Prevalence of virulence-associated genotypes of helicobacter pylori and correlation with severity of gastric pathology in patients from western sicily, Italy

European Journal of Clinical Microbiology and Infectious Diseases

Volumn 28, Issue 5, 2009, Pages 437-446

  Chiarini, A ^a   Cala C ^a   Bonura, C ^a   Gullo, A ^a   Giuliana, G ^b   Peralta, S ^a   D'Arpa, F ^a   Giammanco, A ^a  

^a UNIVERSITY OF PALERMO   (Italy)

^b Azienda Ospedaliera OCR   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CAGA PROTEIN; GENOMIC DNA; OLIGONUCLEOTIDE; VACUOLATING TOXIN; VIRULENCE FACTOR;

ADULT; AGED; ALLELE; ARTICLE; BABA2 GENE; BACTERIAL GENE; DISEASE ASSOCIATION; DISEASE SEVERITY; GASTRITIS; GENE EXPRESSION; GENE FUNCTION; GENETIC CODE; GENOTYPE; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HOPQ GENE; HOPZ GENE; HUMAN; ISOLATION PROCEDURE; ITALY; MAJOR CLINICAL STUDY; NONHUMAN; OIPA GENE; OUTCOME ASSESSMENT; PEPTIC ULCER; POPULATION STRUCTURE; PREVALENCE; PRIORITY JOURNAL; SABA GENE; STOMACH BIOPSY; VIRULENCE;

ADULT; AGED; BACTERIAL PROTEINS; BIOPSY; GASTRIC MUCOSA; GASTRITIS; GENE EXPRESSION PROFILING; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; MIDDLE AGED; SICILY; VIRULENCE FACTORS;

EID: 67349232050     PISSN: 09349723     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10096-008-0644-x     Document Type: Article

References (51)

