Peripheral nerve lesion induces an up-regulation of spy1 in rat spinal cord

Cellular and Molecular Neurobiology

Volumn 29, Issue 3, 2009, Pages 403-411

  Huang, Ye ^a,b   Liu, Yonghua ^a,b,c   Chen, Ying ^c   Yu, Xiaowei ^a,b   Yang, Junling ^c   Lu, Mudan ^c   Lu, Qiuyan ^c   Ke, Qing ^c   Shen, Aiguo ^b   Yan, Meijuan ^b  

^a THE SECOND AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

^b NANTONG UNIVERSITY   (China)

^c NANTONG MEDICAL COLLEGE   (China)

Author keywords

Glial cells; Proliferation; Sciatic nerve injury; Spinal cord; Spy1

Indexed keywords

CYCLIN DEPENDENT KINASE 2; PROTEIN; PROTEIN P27; PROTEIN SPY1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTE; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; GLIA CELL; LUMBAR SPINAL CORD; MALE; MICROGLIA; NERVE CELL; NERVE CRUSH; NONHUMAN; PERIPHERAL NERVE INJURY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SCIATIC NERVE; UPREGULATION;

ANIMALS; BIOLOGICAL MARKERS; CELL CYCLE PROTEINS; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE 2; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION; IMMUNOHISTOCHEMISTRY; LUMBAR VERTEBRAE; MALE; PHENOTYPE; PROLIFERATING CELL NUCLEAR ANTIGEN; PROTEIN TRANSPORT; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SCIATIC NERVE; SPINAL CORD; TIME FACTORS; UP-REGULATION;

RATTUS;

EID: 67349209491     PISSN: 02724340     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10571-008-9332-8     Document Type: Article

References (20)

1. EA Barnes LA Porter JL Lenormand RW Dellinger DJ Donoghue 2003 Human Spy1 promotes survival of mammalian cells following DNA damage Cancer Res 63 3701 3707
2. RN Bhattacharjee GC Banks KW Trotter HL Lee TK Archer 2001 Histone H1 phosphorylation by Cdk2 selectively modulates mouse mammary tumor virus transcription through chromatin remodeling Mol Cell Biol 21 5417 5425 10.1128/MCB.21.16.5417-5425.2001
3. A Cheng W Xiong JE Ferrell Jr MJ Solomon 2005 Identification and comparative analysis of multiple mammalian speedy/ringo proteins Cell Cycle 4 155 165
4. A Dinarina LH Perez A Davila M Schwab T Hunt AR Nebreda 2004 Characterization of a new family of cyclin-dependent kinase activators Biochem J 386 349 355
5. JW Fawcett RJ Keynes 1990 Peripheral nerve regeneration Annu Rev Neurosci 13 43 60 10.1146/annurev.neuro.13.1.43
6. I Ferby M Blazquez A Palmer R Eritja AR Nebreda 1999 A novel p34(cdc2)-binding and activating protein that is necessary and sufficient to trigger G2/M progression in Xenopus oocytes Genes Dev 13 2177 2189 10.1101/gad.13.16.2177
7. SY Fu T Gordon 1997 The cellular and molecular basis of peripheral nerve regeneration Mol Neurobiol 14 67 116 10.1007/BF02740621
8. RF Gastwirt DA Slavin CW McAndrew DJ Donoghue 2006 Spy1 expression prevents normal cellular responses to DNA damage: inhibition of apoptosis and checkpoint activation J Biol Chem 281 35425 35435 10.1074/jbc.M604720200
9. T Hokfelt X Zhang Z Wiesenfeld-Hallin 1994 Messenger plasticity in primary sensory neurons following axotomy and its functional implications Trends Neurosci 17 22 30 10.1016/0166-2236(94)90031-0
10. T Hunter J Pines 1994 Cyclins and cancer II: Cyclin D and CDK inhibitors come of age Cell 79 573 582 10.1016/0092-8674(94)90543-6
11. A Karaiskou LH Perez I Ferby R Ozon C Jessus AR Nebreda 2001 Differential regulation of Cdc2 and Cdk2 by RINGO and cyclins J Biol Chem 276 36028 36034 10.1074/jbc.M104722200
12. JL Lenormand RW Dellinger KE Knudsen S Subramani DJ Donoghue 1999 Speedy: a novel cell cycle regulator of the G2/M transition EMBO J 18 1869 1877 10.1093/emboj/18.7.1869
13. CW McAndrew RF Gastwirt AN Meyer LA Porter DJ Donoghue 2007 Spy1 enhances phosphorylation and degradation of the cell cycle inhibitor p27 Cell Cycle 6 1937 1945
14. DO Morgan 1995 Principles of CDK regulation Nature 374 131 134 10.1038/374131a0
15. GF Morris MB Mathews 1989 Regulation of proliferating cell nuclear antigen during the cell cycle J Biol Chem 264 13856 13864
16. AR Nebreda 2006 CDK activation by non-cyclin proteins Curr Opin Cell Biol 18 192 198 10.1016/j.ceb.2006.01.001
17. LA Porter RW Dellinger JA Tynan EA Barnes M Kong JL Lenormand DJ Donoghue 2002 Human speedy: a novel cell cycle regulator that enhances proliferation through activation of Cdk2 J Cell Biol 157 357 366 10.1083/jcb.200109045
18. LA Porter M Kong-Beltran DJ Donoghue 2003 Spy1 interacts with p27Kip1 to allow G1/S progression Mol Biol Cell 14 3664 3674 10.1091/mbc.E02-12-0820
19. CJ Sherr JM Roberts 1999 CDK inhibitors: positive and negative regulators of G1-phase progression Genes Dev 13 1501 1512 10.1101/gad.13.12.1501
20. SX Shi C Cheng J Zhao ML Chen J Qin SF Gao AG Shen 2007 Expression of p27kip1 and Skp2 in the adult spinal cord following sciatic nerve injury J Mol Neurosci 32 64 71 10.1007/s12031-007-0015-6