Twin pregnancy, contrary to consensus, is a desirable outcome in infertility

Fertility and Sterility

Volumn 91, Issue 6, 2009, Pages 2426-2431

  Gleicher, Norbert ^a,b,c   Barad, David ^a,b,d  

^a CENTER FOR HUMAN REPRODUCTION   (United States)

^b Foundation for Reproductive Medicine   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

adverse outcomes; fertility treatment; in vitro fertilization; infertility; multiple births; twin pregnancy; Twins

Indexed keywords

ARTICLE; CHILD; CONCEPTION; CONSENSUS; CONTROLLED STUDY; COST EFFECTIVENESS ANALYSIS; FEMALE; FEMALE INFERTILITY; FERTILIZATION IN VITRO; HIGH RISK PREGNANCY; HUMAN; OUTCOME ASSESSMENT; PERINATAL PERIOD; PREGNANCY OUTCOME; PRIORITY JOURNAL; PROGENY; RISK ASSESSMENT; RISK BENEFIT ANALYSIS; TWIN PREGNANCY;

CHOICE BEHAVIOR; COST-BENEFIT ANALYSIS; DELIVERY, OBSTETRIC; FEMALE; FERTILIZATION IN VITRO; HUMANS; INFERTILITY, FEMALE; PREGNANCY; PREGNANCY OUTCOME; RISK ASSESSMENT; SAFETY; TWINS;

EID: 67349200010     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2008.02.160     Document Type: Article

References (61)

