The LOX-1 scavenger receptor cytoplasmic domain contains a transplantable endocytic motif

Biochemical and Biophysical Research Communications

Volumn 383, Issue 2, 2009, Pages 269-274

  Vohra, Ravinder S ^a,b   Walker, John H ^a   Howell, Gareth J ^a   Homer Vanniasinkam, Shervanthi ^a,b   Ponnambalam, Sreenivasan ^a  

^a Leeds Institute of Genetics   (United Kingdom)

^b LEEDS GENERAL INFIRMARY   (United Kingdom)

Author keywords

Acidic motif; Endocytosis; LOX 1; Oxidized LDL particle

Indexed keywords

ALANINE; ASPARTIC ACID; HYBRID PROTEIN; MEMBRANE PROTEIN; OXIDIZED LOW DENSITY LIPOPROTEIN RECEPTOR 1; TRANSFERRIN RECEPTOR;

ARTICLE; BETA SHEET; CHEMICAL MODEL; CONTROLLED STUDY; CYTOPLASM; CYTOSOL; ENDOCYTOSIS; HUMAN; HUMAN CELL; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; PROTEIN MOTIF; PROTEIN TRANSPORT; STRUCTURE ANALYSIS; SUBSTITUTION REACTION;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; CYTOPLASM; ENDOCYTOSIS; HUMANS; LIPOPROTEINS, LDL; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, TERTIARY; SCAVENGER RECEPTORS, CLASS E;

EID: 67349225118     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.04.012     Document Type: Article

References (29)

