An initial investigation of the orbitofrontal cortex hyperactivity in obsessive-compulsive disorder: Exaggerated representations of anticipated aversive events?

Neuropsychologia

Volumn 47, Issue 10, 2009, Pages 2145-2148

  Ursu, Stefan ^a   Carter, Cameron S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Anxiety; Continuous performance task; Errors; Executive control; Negative affect; Orbital cortex; Prefrontal cortex

Indexed keywords

ADULT; ARTICLE; AVERSION; CLINICAL ARTICLE; COGNITION; CONTROLLED STUDY; DISEASE SEVERITY; ELECTROENCEPHALOGRAM; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; HYPERACTIVITY; MALE; OBSESSIVE COMPULSIVE DISORDER; ORBITAL CORTEX; TASK PERFORMANCE;

ADOLESCENT; ADULT; AFFECT; ANALYSIS OF VARIANCE; ATTENTION; CONFLICT (PSYCHOLOGY); FEMALE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; OBSESSIVE-COMPULSIVE DISORDER; OXYGEN; PHOTIC STIMULATION; PREFRONTAL CORTEX; PSYCHIATRIC STATUS RATING SCALES; REACTION TIME; YOUNG ADULT;

EID: 67349175620     PISSN: 00283932     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropsychologia.2009.03.018     Document Type: Article

References (32)