1. D Lamarque RM Peek Jr 2003 Pathogenesis of Helicobacter pylori infection Helicobacter 8 Suppl 1 21 30 (Pubitemid 37295401)
2. A Nomura GN Stemmermann PH Chyou GI Perez-Perez MJ Blaser 1994 Helicobacter pylori infection and the risk for duodenal and gastric ulceration Ann Intern Med 120 977 981 (Pubitemid 24169275)
3. N Ahmed 2005 23 years of the discovery of Helicobacter pylori: is the debate over? Ann Clin Microbiol Antimicrob 4 17
4. RM Peek Jr JE Crabtree 2006 Helicobacter infection and gastric neoplasia J Pathol 208 233 248 (Pubitemid 43126116)
5. LJ van Doorn C Figueiredo F Megraud AS Pena P Midolo DM Queiroz 1999 Geographic distribution of vacA allelic types of Helicobacter pylori Gastroenterology 116 823 830 (Pubitemid 29153530)
6. DI Campbell BF Warren JE Thomas N Figura JL Telford PB Sullivan 2001 The African enigma: low prevalence of gastric atrophy, high prevalence of chronic inflammation in West African adults and children Helicobacter 6 263 267 (Pubitemid 34015006)
7. D Rothenbacher MJ Blaser G Bode H Brenner 2000 Inverse relationship between gastric colonization of Helicobacter pylori and diarrheal illnesses in children: results of a population-based cross-sectional study J Infect Dis 182 1446 1449
8. JE Richter GW Folk MF Vaezi 1999 Helicobacter pylori and gastro-esophageal reflux disease: the bug may not be all bad Am J Gastroenterol 93 1800 1802
9. C de Martel AE Llosa SM Farr GD Friedman JH Vogelman N Orentreich 2005 Helicobacter pylori infection and the risk of development of esophageal adenocarcinoma J Infect Dis 191 761 767 (Pubitemid 40271067)
10. F Pakodi OME Abdel-Salam A Debreceni G Mózsik 2000 Helicobacter pylori. One bacterium and a broad spectrum of human disease! An overview J Physiol 94 139 152 (Pubitemid 30202867)
11. BC Wong SK Lam WM Wong JS Chen TT Zheng RE Feng 2004 Helicobacter pylori eradication to prevent gastric cancer in a high-risk region of China: a randomised controlled trial JAMA 291 187 194 (Pubitemid 38082812)
12. JC Atherton P Cao RMJ Peek MK Tummuru MJ Blaser TL Cover 1995 Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. Association of specific vacA types with cytotoxin production and peptic ulceration J Biol Chem 270 17771 17777
13. MJ Blaser GI Perez-Perez H Kleanthous TL Cover RM Peek PH Chyou 1995 Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach Cancer Res 55 2111 2115
14. JL Rhead DP Letley M Mohammadi N Hussein MA Mohagheghi M Eshagh Hosseini 2007 A new Helicobacter pylori vacuolating cytotoxin determinant, the intermediate region, is associated with gastric cancer Gastroenterology 133 926 936 (Pubitemid 47374139)
15. MSP Rodrigues MAM Ladeira DMF Salvadori P Padulla Neto P Achilles MM Lerco PA Rodrigues ĺ Gonçalves Jr DMM Queiroz DV Freire-Maia 2004 Relationships between cagA, vacA, and iceA genotypes of Helicobacter pylori and DNA damage in the gastric mucosa Environ Mol Mutagen 44 91 98 (Pubitemid 39063337)
16. M Gerhard N Lehn N Neumayer T Borén R Rad W Schepp 1999 Clinical relevance of the Helicobacter pylori gene for blood-group antigen-binding adhesion Proc Natl Acad Sci USA 96 12778 12783 (Pubitemid 29513579)
17. N Salama K Guillemin TK [tmp] McDaniel G Sherlock L Tompkins S Falkow 2000 A whole-genome microarray reveals genetic diversity among Helicobacter pylori strains Proc Natl Acad Sci USA 97 14668 14673 (Pubitemid 32016633)
18. J Mahdavi B Sondén M Hurtig FO Olfat L Forsberg N Roche 2002 Helicobacter pylori SabA adhesion in persistent infection and chronic inflammation Science 297 573 578 (Pubitemid 34815336)
19. R de Jonge RGJ Pot RJLF Loffeld AHM van Vliet EJ Kuipers JG Kusters 2004 The functional status of the Helicobacter pylori sabB adhesion gene as a putative marker for disease outcome Helicobacter 9 158 164 (Pubitemid 38506599)
20. C-F Zambon F Navaglia D Basso M Rugge M Plebani 2003 Helicobacter pylori babA2, cagA and s1 vacA genes work synergistically in causing intestinal metaplasia J Clin Pathol 56 287 291 (Pubitemid 36459799)
21. P Cao TL Cover 2002 Two different families of hopQ alleles in Helicobacter pylori J Clin Microbiol 40 4504 4511 (Pubitemid 35434938)
22. MF Go V Kapur DY Graham JM Musser 1996 Population genetic analysis of Helicobacter pylori by multilocus enzyme electrophoresis: extensive allelic diversity and recombinational population structure J Bacteriol 178 3934 3938 (Pubitemid 26227212)
23. ZJ Pan RW van der Hulst M Feller SD Xiao GN Tytgat J Dankert 1997 Equally high prevalences of infection with cagA positive Helicobacter pylori in Chinese patients with peptic ulcer disease and those with chronic gastritis associated dyspepsia J Clin Microbiol 35 1344 1377
24. ZJ Pan RW van der Hulst GN Tytgat J Dankert A van der Ende 1999 Relation between vacA subtypes, cytotoxin activity, and disease in Helicobacter pylori infected patients from the Netherlands Am J Gastroenterol 94 1517 1521 (Pubitemid 29260438)
25. PY Zheng J Hua KG Yeoh B Ho 2000 Association of peptic ulcer with increased expression of Lewis antigens but not cagA, iceA, and vacA in Helicobacter pylori isolates in an Asian population Gut 47 18 22
26. S Backert T Schwarz S Miehlke C Kirsch C Sommer T Kwok 2004 Functional analysis of the cag pathogenicity island in Helicobacter pylori isolates from patients with gastritis, peptic ulcer, and gastric cancer Infect Immun 72 1043 1056 (Pubitemid 38166687)