1. Murphy J.E., Tedbury P.R., Homer-Vanniasinkam S., Walker J.H., and Ponnambalam S. Biochemistry and cell biology of mammalian scavenger receptors. Atherosclerosis 182 (2005) 1-15
2. Lusis A.J. Atherosclerosis. Nature 407 (2000) 233-241
3. Hansson G.K. Inflammation, atherosclerosis, and coronary artery disease. N. Eng. J. Med. 352 (2005) 1685-1695
4. Sawamura T., Kume N., Aoyama T., Moriwaki H., Hoshikawa H., Aiba Y., Tanaka T., Miwa S., Katsura Y., Kita T., and Masaki T. An endothelial receptor for oxidized low-density lipoprotein. Nature 386 (1997) 73-77
5. Dunn S., Vohra R.S., Murphy J.E., Homer-Vanniasinkam S., Walker J.H., and Ponnambalam S. The lectin-like oxidized low-density-lipoprotein receptor: a pro-inflammatory factor in vascular disease. Biochem. J. 409 (2008) 349-355
6. Vohra R.S., Murphy J.E., Walker J.H., Ponnambalam S., and Homer-Vanniasinkam S. Atherosclerosis and the Lectin-like OXidized low-density lipoprotein scavenger receptor. Trends Cardiovasc Med. 16 (2006) 60-64
7. Inoue K., Arai Y., Kurihara H., Kita T., and Sawamura T. Overexpression of lectin-like oxidized low-density lipoprotein receptor-1 induces intramyocardial vasculopathy in apolipoprotein E-null mice. Circ. Res. 97 (2005) 176-184
8. Mehta J.L., Sanada N., Hu C.P., Chen J., Dandapat A., Sugawara F., Satoh H., Inoue K., Kawase Y., Jishage K., Suzuki H., Takeya M., Schnackenberg L., Beger R., Hermonat P.L., Thomas M., and Sawamura T. Deletion of LOX-1 reduces atherogenesis in LDLR knockout mice fed high cholesterol diet. Circ. Res. 100 (2007) 1634-1642
9. Ishigaki T., Ohki I., Utsunomiya-Tate N., and Tate S.I. Chimeric structural stabilities in the coiled-coil structure of the NECK domain in human lectin-like oxidized low-density lipoprotein receptor 1 (LOX-1). J. Biochem. 141 (2007) 855-866
10. Ohki I., Ishigaki T., Oyama T., Matsunaga S., Xie Q., Ohnishi-Kameyama M., Murata T., Tsuchiya D., Machida S., Morikawa K., and Tate S. Crystal structure of human lectin-like, oxidized low-density lipoprotein receptor 1 ligand binding domain and its ligand recognition mode to OxLDL. Structure (Camb.) 13 (2005) 905-917
11. Park H., Adsit F.G., and Boyington J.C. The 1.4 angstrom crystal structure of the human oxidized low density lipoprotein receptor lox-1. J. Biol. Chem. 280 (2005) 13593-13599
12. Kakutani M., Masaki T., and Sawamura T. A platelet-endothelium interaction mediated by lectin-like oxidized low-density lipoprotein receptor-1. Proc. Natl. Acad. Sci. USA 97 (2000) 360-364
13. Shimaoka T., Kume N., Minami M., Hayashida K., Sawamura T., Kita T., and Yonehara S. LOX-1 supports adhesion of Gram-positive and Gram-negative bacteria. J. Immunol. 166 (2001) 5108-5114
14. Murphy J.E., Tacon D., Tedbury P.R., Hadden J.M., Knowling S., Sawamura T., Peckham M., Phillips S.E., Walker J.H., and Ponnambalam S. LOX-1 scavenger receptor mediates calcium-dependent recognition of phosphatidylserine and apoptotic cells. Biochem. J. 393 (2006) 107-115
15. Chen M., Narumiya S., Masaki T., and Sawamura T. Conserved C-terminal residues within the lectin-like domain of LOX-1 are essential for oxidized low-density-lipoprotein binding. Biochem. J. 355 (2001) 289-296
16. Chen M., Inoue K., Narumiya S., Masaki T., and Sawamura T. Requirements of basic amino acid residues within the lectin-like domain of LOX-1 for the binding of oxidized low-density lipoprotein. FEBS Lett. 499 (2001) 215-219
17. Shi X., Niimi S., Ohtani T., and Machida S. Characterization of residues and sequences of the carbohydrate recognition domain required for cell surface localization and ligand binding of human lectin-like oxidized LDL receptor. J. Cell Sci. 114 (2001) 1273-1282
18. Murphy J.E., Vohra R.S., Dunn S., Holloway Z.G., Monaco A.P., Homer-Vanniasinkam S., Walker J.H., and Ponnambalam S. Oxidised LDL internalisation by the LOX-1 scavenger receptor is dependent on a novel cytoplasmic motif and is regulated by dynamin-2. J. Cell Sci. 121 (2008) 2136-2147
19. Cominacini L., Pasini A.F., Garbin U., Davoli A., Tosetti M.L., Campagnola M., Rigoni A., Pastorino A.M., Lo Cascio V., and Sawamura T. Oxidized low density lipoprotein (ox-LDL) binding to ox-LDL receptor-1 in endothelial cells induces the activation of NF-kappaB through an increased production of intracellular reactive oxygen species. J. Biol. Chem. 275 (2000) 12633-12638
20. Vohra R.S., Murphy J.E., Walker J.H., Homer-Vanniasinkam S., and Ponnambalam S. Functional refolding of a recombinant disulfide-bonded C-type lectin-like domain. Protein Expr. Purif. 52 (2007) 415-421
21. Ponnambalam S., Rabouille C., Luzio J.P., Nilsson T., and Warren G. The TGN38 glycoprotein contains two non-overlapping signals that mediate localization to the trans-Golgi network. J. Cell Biol. 125 (1994) 253-268
22. Bystroff C., Thorsson V., and Baker D. HMMSTR: a hidden Markov model for local sequence-structure correlations in proteins. J. Mol. Biol. 301 (2000) 173-190
23. Trowbridge I.S. Endocytosis and signals for internalization. Curr. Opin. Cell Biol. 3 (1991) 634-641
24. Ohki I., Ishigaki T., Oyama T., Matsunaga S., Xie Q., Ohnishi-Kameyama M., Murata T., Tsuchiya D., Machida S., Morikawa K., and Tate S. Crystal structure of human lectin-like, oxidized low-density lipoprotein receptor 1 ligand binding domain and its ligand recognition mode to OxLDL. Structure 13 (2005) 905-917
25. Park H., Adsit F.G., and Boyington J.C. The 1.4 angstrom crystal structure of the human oxidized low density lipoprotein receptor lox-1. J. Biol. Chem. 280 (2005) 13593-13599
26. Xie Q., Matsunaga S., Niimi S., Ogawa S., Tokuyasu K., Sakakibara Y., and Machida S. Human lectin-like oxidized low-density lipoprotein receptor-1 functions as a dimer in living cells. DNA Cell Biol. 23 (2004) 111-117
27. Chen M., and Sawamura T. Essential role of cytoplasmic sequences for cell-surface sorting of the lectin-like oxidized LDL receptor-1 (LOX-1). J. Mol. Cell Cardiol. 39 (2005) 553-561
28. Matsunaga S., Xie Q., Kumano M., Niimi S., Sekizawa K., Sakakibara Y., Komba S., and Machida S. Lectin-like oxidized low-density lipoprotein receptor (LOX-1) functions as an oligomer and oligomerization is dependent on receptor density. Exp. Cell Res. 313 (2007) 1203-1214
29. Mayor S., and Pagano R.E. Pathways of clathrin-independent endocytosis. Nat. Rev. Mol. Cell Biol. 8 (2007) 603-612