The n-hexane and chloroform fractions of Piper betle L. trigger different arms of immune responses in BALB/c mice and exhibit antifilarial activity against human lymphatic filarid Brugia malayi

International Immunopharmacology

Volumn 9, Issue 6, 2009, Pages 716-728

  Singh, Meghna ^a   Shakya, Shilpy ^a   Soni, Vishal Kumar ^a   Dangi, Anil ^a   Kumar, Nikhil ^b   Bhattacharya, Shailja Misra ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

^b CSIR NATIONAL BOTANICAL RESEARCH INSTITUTE   (India)

Author keywords

Antibody; Antifilarial activity; Brugia malayi; Flow cytometry; Immunomodulation; Piper betle; Th1 Th2 cytokines

Indexed keywords

BETEL EXTRACT; CD19 ANTIGEN; CHLOROFORM; GAMMA INTERFERON; INTERLEUKIN 4; METHANOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMALARIAL ACTIVITY; ARTICLE; B LYMPHOCYTE; BRUGIA MALAYI; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG ISOLATION; FEMALE; FLOW CYTOMETRY; HELPER CELL; IMMUNOSTIMULATION; MALE; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; SPLEEN CELL;

ANIMALS; ANTIBODY FORMATION; B-LYMPHOCYTES; BRUGIA MALAYI; CHEMICAL FRACTIONATION; CHLOROFORM; CYTOKINES; FILARIASIS; HEXANES; IMMUNITY, CELLULAR; IMMUNOLOGIC FACTORS; MACROPHAGES; MICE; MICE, INBRED BALB C; NITRIC OXIDE; PIPER BETLE; PLANT EXTRACTS; REACTIVE OXYGEN SPECIES; T-LYMPHOCYTES;

EID: 67349229767     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2009.02.012     Document Type: Article

References (62)

