmonella serotypes with porcine macrophages in vitro does not correlate with virulence. Microbiology 146 (2000) 1639-1649
50. Werling D., and Jungi T.W. TOLL-like receptors linking innate and adaptive immune response. Vet. Immunol. Immunopathol. 91 (2003) 1-12