A 16-bp RBE element mediated Rep-dependent site-specific integration in AAVS1 transgenic mice for expression of hFIX

Gene Therapy

Volumn 16, Issue 5, 2009, Pages 589-595

  Xu, Z X ^a,b   Chen, J Z ^b   Yue, Y B ^b   Zhang, J Q ^b   Li, Z H ^b   Feng, D M ^b   Ruan, Z C ^b   Tian, L ^b   Xue, J L ^b   Wang, Q J ^a   Jia, W ^b,c  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; BLOOD CLOTTING FACTOR 9; PARVOVIRUS VECTOR; PLASMID VECTOR; REP BINDING ELEMENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GENE INSERTION; GENE INTERACTION; GENE LOCUS; GENOME SIZE; HYDRODYNAMICS BASED TRANSFECTION; IN VIVO STUDY; LIVER TOXICITY; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; NONVIRAL GENE THERAPY; PARTIAL HEPATECTOMY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SEQUENCE ANALYSIS; SITE SPECIFIC INTEGRATION; TRANSGENIC MOUSE; VIRUS DNA CELL DNA INTERACTION;

ANIMALS; BASE SEQUENCE; DEPENDOVIRUS; FACTOR IX; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HUMANS; LIVER DISEASES; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; PLASMIDS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TISSUE DISTRIBUTION; TRANSGENES; VIRUS INTEGRATION;

ANIMALIA; MUS; MUS MUSCULUS;

EID: 67349204467     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/gt.2009.9     Document Type: Article

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