Inflammatory and thrombotic processes are associated with vascular dysfunction in children with familial hypercholesterolemia

Atherosclerosis

Volumn 204, Issue 2, 2009, Pages 532-537

  Charakida, Marietta ^a   Tousoulis, Dimitris ^a   Skoumas, Ioannis ^a   Pitsavos, Christos ^a   Vasiliadou, Carmen ^a   Stefanadi, Elli ^a   Antoniades, Charalambos ^a   Latsios, George ^a   Siasos, Gerasimos ^a   Stefanadis, Christodoulos ^a  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

Author keywords

Endothelium; Inflammation; Lipids; Thrombosis

Indexed keywords

C REACTIVE PROTEIN; CHOLESTEROL; FIBRINOGEN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1BETA; INTERLEUKIN 6; LOW DENSITY LIPOPROTEIN CHOLESTEROL; NITRATE; PLASMINOGEN ACTIVATOR INHIBITOR 1; TISSUE PLASMINOGEN ACTIVATOR; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1; VON WILLEBRAND FACTOR;

ADOLESCENT; ARM BLOOD FLOW; ARTICLE; CHILD; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOTHELIAL DYSFUNCTION; FAMILIAL HYPERCHOLESTEROLEMIA; FEMALE; FIBRINOLYSIS; HUMAN; HYPEREMIA; INFLAMMATION; LIPOPROTEIN BLOOD LEVEL; MALE; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SCHOOL CHILD; THROMBOSIS; VASCULAR ENDOTHELIUM; VASODILATATION; VASOMOTOR REFLEX;

ADOLESCENT; AGE FACTORS; BIOLOGICAL MARKERS; C-REACTIVE PROTEIN; CARDIOVASCULAR DISEASES; CASE-CONTROL STUDIES; CHOLESTEROL; ENDOTHELIUM, VASCULAR; FEMALE; HETEROZYGOTE; HUMANS; HYPEREMIA; HYPERLIPOPROTEINEMIA TYPE II; INFLAMMATION; INFLAMMATION MEDIATORS; INTERCELLULAR ADHESION MOLECULE-1; INTERLEUKIN-1BETA; INTERLEUKIN-6; LINEAR MODELS; LIPOPROTEINS; MALE; NITROGLYCERIN; PLASMINOGEN ACTIVATOR INHIBITOR 1; RISK ASSESSMENT; RISK FACTORS; THROMBOSIS; VASODILATION; VASODILATOR AGENTS;

EID: 67349235294     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2008.09.025     Document Type: Article

References (29)

