Glutamine inhibits ammonia-induced accumulation of cGMP in rat striatum limiting arginine supply for NO synthesis

Neurobiology of Disease

Volumn 35, Issue 1, 2009, Pages 75-81

  Hilgier, Wojciech ^a   Freśko, Inez ^a   Klemenska, Emilia ^b   Beresewicz, Andrzej ^b   Oja, Simo S ^c,d   Saransaari, Pirjo ^d   Albrecht, Jan ^a   Zielińska, Magdalena ^a  

^a MOSSAKOWSKI MEDICAL RESEARCH CENTRE   (Poland)

^b MEDICAL CENTER FOR POSTGRADUATE EDUCATION   (Poland)

^c TAMPERE UNIVERSITY HOSPITAL   (Finland)

^d UNIVERSITY OF TAMPERE MEDICAL SCHOOL   (Finland)

Author keywords

Ammonia neurotoxicity; Arginine; Cyclic GMP; Glutamine; Microdialysis; Striatum

Indexed keywords

6 DIAZO 5 OXONORLEUCINE; AMMONIA; ARGININE; CYCLIC GMP; GLUTAMINE; ISOBUTYRIC ACID DERIVATIVE; LEUCINE; NITRIC OXIDE; NITROPRUSSIDE SODIUM;

AMINO ACID TRANSPORT; ANIMAL TISSUE; ARTICLE; ATTENUATION; BRAIN CORTEX; BRAIN LEVEL; CONTROLLED STUDY; CORPUS STRIATUM; DIALYSATE; IN VITRO STUDY; IN VIVO STUDY; MALE; MICRODIALYSIS; NONHUMAN; PRIORITY JOURNAL; RAT; SYNTHESIS;

AMMONIA; ANIMALS; ARGININE; BUTYRIC ACIDS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CORPUS STRIATUM; CYCLIC GMP; DIAZOOXONORLEUCINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ELECTROCHEMICAL TECHNIQUES; GLUTAMINE; MALE; MICRODIALYSIS; NITRIC OXIDE; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 67349226335     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2009.04.004     Document Type: Article

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