Serum C-reactive Protein (CRP) levels in cancer patients are linked with tumor burden and are reduced by anti-hypertensive medication

Inflammation

Volumn 32, Issue 3, 2009, Pages 169-175

  Koukourakis, Michael I ^a   Kambouromiti, Georgia ^a   Pitsiava, Dimitra ^a   Tsousou, Pelagia ^a   Tsiarkatsi, Maria ^a   Kartalis, George ^a  

^a DEMOCRITUS UNIVERSITY OF THRACE   (Greece)

Author keywords

Cancer; Coronary disease; CRP; Hypertension; Obesity

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT; C REACTIVE PROTEIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR;

ADULT; ARTICLE; AUTOIMMUNE DISEASE; BREAST CANCER; CANCER INHIBITION; CANCER PATIENT; CORONARY ARTERY DISEASE; DIABETES MELLITUS; DISEASE ASSOCIATION; DRUG DOSE INCREASE; DRUG DOSE REDUCTION; FEMALE; GENDER; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; OBESITY; PROGNOSIS; PROTEIN BLOOD LEVEL; THYROID DISEASE; TUMOR VOLUME;

ANTIHYPERTENSIVE AGENTS; C-REACTIVE PROTEIN; CORONARY DISEASE; FEMALE; HUMANS; HYPERTENSION; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; NEOPLASMS; OBESITY; TUMOR BURDEN;

EID: 67349180253     PISSN: 03603997     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10753-009-9116-4     Document Type: Article

References (41)

