Immune thrombocytopenic purpura: Pathophysiology and treatment;Purpura thrombopénique immunologique : physiopathologie et traitement

Transfusion Clinique et Biologique

Volumn 16, Issue 2, 2009, Pages 101-105

  Godeau, B ^a,b,c  

^a Serv Med Nucl   (France)

^b HENRI MONDOR HOSPITAL   (France)

^c UNIVERSITÉ PARIS EST CRÉTEIL   (France)

Author keywords

Helicobacter pylori; Immune thrombocytopenic purpura; Rituximab; Splenectomy; Thrombopoietin receptor agonist

Indexed keywords

CD20 ANTIBODY; ELTROMBOPAG; IMMUNOGLOBULIN; PREDNISONE; RITUXIMAB; ROMIPLOSTIM; THROMBOPOIETIN RECEPTOR;

B LYMPHOCYTE; CELLULAR IMMUNITY; CHRONIC DISEASE; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HUMAN; HUMORAL IMMUNITY; IDIOPATHIC THROMBOCYTOPENIC PURPURA; IMMUNOSUPPRESSIVE TREATMENT; PATHOPHYSIOLOGY; SHORT SURVEY; SPLENECTOMY; THROMBOCYTE; THROMBOCYTOPOIESIS;

ANTIBODIES, MONOCLONAL; ANTIGENS, CD20; HELICOBACTER PYLORI; HUMANS; IMMUNOGLOBULINS, INTRAVENOUS; PREDNISONE; PURPURA, THROMBOCYTOPENIC, IDIOPATHIC; RECEPTORS, THROMBOPOIETIN; SPLENECTOMY;

EID: 67349180777     PISSN: 12467820     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tracli.2009.03.012     Document Type: Short Survey

References (24)

1. Cines D.B., and Blanchette V.S. Immune thrombocytopenic purpura. N Engl J Med 346 (2002) 995-1008
2. Harrington W.J., Minnich V., Hollingsworth J.W., and Moore C.V. Demonstration of a thrombocytopenic factor in the blood of patients with thrombocytopenic purpura. J Lab Clin Med 38 (1951) 1-10
3. He R., Reid D.M., Jones C.E., and Shulman N.R. Spectrum of Ig classes, specificities, and titers of serum antiglycoproteins in chronic idiopathic thrombocytopenic purpura. Blood 83 (1994) 1024-1032
4. van Leeuwen E.F., van der Ven J.T., Engelfriet C.P., and von dem Borne A.E. Specificity of autoantibodies in autoimmune thrombocytopenia. Blood 59 (1982) 23-26
5. Kuwana M., Okazaki Y., and Ikeda Y. Splenic macrophages maintain the anti-platelet autoimmune response via uptake of opsonized platelets in patients with immune thrombocytopenic purpura. J Thromb Haemost 7 (2009) 322-329
6. Olsson B., Andersson P.O., Jernas M., Jacobsson S., Carlsson B., Carlsson L.M., et al. T-cell-mediated cytotoxicity toward platelets in chronic idiopathic thrombocytopenic purpura. Nat Med 9 (2003) 1123-1124
7. Arnold D.M., Dentali F., Crowther M.A., Meyer R.M., Cook R.J., Sigouin C., et al. Systematic review: efficacy and safety of rituximab for adults with idiopathic thrombocytopenic purpura. Ann Intern Med 146 (2007) 25-33
8. Stasi R., Del Poeta G., Stipa E., Evangelista M.L., Trawinska M.M., Cooper N., et al. Response to B-cell depleting therapy with rituximab reverts the abnormalities of T-cell subsets in patients with idiopathic thrombocytopenic purpura. Blood 110 (2007) 2924-2930
9. McMillan R., Wang L., Tomer A., Nichol J., and Pistillo J. Suppression of in vitro megakaryocyte production by antiplatelet autoantibodies from adult patients with chronic ITP. Blood 103 (2004) 1364-1369
10. Houwerzijl E.J., Blom N.R., van der Want J.J., Esselink M.T., Koornstra J.J., Smit J.W., et al. Ultrastructural study shows morphologic features of apoptosis and para-apoptosis in megakaryocytes from patients with idiopathic thrombocytopenic purpura. Blood 103 (2004) 500-506
11. Olsson B., Ridell B., Carlsson L., Jacobsson S., and Wadenvik H. Recruitement of T celles into bone marrow of ITP patients possibly due to elevated expression of VLA-4 and CX3CR1. Blood 112 (2008) 1078-1084
12. Bussel J.B., Kuter D.J., George J.N., McMillan R., Aledort L.M., Conklin G.T., et al. AMG 531, a thrombopoiesis-stimulating protein, for chronic ITP. N Engl J Med 355 (2006) 1672-1681
13. Bussel J.B., Cheng G., Saleh M.N., Psaila B., Kovaleva L., Meddeb B., et al. Eltrombopag for the treatment of chronic idiopathic thrombocytopenic purpura. N Engl J Med 357 (2007) 2237-2247
14. Kuter D.J., Bussel J.B., Lyons R.M., Pullarkat V., Gernsheimer T.B., Senecal F.M., et al. Efficacy of romiplostim in patients with chronic immune thrombocytopenic purpura: a double-blind randomised controlled trial. Lancet 371 (2008) 395-403
15. Bussel J.B., Provan D., Shamsi T., Cheng G., Psaila B., Kovaleva L., et al. Effect of eltrombopag on platelet counts and bleeding during treatment of chronic idiopathic thrombocytopenic purpura: a randomised, double-blind, placebo-controlled trial. Lancet 373 (2009) 641-648
16. Godeau B., Provan D., and Bussel J. Current Opinion. Hematol J 14 (2007) 535-556
17. Rodeghiero F, Stasi R, Gernsheimer T, Michel M, Provan D, Arnold DM et al. Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura (ITP) of adults and children: report from an International Working Group. Blood 2009;113:2386-93.
18. Kojouri K., Vesely S.K., Terrell D.R., and George J.N. Splenectomy for adult patients with idiopathic thrombocytopenic purpura: a systematic review to assess long-term platelet count responses, prediction of response, and surgical complications. Blood 104 (2004) 2623-2634
19. Stasi R., and Provan D. Helicobacter pylori and chronic ITP. Hematology Am Soc Hematol Educ Program 2008 (2008) 206-211
20. Godeau B., Porcher R., Fain O., Lefrère F., Fenaux P., Cheze S., et al. Rituximab efficacy and safety in adult splenectomy candidates with chronic immune thrombocytopenic purpura: results of a prospective multicenter phase 2 study. Blood 112 (2008) 999-1004
21. Zaja F., Baccarani M., Mazza P., Vianelli N., Bocchia M., Gugliotta L., et al. A prospective randomized study comparing rituximab and dexamethasone VS dexamethasone alone in ITP: results of final analysis and long term follow-up. Blood (ASH annual meeting) 112 (2008) Abstract1
22. Zaja F., Battista M.L., Pirrotta M.T., Palmieri S., Montagna M., Vianelli N., et al. Lower dose rituximab is active in adult patients with idiopathic thrombocytopenic purpura. Haematologica 93 (2008) 930-933
23. Provan D., Butler T., Evangelista M.L., Amadori S., Newland A.C., and Stasi R. Activity and safety profile of low-dose rituximab for the treatment of autoimmune cytopenias in adults. Haematologica 92 (2007) 1695-1698
24. Calabrese L.H., Molloy E.S., Huang D.R., and Ransohoff R.M. Progressive multifocal leukoencephalopathy in rheumatic diseases. Arthritis Rheum 56 (2007) 2116-2128