C-reactive protein augments hypoxia-induced apoptosis through mitochondrion-dependent pathway in cardiac myocytes

Molecular and Cellular Biochemistry

Volumn 310, Issue 1-2, 2008, Pages 215-226

  Yang, Jin ^a   Wang, Junhong ^a   Zhu, Shushu ^a   Chen, Xiangjian ^a   Wu, Hengfang ^a   Yang, Di ^a   Zhang, Jinan ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Bax; Bcl 2; C reactive protein; Infarction; Mitochondria; Myocytes

Indexed keywords

C REACTIVE PROTEIN; CASPASE 3; CASPASE 9; CYTOCHROME C; MESSENGER RNA; PROTEIN BAX; PROTEIN BCL 2;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL HYPOXIA; CELL STIMULATION; CELL VIABILITY; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; HEART MITOCHONDRION; HEART MUSCLE CELL; HUMAN; NEWBORN; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SYNTHESIS INHIBITION; RAT;

AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BLOTTING, WESTERN; C-REACTIVE PROTEIN; CASPASE 3; CASPASE 9; CELL HYPOXIA; CYTOCHROMES C; ENZYME ACTIVATION; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION; HUMANS; MITOCHONDRIA; MOLECULAR SEQUENCE DATA; MYOCYTES, CARDIAC; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; TRANSFECTION;

RATTUS;

EID: 39949084693     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-007-9683-3     Document Type: Article

References (44)