1. Kogan M.D., Alexander G.R., Kotelchuk M., MacDorman M.F., Buekens P., Martin J.A., et al. Trends in twin birth outcomes and prenatal care utilization in the United States, 1981-1997. JAMA 283 (2000) 335-341
2. Fauser B.C.J.M., Devroey P., and Macklon N.S. Multiple birth resulting from ovarian stimulation for subfertility treatment. Lancet 365 (2005) 1807-1816
3. Jones Jr. H.W. Iatrogenic multiple births: a 2003 checkup. Fertil Steril 87 (2007) 453-455
4. Jones Jr. H.W., and Schnorr J.A. Multiple pregnancies: a call for action. Fertil Steril 75 (2001) 11-13
5. Dickey R.P. A year of inaction on high-order multiple pregnancies due to ovulation induction. Fertil Steril 79 (2003) 14-16
6. Seoud M.A., Toner J.P., Kruithoff C., and Muasher S.J. Outcome of twin, triplet, and quadruplet in vitro fertilization pregnancies: the Norfolk experience. Fertil Steril 57 (1992) 825-834
7. Conde-Agudelo A., Belizan J.M., and Lindmark G. Maternal morbidity and mortality associated with multiple gestations. Obstet Gynecol 95 (2000) 899-904
8. Gleicher N., Oleske D.M., Tur-Kaspa I., Vidali A., and Karande V. Reducing the risk of high-order multiple pregnancy after ovarian stimulation with gonadotropins. N Engl J Med 343 (2000) 2-7
9. Dickey R.P., Taylor A.N., Lu P.Y., Sartor B.M., Rye P.H., and Pyrzak R. Risk factors for high-order multiple pregnancy and multiple birth after controlled ovarian hyperstimulation: results of 4,062 intrauterine insemination cycles. Fertil Steril 83 (2005) 671-683
10. Jones Jr. H.W. Multiple births: how are we doing?. Fertil Steril 79 (2003) 17-21
11. Bardis N., Maruthini D., and Balen A.H. Modes of conception and multiple pregnancy: a national survey of babies born during one week in 2003 in the United Kingdom. Fertil Steril 84 (2005) 1727-1732
12. Schieve L.A. The promise of single-embryo-transfer. N Engl J Med 354 (2006) 1190-1193
13. Veleva Z., Vilska S., Hydėn-Granskog C., Tiitinen A., Tapanainen J.S., and Martikainen H. Elective single embryo transfer in women aged 36-39 years. Hum Reprod (2006) 2098-2102
14. De Neubourg D., and Gerris J. What about the remaining twins since single-embryo transfer? How far can (should) we go?. Hum Reprod 21 (2006) 843-846
15. Karlstro{combining double acute accent}m P.O., and Bergh C. Reducing the number of embryos transferred in Sweden-impact on delivery and multiple birth rates. Hum Reprod 22 (2007) 2202-2207
16. American Society for Reproductive Medicine. Guidelines on number of embryos transferred. Fertil Steril 82 (2004) 773-774
17. Templeton A., and Morris J.K. Reducing the risk of multiple births by transfer of two embryos after in vitro fertilization. N Engl J Med 339 (1998) 573-577
18. Meldrum D.R., and Gardner D.K. Two-embryo transfer-the future looks bright. N Engl J Med 339 (1998) 624-625
19. Pandian Z., Templeton A., Serour G., and Bhattacharya S. Number of embryos for transfer after IVF and ICSI: a Cochran review. Hum Reprod 20 (2005) 2681-2687
20. van Montfoort A.P.A., Fiddelers A.A.A., Janssen J.M., Derhaag J.G., Dirksen C.D., Dunselman G.A.J., et al. In unselected patients, elective single embryo transfer prevents all multiples, but results in significantly lower pregnancy rates compared with double embryo transfer: a randomized controlled trial. Hum Reprod 21 (2006) 338-343
21. Fiddeles A.A.A., van Montfoort A.P.A., Dirksen C.D., Dumoulin J.C.M., Land J.A., Dunselman A.J., et al. Single versus double embryo transfer: cost-effectiveness analysis alongside a randomized clinical trial. Hum Reprod 21 (2006) 2090-2097
22. Gleicher N., Campbell D.P., Chan C.L., Karande V., Rao R., Balin M., et al. The desire for multiple births in couples with infertility problems contradicts present practice patterns. Hum Reprod 10 (1995) 1079-1084
23. BabyCenter Web site. Poll: How many children do you want? Accessed March 5, 2008. Available at: http://www.babycenter.com/4_how-many-children-do-you-want_4190.bc
24. BabyCenter Web site. Poll: What's the ideal family size? Accessed March 5, 2008. Available at: http://www.babycenter.com/4_whats-the-ideal-family-size_74034.bc
25. Rodis J.F., Egan J.F., Craffey A., Clarieglio L., Greenstein R.M., and Scorza W.E. Calculated risk of chromosomal abnormalities in twin gestations. Obstet Gynecol 76 (1990) 1037-1041
26. MacKay A.P., Berg C.J., King J.C., Duran C., and Chang J. Pregnancy-related mortality among women with multifetal pregnancies. Obstet Gynecol 107 (2006) 563-568
27. Fitzsimmons B.P., Bebbington M.W., and Fluker M.R. Perinatal and neonatal outcomes in multiple gestations: assisted reproduction versus spontaneous conception. Am J Obstet Gynecol 179 (1998) 1162-1167
28. Helmerhorst F.M., Perquin D.A.M., Donker D., and Keirse M.J.N.C. Perinatal outcome of singletons and twins after assisted conception: a systemic review of controlled studies. BMJ 328 (2004) 261
29. Barros Delgadillo J.C., Alvarado Mėndez L.M., Gorbea Chávez V., Villalobos Acosta S., Sánchez Solis V., and Gaviño Gaviño F. Perinatal results in pregnancies obtained with embryo transfer in vitro fertilization: a case-control study. [article in Spanish]. Ginecol Obstet Mex 74 (2006) 626-639
30. Manoura A., Korakakie E., Hatzidaki E., Bikouvarakis S., Papageorgiou M., and Giannakopoulou C. Perinatal outcome of twin pregnancies after in vitro fertilization. Acta Obstet Gynecol Scand 83 (2004) 1079-1084
31. Sibai B.M., Hauth J., Caritis S., Lindheimer M.D., MacPherson C., and Klebanoff M. Hypertensive disorders in twin versus singleton gestations. National Institute of Child Health and Human Development Network of Maternal-Fetal Medicine Units. Am J Obstet Gynecol 182 (2000) 938-942
