Pig-major acute phase protein and haptoglobin serum concentrations correlate with PCV2 viremia and the clinical course of postweaning multisystemic wasting syndrome

Veterinary Microbiology

Volumn 138, Issue 1-2, 2009, Pages 53-61

  Grau Roma, L ^a,b   Heegaard, P M H ^c   Hjulsager, C K ^c   Sibila, M ^a   Kristensen, C S ^d   Allepuz, A ^a,b   Pineiro M ^e   Larsen, L E ^c   Segales J ^a,b   Fraile, L ^a,f  

^a CENTRE DE RECERCA EN SANITAT ANIMAL CRESA   (Spain)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^c TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^d Fed Danish Pig Producers S   (Denmark)

^e PigCHAMP Pro Europa   (Spain)

^f IRTA   (Spain)

Author keywords

Acute phase proteins (APPs); Acute phase reaction (APR); Haptoglobin; Pig major acute phase protein (pig MAP); Porcine circovirus type 2 (PCV2); Postweaning multisystemic wasting syndrome (PMWS)

Indexed keywords

ACUTE PHASE PROTEIN; HAPTOGLOBIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CIRCOVIRIDAE; CONTROLLED STUDY; DISEASE COURSE; EPIDEMIC; NONHUMAN; POLYMERASE CHAIN REACTION; POSTWEANING MULTISYSTEMIC WASTING SYNDROME; PROGNOSIS; PROTEIN BLOOD LEVEL; RECEIVER OPERATING CHARACTERISTIC; SENSITIVITY AND SPECIFICITY; SWINE; VIREMIA;

ACUTE-PHASE PROTEINS; ANIMALS; CIRCOVIRUS; HAPTOGLOBINS; MYCOPLASMA HYOPNEUMONIAE; POLYMERASE CHAIN REACTION; PORCINE POSTWEANING MULTISYSTEMIC WASTING SYNDROME; SWINE; SWINE DISEASES; VIREMIA;

PORCINE CIRCOVIRUS 2; SUIDAE;

EID: 67349235494     PISSN: 03781135     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vetmic.2009.03.005     Document Type: Article

References (33)