1. Volanakis JE (2001) Human C-reactive protein: Expression, structure, and function. Mol Immunol 38:189-197
2. Albert CM, Ma J, Rifai N, Stampfer MJ et al (2002) Prospective study of C-reactive protein, homocysteine, and plasma lipid levels as predictors of sudden cardiac death. Circulation 105:2595-2599
3. Koenig W, Sund M, Frohlich M et al (1999) C-Reactive protein, a sensitive marker of inflammation, predicts future risk of coronary heart disease in initially healthy middle-aged men: Results from the MONICA (Monitoring Trends and Determinants in Cardiovascular Disease) Augsburg Cohort Study, 1984 to 1992. Circulation 99:237-242
4. Ridker PM, Cushman M, Stampfer MJ et al (1997) Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. N Engl J Med 336:973-979
5. Ridker PM, Hennekens CH, Buring JE et al (2000) C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med 342:836-843
6. Ridker PM, Stampfer MJ, Rifai N (2001) Novel risk factors for systemic atherosclerosis: A comparison of C-reactive protein, fibrinogen, homocysteine, lipoprotein(a), and standard cholesterol screening as predictors of peripheral arterial disease. JAMA 285:2481-2485
7. Wang J, Zhang S, Jin Y, Qin G et al (2007) Elevated levels of platelet-monocyte aggregates and related circulating biomarkers in patients with acute coronary syndrome. Int J Cardiol 115:361-365
8. Li L, Roumeliotis N, Sawamura T et al (2004) C-reactive protein enhances LOX-1 expression in human aortic endothelial cells: Relevance of LOX-1 to C-reactive protein-induced endothelial dysfunction. Circ Res 95:877-883
9. Suh W, Kim KL, Choi JH et al (2004) C-reactive protein impairs angiogenic functions and decreases the secretion of arteriogenic chemo-cytokines in human endothelial progenitor cells. Biochem Biophys Res Commun 321:65-71
10. Verma S, Wang CH, Li SH et al (2002) A self-fulfilling prophecy: C-reactive protein attenuates nitric oxide production and inhibits angiogenesis. Circulation 106:913-919
11. Verma S, Kuliszewski MA, Li SH et al (2004) C-reactive protein attenuates endothelial progenitor cell survival, differentiation, and function: Further evidence of a mechanistic link between C-reactive protein and cardiovascular disease. Circulation 109:2058-2067
12. Venugopal SK, Devaraj S, Yuhanna I et al (2002) Demonstration that C-reactive protein decreases eNOS expression and bioactivity in human aortic endothelial cells. Circulation 106:1439-1441
13. Devaraj S, Kumaresan PR, Jialal I (2004) Effect of C-reactive protein on chemokine expression in human aortic endothelial cells. J Mol Cell Cardiol 36:405-410
14. Devaraj S, Xu DY, Jialal I (2003) C-reactive protein increases plasminogen activator inhibitor-1 expression and activity in human aortic endothelial cells: Implications for the metabolic syndrome and atherothrombosis. Circulation 107:398-404
15. Wang Q, Zhu X, Xu Q et al (2005) Effect of C-reactive protein on gene expression in vascular endothelial cells. Am J Physiol Heart Circ Physiol 288:H1539-H1545
16. Pepys MB, Hirschfield GM, Tennent GA et al (2006) Targeting C-reactive protein for the treatment of cardiovascular disease. Nature 440:1217-1221
17. Gershov D, Kim S, Brot N et al (2000) C-Reactive protein binds to apoptotic cells, protects the cells from assembly of the terminal complement components, and sustains an antiinflammatory innate immune response: Implications for systemic autoimmunity. J Exp Med 192:1353-1364
18. Griselli M, Herbert J, Hutchinson WL et al (1999) C-reactive protein and complement are important mediators of tissue damage in acute myocardial infarction. J Exp Med 190:1733-1740
19. Kang PM, Haunstetter A, Aoki H et al (2000) Morphological and molecular characterization of adult cardiomyocyte apoptosis during hypoxia and reoxygenation. Circ Res 87:118-125
20. Crow MT, Mani K, Nam YJ et al (2004) The mitochondrial death pathway and cardiac myocyte apoptosis. Circ Res 95:957-970
21. Misao J, Hayakawa Y, Ohno M et al (1996) Expression of bcl-2 protein, an inhibitor of apoptosis, and Bax, an accelerator of apoptosis, in ventricular myocytes of human hearts with myocardial infarction. Circulation 94:1506-1512
22. Chen Z, Chua CC, Ho YS et al (2001) Overexpression of Bcl-2 attenuates apoptosis and protects against myocardial I/R injury in transgenic mice. Am J Physiol Heart Circ Physiol 280:H2313-H2320
23. World Medical Association Declaration of Helsinki (1997) Recommendations guiding physicians in biomedical research involving human subjects. Cardiovasc Res 35:2-3
24. Dong W, Jin GH, Li SF et al (2006) Cross-linked polyethylenimine as potential DNA vector for gene delivery with high efficiency and low cytotoxicity. Acta Biochim Biophys Sin (Shanghai) 38:780-787
25. Li S, Dong W, Zong Y et al (2007) Polyethylenimine-complexed plasmid particles targeting focal adhesion kinase function as melanoma tumor therapeutics. Mol Ther 15:515-523
26. Matoba S, Tatsumi T, Keira N et al (1999) Cardioprotective effect of angiotensin-converting enzyme inhibition against hypoxia/reoxygenation injury in cultured rat cardiac myocytes. Circulation 99:817-822
27. de Beer FC, Hind CR, Fox KM et al (1982) Measurement of serum C-reactive protein concentration in myocardial ischaemia and infarction. Br Heart J 47:239-243
28. Lagrand WK, Niessen HW, Wolbink GJ et al (1997) C-reactive protein colocalizes with complement in human hearts during acute myocardial infarction. Circulation 95:97-103
29. Gill R, Kemp JA, Sabin C, Pepys MB (2004) Human C-reactive protein increases cerebral infarct size after middle cerebral artery occlusion in adult rats. J Cereb Blood Flow Metab 24:1214-1218
30. Chaudhuri A, Janicke D, Wilson MF, Tripathy D et al (2004) Anti-inflammatory and profibrinolytic effect of insulin in acute ST-segment-elevation myocardial infarction. Circulation 109:849-854
31. Visser L, Zuurbier CJ, Hoek FJ, Opmeer BC et al (2005) Glucose, insulin and potassium applied as perioperative hyperinsulinaemic normoglycaemic clamp: Effects on inflammatory response during coronary artery surgery. Br J Anaesth 95:448-457
32. Yaoita H, Ogawa K, Maehara K et al (1998) Attenuation of ischemia/ reperfusion injury in rats by a caspase inhibitor. Circulation 97:276-281
33. Holly TA, Drincic A, Byun Y et al (1999) Caspase inhibition reduces myocyte cell death induced by myocardial ischemia and reperfusion in vivo. J Mol Cell Cardiol 31:1709-1715
34. Liu C, Wang S, Deb A et al (2005) Proapoptotic, antimigratory, antiproliferative, and antiangiogenic effects of commercial C-reactive protein on various human endothelial cell types in vitro: Implications of contaminating presence of sodium azide in commercial preparation. Circ Res 97:135-143
35. Danesh J, Wheeler JG, Hirschfield GM, Eda S et al (2004) C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease. N Engl J Med 350:1387-1397
36. Malik S, Wong ND, Franklin S, Pio J et al (2005) Cardiovascular disease in U.S. patients with metabolic syndrome, diabetes, and elevated C-reactive protein. Diabetes Care 28:690-693
37. Gabay C, Kushner I (1999) Acute-phase proteins and other systemic responses to inflammation. N Engl J Med 340:448-454
38. Calabro P, Willerson JT, Yeh ET (2003) Inflammatory cytokines stimulated C-reactive protein production by human coronary artery smooth muscle cells. Circulation 108:1930-1932
39. Haider DG, Leuchten N, Schaller G et al (2006) C-reactive protein is expressed and secreted by peripheral blood mononuclear cells. Clin Exp Immunol 146:533-539
40. Blaschke F, Bruemmer D, Yin F et al (2004) C-reactive protein induces apoptosis in human coronary vascular smooth muscle cells. Circulation 110:579-587
41. Ikeda U, Maeda Y, Yamamoto K et al (2002) C-Reactive protein augments inducible nitric oxide synthase expression in cytokine-stimulated cardiac myocytes. Cardiovasc Res 56:86-92
42. Green DR, Reed JC (1998) Mitochondria and apoptosis. Science 281:1309-1312
43. Bialik S, Cryns VL, Drincic A et al (1999) The mitochondrial apoptotic pathway is activated by serum and glucose deprivation in cardiac myocytes. Circ Res 85:403-414
44. Oltvai ZN, Milliman CL, Korsmeyer SJ (1993) Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74:609-619