1. Holland B.K. Prospecting for drugs in ancient texts. Nature 369 (1994) 702-705
2. Newman D.J., Cragg G.M., and Snader K.M. The influence of natural products upon drug discovery. Nat Prod Rep 17 (2000) 215-234
3. Ganju L., Karan D., Chanda Srivastava K.K., Sawhney R.C., and Selvamurthy W. Immunomodulatory effects of agents of plant origin. Biomed Pharmacother 57 (2003) 296-300
4. CSIR (Council of Scientific and Industrial Research, New Delhi). The Wealth of India vol. 8 (1969) 84-94
5. Guha P., and Jain R.K. Status Report on Production, Processing and Marketing of Betel Leaf (Piper betle L.) (1997), Agricultural and Food Engineering Department, IIT, Kharagpur, India
6. Norton S.A. Betel: consumption and consequences. J Am Acad Dermatol 38 (1998) 81-88
7. Nagabhushan M., Amonkar A.J., D'Souza A.V., and Bhide S.V. Nonmutagenicity of betel leaf and its antimutagenic action against environmental mutagens. Neoplasma 34 (1987) 159-167
8. Garg S.C., and Jain R. Biological activity of the essential oil of Piper betle L. J Essent Oil Res 4 (1992) 601-606
9. Ganguly M.S., Chattopadhyay S., Chatterjee S., and Mitali. An ethanol extract of Piper betle Linn. mediates its anti-inflammatory activity via down-regulation of nitric oxide. J Pharm Pharmacol 59 5 (2007) 711-718
10. Majumdar B., Chaudhuri S.R., Roy A., and Bandyopadhyay S.K. Potent anti-ulcerogenic activity of ethanol extract of leaf of Piper betle Linn. by anti-oxidative mechanism. Indian J Clin Biochem 17 (2002) 49-57
11. Bhattacharya S., Subramanian M., Roychowdhury S., Bauri A.K., Kamat J.P., Chattopadhyay S., et al. Radioprotective property of the ethanolic extract of Piper betel leaf. J Radiat Res 46 (2005) 165-171
12. Guha P. Betel leaf: the neglected green gold of India. J Hum Ecol 19 2 (2006) 87-93
13. Kumar N., Gupta S., and Tripathi A. Gender-specific responses of Piper betle L. to low temperature stress: changes in chlorophyllase activity. Biol Plant 50 (2006) 705-708
14. Sarkar A., Sen R., Saha P., Ganguly S., Mandal G., and Chatterjee M. An ethanolic extract of leaves of Piper betle (Paan) Linn mediates its anti-leishmanial activity via apoptosis. Parasitol Res 102 (2008) 1249-1255
15. Wirotesangthong M., Inagaki N., Tanaka H., Thanakijcharoenpath W., and Nagai H. Inhibitory effects of Piper betle on production of allergic mediators by bone marrow-derived mast cells and lung epithelial cells. Int Immunopharmacol 8 (2008) 453-457
16. Philip H.E., and William S.B. Identification of fungicidal and nemotocidal components in the leaves of Piper betle (Piperaceae). J Agric Food Chem 32 (1984) 1254-1256
17. Bhide S.V., Zariwala M.B.A., Amonlar A.J., and Azuine M.A. Chemo-preventive efficacy of betel leaf extract against benzo (a) pyrene induced fore-stomach tumors in mice. J Ethnopharmacol 34 (1991) 207-213
18. Kumar N. Betel vine (Piper betle L.) cultivation: a unique case of plant establishment under anthropogenically regulated microclimatic conditions. Indian J Hist Sci 34 (1999) 19-32
19. Verma A., Kumar N., and Ranade S.A. Genetic diversity among landraces of a dioecious vegetatively propagated plant, betel vine (Piper betel L.). J Biosci 29 (2004) 319-328
20. Tripathi S., Singh N., Shakya S., Dangi A., Misra-Bhattacharya S., Dube A., et al. Gender based differences in phenol and thiocyanate contents and biological activity in Piper betle L. Curr Sci 91 6 (2008) 746-749
21. Nelson D.S., and Mildenhall P. Studies on cytophillic antibodies. The production by mice of macrophage cytophillic antibodies to sheep erthrocytes, relationship to the production of other antibodies and development of delayed type hypersensitivity. Aust J Exp Biol Med Sci 45 (1967) 113-130
22. Puri A., Saxena, Sumati R.P., Guru P.Y., Kulshrestha D.K., and Saxena K.C. Immunostimulant activity of P. kurroa and protection against L. donovani infection in hamsters. Planta Med 58 (1992) 519-524