32. Yukobowich E., Anteby E.Y., Cohen S.M., Lavy Y., Granat M., and Yagel S. Risk of fetal loss in twin pregnancies undergoing second trimester amniocentesis. Obstet Gynecol 98 (2001) 231-234
33. Millaire M., Bujold E., Morency A.M., and Gauthier R.J. Mid-trimester genetic amniocentesis in twin pregnancy and the risk of fetal loss. J Obstet Gynecol Can 28 (2006) 512-518
34. Hernández-Diáz S., Werler M.M., and Mitchell A.A. Gestational hypertension in pregnancy supported by infertility treatments: role of infertility, treatments and multiple gestations. Fertil Steril 88 (2007) 438-445
35. Ombelet W., Martens G., De Sutter P., Gerris J., Bosmans E., Russinck G., et al. Perinatal outcome of 12 021 singleton and 3108 twin births after non-IVF assisted reproduction: a cohort study. Hum Reprod 21 (2006) 1025-1032
36. van Wely M., Twisk M., Mol B.W., and van der Veen F. Is twin pregnancy necessarily an adverse outcome of assisted reproductive technologies?. Hum Reprod 21 (2006) 2736-2738
37. ESHRE Capri Workshop Group. Multiple gestation pregnancy. The ESHRE Capri Workshop Group. Hum Reprod 15 (2000) 1856-1864
38. Pinborg A., Loft A., Rasmussen S., Schmidt L., Langhoff-Roos J., Greisen G., et al. Neonatal outcome in a Danish national cohort of 3438 IVF/ICSI and 10,362 non-IVF/ICSI twins born between 1995 and 2000. Hum Reprod 19 (2004) 435-441
39. Pinborg A., Loft A., Schmidt L., Greisen G., Rasmussen A., and Andersen A.N. Neurological sequelae in twins born after assisted conception: controlled national cohort study. BMJ 329 (2004) 311
40. Pinborg A., Loft A., and Nyboe Andersen A. Neonatal outcome in a Danish national cohort of 8602 children born after in vitro fertilization or intracytoplasmic sperm injection: the role of twin pregnancy. Acta Obstet Gynecol Scand 83 (2004) 1071-1078
41. Gleicher N. Strategies to improve insurance coverage for infertility services. Fertil Steril 70 (1998) 1006-1008
42. De Neubourg D., Gerris J., Mangelschots K., Van Royen E., Vercruyssen M., Steylemans A., and Elseviers M. The obstetrical and neonatal outcome of babies born after single-embryo transfer in IVF/ICSI compares favourable to spontaneously conceived babies. Hum Reprod 21 (2006) 1041-1046
43. Callahan T.L., Hall J.E., Ettner S.L., Christiansen C.L., Greene M.F., and Crowley Jr. W.F. The economic impact of multiple gestation pregnancies and the contribution of assisted-reproduction techniques on their incidence. N Engl J Med 331 (1994) 244-249
44. Kinzler W.L., Ananth C.V., and Vintzileos A.M. Medical and economic effects of twin gestations. J Soc Gynecol Invest 7 (2000) 321-327
45. Koivurova S., Hartikainen A.-L., Gissler M., Hemminki E., and Järvelin M.-J. Post-neonatal hospitalization and health care costs among IVF children: a 7-year follow-up study. Hum Reprod 22 (2007) 2136-2141
46. Luke B., Bigger H.R., Leurgans S., and Sietsema D. The cost of prematurity: a case-control study of twins vs singletons. Am J Public Health 86 (1996) 809-814
47. Kjellberg A.T., Carlsson P., and Bergh C. Randomized single versus double embryo transfer: obstetric and paediatric outcome and cost-effectiveness analysis. Hum Reprod 21 (2006) 210-216
48. Van der Gaag N., and De Jong A.H. Population scenarios for the European Union: regional scenarios. Maandstat Bevolking 45 (1997) 17-31
49. Hoorens S., Gallo F., Cave J.A.K., and Grant J.C. Can assisted reproductive technologies help offset population ageing? An assessment of the demographic and economic impact of ART in Denmark and UK. Hum Reprod 22 (2007) 2471-2475
50. Ryan G.L., Zhang S.H., Fokras A., Syrop C.H., and Van Voorhis B.J. The desire of infertile patients for multiple births. Fertil Steril 81 (2004) 500-504
51. Newton C.R., McBride J., Feyles V., Tekpetey F., and Power S. Factors affecting patients' attitudes toward single- and multiple-embryo transfer. Fertil Steril 87 (2007) 269-278
52. Stillman R.J. A 47-year-old woman with fertility problems who desires a multiple pregnancy. JAMA 297 (2007) 858-867
53. Scotland G.S., McNamee P., Peddie V.L., and Bhattacharya S. Safety versus success in elective single embryo transfer: women's preferences for outcomes of in vitro fertilization. BJOG 114 (2007) 977-983
54. Belaisch-Allart J. Is twin pregnancy necessarily an adverse outcome of assisted reproductive technologies?. Hum Reprod 22 (2007) 1495
55. Gleicher N., and Barad D. The relative myth of elective single embryo transfer. Hum Reprod 21 (2006) 1337-1344
56. Ellison M.A., Hotamisligil S., Lee H., Rich-Edwards J.W., Pang S.C., and Hall J.E. Psychological risks associated with multiple births resulting from assisted reproduction. Fertil Steril 83 (2005) 1422-1428
57. Karla S.K., Milad M.P., Klock S.C., and Grobman W.A. Infertility patients and their partners: Differences in the desire for twin gestation. Obstet Gynecol 102 (2003) 152-155
58. Martin J.A., and Park M.M. Trends in twin and triplet births: 1980-97. Natl Vital Stat Rep 14 47 (1999) 1-16
59. Fiddelers A.A., van Montfoort A.P., Dirksen C.D., Domoulin J.C., Land J.A., Dunselman G.A., et al. Single versus double embryo transfer: cost effectiveness analysis alongside a randomized clinical trial. Hum Reprod 21 (2006) 2090-2097
60. van Moontfoort A.P.A., Fiddeleres A.A.A., Land J.A., Dirksen C.D., Severens J.L., Geraedts J.P.M., et al. eSET irrespective of the availability of a good-quality embryo in the first cycle only is not effective in reducing overall twin pregnancy rates. Hum Reprod 22 (2007) 1669-1674
61. Mastenbroek S., Twisk M., van Echten-Arends J., Sikkema-Raddatz B., Korevaar J.C., Verhoeve H.R., et al. In vitro fertilization with preimplantation genetic screening. N Engl J Med 357 (2007) 9-17