1. Asai T., Mori M., Okada M., Uruno K., Yazawa S., and Shibata I. Elevated serum haptoglobin in pigs infected with porcine reproductive and respiratory syndrome virus. Vet. Immunol. Immunopathol. 70 (1999) 143-148
2. Baumann H., and Gauldie J. The acute phase response. Immunol. Today 15 (1994) 74-80
3. Boesen H.T., Jensen T.K., Moller K., Nielsen L.H., and Jungersen G. Evaluation of a novel enzyme-linked immunosorbent assay for serological diagnosis of porcine proliferative enteropathy. Vet. Microbiol. 109 (2005) 105-112
4. Brunborg I.M., Moldal T., and Jonassen C.M. Quantitation of porcine circovirus type 2 isolated from serum/plasma and tissue samples of healthy pigs and pigs with postweaning multisystemic wasting syndrome using a TaqMan-based real-time PCR. J. Virol. Methods 122 (2004) 171-178
5. Calsamiglia M., Pijoan C., and Trigo A. Application of a nested polymerase chain reaction assay to detect Mycoplasma hyopneumoniae from nasal swabs. J. Vet. Diagn. Invest. 11 (1999) 246-251
6. Ellis J., Clark E., Haines D., West K., Krakowka S., Kennedy S., and Allan G.M. Porcine circovirus-2 and concurrent infections in the field. Vet. Microbiol. 98 (2004) 159-163
7. Ghebremariam M.K., and Gruys E. Postweaning multisystemic wasting syndrome (PMWS) in pigs with particular emphasis on the causative agent, the mode of transmission, the diagnostic tools and the control measures. A review. Vet. Q. 27 (2005) 105-116
8. Grau-Roma L., Hjulsager C.H., Sibila M., Kristensen C.S., López-Soria S., Enøe C., Casal J., Bøtner A., Nofrarías M., Bille-Hansen V., Fraile L., Baekbo P., Segalés J., and Larsen E.L. Infection, excretion and seroconversion dynamics of porcine circovirus type 2 (PCV2) in pigs from postweaning multisystemic wasting syndrome (PMWS) affected farms in Spain and Denmark. Vet. Microbiol. 135 (2009) 272-282
9. Gruys E., Toussaint M.J., Niewold T.A., and Koopmans S.J. Acute phase reaction and acute phase proteins. J. Zhejiang Univ. Sci. B 6 (2005) 1045-1056
10. Gruys E., Toussaint M.J., Upragarin N., Van E.A., Adewuyi A.A., Candiani D., Nguyen T.K., and Sabeckiene J. Acute phase reactants, challenge in the near future of animal production and veterinary medicine. J. Zhejiang Univ. Sci. B 6 (2005) 941-947
11. Harding J.C. The clinical expression and emergence of porcine circovirus 2. Vet. Microbiol. 98 (2004) 131-135
12. Harding J.C.E. Recognizing and diagnosing porcine multisystemic wasting syndrome (PMWS). J. Swine Health Prod. 5 (1997) 201-203
13. Hjulsager C.K., Grau-Roma L., Sibila M., Enoe C., Larsen L., and Segalés J. Inter-laboratory and inter-assay comparison on two real-time PCR techniques for quantification of PCV2 nucleic acid extracted from field samples. Vet. Microbiol. 133 1-2 (2009) 172-178
14. Jensen T.K., Vigre H., Svensmark B., and Bille-Hansen V. Distinction between porcine circovirus type 2 enteritis and porcine proliferative enteropathy caused by Lawsonia intracellularis. J. Comp. Pathol. 135 (2006) 176-182
15. Jungersen G., Jensen L., Riber U., Heegaard P.M., Petersen E., Poulsen J.S., Bille-Hansen V., and Lind P. Pathogenicity of selected Toxoplasma gondii isolates in young pigs. Int. J. Parasitol. 29 (1999) 1307-1319
16. Krakowka S., Ellis J., McNeilly F., Waldner C., and Allan G. Features of porcine circovirus-2 disease: correlations between lesions, amount and distribution of virus, and clinical outcome. J. Vet. Diagn. Invest. 17 (2005) 213-222
17. Madsen E.S., Madsen K.G., Nielsen J., Jensen M.H., Lei J.C., and Have P. Detection of antibodies against porcine parvovirus nonstructural protein NS1 may distinguish between vaccinated and infected pigs. Vet. Microbiol. 54 (1997) 1-16
18. Murata H., Shimada N., and Yoshioka M. Current research on acute phase proteins in veterinary diagnosis: an overview. Vet. J. 168 (2004) 28-40
19. Olvera A., Sibila M., Calsamiglia M., Segalés J., and Domingo M. Comparison of porcine circovirus type 2 load in serum quantified by a real time PCR in postweaning multisystemic wasting syndrome and porcine dermatitis and nephropathy syndrome naturally affected pigs. J. Virol. Methods 117 (2004) 75-80
20. Parra M.D., Fuentes P., Tecles F., Martínez-Subiela S., Martínez J.S., Munoz A., and Ceron J.J. Porcine acute phase protein concentrations in different diseases in field conditions. J. Vet. Med. B Infect. Dis. Vet. Public Health 53 (2006) 488-493
21. Petersen H.H., Nielsen J.P., and Heegaard P.M. Application of acute phase protein measurements in veterinary clinical chemistry. Vet. Res. 35 (2004) 163-187
22. Piñeiro C., Piñeiro M., Morales J., Andres M., Lorenzo E., Pozo M.D., Alava M.A., and Lampreave F. Pig-MAP and haptoglobin concentration reference values in swine from commercial farms. Vet. J. 179 (2009) 78-84
23. Piñeiro M., Lampreave F., and Alava M.A. Development and validation of an ELISA for the quantification of pig Major Acute-phase Protein (pig-MAP). Vet. Immunol. Immunopathol. 127 3-4 (2009) 228-234
24. Piñeiro M., Piñeiro C., Carpintero R., Morales J., Campbell F.M., Eckersall P.D., Toussaint M.J., and Lampreave F. Characterisation of the pig acute phase protein response to road transport. Vet. J. 173 (2007) 669-674
25. Rosell C., Segalés J., Plana-Duran J., Balasch M., Rodríguez-Arrioja G.M., Kennedy S., Allan G.M., McNeilly F., Latimer K.S., and Domingo M. Pathological, immunohistochemical, and in-situ hybridization studies of natural cases of postweaning multisystemic wasting syndrome (PMWS) in pigs. J. Comp. Pathol. 120 (1999) 59-78
26. Salamano G., Mellia E., Candiani D., Ingravalle F., Bruno R., Ru G., and Doglione L. Changes in haptoglobin, C-reactive protein and pig-MAP during a housing period following long distance transport in swine. Vet. J. 177 (2008) 110-115
27. Segalés J. Update on postweaning multisystemic wasting syndrome and porcine dermatitis and nephropathy syndrome diagnostics. J. Swine Health Prod. 10 (2002) 277-281
28. Segalés J., Piñeiro C., Lampreave F., Nofrarías M., Mateu E., Calsamiglia M., Andres M., Morales J., Piñeiro M., and Domingo M. Haptoglobin and pig-major acute protein are increased in pigs with postweaning multisystemic wasting syndrome (PMWS). Vet. Res. 35 (2004) 275-282
29. Segalés J., Allan G.M., and Domingo M. Porcine circovirus diseases. Anim. Health Res. Rev. 6 (2005) 119-142
30. Sitjar M., Noyes E.P., and Simon X. Relationships among seroconversion to Mycoplasma hyopneumoniae, lung lesions, and production parameters in pigs. J. Swine Health Prod. 4 (1996) 273-277
31. Sorden S.D. Update on porcine circovirus and postweaning multisystemic wasting syndrome. J. Swine Health Prod. 8 (2000) 133-136
32. Sørensen K.J., Strandbygaard B., Botner A., Madsen E.S., Nielsen J., and Have P. Blocking ELISA's for the distinction between antibodies against European and American strains of porcine reproductive and respiratory syndrome virus. Vet. Microbiol. 60 (1998) 169-177
33. Sørensen N.S., Tegtmeier C., Andresen L.O., Piñeiro M., Toussaint M.J., Campbell F.M., Lampreave F., and Heegaard P.M. The porcine acute phase protein response to acute clinical and subclinical experimental infection with Streptococcus suis. Vet. Immunol. Immunopathol. 113 (2006) 157-168