1. Marks D., Thorogood M., Neil H.A., and Humphries S.E. A review on the diagnosis, natural history, and treatment of familial hypercholesterolaemia. Atherosclerosis 168 1 (2003) 1-14
2. Raitakari O.T. Arterial abnormalities in children with familial hypercholesterolaemia. Lancet 363 9406 (2004) 342-343
3. Wiegman A., De G.E., Hutten B.A., et al. Arterial intima-media thickness in children heterozygous for familial hypercholesterolaemia. Lancet 363 9406 (2004) 369-370
4. Celermajer D.S., Sorensen K.E., Gooch V.M., et al. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet 340 8828 (1992) 1111-1115
5. Smilde T.J., van W.S., Wollersheim H., Kastelein J.J., and Stalenhoef A.F. Genetic and metabolic factors predicting risk of cardiovascular disease in familial hypercholesterolemia. Neth J Med 59 4 (2001) 184-195
6. Napoli C., D'Armiento F.P., Mancini F.P., et al. Fatty streak formation occurs in human fetal aortas and is greatly enhanced by maternal hypercholesterolemia intimal accumulation of low density lipoprotein and its oxidation precede monocyte recruitment into early atherosclerotic lesions. J Clin Invest 100 11 (1997) 2680-2690
7. McGill Jr. H.C., McMahan C.A., Herderick E.E., et al. Obesity accelerates the progression of coronary atherosclerosis in young men. Circulation 105 23 (2002) 2712-2718
8. Antoniades C., Tousoulis D., Vasiliadou C., et al. Combined effects of smoking and hypercholesterolemia on inflammatory process, thrombosis/fibrinolysis system, and forearm hyperemic response. Am J Cardiol 94 9 (2004) 1181-1184
9. Tousoulis D., Antoniades C., Koumallos N., and Stefanadis C. Pro-inflammatory cytokines in acute coronary syndromes: from bench to bedside. Cytokine Growth Factor Rev 17 4 (2006) 225-233
10. Ueland T., Vissers M.N., Wiegman A., et al. Increased inflammatory markers in children with familial hypercholesterolaemia. Eur J Clin Invest 36 3 (2006) 147-152
11. Sebestjen M., Zegura B., Guzic-Salobir B., and Keber I. Fibrinolytic parameters and insulin resistance in young survivors of myocardial infarction with heterozygous familial hypercholesterolemia. Wien Klin Wochenschr 113 3-4 (2001) 113-118
12. Scientific Steering Committee on behalf of the Simon Broome Register Group. Risk of fatal coronary heart disease in familial hypercholesterolaemia. BMJ 303 6807 (1991) 893-896
13. Feron O., Dessy C., Moniotte S., Desager J.P., and Balligand J.L. Hypercholesterolemia decreases nitric oxide production by promoting the interaction of caveolin and endothelial nitric oxide synthase. J Clin Invest 103 6 (1999) 897-905
14. Cai H., and Harrison D.G. Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ Res 87 10 (2000) 840-844
15. Sorensen K.E., Celermajer D.S., Georgakopoulos D., Hatcher G., Betteridge D.J., and Deanfield J.E. Impairment of endothelium-dependent dilation is an early event in children with familial hypercholesterolemia and is related to the lipoprotein (a) level. J Clin Invest 93 1 (1994) 50-55
16. de J.S., Lilien M.R., Bakker H.D., Hutten B.A., Kastelein J.J., and Stroes E.S. Family history of cardiovascular events and endothelial dysfunction in children with familial hypercholesterolemia. Atherosclerosis 163 1 (2002) 193-197
17. Junyent M., Cofan M., Nunez I., Gilabert R., Zambon D., and Ros E. Influence of HDL cholesterol on preclinical carotid atherosclerosis in familial hypercholesterolemia. Arterioscler Thromb Vasc Biol 26 5 (2006) 1107-1113
18. Neil H.A., Seagroatt V., Betteridge D.J., et al. Established and emerging coronary risk factors in patients with heterozygous familial hypercholesterolaemia. Heart 90 12 (2004) 1431-1437
19. Ferrieres J., Lambert J., Lussier-Cacan S., and Davignon J. Coronary artery disease in heterozygous familial hypercholesterolemia patients with the same LDL receptor gene mutation. Circulation 92 3 (1995) 290-295
20. Tousoulis D., Charakida M., and Stefanadis C. Endothelial function and inflammation in coronary artery disease. Heart 92 4 (2006) 441-444
21. Vallance P., Collier J., and Bhagat K. Infection, inflammation, and infarction: does acute endothelial dysfunction provide a link?. Lancet 349 9062 (1997) 1391-1392
22. Verma S., Wang C.H., Li S.H., et al. A self-fulfilling prophecy: C-reactive protein attenuates nitric oxide production and inhibits angiogenesis. Circulation 106 8 (2002) 913-919
23. Tousoulis D., Davies G., Stefanadis C., Toutouzas P., and Ambrose J.A. Inflammatory and thrombotic mechanisms in coronary atherosclerosis. Heart 89 9 (2003) 993-997
24. Puccetti L., Bruni F., Pasqui A.L., et al. Dyslipidemias and fibrinolysis. Ital Heart J 3 10 (2002) 579-586
25. Amundsen A.L., Khoury J., Sandset P.M., et al. Altered hemostatic balance and endothelial activation in pregnant women with familial hypercholesterolemia. Thromb Res 120 1 (2007) 21-27
26. Di Minno G., Cerbone A.M., Cirillo F., et al. Hemostatic variables in homozygous familial hypercholesterolemia Effect of regular plasma cholesterol removal by low density lipoprotein apheresis. Arteriosclerosis 10 6 (1990) 1119-1126
27. Jarvisalo M.J., Lehtimaki T., and Raitakari O.T. Determinants of arterial nitrate-mediated dilatation in children: role of oxidized low-density lipoprotein, endothelial function, and carotid intima-media thickness. Circulation 109 23 (2004) 2885-2889
28. Laursen J.B., Mulsch A., Boesgaard S., et al. In vivo nitrate tolerance is not associated with reduced bioconversion of nitroglycerin to nitric oxide. Circulation 94 9 (1996) 2241-2247
29. Mulsch A., Oelze M., Kloss S., et al. Effects of in vivo nitroglycerin treatment on activity and expression of the guanylyl cyclase and cGMP-dependent protein kinase and their downstream target vasodilator-stimulated phosphoprotein in aorta. Circulation 103 17 (2001) 2188-2194