1. W. S. Tillett T. Francis Jr 1930 Serological reactions in pneumonia with a nonprotein fraction of pneumococcus J. Exp. Med. 52 561 571 10.1084/jem.52.4.561
2. J. Hurlimann G. J. Thorbecke G. M. Hochwald 1966 The liver as the site of C-reactive protein formation J. Exp. Med. 123 365 378 10.1084/jem.123.2.365
3. B. Weinhold A. Bader V. Poli U. Rüther 1997 Interleukin-6 is necessary, but not sufficient, for induction of the human C-reactive protein gene in vivo Biochem. J. 325 617 621 (Pubitemid 27367749)
4. M. K. Ganapathi D. Rzewnicki D. Samols S. L. Jiang I. Kushner 1991 Effect of combinations of cytokines and hormones on synthesis of serum amyloid A and C-reactive protein in Hep 3B cells J. Immunol. 147 1261 1265
5. L. L. Marnell C. Mold M. A. Volzer R. W. Burlingame T. W. Du Clos 1995 C-reactive protein binds to Fc gamma RI in transfected COS cells J. Immunol. 155 2185 2193
6. C. Mold H. Gewurz T. W. Du Clos 1999 Regulation of complement activation by C-reactive protein Immunopharmacology 42 23 30 10.1016/S0162-3109(99)00007-7
7. F. A. Robey K. D. Jones T. Tanaka T. Y. Liu 1984 Binding of C-reactive protein to chromatin and nucleosome core particles. A possible physiological role of C-reactive protein J. Biol. Chem. 259 7311 7316 (Pubitemid 14077816)
8. T. W. Du Clos L. T. Zlock P. S. Hicks C. Mold 1994 Decreased autoantibody levels and enhanced survival of (NZB x NZW) F1 mice treated with C-reactive protein Clin. Immunol. Immunopathol. 70 22 27 10.1006/clin.1994.1005
9. D. Gershov S. Kim N. Brot K. B. Elkon 2000 C-Reactive protein binds to apoptotic cells, protects the cells from assembly of the terminal complement components, and sustains an antiinflammatory innate immune response: implications for systemic autoimmunity J. Exp. Med. 192 1353 1364 10.1084/jem.192.9.1353
10. K. K. Tsilidis C. Branchini E. Guallar K. J. Helzlsouer T. P. Erlinger E. A. Platz 2008 C-reactive protein and colorectal cancer risk: a systematic review of prospective studies Int. J. Cancer 123 1133 1140 10.1002/ijc.23606
11. C. Siemes L. E. Visser J. W. Coebergh T. A. Splinter J. C. Witteman A. G. Uitterlinden A. Hofman H. A. Pols B. H. Stricker 2006 C-reactive protein levels, variation in the C-reactive protein gene, and cancer risk: the Rotterdam Study J. Clin. Oncol. 24 5216 5222 10.1200/JCO.2006.07.1381
12. J. G. Lee B. C. Cho M. K. Bae C. Y. Lee I. K. Park D. J. Kim S. V. Ahn K. Y. Chung 2009 Preoperative C-reactive protein levels are associated with tumor size and lymphovascular invasion in resected non-small cell lung cancer Lung Cancer 63 106 110
13. H. M. Chiu J. T. Lin T. H. Chen Y. C. Lee Y. H. Chiu J. T. Liang C. T. Shun M. S. Wu 2008 Elevation of C-reactive protein level is associated with synchronous and advanced colorectal neoplasm in men Am. J. Gastroenterol. 103 2317 2325 10.1111/j.1572-0241.2008.01952.x
14. M. Groblewska B. Mroczko U. Wereszczyńska-Siemiatkowska B. Kedra M. Lukaszewicz A. Baniukiewicz M. Szmitkowski 2008 Serum interleukin 6 (IL-6) and C-reactive protein (CRP) levels in colorectal adenoma and cancer patients Clin. Chem. Lab. Med. 46 1423 1428 10.1515/CCLM.2008.278
15. Nakamura, R. M., E. S. Tucker III, and J. H. Carlson. 1991. Immunoassay in the clinical laboratory. In: John Bernard Henry. Clinical Diagnosis and Management by Laboratory method, 18th ed. New York, Part V, Chapter 34, pp 859-860.
16. H. W. Chung J. W. Kim J. H. Lee S. Y. Song J. B. Chung O. H. Kwon J. B. Lim 2009 Comparison of the validity of three biomarkers for gastric cancer screening: carcinoembryonic antigen, pepsinogens, and high sensitive C-reactive protein J. Clin. Gastroenterol 43 19 26 10.1016/S0140-6736(77)91719-6
17. R. C. Coombes T. J. Powles J. C. Gazet H. T. Ford J. P. Sloane D. J. Laurence A. M. Neville 1977 Biochemical markers in human breast cancer Lancet 1 132 134 10.1016/S0140-6736(77)91719-6 (Pubitemid 8015969)
18. S. A. Duffy J. M. Taylor J. E. Terrell M. Islam Y. Li K. E. Fowler G. T. Wolf T. N. Teknos 2008 Interleukin-6 predicts recurrence and survival among head and neck cancer patients Cancer 113 750 757 10.1002/cncr.23615
19. W. C. Liao J. T. Lin C. Y. Wu S. P. Huang M. T. Lin A. S. Wu Y. J. Huang M. S. Wu 2008 Serum interleukin-6 level but not genotype predicts survival after resection in stages II and III gastric carcinoma Clin. Cancer Res. 14 428 434 10.1158/1078-0432.CCR-07-1032
20. A. Macrì A. Versaci S. Loddo G. Scuderi M. Travagliante G. Trimarchi D. Teti C. Famulari 2006 Serum levels of interleukin 1beta, interleukin 8 and tumour necrosis factor alpha as markers of gastric cancer Biomarkers 11 184 193 10.1080/13547500600565677
21. A. W. Taylor N. O. Ku R. F. Mortensen 1990 Regulation of cytokine-induced human C-reactive protein production by transforming growth factor-beta J. Immunol. 145 2507 2513 (Pubitemid 20374571)
22. S. H. Yap H. J. Moshage B. P. Hazenberg H. M. Roelofs J. Bijzet P. C. Limburg L. A. Aarden M. H. van Rijswijk 1991 Tumor necrosis factor (TNF) inhibits interleukin (IL)-1 and/or IL-6 stimulated synthesis of C-reactive protein (CRP) and serum amyloid A (SAA) in primary cultures of human hepatocytes Biochim. Biophys. Acta 1091 405 408 10.1016/0167-4889(91)90207-E