23. Jerne N.K., and Nordin A.A. Plaque formation in agar by single antibody-producing cells. Science 140 (1963) 405-408
24. Barua C.C., Gupta P.P., Patnaik G.K., Misra-Bhattacharya S., Goel R.K., Kulshrestha D.K., et al. Immunomodulatory effect of Albizzia Lebbeck. Pharm Biol 38 (2000) 161-166
25. Misra S., Mukherjee M., Dikshit M., and Chatterjee R.K. Cellular immune response of gerbils and mastomys in experimental filariasis. Trop Med Int Hlth 3 (1998) 124-129
26. Gupta R., Bajpai P., Tripathi L.M., Srivastava V.M.L., Jain S.K., and Misra-Bhattacharya S. Macrophages in the development of protective immunity against experimental Brugia malayi infection. Parasitology 129 (2004) 1-13
27. Green L.C., Wagner D.A., Glogowski J., Skipper P.L., Wishnok J.S., and Tannenbaum S.A. Analysis of nitrate, nitrite and [15N] nitrate in biological fluids. Anal Biochem 126 (1982) 131-138
28. Zurgil N., Shafran Y., Afrimzon E., Fixler D., Shainberg A., and Deutsch M. Concomitant real-time monitoring of intracellular reactive oxygen species and mitochondrial membrane potential in individual living promonocytic cells. J Immunol Methods 20 (2006) 27-41
29. Ash L.R., and Riley J.M. Development of sub periodic B. malayi in the jird (Meriones unguiculatus) with notes on infection in other rodents. J Parasitol 56 (1970) 969-972
30. Misra-Bhattacharya S., Katiyar D., Bajpai P., Tripathi R.P., and Saxena J.K. 4-Methyl-7-(tetradecanoyl)-2H-1-benzopyran-2-one: a novel DNA topoisomerase II inhibitor with adulticidal and embryo static activity against sub periodic Brugia malayi. Parasitol Res 92 (2004) 177-182
31. Singh U., Misra S., Murthy P.K., Katiyar J.C., Agarwal A., and Sircar A.R. Immunoreactive molecules of Brugia malayi and their diagnostic potential. Serodiagn Immunother Infect Dis 8 (1997) 207-212
32. Misra S., Chatterjee R.K., and Sen A.B. Antifilarial action of furazolidone. Indian J Med Res 73 (1981) 725-728
33. Misra S., Chatterjee R.K., and Sen A.B. The response of Litomosoides carinii to antifilarial agents in cotton rat Sigmodon hispidus and multimammate rat (Mastomys natalensis). Indian J Med Res 7 (1984) 749-752
34. Singh U., Misra S., Murthy P.K., Katiyar J.C., Agarwal A., and Sircar A.R. Immunoreactive molecules of Brugia malayi and their diagnostic potential. Serodiagn Immunother Infect Dis 8 (1997) 207-212
35. O'Brien J., Wilson I., Orton T., and Pognan F. Investigation of the Alamar Blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity. Euro J Biochem 267 267 (2003) 17: 5421-5426
36. Brekhman I.I., and Dardimov I.V. New substances of plant origin which increase non-specific resistance. Annu Rev Pharmacol 21 (1969) 219-226
37. Dahanukar S.A., Kulkarni R.A., and Rege N.N. Pharmacology of medicinal plants and natural products. Indian J Pharmacol 32 (2000) S81-S118
38. Jayathirtha M.G., and Mishra S.H. Preliminary immunomodulatory activities of methanol extracts of Eclipta alba and Centella asiatica. Phytomedicine 11 (2004) 361-365
39. Ottesen E.A., Weller P.F., and Heck L. Specific cellular immune unresponsiveness in human filariasis. Immunology 33 (1977) 413-421
40. Lawrence R.A., and Devaney E. Lymphatic filariasis: parallels between the immunology of infection in humans and mice. Parasite Immunol 23 (2001) 353-361
41. Zeng H.W., Jiang Y.Y., Bian D.G.J., Long K., and Cghen Z.L. Piperbetol, methylpiperbetol, Piperol A, and Piperol B: a new series of highly specific PAf receptor antagonists from Piper betle. Planta Med 63 (1997) 296-298
42. Sarkar A., Sen R., Saha P., Ganguly S., Mandal G., and Chatterjee M. An ethanolic extract of leaves of Piper betle (Paan) Linn mediates its antileishmanial activity via apoptosis. Parasitol Res 102 6 (2008) 1249-1255
43. Sharma S., Khan I.A., Ali I., Ali F., Kumar M., Kumar A., et al. Evaluation of hydroxychavicol for its antimicrobial, antioxidant and anti-inflammatory activity for its potential use as oral care agent. Antimicrob Agents Chemother (2008) 10.1128/AAC.00045-08 [Published online ahead of print]
