In unselected patients, elective single embryo transfer prevents all multiples, but results in significantly lower pregnancy rates compared with double embryo transfer: A randomized controlled trial

Human Reproduction

Volumn 21, Issue 2, 2006, Pages 338-343

  van Montfoort, Aafke P A ^a   Fiddelers, Audrey A A ^a   Janssen, J Marij ^a   Derhaag, Josien G ^a   Dirksen, Carmen D ^a   Dunselman, Gerard A J ^a   Land, Jolande A ^a   Geraedts, Joep P M ^a   Evers, Johannes L H ^a   Dumoulin, John C M ^a  

^a MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Assisted reproductive technology; Multiple pregnancy; Randomized controlled trial; Single embryo transfer

Indexed keywords

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE EMBRYO TRANSFER; EMBRYO TRANSFER; FEMALE; FERTILIZATION IN VITRO; HUMAN; INFERTILITY; MAJOR CLINICAL STUDY; MATERNAL AGE; MULTIPLE PREGNANCY; PATIENT SELECTION; PREGNANCY RATE; PROGNOSIS; RANDOMIZED CONTROLLED TRIAL; SINGLE EMBRYO TRANSFER; TREATMENT INDICATION; TREATMENT OUTCOME; TWIN PREGNANCY; ZYGOTE;

EID: 31544443238     PISSN: 02681161     EISSN: 14602350     Source Type: Journal    
DOI: 10.1093/humrep/dei359     Document Type: Article

References (24)

1. Debrock S, Spiessens C, Meuleman C, Segal L, De Loecker P, Meeuwis L and D'Hooghe TM (2005) New Belgian legislation regarding the limitation of transferable embryos in in vitro fertilization cycles does not significantly influence the pregnancy rate but reduces the multiple pregnancy rate in a threefold way in the Leuven University Fertility Center. Fertil Steril 83,1572-1574.
2. De Neubourg D, Gerris J, Mangelschots K, Van Royen E, Vercruyssen M and Elseviers M (2004) Single top quality embryo transfer as a model for prediction of early pregnancy outcome. Hum Reprod 19,1476-1479.
3. De Sutter P, Gerris J and Dhont M (2002) A health-economic decision-analytic model comparing double with single embryo transfer in IVF/ICSI. Hum Reprod 17,2891-2896.
4. Dumoulin JCM, Coonen E, Bras M, Van Wissen LCP, Ignoul-Vanvuchelen RCM, Bergers-Janssen JM, Derhaag JG, Geraedts JPM and Evers JLH (2000) Comparison of in vitro development of embryos originating from either conventional IVF or ICSI. Hum Reprod 15,402-409.
5. ESHRE Capri Workshop (2000) Multiple gestation pregnancy. 15, August.
6. Fiddelers A, Dirksen C, Van Montfoort A, Dumoulin J, Evers J and Severens J (2005) Economic evaluation of single and double embryo transfer: Results of a Markov model. Hum Reprod 20, Suppl 1,142.
7. Gardner DK, Surrey E, Minjarez D, Leitz A, Stevens J and Schoolcraft WB (2004) Single blastocyst transfer: A prospective randomized trial. Fertil Steril 81,551-555.
8. Gerris J, De Neubourg D, Mangelschots K, Van Royen E, Van de Meerssche M and Valkenburg M (1999) Prevention of twin pregnancy after in-vitro fertilization or intracytoplasmatic sperm injection based on strict embryo criteria: A prospective randomized clinical trial. Hum Reprod 14,2581-2587.
9. Gerris J, De Neubourg D, Mangelschots K, Van Royen E, Vercruyssen M, Barudy-Vasquez J, Valkenburg M and Ryckaert G (2002) Elective single day 3 embryo transfer halves the twinning rate without decrease in the ongoing pregnancy rate of an IVF/ICSI programme. Hum Reprod 17,2626-2631.
10. Gerris J, De Sutter P, De Neubourg D, Van Royen E, Vander Elst J, Mangelschots K, Vercruyssen M, Kok P, Elseviers M, Annemans L et al. (2004) A real-life prospective health economic study of elective single embryo transfer versus two-embryo transfer in first IVF/ICSI cycles. Hum Reprod 19,917-923.
11. Helmerhorst FM, Perquin DA, Donker D and Keirse MJ (2004) Perinatal outcome of singletons and twins after assisted conception: A systematic review of controlled studies. Br Med J 328,261.
12. Land JA and Evers JL (2003) Risks and complications in assisted reproduction techniques: Report of an ESHRE consensus meeting. Hum Reprod 18,455-457.
13. Landy HJ and Keith LG (1998) The vanishing twin: A review. Hum Reprod Update 4,177-183.
14. Lukassen HG, Schonbeck Y, Adang EM, Braat DD, Zielhuis GA and Kremer JA (2004) Cost analysis of singleton versus twin pregnancies after in vitro fertilization. Fertil Steril 81,1240-1246.
15. Lukassen HG, Braat DD, Wetzels AM, Zielhuis GA, Adang EM, Scheenjes E and Kremer JA (2005) Two cycles with single embryo transfer versus one cycle with double embryo transfer: A randomized controlled trial. Hum Reprod 20,702-708.
16. Martikainen H, Tiitinen A, Tomas C, Tapanainen J, Orava M, Tuomivaara L, Vilska S, Hyden-Granskog C and Hovatta O (2001) One versus two embryo transfer after IVF and ICSI: A randomised study. Hum Reprod 16,1900-1903.
17. Nyboe Andersen A, Gianaroli L and Nygren KG (2004) Assisted reproductive technology in Europe, 2000. Results generated from European registers by ESHRE. Hum Reprod 19,490-503.
18. Ombelet W (2004) Prevention of multiple pregnancies; the Belgian project. Int Congr Ser 1271,108-111.
19. Thurin A, Hausken J, Hillensjo T, Jablonowska B, Pinborg A, Strandell A and Bergh C (2004) Elective single-embryo transfer versus double-embryo transfer in in vitro fertilization. N Engl J Med 351,2392-2402.
20. Tiitinen A, Halttunen M, Harkki P, Vuoristo P and Hyden-Granskog C (2001) Elective single embryo transfer: The value of cryopreservation. Hum Reprod 16,1140-1144.
21. Tiitinen A, Unkila-Kallio L, Halttunen M and Hyden-Granskog C (2003) Impact of elective single embryo transfer on the twin pregnancy rate. Hum Reprod 18,1449-1453.
22. Tummers P, De Sutter P and Dhont M (2003) Risk of spontaneous abortion in singleton and twin pregnancies after IVF/ICSI. Hum Reprod 18,1720-1723.
23. Van Montfoort AP, Dumoulin JC, Land JA, Coonen E, Derhaag JG and Evers JL (2005) Elective single embryo transfer (eSET) policy in the first three IVF/ICSI treatment cycles. Hum Reprod 20,433-436.
24. Winter E, Wang J, Davies MJ and Norman R (2002) Early pregnancy loss following assisted reproductive technology treatment. Hum Reprod 17,3220-3223.