23. J. Sainz E. Pérez S. Gómez-Lopera M. Jurado 2008 IL1 gene cluster polymorphisms and its haplotypes may predict the risk to develop invasive pulmonary aspergillosis and modulate c-reactive protein level J. Clin. Immunol. 28 473 485 10.1007/s10875-008-9197-0
24. J. P. Casas T. Shah A. D. Hingorani J. Danesh M. B. Pepys 2008 C-reactive protein and coronary heart disease: a critical review J. Intern. Med. 264 295 314 10.1111/j.1365-2796.2008.02015.x
25. J. S. Gortney R. M. Sanders 2007 Impact of C-reactive protein on treatment of patients with cardiovascular disease Am. J. Health Syst. Pharm. 64 2009 2016 10.2146/ajhp060542
26. E. Magen J. Mishal J. Paskin Z. Glick C. Yosefy M. Kidon M. Schlesinger 2008 Resistant arterial hypertension is associated with higher blood levels of complement c3 and C-reactive protein J. Clin. Hypertens. (Greenwich) 10 677 683 10.1111/j.1751-7176.2008.00002.x
27. H. Li T. Xu W. Tong Y. Liu L. Zhao Y. Zhang 2008 Comparison of cardiovascular risk factors between prehypertension and hypertension in a Mongolian population, inner Mongolia, China Circ. J. 72 1666 1673 10.1253/circj.CJ-08-0138
28. E. Nakou T. D. Filippatos E. N. Liberopoulos A. D. Tselepis D. N. Kiortsis D. P. Mikhailidis M. S. Elisaf 2008 Effects of sibutramine plus verapamil sustained release/trandolapril combination on blood pressure and metabolic variables in obese hypertensive patients Expert Opin. Pharmacother. 9 1629 1639 10.1517/14656566.9.10.1629
29. S. Rajagopalan F. Zannad A. Radauceanu R. Glazer Y. Jia M. F. Prescott M. Kariisa B. Pitt 2007 Effects of valsartan alone versus valsartan/simvastatin combination on ambulatory blood pressure, C-reactive protein, lipoproteins, and monocyte chemoattractant protein-1 in patients with hyperlipidemia and hypertension Am. J. Cardiol. 100 222 226 10.1016/j.amjcard.2007.02.085
30. W. Palmas S. Ma B. Psaty D. C. Goff Jr C. Darwin R. G. Barr 2007 Antihypertensive medications and C-reactive protein in the multi-ethnic study of atherosclerosis Am. J. Hypertens. 20 233 241 10.1016/j.amjhyper.2006.08.006
31. A. Schmeisser O. Soehnlein T. Illmer H. M. Lorenz S. Eskafi O. Roerick C. Gabler R. Strasser W. G. Daniel C. D. Garlichs 2004 ACE inhibition lowers angiotensin II-induced chemokine expression by reduction of NF-kappaB activity and AT1 receptor expression Biochem. Biophys. Res. Commun. 325 532 540 10.1016/j.bbrc.2004.10.059
32. J. R. Gage G. Fonarow M. Hamilton M. Widawski O. Martínez-Maza D. L. Vredevoe 2004 Beta blocker and angiotensin-converting enzyme inhibitor therapy is associated with decreased Th1/Th2 cytokine ratios and inflammatory cytokine production in patients with chronic heart failure Neuroimmunomodulation 11 173 180 10.1159/000076766
33. J. Yang J. Wang S. Zhu X. Chen H. Wu D. Yang J. Zhang 2008 C-reactive protein augments hypoxia-induced apoptosis through mitochondrion-dependent pathway in cardiac myocytes Mol. Cell. Biochem. 310 215 226 10.1007/s11010-007- 9683-3
34. A. Nabata M. Kuroki H. Ueba S. Hashimoto T. Umemoto H. Wada T. Yasu M. Saito S. Momomura M. Kawakami 2008 C-reactive protein induces endothelial cell apoptosis and matrix metalloproteinase-9 production in human mononuclear cells: implications for the destabilization of atherosclerotic plaque Atherosclerosis 196 129 135 10.1016/j.atherosclerosis.2007.03.003
35. J. Yang M. Wezeman X. Zhang P. Lin M. Wang J. Qian B. Wan L. W. Kwak L. Yu Q. Yi 2007 Human C-reactive protein binds activating Fcgamma receptors and protects myeloma tumor cells from apoptosis Cancer Cell. 12 252 265 10.1016/j.ccr.2007.08.008
36. M. Tatokoro K. Saito Y. Iimura Y. Fujii S. Kawakami K. Kihara 2008 Prognostic impact of postoperative C-reactive protein level in patients with metastatic renal cell carcinoma undergoing cytoreductive nephrectomy J. Urol. 180 515 519 10.1016/j.juro.2008.04.025
37. L. A. Hefler N. Concin G. Hofstetter C. Marth A. Mustea J. Sehouli R. Zeillinger H. Leipold H. Lass C. Grimm C. B. Tempfer A. Reinthaller 2008 Serum C-reactive protein as independent prognostic variable in patients with ovarian cancer Clin. Cancer Res. 14 710 714 10.1158/1078-0432.CCR-07-1044
38. Y. C. Shiu J. K. Lin C. J. Huang J. K. Jiang L. W. Wang H. C. Huang S. H. Yang 2008 Is C-reactive protein a prognostic factor of colorectal cancer Dis. Colon Rectum. 51 443 449 10.1007/s10350-007-9133-z
39. A. Sawaki Y. Kanemitsu N. Mizuno K. Takahashi T. Nakamura T. Ioka S. Tanaka A. Nakaizumi A. A. Salem R. Ueda K. Yamao 2008 Practical prognostic index for patients with metastatic pancreatic cancer treated with gemcitabine J. Gastroenterol. Hepatol. 23 1292 1297 10.1111/j.1440-1746.2006.04734.x
40. T. M. Beer A. S. Lalani S. Lee M. Mori K. M. Eilers J. G. Curd W. D. Henner C. W. Ryan P. Venner J. D. Ruether K. N. Chi 2008 ASCENT Investigators. C-reactive protein as a prognostic marker for men with androgen-independent prostate cancer: results from the ASCENT trial Cancer 112 2377 2383 10.1002/cncr.23461
41. S. Yoshida K. Saito F. Koga M. Yokoyama Y. Kageyama H. Masuda T. Kobayashi S. Kawakami K. Kihara 2008 C-reactive protein level predicts prognosis in patients with muscle-invasive bladder cancer treated with chemoradiotherapy BJU Int. 101 978 981 10.1111/j.1464-410X.2007.07408.x