44. Sawangjaroen N., Subhadhirasakul S., Phongpaichit S., Siripanth C., and Jamjaroen K. Sawangjaroen K. The in vitro anti-giardial activity of extracts from plants that are used for self-medication by AIDS patients in southern Thailand. Parasitol Res 95 1 (2005) 17-21
45. Sawangjaroen N., Phongpaichit S., Subhadhirasakul S., Visutthi M., Srisuwan N., and Thammapalerd N. The anti-amoebic activity of some medicinal plants used by AIDS patients in southern Thailand. Parasitol Res 98 6 (2006) 588-592
46. Wirotesangthong M., Inagaki N., Tanaka H., Thanakijcharoenpath W., and Nagai H. Inhibitory effects of Piper betle on production of allergic mediators by bone marrow-derived mast cells and lung epithelial cells. Int Immunopharmacol 8 3 (2008) 453-457
47. Ganguly S, Mula S, Chattopadhyay S, Chatterjee M. An ethanol extract of Piper betle Linn. mediates its anti-inflammatory activity via down-regulation of nitric oxide. Journal of Pharmacy and Pharmacology, 2007; 59(5): 711-718 (8).
48. Edgardo E.T., and Zenaida T.E. Cytokine-mimetic properties of some philippine food and medicinal plants. J Med Food 10 2 (2007) 290-299
49. Bandyopadhyay S, Roy KC, Roy M, Pal BC, Bhadra R, Das K, Bhattacharaya S. Herbal formulation of a combination of Piper betel and Murrya koenigii extracts for blocking 5 lipoxygenase activity. United States Patent 6413553, 2002.
50. Jana B.L. Improved technology for betel leaf cultivation. A paper presented in the "Seminar-cum-Workshop on Betel leaf Marketing", held at State cashew nut farm, Directorate of Agricultural Marketing, Digha, Midnapur (W. B.), India (1996)
51. Jeng J.H., Chen S.Y., Liar C.H., Tung Y.Y., Lin B.R., Hahn L.J., et al. Modulation of platelet aggregation by areca nut and betel leaf ingredients: roles of relative oxygen species and cyclooxygenase. Free Radic Biol Med 32 9 (2002) 860-871
52. Wu M.T., Wu D.C., Hsu H.K., Kao E.L., and Lee J.M. Constituents of areca chewing related to esophageal cancer risk in Taiwanese men. Dis Esophagus 17 3 (2004) 257-259
53. Ramji N., Ramji N., Iyer R., and Chandrasekaran S. Phenolic antibacterials from Piper betle in the prevention of halitosis. J Ethnopharmacol 83 1-2 (2002) 149-152
54. Jenie B.S.L., Andarwulan N., Puspitasari-Nienaber N.L., and Nuraida L. Antimicrobial activity of Piper betle Linn extract towards foodborne pathogens and food spoilage microorganisms. Food Microbiology: General, IFT Annual Meeting - New Orleans, Louisiana 3 1 (2001)
55. Coffmann R.L., Seymour W.P., Lebman D.A., Hiraki D.D., Christiansen J.A., Shrader B., et al. The role of helper t cell products in mouse b-cell differentiation and isotype regulation. Immunol Rev 102 1 (2006) 5-28
56. Murphy K.M., and Reiner S.L. The lineage decisions of helper T cells. Nat Rev Immunol 2 (2002) 933-944
57. Belardelli F. Role of interferons and other cytokines in the regulation of the immune response. APMIS 103 3 (1995) 161-179
58. Kidd P. Th1/Th2 balance: the hypothesis, its limitations, and implications for health and disease. Altern Med Rev 8 (2003) 223-246
59. Bandyopadhyay S, Pal B, Bhattacharya S, Ray M, Roy KC. Use of betel leaf extracts to induce IFN-gamma production from human peripheral blood T cells and as a Th1 type immunomodulator. United States Patent: 2003; 6: 531,166. Council of Scientific and Industrial Research (New Delhi, IN).
60. Semnani R.T., Law M., Kubofcik J., and Nutman T.B. Filaria-induced immune evasion:suppression by the infective stage of Brugia malayi at the earliest host-parasite interface. J Immunol 172 (2004) 6229-6238
61. Calabrese E.J., and Baldvin L.A. Hormesis: u-shaped dose responses and their centrality in toxicology. Trends Pharmacol Sci 22 (2001) 285-288
62. Tawill S., Le G.L., Ali F., Blaxter M., and Allen J.E. Both free-living and parasitic nematodes induce a characteristic Th2 response that is dependent on the presence of intact glycans. Infect Immun (2004) 398-407