27. D Kersulyte AK Mukhopadhyay B Velapatino WW Su ZJ Pan C Garcia 2000 Differences in genotypes of Helicobacter pylori from different human populations J Bacteriol 182 3210 3218 (Pubitemid 30326938)
28. T Ando RM Peek D Pride 2002 Polymorphisms of Helicobacter pylori HP0638 reflect geographic origin and correlate with cagA status J Clin Microbiol 40 239 246 (Pubitemid 34027630)
29. S Datta S Chattopadhyay GB Nair AK Mukhopadhyay J Hembram DE Berg 2005 Virulence genes and neutral DNA markers of Helicobacter pylori isolates from different ethnic communities of West Bengal, India J Clin Microbiol 41 3737 3743 (Pubitemid 36994710)
30. JT Wang JT Lin JC Sheu JC Yang DS Chen TH Wang 1993 Detection of Helicobacter pylori in gastric biopsy tissue by polymerase chain reaction Eur J Clin Microbiol Infect Dis 12 367 371 (Pubitemid 23184853)
31. M Mravak-Stipetić K Gall-Trošelj J Lukač Z Kusić K Pavelić J Pavelić 1998 Detection of Helicobacter pylori in various oral lesions by nested polymerase chain reaction (PCR) J Oral Pathol Med 27 1 3 (Pubitemid 28059159)
32. MK Tummuru TL Cover MJ Blaser 1993 Cloning and expression of a high-molecular-mass major antigen of Helicobacter pylori: evidence of linkage to cytotoxin production Infect Immun 61 1799 1809 (Pubitemid 23145878)
33. B Peck M Ortkamp KD Diehl E Hundt B Knapp 1999 Conservation, localization and expression of HopZ, a protein involved in adhesion of Helicobacter pylori Nucleic Acids Res 27 3325 3333 (Pubitemid 29381326)
34. r 34,000 proinflammatory outer membrane protein (oipA) of Helicobacter pylori Proc Natl Acad Sci USA 97 7533 7538 (Pubitemid 30431498)
35. Y-H Gong Y Wang Y Yuan 2005 Distribution of Helicobacter pylori in north China World J Gastroenterol 11 3523 3527 (Pubitemid 40903505)
36. J Yu WK Leung MYY Go MCW Chan KF To EKW Ng 2002 Relationship between Helicobacter pylori babA2 status with gastric epithelial cell turnover and premalignant gastric lesions Gut 51 480 484
37. C Nogueira C Figueiredo F Carneiro A Taveira Gomes A Barriera P Figueira 2001 Helicobacter pylori genotypes may determine gastric histopathology Am J Pathol 158 647 654 (Pubitemid 32158625)
38. Y Erzin V Koksal S Altun A Dobrucali M Aslan S Erdamar 2006 Prevalence of Helicobacter pylori vacA, cagA, cagE, iceA, babA2 genotypes and correlation with clinical outcome in Turkish patients with dyspepsia Helicobacter 11 574 580 (Pubitemid 44674143)
39. R Mattar A Ferreira dos Santos J Natan Eisig T Navarro Rodrigues FM Silva R Micelli Lupinacci 2005 No correlation of babA2 with vacA and cagA genotypes of Helicobacter pylori and grading of gastritis from peptic ulcer disease patients in Brazil Helicobacter 10 601 608 (Pubitemid 41668345)
40. P Lehours A Ménard S Dupouy B Bergey F Richy F Zerbib 2004 Evaluation of the association of nine Helicobacter pylori virulence factors with strains involved in low-grade gastric mucosa-associated lymphoid tissue lymphoma Infect Immun 72 880 888 (Pubitemid 38166667)
41. A Al Quabandi AS Mustafa I Siddique AK Khajah JP Madda TA Junaid 2005 Distribution of vacA and cagA genotypes of Helicobacter pilori in Kuwait Acta Trop 93 283 288 (Pubitemid 40352537)
42. B-S Sheu S Odenbreit K-H Hung C-P Liu S-M Sheu H-B Yang 2006 Interaction between host gastric Sialyl-Lewis X and H. pylori Sab A enhances H. pylori density in patients lacking gastric Lewis B antigen Am J Gastroenterol 101 36 44 (Pubitemid 43381706)
43. HS Lee G Choe WH Kim J Song KU Park 2006 Expression of Lewis antigens and their precursors in gastric mucosa: relationship with Helicobacter pylori infection and gastric carcinogenesis J Pathol 209 88 94
44. TL Cover MK Tummuru P Cao SA Thompson MJ Blaser 1994 Divergence of genetic sequences for the vacuolating cytotoxin among Helicobacter pylori strains J Biol Chem 269 10566 10573 (Pubitemid 24198258)
45. C Figueiredo LJ van Doorn C Nogueira JM Soares C Pinho P Figueira 2001 Helicobacter pylori genotypes are associated with clinical outcome in Portuguese patients and show a high prevalence of infections with multiple strains Scand J Gastroenterol 36 128 135 (Pubitemid 32183422)
46. S Chattopadhyay S Datta A Chowdhury S Chowdhury AK Mukhopadhyay K Rajendran 2002 Virulence genes in Helicobacter pylori strains from West Bengal residents with overt H. pylori-associated disease and healthy volunteers J Clin Microbiol 40 2622 2625 (Pubitemid 34747374)
47. S Yamazaki A Yamakawa T Ohuda M Ohtani H Suto Y Ito 2005 Distinct diversity of vacA, cagA, and cagE genes of Helicobacter pylori associated with peptic ulcer in Japan J Clin Microbiol 43 3906 3916 (Pubitemid 41129680)
48. YH Han WZ Liu HY Zhu SD Xiao 2004 Clinical relevance of iceA and babA2 genotypes of Helicobacter pylori in a Shanghai population Chin J Dig Dis 5 181 185 (Pubitemid 40028571)
49. D Basso CF Zambon DP Letley A Stranges A Marchet JL Rhead 2008 Clinical relevance of Helicobacter pylori cagA and vacA gene polymorphisms Gastroenterology 135 91 99
50. Y Yamaoka S Kikuchi HM el-Zimaity O Gutierrez MS Osato DY Graham 2002 Importance of Helicobacter pylori oipA in clinical presentation, gastric inflammation, and mucosal interleukin 8 production Gastroenterology 123 414 424 (Pubitemid 34827185)
51. T Kudo ZZ Nurgalieva ME Conner S Crawford S Odenbreit R Haas 2004 Correlation between Helicobacter pylori OipA protein expression and oipA gene switch status J Clin Microbiol 42 2279 2281 (Pubitemid 38637865)