1. Alptekin K., Degirmenci B., Kivircik B., Durak H., Yemez B., Derebek E., et al. Tc-99m HMPAO brain perfusion SPECT in drug-free obsessive-compulsive patients without depression. Psychiatry Research 107 1 (2001) 51-56
2. Botvinick M.M. Conflict monitoring and decision making: reconciling two perspectives on anterior cingulate function. Cognitive, Affective & Behavioral Neuroscience 7 4 (2007) 356-366
3. Brody A.L., Saxena S., Fairbanks L.A., Alborzian S., Demaree H.A., Maidment K.M., et al. Personality changes in adult subjects with major depressive disorder or obsessive-compulsive disorder treated with paroxetine. Journal of Clinical Psychiatry 61 5 (2000) 349-355
4. Carter C.S., Braver T.S., Barch D.M., Botvinick M.M., Noll D., and Cohen J.D. Anterior cingulate cortex, error detection, and the online monitoring of performance. Science 280 5364 (1998) 747-749
5. Carter C.S., Macdonald A.M., Botvinick M., Ross L.L., Stenger V.A., Noll D., et al. Parsing executive processes: strategic vs. evaluative functions of the anterior cingulate cortex. Proceedings of the National Academy of Science of the United States of America 97 4 (2000) 1944-1948
6. Critchley H.D., Mathias C.J., and Dolan R.J. Neural activity in the human brain relating to uncertainty and arousal during anticipation. Neuron 29 2 (2001) 537-545
7. Forman S.D., Cohen J.D., Fitzgerald M., Eddy W.F., Mintun M.A., and Noll D.C. Improved assessment of significant activation in functional magnetic resonance imaging (fMRI): use of a cluster-size threshold. Magnetic Resonance in Medicine 33 5 (1995) 636-647
8. Goodman W.K., Price L.H., Rasmussen S.A., Mazure C., Fleischmann R.L., Hill C.L., et al. The Yale-Brown Obsessive Compulsive Scale. I. Development, use, and reliability. Archives of General Psychiatry 46 11 (1989) 1006-1011
9. Kwon J.S., Kim J.J., Lee D.W., Lee J.S., Lee D.S., Kim M.S., et al. Neural correlates of clinical symptoms and cognitive dysfunctions in obsessive-compulsive disorder. Psychiatry Research 122 1 (2003) 37-47
10. MacDonald III A.W., Cohen J.D., Stenger V.A., and Carter C.S. Dissociating the role of the dorsolateral prefrontal and anterior cingulate cortex in cognitive control. Science 288 5472 (2000) 1835-1838
11. Maltby N., Tolin D.F., Worhunsky P., O'Keefe T.M., and Kiehl K.A. Dysfunctional action monitoring hyperactivates frontal-striatal circuits in obsessive-compulsive disorder: an event-related fMRI study. Neuroimage 24 2 (2005) 495-503
12. O'Doherty J., Kringelbach M.L., Rolls E.T., Hornak J., and Andrews C. Abstract reward and punishment representations in the human orbitofrontal cortex. Nature Neuroscience 4 1 (2001) 95-102
13. Rapoport J.L. Recent advances in obsessive-compulsive disorder [see comments]. Neuropsychopharmacology 5 1 (1991) 1-10
14. Rauch S.L. Neuroimaging research and the neurobiology of obsessive-compulsive disorder: where do we go from here?. Biological Psychiatry 47 3 (2000) 168-170
15. Rauch S.L., Jenike M.A., Alpert N.M., Baer L., Breiter H.C., Savage C.R., et al. Regional cerebral blood flow measured during symptom provocation in obsessive-compulsive disorder using oxygen 15-labeled carbon dioxide and positron emission tomography [see comments]. Archives of General Psychiatry 51 1 (1994) 62-70
16. Rauch S.L., Savage C.R., Alpert N.M., Fischman A.J., and Jenike M.A. The functional neuroanatomy of anxiety: a study of three disorders using positron emission tomography and symptom provocation. Biological Psychiatry 42 6 (1997) 446-452
17. Rauch S.L., Shin L.M., Dougherty D.D., Alpert N.M., Fischman A.J., and Jenike M.A. Predictors of fluvoxamine response in contamination-related obsessive compulsive disorder: a PET Symptom Provocation Study. Neuropsychopharmacology 27 5 (2002) 782-791
18. Rauch S.L., Wedig M.M., Wright C.I., Martis B., McMullin K.G., Shin L.M., et al. Functional magnetic resonance imaging study of regional brain activation during implicit sequence learning in obsessive-compulsive disorder. Biological Psychiatry 61 3 (2007) 330-336
19. Remijnse P.L., Nielen M.M., Uylings H.B., and Veltman D.J. Neural correlates of a reversal learning task with an affectively neutral baseline: an event-related fMRI study. Neuroimage 26 2 (2005) 609-618
20. Remijnse P.L., Nielen M.M., van Balkom A.J., Cath D.C., van Oppen P., Uylings H.B., et al. Reduced orbitofrontal-striatal activity on a reversal learning task in obsessive-compulsive disorder. Archives of General Psychiatry 63 11 (2006) 1225-1236
21. Saxena S., Brody A.L., Schwartz J.M., and Baxter L.R. Neuroimaging and frontal-subcortical circuitry in obsessive-compulsive disorder. British Journal of Psychiatry Suppl. 35 (1998) 26-37
22. Saxena S., Brody A.L., Maidment K.M., Dunkin J.J., Colgan M., Alborzian S., et al. Localized orbitofrontal and subcortical metabolic changes and predictors of response to paroxetine treatment in obsessive-compulsive disorder. Neuropsychopharmacology 21 6 (1999) 683-693
23. Saxena S., Brody A.L., Ho M.L., Zohrabi N., Maidment K.M., and Baxter Jr. L.R. Differential brain metabolic predictors of response to paroxetine in obsessive-compulsive disorder versus major depression. The American Journal of Psychiatry 160 3 (2003) 522-532
24. Saxena S., Brody A.L., Maidment K.M., Smith E.C., Zohrabi N., Katz E., et al. Cerebral glucose metabolism in obsessive-compulsive hoarding. The American Journal of Psychiatry 161 6 (2004) 1038-1048
25. Schwartz J.M., Stoessel P.W., Baxter Jr. L.R., Martin K.M., and Phelps M.E. Systematic changes in cerebral glucose metabolic rate after successful behavior modification treatment of obsessive-compulsive disorder. Archives of General Psychiatry 53 2 (1996) 109-113
26. Simmons A., Strigo I., Matthews S.C., Paulus M.P., and Stein M.B. Anticipation of aversive visual stimuli is associated with increased insula activation in anxiety-prone subjects. Biological Psychiatry 60 4 (2006) 402-409
27. Spielberger C.D., Gorsuch R.L., Lushene R., Vagg P.R., and Jacobs G.A. Manual for the state-trait anxiety inventory (1980), Consulting Psychology Press, Palo Alto
28. Stein M.B., Simmons A.N., Feinstein J.S., and Paulus M.P. Increased amygdala and insula activation during emotion processing in anxiety-prone subjects. The American Journal of Psychiatry 164 2 (2007) 318-327
29. Swedo S.E., Schapiro M.B., Grady C.L., Cheslow D.L., Leonard H.L., Kumar A., et al. Cerebral glucose metabolism in childhood-onset obsessive-compulsive disorder. Archives of General Psychiatry 46 6 (1989) 518-523
30. Swedo S.E., Pietrini P., Leonard H.L., Schapiro M.B., Rettew D.C., Goldberger E.L., et al. Cerebral glucose metabolism in childhood-onset obsessive-compulsive disorder: revisualization during pharmacotherapy. Archives of General Psychiatry 49 9 (1992) 690-694
31. Ursu S., and Carter C.S. Outcome representations, counterfactual comparisons and the human orbitofrontal cortex: implications for neuroimaging studies of decision-making. Brain Research. Cognitive Brain Research 23 1 (2005) 51-60
32. Ursu S., Stenger V.A., Shear M.K., Jones M.R., and Carter C.S. Overactive action monitoring in obsessive-compulsive disorder: evidence from functional magnetic resonance imaging. Psychological Science 14 4 (2003) 347-353